ライフサイエンスコーパス: IPP

1 IPP also induced the rapid and persistent phosphorylatio

2 IPP is produced by the mevalonate pathway in archaea, fu

3 IPP isomerase activity could not be demonstrated for the

4 he sll1556 gene, distantly related to type 2 IPP isomerase genes, was disrupted by insertion of a Kan

5 nth compared to nonpandemic periods in 5-24 (IPP rate per 10 million: 48 vs 9 (95% confidence interva

6 When (R)-[2-2H]IPP was a substrate for chain elongation, no deuterium w

7 In contrast, the deuterium in (S)-[2-2H]IPP was incorporated into all of the products.

8 er stopped-flow experiments using (R)-[2-2H]-IPP.

9 A 3kb IPP cDNA clone was isolated from a human placenta librar

10 insight into the lack of cooperativity by 4-IPP and into tuning the properties of the covalent inhib

11 e have identified four unique congeners of 4-IPP that exhibit MIF inhibitory activity at concentratio

12 ons 10x to 20x lower than that of parental 4-IPP.

13 very different, 4-iodo-6-phenylpyrimidine (4-IPP) forms a covalent bond with Pro-1 of both proteins,

14 this compound, 4-iodo-6-phenylpyrimidine (4-IPP), is approximately 5x to 10x times more potent in bl

15 the overall database, which includes 185 446 IPPs and approximately 1.5 billion NIPs from five primar

16 on the ability of rubber transferase to add IPP to the allylic diphosphate initiator were determined

17 The importance of influenza for adult IPP varies by serotype and host comorbidity.

18 ified in three steps, and its identity as an IPP isomerase was established biochemically.

19 V lambda sequences within the confines of an IPP follicle.

20 rase) were isolated by complementation of an IPP isomerase mutant strain of Saccharomyces cerevisiae.

21 Ablation of BB and IPP decreased RA DF from 10.9+/-1.2 to 9.0+/-1.5 Hz (P<0

22 BB and IPP were subsequently ablated.

23 n 81+/-5% and 80+/-10% of cases along BB and IPP, respectively.

24 -right decrease in DFs occurred along BB and IPP, resulting in an LA-right atrium (RA) frequency grad

25 d, influenza-associated hospitalizations and IPP cases (pneumococcus isolated from normally sterile s

26 Thus, the IP and IPP protocols coupled with the ability to isolate GGT+ a

27 nalogues for DMAPP (E-2-OPP and Z-2-OPP) and IPP (4-OPP) were synthesized and found to be potent acti

28 VPP and IPP largely prevailed in almost all cheeses.

29 treated neutrophils produced little, if any, IPP and expressed much lower levels of farnesyl pyrophos

30 entified in this study, including PPL, APPH, IPP and PPG with corresponding IC50 values of 2.86, 3.95

31 gest that only pyrophosphomonoesters such as IPP are true Vgamma9Vdelta2 T-cell agonists, whereas alk

32 karyotes, archaebacteria, and some bacteria, IPP is synthesized from acetyl coenzyme A by the mevalon

33 o form geranyl diphosphate (GPP) and between IPP and GPP to give farnesyl diphosphate (FPP).

34 inhibited by statin treatment, which blocks IPP production.

35 nactive oxidized flavin-enzyme complex bound IPP in a Mg2+-dependent manner for which KD approximatel

36 knockdown of BTN3A1 abolished stimulation by IPP that could be restored by re-expression of BTN3A1 bu

37 the cyanobacterium, nor did it affect [(14)C]IPP incorporation stimulated by DHAP plus GA3P.

38 lity to catalyze the isomerization of [(14)C]IPP to [(14)C]DMAPP.

39 ctivity; K(m)(IPP) was 52 microM, and k(cat)(IPP) was 0.23 s(-1).

40 Vgamma2Vdelta2 cells and increased cellular IPP.

41 We compared IPP rates during peak pandemic months (April 2009-March

42 plasmid-encoded copy of the ORF complemented IPP isomerase activity in vivo in Salmonella enterica se

43 compared with one subjected to the complete IPP protocol.

44 inhibitory potential at peak concentration (IPP), which integrates IC(50), slope, and peak concentra

45 In contrast, IPP is synthesized by a mevalonate-independent pathway i

46 s, which are isomerized to the corresponding IPP derivatives.

47 PP) from two molecules of DMAPP, and couples IPP to DMAPP to give GPP.

48 PP labeled with 1 mol of deuterium at C-2 (d-IPP).

49 (d-DMAPP) is slower than its conversion to d-IPP.

50 The alpha D60N-IPP-Ser alpha 2 beta 2 complex does not undergo the foll

51 L-serine bound to the beta-site (alpha D60N-IPP-Ser), and this structure is compared with that of th

52 t been possible to unequivocally demonstrate IPP isomerase activity in this cyanobacterium.

53 9-fold and reduced isopentenyl diphosphate (IPP) accumulation by 4-fold.

54 n reactions between isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) to form geran

55 interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), the basic bu

56 interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), the basic fi

57 Archaea synthesize isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), the essentia

58 ate and pyruvate to isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), where it int

59 trate analogues for isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), where the C3

60 interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).

61 ay for synthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).

62 ay branches to form isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).

63 interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).

64 prenoid precursors: isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).

65 d diphosphates from isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).

66 interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP).

67 of all terpenoids, isopentenyl diphosphate (IPP) and dimethylallyl diphosphate, are derived from two

68 oprenoid precursors isopentenyl diphosphate (IPP) and dimethylallyl diphosphate.

69 also forms between isopentenyl diphosphate (IPP) and GcpE.

70 ne building blocks, isopentenyl diphosphate (IPP) and its isomer dimethylallyl diphosphate (DMAPP), t

71 on building blocks, isopentenyl diphosphate (IPP) and its isomer dimethylallyl diphosphate (DMAPP), w

72 ase (IDI) activates isopentenyl diphosphate (IPP) for polymerization by converting it to its highly n

73 lyl diphosphate and isopentenyl diphosphate (IPP) in a reaction catalyzed by homodimeric or heterodim

74 talyzed reaction of isopentenyl diphosphate (IPP) in D(2)O gives a 66% yield of dimethylallyl diphosp

75 phate acceptor with isopentenyl diphosphate (IPP) in the cis (Z) configuration to generate linear pol

76 rbon double bond in isopentenyl diphosphate (IPP) in the primary building reactions in the isoprenoid

77 Isopentenyl diphosphate (IPP) is the central intermediate in the biosynthesis of

78 Isopentenyl diphosphate (IPP) isomerase catalyzes an essential activation step in

79 Type II isopentenyl diphosphate (IPP) isomerase catalyzes the interconversion of IPP and

80 a putative type II isopentenyl diphosphate (IPP) isomerase.

81 ion of thousands of isopentenyl diphosphate (IPP) molecules to an allylic diphosphate initiator, such

82 soprenoid precursor isopentenyl diphosphate (IPP) proceeds via two distinct pathways.

83 e (FPP) by coupling isopentenyl diphosphate (IPP) to dimethylallyl diphosphate (DMAPP) and then to ge

84 ntial conversion of isopentenyl diphosphate (IPP) to dimethylallyl diphosphate (DMAPP) in the mevalon

85 te pathway produces isopentenyl diphosphate (IPP), a building block for polyisoprenoid synthesis, and

86 sphate analogues of isopentenyl diphosphate (IPP), dimethylallyl diphosphate (DMAPP), geranyl diphosp

87 monoesters, such as isopentenyl diphosphate (IPP), nitrogen-containing bisphosphonates (N-BPs), and a

88 ive condensation of isopentenyl diphosphate (IPP), with farnesyl diphosphate catalysed by a cis-isopr

89 bolic intermediate, isopentenyl diphosphate (IPP).

90 of two molecules of isopentenyl diphosphate (IPP).

91 oid building block, isopentenyl diphosphate (IPP).

92 (MVAPP), producing isopentenyl diphosphate (IPP).

93 identified type II isopentenyl diphosphate (IPP):dimethylallyl diphosphate (DMAPP) isomerase (IDI-2)

94 Isopentenyl diphosphate (IPP):dimethylallyl diphosphate isomerase catalyzes the i

95 il condensations of isopentenyl diphosphate (IPP, C5) with dimethylallyl diphosphate (DMAPP, C5) and

96 ux amplification to isopentenyl-diphosphate (IPP) and dimethylallyl-diphosphate (DMAPP) precursors of

97 to the homoallylic (isopentenyl diphosphate, IPP) site, not to the allosteric site, whereas zoledrona

98 e determining step in the forward direction (IPP to DMAPP) occurs prior to DMAPP formation.

99 the combination of lytB and a cDNA encoding IPP isomerase (ipi) was no more effective in enhancing c

100 Two cDNAs encoding IPP isomerase in Haematococcus, ipiHp1 and ipiHp2, were

101 highly conserved regions in three eukaryotic IPP isomerases revealed substantial similarity with ORF1

102 actions with DMAPP in the presence of excess IPP and by comparing the steady-state kinetic constants

103 Somatic hypermutation was very low in fetal IPP and the IPP of germ-free piglets but increased 3- to

104 rink, 6.9 mg L(-1) for VPP, 6.1 mg L(-1) for IPP, 0.8 mg L(-1) for LPP and 3.2 mg L(-1) for FP were d

105 es were synthesized by joining fragments for IPP and the allylic diphosphates with a C-C bond between

106 additional putative open reading frames for IPP isomerase in seed-bearing plants (Oryza sativa, Arab

107 The gene for IPP isomerase, idi, is not clustered with other known ge

108 at eukaryotes have inherited their genes for IPP biosynthesis from prokaryotes.

109 mploy exclusively the mevalonate pathway for IPP biosynthesis.

110 ce of the non-mevalonate DXP/MEP pathway for IPP synthesis in latex was noted by up-regulation of the

111 lDMAPP) (with IPP) were similar to those for IPP and DMAPP; however, values of k(cat) for both analog

112 lex, but the quaternary complex, UPPS.TA.FPP.IPP, cannot be formed.

113 distinct biosynthetic pathways can generate IPP; the cytosolic mevalonate pathway and the plastid-as

114 Higher IPP rates occurred during the peak pandemic month compar

115 hromosomal knockouts in the genes for type I IPP isomerase (idi) and 1-deoxy-D-xylulose 5-phosphate (

116 Type I IPP isomerase (IDI-1) utilizes a divalent metal in a pro

117 Type I IPP isomerase (IDI-1) utilizes a divalent metal in a pro

118 e type II enzyme and the well-studied type I IPP isomerase are identical, the type II protein require

119 e kinetic constants for the archaeal type II IPP isomerase from M. thermautotrophicus are as follows:

120 Recombinant type II IPP isomerase from Thermus thermophilus HB27 was purifie

121 His6-tagged M. thermautotrophicus type II IPP isomerase was produced in Escherichia coli and purif

122 flavin, has not been established for type II IPP isomerase.

123 hermautotrophicus encodes a putative type II IPP isomerase.

124 If allosteric activation of type II IPPs by PI(4)P and PS is a widespread feature of the gro

125 tonation of the carbon-carbon double bond in IPP or DMAPP to form a tertiary carbocation, followed by

126 a C-C bond between the methyl group at C3 in IPP and the Z-methyl group at C3 in DMAPP (3-OPP) and GP

127 both conventional and novel PKC isoforms in IPP-induced proliferation, CD25 expression, and cytokine

128 can be partially suppressed by a mutation in IPP-5, an inositol polyphosphate 5-phosphatase, indicati

129 J signal joint circles were not recovered in IPP, and V-DJ signal joint circles were 5-fold lower tha

130 s all of the enzymes required to incorporate IPP into the ultimate carotenoid and bacteriochlorophyll

131 cause 20.1 treatment of APC did not increase IPP levels.

132 tabolite, appears to enter cells to increase IPP levels, whereas the alcohol of HMBPP and alkenyl pho

133 n the mevalonate pathway, thereby increasing IPP/triphosphoric acid 1-adenosin-5'-yl ester 3-(3-methy

134 igate follicular diversification, individual IPP follicles were isolated by microdissection; VA diver

135 In installing IPP, tourniquets were positioned around both thighs, and

136 itor that increases endogenous intracellular IPP.

137 hodnius prolixus IPPRp exists as an isolated IPP domain which is secreted into the saliva of this blo

138 encoding isopentenyl diphosphate isomerase (IPP isomerase) were isolated by complementation of an IP

139 osphate:dimethylallyl diphosphate isomerase (IPP isomerase; EC 5.3.3.2) is presumed to have a cytosol

140 ro in the presence isopentenylpyrophosphate (IPP), induce NK cell-mediated killing of tumors that are

141 netics and mechanism of p-isopropenylphenol (IPP) synthesis via bisphenol A (BPA) cleavage in HTW.

142 3 micromol min(-1) mg(-1) at pH 8.0 with a K(IPP)(m) value of 22.8 microm IPP.

143 the presence of the same ligands (beta K87T-IPP-Ser).

144 ary lymphoid tissues between piglets lacking IPP and colonized controls, whereas both groups displaye

145 ononucleotide, and Mg(2+) for activity; K(m)(IPP) was 52 microM, and k(cat)(IPP) was 0.23 s(-1).

146 demic months (April 2009-March 2010) to mean IPP rates in nonpandemic years (April 2004-March 2009) a

147 pH 8.0 with a K(IPP)(m) value of 22.8 microm IPP.

148 logenetically distant GGPPS and can modulate IPP flux distribution between GPP and GGPP synthesis in

149 seasonal influenza rates included, observed IPP rates during the pandemic peak were within the predi

150 in the closed conformation in the absence of IPP.

151 mmon mechanism involving the accumulation of IPP.

152 thway) and the intracellular accumulation of IPP.

153 culture medium with the alcohol analogues of IPP and DMAPP (3-methyl-3-buten-1-ol and 3-methyl-2-bute

154 pectral changes indicate that the binding of IPP, DMAPP, and a saturated analogue isopentyl diphospha

155 er, these data suggest that the C2-H bond of IPP is cleaved in the rate determining step and that gen

156 Thus, the pro-R hydrogen at C2 of IPP is lost when the E- and Z-double bond isomers are fo

157 the cloning and initial characterization of IPP, a novel human gene that predicts a kelch family pro

158 ying a critical role in the deprotonation of IPP en route to DMAPP formation.

159 d specifically by the kelch repeat domain of IPP.

160 ibiting the mevalonate pathway downstream of IPP synthesis.

161 Expression of IPP isomerase, and of two enzymes specific to the carote

162 The temporal and spatial expression of IPP-5 is consistent with its proposed inhibition of IP(3

163 data for BPA disappearance and formation of IPP and phenol and accurately predicted the yield of the

164 catalyzing the final step, the formation of IPP.

165 ave cloned the rat and hamster homologues of IPP isomerase and identified the signal that targets thi

166 Incubation of IPP with 3-ClDMAPP gave 11-ClFPP as the sole product.

167 ) isomerase catalyzes the interconversion of IPP and dimethylallyl diphosphate (DMAPP).

168 matography, catalyzed the interconversion of IPP and dimethylallyl diphosphate.

169 any Bacteria, catalyzes the isomerization of IPP and DMAPP by a protonation-deprotonation mechanism.

170 sm for the enzyme-catalyzed isomerization of IPP and DMAPP.

171 The subsequent isomerization of IPP to DMAPP activates the five-carbon isoprene unit for

172 till likely to catalyze the isomerization of IPP to DMAPP.

173 se catalyzes the reversible isomerization of IPP to produce dimethylallyl pyrophosphate, the initial

174 refore rate determining for isomerization of IPP with a rate constant k(dis) approximately k(cat) = 0

175 evidence for the subcellular localization of IPP isomerase, in this study, we have cloned the rat and

176 Redox potentials of IPP-bound enzyme indicate that the neutral semiquinone s

177 and reoxidation processes in the presence of IPP and related analogues.

178 emiquinone, but evidence for the presence of IPP-based radicals could not be obtained by EPR spectros

179 n analogues were observed in the presence of IPP.

180 Next, we expressed a fusion protein of IPP isomerase and the phosphatase (Idi1~NudB) along with

181 However, high rates of IPP incorporation were obtained with addition of dihydro

182 than ipi alone, indicating that the ratio of IPP and DMAPP produced via the DOXP pathway is influence

183 The steady-state equilibrium ratio of IPP/DMAPP in the enzymatic reactions was approximately 1

184 Two distinct routes of IPP biosynthesis occur in nature: the mevalonate pathway

185 Cp[b]Pyr ligand produced the first sample of IPP with all the steric pentad intensities fitting the e

186 Synthesis of IPP, an isoprenoid precursor molecule that is a critical

187 ibitors bind in a fashion similar to that of IPP.

188 The trafficking of IPP occurs unidirectionally from the plastids to cytosol

189 ctivate the enzyme for multiple turnovers of IPP to DMAPP.

190 E)-methyl group (d-DMAPP) and a 34% yield of IPP labeled with 1 mol of deuterium at C-2 (d-IPP).

191 idities, influenza had the largest impact on IPP incidence among low-invasiveness serotypes (influenz

192 Only one substrate, FPP or IPP, is able to bind to the UPPS.TA complex, but the qua

193 T cells in medium containing zoledronate or IPP strongly increased SF-derived fibroblasts' apoptosis

194 lutamate active-site residues found in other IPP isomerases.

195 -use data sets of interacting protein pairs (IPPs), non-interacting protein pairs (NIPs) and associat

196 e integrin-linked kinase (ILK)-PINCH-parvin (IPP) complex interacts with the cytoplasmic domain of be

197 ttle was studied in the ileal Peyer's patch (IPP) follicles of young calves and in the spleens of lat

198 The continuous ileal Peyer's patches (IPP) of sheep are regarded as a type of mammalian bursal

199 ma transcripts in the ileal Peyer's patches (IPPs) and mesenteric lymph nodes but on average only app

200 bundle (BB) and the inferoposterior pathway (IPP) during AF.

201 The well-known antihypertensive peptide IPP and several novel peptides that have structural simi

202 Inositol polyphosphate 1-phosphatase (IPP) is an enzyme essential for the hydrolysis of the 1-

203 pe II inositol polyphosphate 5-phosphatases (IPPs) act on both soluble inositol phosphate and phospho

204 olyzable analogue indole propanol phosphate (IPP).

205 e evaluated invasive pneumococcal pneumonia (IPP) rates during the 2009 influenza A(H1N1) pandemic.

206 ly rates of invasive pneumococcal pneumonia (IPP) were obtained from the Danish National Laboratory S

207 iospecificites, and isotactic polypropylene (IPP) Mw.

208 We conclude that the porcine IPP are not a site of B cell lymphogenesis, do not under

209 Pre-IPP/post-IPP median percentage of necrosis on magnetic resonance

210 Pre-IPP/post-IPP median percentage of necrosis on magnetic r

211 sible for producing the isoprenoid precursor IPP in many gram-positive bacteria and eukaryotes, we co

212 opologues from the respective C5-precursors, IPP and DMAPP, whereas one isoprene unit in the ring E o

213 ted peptides Val-Pro-Pro (VPP), Ile-Pro-Pro (IPP), Leu-Pro-Pro (LPP) and Phe-Pro (FP) were separated

214 on mevalonate diphosphate (MVAPP) to produce IPP while consuming ATP.

215 ate (IP), which is phosphorylated to produce IPP.

216 ment of an initiation-promotion-progression (IPP) protocol that permits separation and characterizati

217 lized in the plastids, is thought to provide IPP and dimethylallyl diphosphate for hemiterpene, monot

218 The MEP pathway provides IPP precursors for both plastidial monoterpene and cytos

219 n reading frame (ORF696) encoding a putative IPP isomerase was identified in the E. coli chromosome a

220 on was not due to isopentenyl pyrophosphate (IPP) accumulation because 20.1 treatment of APC did not

221 s isoprene units, isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP), which are

222 Isopentenyl pyrophosphate (IPP) is a common precursor for the synthesis of all isop

223 The enzyme isopentenyl pyrophosphate (IPP) isomerase catalyzes the reversible isomerization of

224 phate (DMAPP) and isopentenyl pyrophosphate (IPP) to all of the known terpenes.

225 aIPPI1 isomerized isopentenyl pyrophosphate (IPP) to dimethyl allyl pyrophosphate (DMAPP) and vice ve

226 isomerization of isopentenyl pyrophosphate (IPP) to dimethylallyl pyrophosphate (DMAPP), a reaction

227 When [14C]isopentenyl pyrophosphate (IPP) was used as the substrate for phytoene synthase a r

228 ight molecules of isopentenyl pyrophosphate (IPP) with farnesyl pyrophosphate (FPP) to generate the C

229 stimulation with isopentenyl pyrophosphate (IPP), a metabolite in the mevalonate pathway, which is a

230 sults showed that isopentenyl pyrophosphate (IPP), a soluble phospholigand released by mycobacteria,

231 by microbes, and isopentenyl pyrophosphate (IPP), an intermediate in the mevalonate pathway used by

232 e biosynthesis of isopentenyl pyrophosphate (IPP), the precursor of all isoprenoids, including carote

233 rbon starter unit isopentenyl pyrophosphate (IPP).

234 e phosphoantigen {isopentenyl pyrophosphate [IPP] and (E)-4-hydroxy-3-methyl-but-2-enylpyrophosphate

235 s pyrophosphates (isopentenyl pyrophosphate [IPP]).

236 m, measured by incorporation of radiolabeled IPP, was not stimulated by pyruvate, an initial substrat

237 pandemic likely resulted in an out-of-season IPP peak among persons >/=5 years.

238 rved in the betaK87T-Ser-GP and betaK87T-Ser-IPP structures, with exception of the disordered alpha-s

239 or indole-3-propanol phosphate (betaK87T-Ser-IPP) bound to the active site of the alpha-subunit.

240 Anatomically and developmentally similar IPP occur in swine.

241 lta T cell activation because they stimulate IPP production in monocytes by inhibiting the mevalonate

242 change in redox state between the substrate (IPP) and product (DMAPP), indicating that the FMN cofact

243 ly less reactive toward proton addition than IPP and DMAPP but have similar reactivities toward hydro

244 -fmDMAPP are approximately 50-fold less than IPP and DMAPP, respectively.

245 We conclude that IPP is not the sole site of VA diversification in cattle

246 In addition, we also demonstrate that IPP isomerase is regulated at the mRNA level.

247 The findings that IPP-responsive proinflammatory synovial Vgamma9(+) T cel

248 We infer that IPP-5 negatively regulates IP(3) signaling to ensure pro

249 mapping and Southern blot analysis show that IPP comprises eight exons spanning more than 47kb of gen

250 The IPP analogue (3-ClIPP) was a cosubstrate when incubated

251 The IPP cDNA clone contains a 1752bp open reading frame that

252 The IPP group was initiated with diethylnitrosamine, maintai

253 The IPP peak's magnitude was similar to that seen during sea

254 The IPP set can be set to specific model organisms, interact

255 ermutation was very low in fetal IPP and the IPP of germ-free piglets but increased 3- to 5-fold afte

256 ivity and the need to exclude DMAPP from the IPP binding site.

257 romosomal changes observed in cells from the IPP protocol included duplication of all or part (1q37-4

258 ) compared with corresponding cells from the IPP protocol, but a higher level of background aneuploid

259 s a single electron transfer to and from the IPP substrate during catalysis.

260 r studies in cattle and sheep implicated the IPP as a likely site of Ab diversification, a close inve

261 us binding of inorganic pyrophosphate in the IPP subpocket leads to conformational closing of the act

262 iple features can be provided for all of the IPP and NIP pairs.

263 ined the role of ILK, a key component of the IPP complex, in diet-induced muscle insulin resistance.

264 ol and accurately predicted the yield of the IPP hydrolysis product acetone.

265 Resection of approximately 90% of the IPP in piglets at birth did not alter Ig levels in serum

266 R. capsulatus enzyme is the smallest of the IPP isomerases to be identified thus far and may consist

267 alleled the developmental persistence of the IPP, and its near disappearance corresponds to the diver

268 The GGT+ hepatocytes from animals on the IPP protocol had a 35% incidence of aneuploidy.

269 These rats on the IPP protocol were then maintained on phenobarbital for a

270 noids and sesquiterpenoids, that bind to the IPP site and may be of interest as anticancer and antiin

271 s occur as multidomain proteins in which the IPP domain is linked to lipid-binding or additional cata

272 Except for IgG3 in the IPPs and mesenteric lymph nodes, no stochastic pattern o

273 allow the user to control the make-up of the IPPs and NIPs as well as the quality of the resultant da

274 wing for the conversion of mevalonic acid to IPP by the mevalonate pathway.

275 intermediate in the pathway, is converted to IPP and DMAPP by the consecutive action of the IspD-H pr

276 ounds by controlling the ratio of IP/DMAP to IPP/DMAPP.

277 protein responsible for converting HMBPP to IPP and DMAPP in the ultimate step in the nonmevalonate

278 reaction similar to the conversion of IP to IPP.

279 equired to convert phosphomevalonate (PM) to IPP in eukaryotes.

280 amma9(+) T cell proliferation in response to IPP was significantly lower in SF than PBMC cultures, it

281 enous cellular substrate in Synechocystis to IPP and DMAPP, overcoming flux limitations of the native

282 ), methyl transfers (SAM), prenyl transfers (IPP), glucosyl transfers (UDP-glucose), and electron and

283 unt of ACE-I peptides changed, and only VPP, IPP, HLPLP and LHLPLP were detected in the intestinal di

284 rting enzyme-inhibitor (ACE-I) peptides VPP, IPP, RYLGY, RYLG, AYFYPEL, AYFYPE, LHLPLP and HLPLP were

285 lIPP) (with DMAPP) and K(M)(3-ClDMAPP) (with IPP) were similar to those for IPP and DMAPP; however, v

286 , the structure of the mutant complexed with IPP and serine exhibits ligand-induced conformational ch

287 e similar to those for chain elongation with IPP and DMAPP.

288 e when the reduced enzyme was incubated with IPP or DMAPP.

289 P and GPP gave FSPP, whereas incubation with IPP and GSPP gave FPP.