ライフサイエンスコーパス: IVH

1 IVH and intracerebral hemorrhage (ICH) volume were measu

2 IVH treatment by intraventricular fibrinolysis (IVF) was

3 IVH volume may be important in outcome prediction and ma

4 IVH was also graded using a simple classification system

5 IVH-induced hypersecretion of CSF is mediated by TLR4-de

6 receptor inhibition alleviates OPC loss and IVH-induced inflammation and restores myelination and ne

7 ere 349 (27%) of 1310 patients with baseline IVH, and 107 (11%) of 961 initially IVH-free patients wh

8 proximately 12,000 premature infants develop IVH every year in the United States, and a large number

9 IVHS enables clinicians to rapidly estimate IVH volume.

10 yielded the following formula for estimating IVH volume (mL): eIVHS/5 (R = .75, p < 0.001).

11 ytopenia did not correlate with the risk for IVH, and platelet transfusions did not reduce this risk.

12 en severity of thrombocytopenia and risk for IVH.

13 better sensitivity than SO2 in detecting GM-IVH-related effects on infant brain development.

14 nd CMRO2i in ELGA neonates with low-grade GM-IVH compared to neonates without hemorrhages.

15 in, yet the long-term impact of low-grade GM-IVH on cerebral blood flow and neuronal health have not

16 age (ELGA) neonates (seven with low-grade GM-IVH) and monitored them weekly until they reached full-t

17 minal matrix-intraventricular hemorrhage (GM-IVH) is the most common complication in extremely premat

18 The occurrence of GM-IVH is highly associated with hemodynamic instability in

19 l benefit for monitoring the evolution of GM-IVH, evaluating treatment response, and potentially pred

20 aging than with US for the detection of GMH, IVH, and cortical infarction or ischemia (P < .005).

21 th CT than with US for the detection of GMH, IVH, IPH, and cortical infarction or ischemia (P <.005).

22 after 24 h, absolute increase in haematoma+/-IVH volume was larger (5.2/5.0 mL) in those with compare

23 Intensive BP lowering reduced haematoma+/-IVH growth by 4.7/7.1 mL in patients on antithrombotics

24 defined as new intraventricular haemorrhage (IVH) on the latter scan.

25 ) with/without intraventricular haemorrhage (IVH) over 24 h were estimated in analyses of covariance.

26 death, severe intraventricular haemorrhage (IVH), and periventricular leucomalacia (PVL) in preterm

27 cular extension of intracerebral hemorrhage (IVH) is an independent predictor of poor outcome.

28 bocytopenia and intraventricular hemorrhage (IVH) are common among very-low-birth-weight (VLBW) infan

29 Intraventricular hemorrhage (IVH) in premature infants results in inflammation, arres

30 Intraventricular hemorrhage (IVH) in preterm infants leads to cerebral inflammation,

31 Intraventricular hemorrhage (IVH) is a major complication of prematurity and a large

32 Intraventricular hemorrhage (IVH) is a negative prognostic factor in intracerebral he

33 Intraventricular hemorrhage (IVH) remains a major cause of white matter injury in pre

34 Intraventricular hemorrhage (IVH) results in neural cell death and white matter injur

35 ation following intraventricular hemorrhage (IVH), is a common disease usually treated by suboptimal

36 hlights the role of AMPA-kainate receptor in IVH-induced white matter injury and identifies a novel s

37 en that TH promotes neurological recovery in IVH, TH treatment might improve the neurodevelopmental o

38 aperitoneal glycerol at 2 h of age to induce IVH; and the pups with IVH exhibit hypomyelination and g

39 the preterm rabbit model of glycerol-induced IVH and analyzed autopsy samples from premature infants.

40 theses in a rabbit model of glycerol-induced IVH and evaluated the expression of AMPA receptors in au

41 day death or major disability versus initial IVH (adjusted ORs 2.84 (95% CI 1.52 to 5.28) and 1.87 (1

42 baseline IVH, and 107 (11%) of 961 initially IVH-free patients who developed dIVH.

43 p<0.001) and intraventricular blood (median IVH sum score 2 vs 1, p<0.001), and more often with intr

44 llowing correlations with mRS were obtained: IVH volume R = .305; ICH volume R = .468; total volume [

45 The addition of IVH to ICH volume increases its predictive power for poo

46 The development of IVH leads to inflammation of the periventricular white m

47 ave a significant effect on the incidence of IVH (hazard ratio, 0.92; 95% CI, 0.49-1.73; P = .80).

48 er of platelet transfusions and incidence of IVH.

49 To test the hypotheses, a rabbit model of IVH was used in which premature rabbit pups (E29) are tr

50 ological recovery in preterm rabbit model of IVH.

51 human preterm infants and a rabbit model of IVH.

52 The onset of IVH induces inflammation of the periventricular white ma

53 is, and motor impairment in the survivors of IVH.

54 ith increasing CA, children with early-onset IVH and subsequent significant central nervous system in

55 Only children with early-onset IVH followed by significant central nervous system injur

56 death (47/449 [11%] vs 58/449 [13%]), severe IVH (46/429 [11%] vs 55/411 [13%]), and PVL (34/367 [9%]

57 [24%] vs 27/179 [15%], p=0.0338) and severe IVH (19/219 [9%] vs 6/189 [3%], p=0.0209) were higher in

58 < 60ml, Glasgow Coma Scale of <9, and severe IVH with tamponade of the third and fourth ventricles re

59 t dependency in patients with ICH and severe IVH.

60 morphine were more likely to develop severe IVH (36/190 [19%] vs 19/219 [9%], p=0.0024).

61 sions did not reduce the frequency of severe IVH, PVL, or death in ventilated preterm neonates, but i

62 ovide evidence that, in patients with severe IVH, as compared to IVF alone, a combined approach of IV

63 using a simple classification system termed IVH score (IVHS).

64 In a rat model of PHH, we demonstrate that IVH causes a Toll-like receptor 4 (TLR4)- and NF-kappaB-

65 We found that IVH resulted in apoptosis and reduced proliferation of o

66 Here, we hypothesized that IVH damages white matter via AMPA receptor activation, a

67 Therefore, we hypothesized that IVH in premature newborns initiates degeneration and mat

68 Therefore, we hypothesized that IVH would decrease TH signaling via changes in the expre

69 Therefore, we hypothesized that IVH would result in accumulation of HA, and that either

70 The IVH estimation formula was then verified in the validati

71 No therapeutic strategy exists against the IVH-induced white matter injury.

72 ematoma+intraventricular haemorrhage volume (IVH) with/without intraventricular haemorrhage (IVH) ove

73 Compared with those who were IVH-free, dIVH had greater odds of 90-day death or major

74 rabbit pups and human premature infants with IVH compared with controls.

75 Thus, in infants with IVH the combined elevation in deiodinase-3 and reduction

76 urological outcome of premature infants with IVH.

77 rological outcome for premature infants with IVH.

78 neurologic outcome in premature infants with IVH.

79 ytes and myelination in preterm infants with IVH.

80 ion was also increased in human infants with IVH.

81 evelopmental outcome of preterm infants with IVH.

82 rological recovery in premature infants with IVH.

83 neurologic recovery in preterm newborns with IVH.

84 ulated gene-6 were elevated in newborns with IVH; and depletion of HC-HA levels by HA oligosaccharide

85 2 h of age to induce IVH; and the pups with IVH exhibit hypomyelination and gliosis at 2 weeks of po

86 he density of Iba1(+) microglia in pups with IVH.

87 restored neurological function in pups with IVH.

88 y, and motor function in premature pups with IVH.

89 rain samples of both humans and rabbits with IVH compared with controls without IVH.

90 Hyaluronidase treatment of rabbits with IVH reduced CD44 and TLR4 expression, proinflammatory cy

91 neurologic recovery in preterm rabbits with IVH.

92 on and neurological recovery in rabbits with IVH.

93 on and neurological function in rabbits with IVH.

94 tion and neurologic recovery in rabbits with IVH.

95 as clinical recovery in preterm rabbits with IVH.

96 on and neurological recovery in rabbits with IVH.

97 he forebrain of both humans and rabbits with IVH.

98 aturity and a large number of survivors with IVH develop cerebral palsy and cognitive deficits.

99 States, and a large number of survivors with IVH develop cerebral palsy and cognitive deficits.

100 and neurological function in survivors with IVH.

101 bbit pups and human infants with and without IVH, but HA receptors--CD44, TLR2, TLR4--were elevated i

102 e neocortex in both infants with and without IVH.

103 preterm humans and rabbits with and without IVH.

104 bits with IVH compared with controls without IVH.