ライフサイエンスコーパス: IVM

1 IVM also markedly increased the potency of ATP and that

2 IVM effectiveness depends on coverage with the highest i

3 IVM is an effective treatment for vitreous seeding after

4 IVM of the microcirculation of the mouse ankle could bec

5 IVM resulted in a 4- to 7-fold increased mortality in mo

6 IVM revealed that ROCK blockade strongly reduced the vel

7 patients were included, with a total of 110 IVM injections.

8 Day 7 IVM plasma levels were positively associated with body m

9 Adding IVM increases the reductions in parasite prevalence achi

10 (GluClalphabeta), systemically administered IVM, and then assessed amphetamine-induced rotational be

11 mortality in mosquitoes feeding 1 day after IVM (P < .001).

12 The AL-IVM combination was well tolerated.

13 An IVM approach requires entomological knowledge, technical

14 ma treated with intravenous chemotherapy and IVM as salvage for vitreous seeding, and further to dete

15 ma treated with intravenous chemotherapy and IVM from 2012 to 2016.

16 gle center with intravenous chemotherapy and IVM.

17 at posttreatment reactions following DEC and IVM share a common pathophysiology.

18 heteromeric mutant receptor to both Glu and IVM, and improved the receptor subunits' cooperativity.

19 tly inhibits the binding of [(3)H]NAmide and IVM binds to GluCls.

20 ions from GluClalphabeta-expressing animals, IVM rapidly suppressed spiking.

21 limited by the narrow focus of its approach; IVM strategies aim only to control arthropod vectors.

22 at MR imaging with macrophage quantities at IVM.

23 Conventional video-based IVM allows the visualization of extremely rapid adhesion

24 Mosquitoes ingesting a bloodmeal containing IVM have increased mortality, reducing the probability t

25 for mosquitoes taking bloodmeals containing IVM are used to quantify the mosquitocidal effect of IVM

26 ty, and pharmacokinetics of single-dose DEC, IVM, and ALB in Wuchereria bancrofti-infected Papua New

27 Thus, half of the Drosophila IVM receptors and all of the NA receptors are associated

28 lementation with a methyl donor (SAM) during IVM restored histone H3K4me3 and doubled the IVF success

29 LVEF and WMI were significant predictors for IVM.

30 , named "GluClv2.0," is an improved tool for IVM-induced silencing.

31 illing mosquitoes that take blood meals from IVM-treated humans.

32 The two-subunit GluCl/IVM system permits "intersectional" strategies designed

33 Twelve eyes demonstrated grade 3 or greater IVM-associated retinal or anterior segment toxicity post

34 of [(3)H]NAmide, and about half of the [(3)H]IVM binding sites are inhibited by NA with high affinity

35 In contrast, [(3)H]IVM binding to Caenorhabditis elegans membranes is not i

36 Finally, the binding of [(3)H]IVM is inhibited by NA.

37 The B(max) of [(3)H]IVM is twice that of [(3)H]NAmide, and about half of the

38 e current state of the field and outline how IVM can generate new discoveries and serve as a "reality

39 Secondary measures included IVM-associated toxicity and complications.

40 Including IVM in mass treatment strategies could be a useful adjun

41 Our results suggest that including IVM in a mass treatment strategy can reduce the time tak

42 Titrations of ADP into IVM assays produced a similar inhibitory affect for both

43 early as 4 hr after a single intraperitoneal IVM injection (10 mg/kg), reached maximal levels by 12 h

44 Ivermectin (IVM) has been the drug of choice for the treatment of on

45 Ivermectin (IVM) is widely used in both human and veterinary medicin

46 Ivermectin (IVM) may reduce malaria transmission by killing mosquito

47 Ivermectin (IVM), used alongside mass treatment strategies with an a

48 and allosterically regulated by ivermectin (IVM), a broad-spectrum antiparasitic agent.

49 drugs diethylcarbamazine (DEC), ivermectin (IVM), and albendazole (ALB) for LF are unknown.

50 xposure to the anthelmintic drug ivermectin (IVM).

51 The endectocide ivermectin (IVM) induces a similar, but larger current than NA.

52 channels serving as targets for ivermectin (IVM), a broad-spectrum anthelmintic drug used to treat h

53 striatum a modified heteromeric ivermectin (IVM)-gated chloride channel from C. elegans (GluClalphab

54 We express invertebrate ivermectin (IVM)-sensitive chloride channels (Caenorhabditis elegans

55 the presence of the large ligand ivermectin (IVM) positioned between all five subunits.

56 e drug of choice for loiasis, or ivermectin (IVM), which is used in mass drug administration programs

57 We show that ivermectin (IVM) is a specific positive allosteric effector of heter

58 We probed these motions using ivermectin (IVM), a macrocyclic lactone that stabilizes the open sta

59 ase in ATP-induced current amplitudes at low IVM concentrations, and the modest increase in the unita

60 r another akin to the Import Vector Machine (IVM).

61 Integrated Vector Management (IVM) strategies are intended to protect communities from

62 HO) recommends integrated vector management (IVM) strategy for combating VBD transmission.

63 II (MII) oocytes after in vitro maturation (IVM).

64 ctive of response to intravitreal melphalan (IVM) in patients treated predominantly with primary intr

65 00 mg (N = 12) or DEC 6 mg/kg + ALB 400 mg + IVM 200 mug/kg (N = 12), and monitored for microfilaria,

66 ted with intravital fluorescence microscopy (IVM), where nearly 90% of all ferumoxytol-containing cel

67 s a preclinical tool, intravital microscopy (IVM) allows for in vivo real-time direct observation of

68 al imaging, including intravital microscopy (IVM) combined with bioluminescence, as a powerful tool t

69 Intravital microscopy (IVM) demonstrated that RvE1 rapidly reduced leukocyte ro

70 maged this process by intravital microscopy (IVM) in the ear skin of transgenic mice bearing red-fluo

71 Using intravital microscopy (IVM) investigators are dissecting the cellular and molec

72 Intravital microscopy (IVM) is an ideal tool to provide the spatial and tempora

73 Accordingly, intravital microscopy (IVM) of PLN HEVs revealed a defect in B-cell tethering a

74 Intravital microscopy (IVM) provides quantitative, qualitative, and dynamic ins

75 Intravital microscopy (IVM) showed that TCMs roll efficiently in BM microvessel

76 Intravital microscopy (IVM) techniques have been employed for more than a centu

77 serial MR imaging and intravital microscopy (IVM) up to 4 weeks after surgery.

78 nsfer experiments and intravital microscopy (IVM) using both S1P1-/- lymphocytes and recipient wild-t

79 We used intravital video microscopy (IVM), which was adapted to the microcirculation of the m

80 nship using an instrumental variables model (IVM), a quasi-randomization technique for drawing causal

81 myosin coated surfaces in in vitro motility (IVM) assays was much slower compared with adult rabbit s

82 ically multiphoton intravital microscopy (MP-IVM), which allows for the investigation of dynamic biol

83 We have recently begun to use MP-IVM in lymph nodes of humanized mice in order to examine

84 Multiphoton IVM is a relatively new tool for imaging the slower dyna

85 ymph nodes (PLNs) as assessed by multiphoton IVM.

86 (NQMI) have more ischemic viable myocardium (IVM) than patients with Q-wave myocardial infarction (QM

87 ces variability in spike suppression at 1 nm IVM.

88 At concentrations as low as 5 nm, IVM activates a Cl- current large enough to silence infe

89 uCl change in the presence versus absence of IVM.

90 (EC(50,) approximately 250 nM) the action of IVM was rapid and reversible, resulting in increased amp

91 Here, we investigated the activity of IVM in a murine model of atopic dermatitis (AD) induced

92 The total amount of IVM was significantly higher in NQMI than in QMI (6.5 +/

93 omic settings, but the aggregate benefits of IVM are limited by the narrow focus of its approach; IVM

94 was limited by 1) the high concentration of IVM necessary to elicit a consistent silencing phenotype

95 These low concentrations of IVM do not potentiate GABA responses.

96 M is official national policy, the degree of IVM implementation, the level of compliance with WHO gui

97 ncreased until 7 days after a single dose of IVM (hazard rate ratio, 1.34 [95% confidence interval, 1

98 s predictive of the total number and dose of IVM injections in eyes treated with intravenous chemothe

99 s predictive of the total number and dose of IVM injections required for treatment in this cohort.

100 There was no significant effect of IVM on DEC or ALB drug levels.

101 used to quantify the mosquitocidal effect of IVM.

102 inding site, which described some effects of IVM on rat P2X4R.

103 Here we report the feasibility of IVM examinations of human malignant disease with an emph

104 transmission model to estimate the impact of IVM in combination with mass treatment strategies with a

105 M, and it assesses the operational impact of IVM.

106 Interestingly, the presence of IVM also has an effect on the structure of the important

107 n endemic area in Ghana after many rounds of IVM, raising concerns of suboptimal response or even the

108 tients, most of them with multiple rounds of IVM, were recruited in areas with IVM suboptimal respons

109 sect GluCls and identifies subpopulations of IVM binding sites.

110 nes, and concordance in the understanding of IVM, and it assesses the operational impact of IVM.

111 fections persist despite the frequent use of IVM.

112 considered risky to continue relying only on IVM to combat this phenomenon, we assessed the effect of

113 a Markov model based on the presence of one IVM binding site, which described some effects of IVM on

114 n sub-Saharan Africa, successful operational IVM experience comes from relatively few countries.

115 Optimally, IVM could incorporate environmental awareness and promot

116 ed following single-dose therapy with DEC or IVM to assess whether these reactions have the same unde

117 adverse events were similar following DEC or IVM, but peaked earlier in subjects who received DEC, co

118 ized to receive single-dose DEC (8 mg/kg) or IVM (200 microg/kg).

119 Other IVM models, particularly in the bone marrow, reveal how

120 We compared our IVM results with a multivariable linear probability mode

121 After a transient rise (post-IVM) or fall (post-DEC) in the first 24 hours posttreatm

122 ted from immunohistochemistry or preclinical IVM, and thereby have lower wall shear stress, which inf

123 ing the regulated in vitro motility assay (R-IVM).

124 Recent IVM work showed that T cell responses to antigen in lymp

125 ne treatment, patients took part in standard IVM treatment.

126 lling of adult worms after repeated standard IVM treatment.

127 Surprisingly, IVM produced no significant effect on the fast ATP-evoke

128 We argue that IVM should encompass environmental modifications at earl

129 We conclude that IVM can be safely given in combination with AL and can r

130 Although we found no evidence that IVM reduced Plasmodium infection rates among surviving m

131 either type of neuron, despite the fact that IVM modulated P2X(4) channels heterologously expressed i

132 We find that IVM partitions into lipid membranes and that transfer of

133 Altogether, our results show that IVM is endowed with topical anti-inflammatory properties

134 Recent reports have suggested that IVM could also have anti-inflammatory properties.

135 sensitivity to the lactone, suggesting that IVM interacts most favorably with the open conformation

136 g at day 5 in the DEC group and day 9 in the IVM group.

137 showed decrease in leukocyte rolling in the IVM mouse model.

138 In the IVM, we found evidence suggesting a causal relationship

139 We identified a mutation in the IVM-binding site (far away from the Glu-binding sites),

140 Therefore, IVM evokes a potent pharmacological gain-of-function phe

141 Third, IVM potently inhibits the binding of [(3)H]NAmide and IV

142 ion rate can be altered by each of the three IVM binding sites.

143 we present two novel models, both with three IVM binding sites.

144 e heteromeric GluCl alphabeta sensitivity to IVM.

145 Our results show that topical IVM improved allergic skin inflammation by reducing the

146 ent changes in desensitization observed upon IVM application, the significant increase in ATP-induced

147 Using IVM, we could detect instant changes in leukocyte adhesi

148 ons of dendritic cells in vivo and in vitro, IVM impaired T-cell activation, proliferation, and cytok

149 utions at a subset of these positions weaken IVM binding.

150 ll of which appears to support a model where IVM binding between subunits stabilizes an open state, a

151 We also tested whether IVM could modulate endogenously expressed P2X channels i

152 le provides an update on the extent to which IVM is official national policy, the degree of IVM imple

153 While IVM had no major impact on the functions of dendritic ce

154 rounds of IVM, were recruited in areas with IVM suboptimal response and treated with 100 mg/day doxy

155 virus and then activate these channels with IVM to produce inhibition via a Cl- conductance.

156 r to each other compared to simulations with IVM bound.

157 Treatment with IVM increases the efficacy of ATP to activate P2X4R, slo

158 to stem cell transplants, as visualized with IVM and histopathologic examination.