ライフサイエンスコーパス: Ig domain

1 % to SLAMF6 in its ligand-binding N-terminal Ig domain.

2 ntegral part of the stabilizing core of this Ig domain.

3 ycan ligands mediated through its N-terminal Ig domain.

4 nt on the sequence RVE in the amino-terminal Ig domain.

5 erent residues to interact with the CD8alpha Ig domain.

6 of the receptors immediately after the first IG domain.

7 ocalized to the N-terminal variable-like (V) Ig domain.

8 imeric protein with the murine CD8 beta beta Ig domain.

9 ciating through the membrane proximal C-type Ig domain.

10 ientation and loop conformation in the beta2 Ig domain.

11 receptors), heterodimers formed by pairs of Ig domains.

12 uires the kinase domain and upstream Fn3 and Ig domains.

13 D4, whereas the other (CD4REL) codes for two Ig domains.

14 exibility compared to the conventional I-set Ig domains.

15 s, or to reciprocal interactions of all five Ig domains.

16 igate the reversible unfolding of individual Ig domains.

17 omophilic adhesion mediated by extracellular Ig domains.

18 zing the binding region(s) to the distal two Ig domains.

19 nd on the reversible unfolding of individual Ig domains.

20 on site which is absent from the first three Ig domains.

21 tional actin-binding proteins, consist of 24 Ig domains.

22 l alignment and the other involving only two Ig domains.

23 ce similarity yet differ from the other FLNa Ig domains.

24 or-ligand stoichiometry conferred by Robo2's Ig domains.

25 ted globular domains, G1 and G2 separated by IGD domain.

26 mutants that lack different immunoglobulin (Ig) domains.

27 en-strand beta-sandwich immunoglobulin-like (Ig) domains.

28 nsmembrane proteins with two immunoglobulin (Ig) domains.

29 004 and 3DL1*002 showed that polymorphism in Ig domains 0 and 1 (D0 and D1) causes the intracellular

30 binding site on MAG maps to arginine 118 in Ig domain 1.

31 ow that when a truncated form of MAG missing Ig domains 1 and 2 is expressed by Chinese hamster ovary

32 a previously unobserved rotation of receptor Ig domain 2 (D2) to introduce specific contacts with FGF

33 Mutagenesis experiments revealed that CD147 Ig domain 2 was required for caveolin-1 association.

34 sucrose fractions, and did not involve CD147 Ig domain 2.

35 an accessory binding site located in VCAM-1 Ig domain 2.

36 acellular, membrane-proximal immunoglobulin (Ig) domains 2 and 3.

37 g sequence of 2DS4, leading to disruption of Ig-domain 2D and a premature termination codon following

38 decrease the actin polymerizing activity of Ig domain 3 of palladin (Palld-Ig3).

39 32) of FGF8b and a hydrophobic groove within Ig domain 3 of the receptor that is also present in FGFR

40 d to Fc), a truncated form of MAG-Fc missing Ig-domains 4 and 5, MAG(d1-3)-Fc, and another sialic aci

41 now map a distinct inhibition site on MAG to Ig domain 5 (Ig-5).

42 hat the inhibition site on MAG is carried by Ig domain 5 and that this site is distinct from the sial

43 tation of three sites (N467Q/N473Q/N494Q) in Ig domain 5 of contactin prevented soluble NF155-Fc bind

44 Here, we report that loss of immunoglobulin (Ig) domains 5 and 6 in Nfasc(NF155) in mice phenocopies

45 ng amino acids Asp443, Asp444, and Glu446 of Ig-domain 5 and residues Glu487, Glu490, Asp491, Glu538,

46 ated by ligands that bind membrane- proximal Ig Domain 6.

47 that the six cation binding residues within Ig-domain 6 are proximal to each other in three-dimensio

48 lu490, Asp491, Glu538, Glu540, and Glu542 of Ig-domain 6.

49 cluster that contains an extracellular V-set Ig domain, a proline-rich region, and an immune receptor

50 racellular region containing two sets of two Ig domains, a transmembrane region, and a previously unr

51 e of the human beta3 subunit immunoglobulin (Ig) domain, a functionally important component of Nav ch

52 Currently, it is the only known muscle Ig domain able to interact with two alternative ligands-

53 e Cys-26, located within the immunoglobulin (Ig) domain, abolishes the covalent linkage between alpha

54 IL-18BPd isoforms, possessing the identical Ig domain, also neutralize >95% murine IL-18 at a molar

55 , and that the C-terminal half contains four Ig domains (amino acids 563-654, 657-738, 742-836, and 8

56 essed membrane protein with an extracellular Ig domain and a multiple membrane-spanning domain that c

57 rough a cysteine at residue 723, between the Ig domain and basic tail.

58 -18BPb and IL-18BPd isoforms lack a complete Ig domain and lack the ability to bind or neutralize IL-

59 T cell Ig domain and mucin domain (TIM)-3 has previously been e

60 of programmed death 1 (PD-1), CTLA-4, T cell Ig domain and mucin domain 3 (TIM-3), and CD28 on HIV-sp

61 T cell Ig domain and mucin domain protein 1 (TIM-1) is a costim

62 lic acids (Sias) via an amino-terminal V-set Ig domain and possesses tyrosine-based inhibitory motifs

63 can mediate trans homophilic-binding via its Ig domain and that the beta3-Ig domain can associate het

64 Whereas both the extracellular Ig domain and the intracellular TIR domains are importan

65 ransmembrane protein with five extracellular Ig domains and a cytoplasmic tail with a consensus ITIM

66 oglobulin (Ig) superfamily member with three Ig domains and a glycosylphosphatidylinositol anchor.

67 tion of hypothetical titin chains containing Ig domains and a PEVK region.

68 globulin superfamily protein containing five Ig domains and comprise the sickle (SS) red cell recepto

69 se domains and ectodomains with three tandem Ig domains and different numbers of tandem fibronectin t

70 LIRs contain either two or four Ig domains and fall into three classes: those with cytop

71 n the configuration of its two extracellular Ig domains and of its transmembrane and cytoplasmic doma

72 Nr-CAM-Fc fusion protein, containing all six Ig domains and the first two fibronectin type III repeat

73 obo), whose extracellular part contains five Ig domains and three fibronectin type III repeats.

74 Dasm1 contains five Ig domains and two fibronectin III domains in the extrac

75 xpressed in CHO cells and all contained five Ig domains and were able to bind sialic acid.

76 ne-rich repeats (LRR) and an immunoglobulin (Ig) domain and is the founding member of the Drosophila

77 domains of collapsin-1, the immunoglobulin (Ig) domain and the basic tail, each potentiate collapsin

78 Beat Ia contains two immunoglobulin (Ig) domains and appears to function as an anti-adhesive

79 proximately 300 regular immunoglobulin-like (Ig) domains and FN-III repeats.

80 The T cell, Ig domain, and mucin domain-1 (TIM-1) gene is associated

81 and the IgV domain of murine TIM-1 (T-cell, Ig domain, and mucin domain-1).

82 Each contains a single Ig domain, and they are expressed mainly in cells of the

83 sphorylation sites with flanking 7th and 8th Ig domains, and a protein containing just the linker reg

84 VCAM has seven Ig domains, and each has a disulfide bond (-S-S-) buried

85 Because palladin has multiple Ig domains, and only one of them binds to F-actin, this

86 enzyme recognition site may exist within the Ig domains, and that glycans in the FN region are polysi

87 The paracaspase and the Ig domains appear as a single folding unit and interact

88 ependently folded catalytic domain, Fn3, and Ig domains are aligned consecutively on the long axis of

89 The O1/OL1 Ig domains are candidate discriminatory structural modul

90 l conditions in relaxed human soleus fibers, Ig domains are more stable than predicted by atomic forc

91 Immunoglobulin-like (Ig) domains are a widely expanded superfamily that act a

92 omain of peroxidasin and its immunoglobulin (Ig) domains are required for efficient sulfilimine bond

93 t the beta-sheet on the opposite side of the Ig domain as in KIT, to bind ligand.

94 eases the mechanical stability of the parent Ig domain as well as its ability to fold.

95 ants of KIR1D exist that encode at least one Ig domain, as well as transmembrane and cytoplasmic doma

96 urprisingly, we found that the beta3 subunit Ig domain assembles as a trimer in the crystal asymmetri

97 , three immunoglobulin (Ig)-like and one non-Ig domain at the C-terminus.

98 nces most closely resemble V (variable)-type Ig domains, based on canonical and hydrophobic residues

99 The KIR1D molecule encodes only one complete Ig domain before a frame-shift in the second Ig domain o

100 ure assembled protein, and (ii) splitting an Ig domain between two proteins to control their folding

101 Recombinant DICP Ig domains bind lipids, a property shared by mammalian C

102 ot sufficient, because a raft-localized CD47 Ig domain bound to the membrane by a glycan phosphoinosi

103 ane tethered ectodomain, including the NH(2)-Ig domains, but not of the intracellular phosphatase dom

104 binding via its Ig domain and that the beta3-Ig domain can associate heterophilically with the beta1

105 d relative unfolding resistance of different Ig domains, can be related to experimental observations.

106 cells, removal of the netrin binding second Ig domain causes an increase in basal tyrosine phosphory

107 Both IgL 1 and 2 adopt the classical Ig domain conformation comprised of two layers of beta-s

108 TCRs), which are composed of immunoglobulin (Ig) domains containing hypervariable loops that bind ant

109 he Dpr family, a subclass of immunoglobulin (Ig)-domain containing proteins, are expressed in unique

110 that the B7 family-related protein V-set and Ig domain-containing 4 (VSIG4) can act as an inhibitor o

111 The CD2 family is a growing family of Ig domain-containing cell surface proteins involved in l

112 Here, we identify LRR and Ig domain-containing, Nogo receptor-interacting protein

113 Previously, LRR and Ig domain-containing, Nogo receptor-interacting protein

114 ember of the IgLON family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)

115 gene family encoding diverse immunoglobulin (Ig) domain-containing proteins (DICPs) was identified in

116 Typically, immunoglobulin (Ig) domain-containing proteins control cell adhesion and

117 stallin associated with immunoglobulin-like (Ig) domain-containing regions, but not the disordered PE

118 was mediated by the isolated amino-terminal Ig domain (D1), but not the carboxyl-terminal Ig domain

119 FGFR) extracellular domain consists of three Ig domains (D1-D3) of which the two membrane-proximal D2

120 a CAR fragment containing both extracellular Ig domains (D1/D2) in Escherichia coli.

121 g domain (D1), but not the carboxyl-terminal Ig domain (D2), of the molecule.

122 ort that Sp-D binds to the membrane-proximal Ig domain (D3) of SIRPalpha in a calcium- and carbohydra

123 onstruct encoding sidekick-1 with the second Ig domain deleted both resulted in nearly abolished adhe

124 e amino acid sequences of all three variable Ig domains determine binding specificity.

125 grity of titin's Ig10 domain and suggests an Ig domain disease mechanism.

126 xpressed by myeloid cells (TREM) 2, a single Ig domain DNAX adaptor protein 12-associated receptor ex

127 on of Dscam, comprising the eight N-terminal Ig domains (Dscam(1-8)).

128 Combinatorial use of alternatively spliced Ig-domains enables the generation of an estimated 18,000

129 The extracellular Ig domain exerts its inhibitory role in IL-1 signaling b

130 sing a unique combination of three variable (Ig) domains, exhibits isoform-specific homophilic bindin

131 echanical unfolding of titin immunoglobulin (Ig) domains exposes buried cysteine residues, which then

132 e Ig superfamily with a single extracellular Ig domain followed by a multiply membrane-spanning (MMS)

133 nin is composed of four immunoglobulin-like (Ig) domains followed by six fibronectin type III-like (F

134 To determine which of the Ig domains for the CD8 alpha beta heterodimer would make

135 tion site (D2) of twitchin with its flanking Ig domains forms a phosphorylation-sensitive complex wit

136 containing a MAM domain, an immunoglobulin (Ig) domain, four fibronectin-type III (FN-III) repeats,

137 stricted to I27, the only structurally known Ig domain from the distal region of the titin I-band.

138 folding I1, the first structurally available Ig domain from the proximal region of the titin I-band.

139 tions of these three MAG Ig domains fused to Ig domains from another Ig family member, sialoadhesin (

140 omain family and reveals close homology with Ig domains from antibodies, T-cell receptors and other a

141 -crystallin increased the unfolding force of Ig domains from the proximal tandem Ig segment by 28 +/-

142 Ig domains from the proximal tandem Ig segment of titin

143 s of various combinations of these three MAG Ig domains fused to Ig domains from another Ig family me

144 mation whereas deletion of the extracellular Ig domains had no effect.

145 Each Ig domain has distinct sequence characteristics that sug

146 The N-terminal V-set Ig domain has most amino acid residues typical of Siglec

147 cific interaction with the recombinant first Ig domain-His protein of sidekick-1.

148 Deletion of immunoglobulin-like (Ig) domain I did not effect ligand binding, thus localiz

149 tiparallel interaction between the first two Ig domains (Ig I and Ig II).

150 Interactions of the N-terminal Ig domains, Ig1 and Ig2, were essential for bead binding

151 we predict the order of unfolding events in Ig domain (Ig27) and two fibronectin III type domains ((

152 eceptors showed that a broad region spanning Ig domain II and sequences further N-terminal determines

153 bit homophilic binding of the purified beta3-Ig domain in free solution.

154 ating that complementation of the incomplete Ig domain in VpreB by the extra beta strand in lambda5/1

155 dynamics simulations to stretch single titin Ig domains in solution with pulling speeds of 0.5 and 1.

156 xamined the aggregation behavior of isolated Ig domains in solution.

157 n variable amino acid sequences within three Ig domains in the extracellular region.

158 sist in the unfolding and refolding of FNIII/Ig domains in the titin molecule, and act as a force "bu

159 cle, possesses about 40 immunoglobulin-like (Ig) domains in its I-band region.

160 It was observed that all N-CAM Ig domains inhibited astrocyte proliferation in parallel

161 mbrane protein with a single immunoglobulin (Ig) domain, instructs the distinct, neuron-type-specific

162 that in the C-terminal rod 2 region of FLN, Ig domains interact with each other forming functional d

163 They display a distinctive, disulfide-linked Ig domain interface and are folded back asymmetrically o

164 uired for BMP inhibitory activity, while the Ig domain is dispensable in this context.

165 n following expression of native Vn, but the Ig domain is not required for Vn localization or for the

166 ransmembrane protein with five extracellular Ig domains, is expressed on the nonradially migrating ce

167 s two different types of receptors, one with Ig domains (killer cell inhibitory receptor), and anothe

168 hibitory receptor (KIR) family, carrying two Ig domains (KIR2D), are unusual among Ig superfamily mem

169 e the specificity of five KIR containing two Ig domains (KIR2D), direct binding of soluble recombinan

170 form of Kit containing just the first three Ig domains (Kit-123) binds to SCF with precisely the sam

171 CAM1 have either two or four immunoglobulin (Ig) domains linked through a transmembrane domain to eit

172 nds to F-actin, this suggests that different Ig domains may be specialized for distinct biological fu

173 e suggested by decreased binding of two anti-Ig domain monoclonal antibodies, decreased SIRPalpha1 bi

174 ltracentrifugation confirmed the presence of Ig domain monomers, dimers, and trimers in free solution

175 type regulator locus, containing the T cell, Ig domain, mucin domain (TIM) genes, is genetically asso

176 n but differs in the number of extracellular Ig domains, number and location of joining (J) region-li

177 in and Obsl1 use their homologous N-terminal Ig domain (O1 in obscurin and OL1 in Obsl1) to bind M10

178 Ig domain before a frame-shift in the second Ig domain occurs, leading to early termination of the mo

179 g chimeric proteins, we show that the murine Ig domain of CD8 beta is responsible for the lack of exp

180 nti-ICAM-1 mAb 84H10 which maps to the first Ig domain of ICAM-1.

181 rostatic and hydrophobic binding site in the Ig domain of IL-18BP, which could account for its high a

182 IL-18BPc shares the Ig domain of IL-18BPa except for the 29 C-terminal amino

183 how that substitution of His-36 in the first Ig domain of KIR2DL1 with alanine (KIR2DL1-H36A) resulte

184 e describe a point mutation within the first Ig domain of MAdCAM-1 that abolishes activation-independ

185 form hydrophobic interactions with the third Ig domain of PDGFRbeta.

186 ding to an amino acid sequence in the second Ig domain of sidekick-1 showed specific interaction with

187 that in HEK293 cells, secretion of the free Ig domain of the beta3 subunit is reduced significantly

188 se line has been produced in which the sixth Ig domain of the L1 cell adhesion molecule has been dele

189 r, we suggest that its integrity ensures the Ig domain of the membrane-tethered beta3 subunit adopts

190 g64-Ile65-Glu66 motif on the membrane-distal Ig domain of the molecule.

191 ic acid embedded within the core of a single Ig domain of the titin protein.

192 Thus, a single amino acid in the first Ig domain of these KIR determines their ability to discr

193 olated growth cones required the first three Ig domains of a NCAM-Fc chimera and were stimulated maxi

194 Here we forcibly unfold the Ig domains of a prototypical Ig superfamily CAM that con

195 ized amino acids fully conserved between the Ig domains of all known beta3 and beta1 sequences.

196 The Ig domains of all such CAMs have conformations homologou

197 The Ig domains of both lambda5/14.1 and VpreB are atypical.

198 he amino acid sequences suggest that the two Ig domains of CD4REL duplicated to generate the four-dom

199 In addition, we demonstrate that the Ig domains of CD8 alpha are also involved in controlling

200 s, immunoreactivity was directed against the Ig domains of contactin and was dependent on N-glycans.

201 The three N-terminal Ig domains of FCRL5 are required for OMCP binding.

202 The encoded Ig domains of IpFcRI are phylogenetically and structural

203 We found that SALM5 interacts with the Ig domains of LAR family receptor protein tyrosine phosp

204 microscopy has been used to extend the five Ig domains of Mel-CAM (melanoma CAM)--a protein that is

205 e complex between PDGF-B and the first three Ig domains of PDGFRbeta, showing that two PDGF-B protome

206 trikingly similar to the fibronectin binding Ig domains of Perlecan/HSPG2.

207 Rs in Slit are sufficient for binding to the Ig domains of Robo.

208 results establish that the first and second Ig domains of sidekick-1 and -2 are necessary and suffic

209 ck-2 are replaced with the corresponding two Ig domains of sidekick-1, form aggregates with sidekick-

210 ith a chimeric sidekick, where the first two Ig domains of sidekick-2 are replaced with the correspon

211 The reverse chimera, where the first two Ig domains of sidekick-2 are substituted onto sidekick-1

212 imilar NC(T/S) motifs in the first or second Ig domains of the I-type lectins myelin-associated glyco

213 ral differences encoded in the extracellular Ig domains of the Robo receptors.

214 uences of titin that span the Z-disk or with Ig domains of titin near the M-line.

215 on on RanBP9 bind directly to the N-terminal Ig domains of titin, which flank the Z-disk.

216 Ank1 interacted with the two most N-terminal Ig domains of titin, ZIg1 and ZIg2, which are present at

217 y receptor created by fusing the first three Ig domains of VEGF receptor 1 to an Ig constant region;

218 characteristic single V-set immunoglobulin (Ig) domain of the family, but its longer cytoplasmic tai

219 M10 is the most C-terminal immunoglobulin (Ig) domain of the giant protein titin and a frequent tar

220 eucine-rich repeat (LRR) and immunoglobulin (Ig) domains of Gpr124, and weakening this interaction by

221 ch of the five extracellular immunoglobulin (Ig) domains of N-CAM in the homophilic adhesion interact

222 The first two extracellular immunoglobulin (Ig) domains of PirB and LilrB2 mediate this interaction,

223 s of interdomain arrangement of two adjacent Ig-domains of titin, Z1, and Z2, using molecular dynamic

224 e protein encoded by this gene contains five Ig domains, one transmembrane domain, and an intracellul

225 ant forms of the molecule missing either the Ig domain or the multiple membrane-spanning domain did n

226 short splice variant (lacking the first two Ig domains) or a construct encoding sidekick-1 with the

227 to reciprocal binding of the two N-terminal Ig domains, or to reciprocal interactions of all five Ig

228 ical measurements that the recently reported Ig domain pair 20-21 of human filamin A acts as an autoi

229 The structures of the tandem immunoglobulin (Ig) domain pairs A164-A165 and A168-A169, from the A-ban

230 e, and act as a force "buffer" for the FNIII/Ig domains, particularly at low and moderate extension f

231 All these proteins have multiple Ig domains, possess properties of cell adhesion molecule

232 Binding of mAb 10G2 to the IAP Ig domain, previously shown to be required for associati

233 nexpectedly that the leucine-rich repeat and Ig domain protein 1 (LINGO1) is expressed in over 90% of

234 us, KIRREL2 protein is a beta-cell-expressed Ig domain protein and may be involved in pancreas develo

235 and the glycosylphosphatidylinositol-linked Ig domain protein CD160.

236 aprotein cleavage of IgSF1, a large cellular Ig domain protein that is processed into two separate Ig

237 ode Caenorhabditis elegans: the secreted two-Ig domain protein ZIG-4, the FGF receptor EGL-15 and the

238 n C. elegans that regulates expression of an Ig domain protein, OIG-1, to control the timing of synap

239 rra and Jin (2016) characterize a small, two-Ig domain protein, ZIG-10, and its role in maintaining s

240 in motion through regulated expression of an Ig domain protein.

241 cribed axon maintenance factors, such as the Ig domain proteins DIG-1 and SAX-7, the C. elegans ortho

242 l signal sequence and generates two separate Ig domain proteins from a polytopic precursor.

243 a family of small secreted or transmembrane Ig domain proteins, encoded by the Caenorhabditis elegan

244 protein that is processed into two separate Ig domain proteins.

245 ly controlled secretion of 2-immunoglobulin (Ig)-domain proteins encoded by the zig genes.

246 alpha alpha-MHC complex showed that one CD8 Ig domain provided the majority of the contact with MHC

247 uence tag database and isolated a new single Ig domain receptor, which we have expressed and characte

248 ngly inhibited by the splice insert B in the Ig domain region of LAR-RPTPs, and mediate SALM5-depende

249 in titin contains two tandem immunoglobulin (Ig) domain regions of distinct mechanical properties.

250 olved whether under physiological conditions Ig domains remain folded and act as "spacers" that set t

251 segments straightened while their individual Ig domains remained folded.

252 One (trout CD4) encodes four extracellular Ig domains reminiscent of mammalian CD4, whereas the oth

253 ptor ectodomain consists of a single C2-type Ig domain resembling the Ig-like domains found in mammal

254 systems, the mechanical properties of a six-Ig domain segment of titin (I65-I70), for which a crysta

255 SIGLEC1 Ig domain shares approximately 22% sequence identity wit

256 yses and multisite substitutions of the CD47 Ig domain show that human to cow mutation of a cluster o

257 conclude that aggregation of unfolded titin Ig domains stiffens myocytes and that sHSPs translocate

258 f extension under increasing external force: Ig domain straightening occurs first (termed tertiary st

259 s among 23 murine strains, differing both in Ig domain structure and cellular distribution of express

260 ize to accommodate a single non-glycosylated Ig domain such as the CD3epsilon ectodomain.

261 ient to accommodate a single nonglycosylated Ig domain such as the CD3epsilon ectodomain.

262 fitting with an atomic structure of a MyBP-C Ig domain suggested that most of the N-terminal domains

263 B and T lymphocyte associated (BTLA) is an Ig domain superfamily protein with cytoplasmic immunorec

264 omain of CAR consists of two immunoglobulin (Ig) domains termed CAR-D1 and CAR-D2.

265 A mutant form of CD47 without its Ig domain that did not induce actin polymerization or lo

266 This LC is composed of two Ig domains that can fold independent of the other and th

267 in also increased the unfolding force of the Ig domains that flank the N2B-Us (by 51 +/- 3 piconewton

268 were studied, using novel antibodies against Ig domains that flank these segments.

269 els possess an extracellular immunoglobulin (Ig) domain that is related to the L1 family of cell-adhe

270 eucine-rich repeat (LRR) and immunoglobulin (Ig) domains that specifically interacts with netrin-G1 t

271 eristic beta-sandwich structure of all titin Ig domains, the crystal structure of I1 showed an intern

272 f crystal structures of single and connected Ig domains, the tertiary and secondary structure elastic

273 We show that Unc5 requires both Ig domains to interact with netrin.

274 ous interaction of the third immunoglobulin (Ig) domain, to reciprocal binding of the two N-terminal

275 The KIR3DH molecules have three Ig domains, transmembrane domains homologous to KIR2DL4

276 The sequence and number of Ig domains, transmembrane regions and signaling motifs v

277 of the Ig superfamily (IgSF) containing five Ig domains (two V-type, three C2-type).

278 e-rich repeats (LRRs) and an immunoglobulin (Ig) domain, two of the most prevalent motifs found withi

279 ntial, as opposed to concerted, unfolding of Ig domains under external stretching forces.

280 may eliminate the necessity for unfolding of Ig domains under physiological conditions.

281 ructure of IgE Fc, which has this additional Ig domain, under the constraint that all of the cysteine

282 At larger extension and force, Ig domains unfold one by one (termed secondary structure

283 opic method for simulating AFM-induced titin Ig domain unfolding and refolding, we simulate the exten

284 AFM force extension and its effect on FNIII/Ig domain unfolding and refolding.

285 oximal tandem Ig segment and PEVK), and that Ig domain unfolding is negligible.

286 stence length of the N2B-Us and reducing the Ig domain unfolding probability.

287 1) PEVK extension overlaps with the onset of Ig domain unfolding, and 2) variations in PEVK content w

288 iles exhibit a single dominant peak for each Ig domain unfolding, consistent with the experimentally

289 mulations feature chain length compensation, Ig domain unfolding/refolding, and force-extension behav

290 Ig-domain unfolding did not become more pronounced after

291 Simulation experiments using Ig-domain unfolding parameters obtained in earlier singl

292 rising its N-terminal MAM (meprin/A5/mu) and Ig domains was determined at 2.7 A resolution; this assi

293 the expression of the two isoforms with two Ig domains was doubled relative to that in wild-type BAL

294 r for the tandem Ig segment (assuming folded Ig domains), we modeled the cardiac titin extensible reg

295 Under reducing conditions, Mel-CAM's Ig domains were found to fully unfold through a partiall

296 l ligand blockers (all recognizing the Tyro3 Ig domains) were the most effective at blocking ligand-m

297 ssion of the two CEACAM1a isoforms with four Ig domains, whereas the expression of the two isoforms w

298 beta-strand of the T cell receptor variable Ig domain, which has been observed to undergo a strand-s

299 N (lacking the extracellular immunoglobulin (Ig) domain with deletion of amino acids 1-119), DeltaC (

300 s determined by "matching" of three variable Ig domains within an approximately 220 kD ectodomain.