ライフサイエンスコーパス: Ig heavy chain

1 omplementarity-determining region III of the Ig heavy chain.

2 express the membrane-bound form of the micro Ig heavy chain.

3 cells that express more than one functional Ig heavy chain.

4 ce used the transgene rather than endogenous Ig heavy chains.

5 membrane-bound forms of the immunoglobulin (Ig) heavy chain.

6 O mice carried fewer hypermutations in their Ig heavy chain alleles than those of WT mice, indicating

7 mples each had rearrangements involving both Ig heavy chain alleles.

8 In plants expressing both the membrane Ig heavy chain and its partner light chain, functional a

9 deficient B cells that harbored preassembled Ig heavy chain and kappa-light chain "knock-in" (HL) all

10 erated via complementation of DP-T mice with Ig heavy chain and light chain knock-in transgenes (DP-T

11 inately assembled into half-molecules of one Ig heavy chain and one Ig light chain.

12 n receptor assembly, D and J segments of the Ig heavy chain and T cell receptor beta loci are recombi

13 he ends of the active DJ domains of both the Ig heavy chain and T cell receptor beta loci.

14 pERp1 promoted correct oxidative folding of Ig heavy chains and prevented off-pathway assembly inter

15 are assembled into complete molecules of two Ig heavy chains and two Ig light chains, whereas the fou

16 reaction (PCR) analyses for immunoglobulin (Ig) heavy chain and T-cell receptor (TCR)-gamma gene rea

17 oprotein 1, HLA, T cell receptor beta chain, Ig heavy chain, antithrombin III, Fas ligand, factor V,

18 Unassembled Ig heavy chains are retained in the ER via the binding o

19 to 10-fold increase in mutation frequency in Ig heavy chain, BCL-6, p53, and beta-catenin genes of in

20 s a component of unassembled immunoglobulin (Ig) heavy chain:BiP complexes.

21 Transcription of unrearranged (germline) Ig heavy chain C region (C(H)) genes is required before

22 in or 5' to the switch regions of nearly all Ig heavy chain C region genes and also is known to incre

23 ged mouse Myc gene, Myc(His), into the mouse Ig heavy-chain Calpha locus.

24 The Ig heavy chain class switch in B lymphocytes involves a

25 Ig heavy chain class switch recombination (CSR) determin

26 Ig heavy chain class switch recombination (CSR) involves

27 homologous DNA end-joining (NHEJ) protein in Ig heavy chain class switch recombination (CSR), we assa

28 ional enhancers speculated to play a role in Ig heavy chain class switch recombination (CSR).

29 ibodies are modulated through the process of Ig heavy chain class switch recombination (CSR).

30 tion and immunodeficient because of impaired Ig heavy chain class switch recombination.

31 The switch in immunoglobulin (Ig) heavy chain class is preceded by germline transcript

32 Immunoglobulin (Ig) heavy chain class switch recombination (CSR) mediate

33 ated by germline encoded and immunoglobulin (Ig) heavy-chain complementarity determining region 3 (HC

34 able B cell clonal populations detectable by Ig heavy chain complementary-determining region 3 mRNA s

35 ctivated mature B cells can change expressed Ig heavy chain constant region exons by class switch rec

36 (S) regions that lie upstream of the various Ig heavy chain constant region exons.

37 between switch (S) regions that precede each Ig heavy chain constant region gene.

38 demonstrate that a transgene containing the Ig heavy chain constant region locus, inserted into five

39 results indicated that the accessibility of Ig heavy chain constant regions targeted for CSR was est

40 on downstream of the most 3' immunoglobulin (Ig) heavy chain constant region gene (Calpha) contains a

41 demonstrate that DIR2 is used to form human Ig heavy chains, contributing to 7% of the human heavy c

42 ace BCR expression in mature B cells through Ig-heavy chain deletion results in apoptosis of these ce

43 for the basic recombination reaction and for Ig heavy chain DH to JH joining, is essential for effici

44 The Ig heavy chain enhancer of the channel catfish (Ictaluru

45 on of a c-myc transgene under control of the Ig heavy-chain enhancer (Emu) results in an increase in

46 The lymphoma-inducing potential of Ig heavy-chain enhancer- and promoter-regulated Epstein-

47 -regulation of CD43 can occur independent of Ig heavy chain expression.

48 client protein interactions, immunoglobulin (Ig) heavy chain folding intermediates containing bound G

49 sequences, and a group of randomly selected Ig heavy chains from Genbank.

50 The juxtaposition of the Ig heavy chain gene and Myc in Burkitt's lymphoma and in

51 the joining (J) gene segment of the chicken Ig heavy chain gene by homologous recombination in primo

52 Analysis of Ig heavy chain gene sequences showed identical variants

53 Transgenic mice were developed bearing an Ig heavy chain gene specific for the D protein component

54 determined cell division dynamics, germ-line Ig heavy chain gene transcription and surface IgG1 (sIgG

55 s as class switching and increased levels of Ig heavy chain gene transcription in plasma cells.

56 r the presence of ongoing mutations in their Ig heavy chain gene.

57 first evidence for a role of IRF proteins in Ig heavy-chain gene expression.

58 Clonal Ig heavy-chain gene rearrangements (lgHGR) have infreque

59 action (PCR) amplification of the rearranged Ig heavy-chain gene showed the same sized dominant produ

60 cells that had not undergone immunoglobulin (Ig) heavy chain gene class switching or somatic hypermut

61 these sequences on the regulation of IgM and IgD heavy chain gene expression in transfectants as well

62 -1/IgH translocation and clonally rearranged Ig heavy chain genes (IgH) provided molecular markers fo

63 ate production of germ-line transcripts from Ig heavy chain genes and subsequent switch recombination

64 hancer (3'alphaE) regulate expression of the Ig heavy chain genes during B cell development.

65 tion of a relatively small proportion of the Ig heavy chain genes expressed by normal adult B cells.

66 We therefore analyzed the expressed Ig heavy chain genes in 23 cases (11 families) of famili

67 Similar to the Ig heavy chain genes, the corresponding Ig light chain g

68 quenced 209 nonproductive and 926 productive Ig heavy chain genes.

69 evel of somatic hypermutations in rearranged IG heavy-chain genes could define two CLL subtypes assoc

70 ncing analysis of rearranged immunoglobulin (Ig) heavy chain genes from biological replicates, coveri

71 -2L(d) and the Fc portion of immunoglobulin (Ig) heavy chain genes mu or gamma1.

72 noglobulin (Ig) proteins derived from single Ig heavy chain (H) and light chain (L) alleles.

73 development, rearrangement and expression of Ig heavy chain (HC) genes promote development and expans

74 , we generated a knock-in mouse in which the Ig heavy chain (HC) variable region rearrangement (V(H)D

75 Immunoglobulin (Ig) heavy chain (HC) class switch recombination (CSR) is

76 talurus punctatus), a novel complex chimeric Ig heavy chain, homologous, in part, to the heavy chain

77 ed Ig genes, and one case expressed switched Ig heavy chain (IgA), suggesting that they originated fr

78 The murine Ig heavy chain (IgH) 3' regulatory region contains four

79 was evaluated for translocations between the Ig heavy chain (IgH) and chromosomes 4, 11, and 16, tran

80 A-specific cytidine deaminase that initiates Ig heavy chain (IgH) class switch recombination (CSR) an

81 plays a dominant role in joining DSBs during Ig heavy chain (IgH) class switch recombination (CSR) in

82 (DSBs) serve as obligatory intermediates for Ig heavy chain (Igh) class switch recombination (CSR).

83 Ig heavy chain (IgH) class-switch recombination (CSR) re

84 The Ig heavy chain (IgH) constant region (CH) genes are orga

85 The intronic Ig heavy chain (IgH) enhancer, which consists of the cor

86 oteins that bind the HE2 region of the human Ig heavy chain (IgH) enhancer.

87 As a master regulator of functional Ig heavy chain (IgH) expression, the IgH 3' regulatory r

88 her B-lineage neoplasm, exhibits oligoclonal Ig heavy chain (IgH) gene rearrangement in 15% to 43% of

89 on (CSR) involves a DNA rearrangement in the Ig heavy chain (IgH) gene that allows the same variable

90 e consensus primers for amplification of all Ig heavy chain (IGH) genes in a mixture of peripheral bl

91 of chimeric mice demonstrated that the core Ig heavy chain (IgH) intronic enhancer (iEmu) functions

92 -restricted regulatory regions including the Ig heavy chain (IgH) intronic enhancer, the IgH 3' enhan

93 Ig heavy chain (IgH) isotypes (e.g., IgM, IgG, and IgE)

94 ing of long primary RNA transcripts from the Ig heavy chain (Igh) locus and serve as the receptors fo

95 Clonal rearrangements of the Ig heavy chain (IGH) locus consisting of either intrachr

96 Clonal rearrangements of the Ig heavy chain (IGH) locus occur in nearly all cases of

97 uperanchor was positioned down-stream of the Ig heavy chain (Igh) locus.

98 YAC) containing a 220 kb region of the human Ig heavy chain (IgH) locus.

99 R) analysis for the presence of an identical Ig heavy chain (IgH) or T-cell receptor (TCR) gene rearr

100 on lymphopoiesis, we initially sequenced the Ig heavy chain (IgH) rearrangements within the late pro-

101 ection of antisense transcripts in assembled Ig heavy chain (IgH) variable region exons and their imm

102 Ig heavy chain (IgH) variable region exons are assembled

103 We used chromosomal translocations and Ig heavy chain (IGH)/T cell antigen receptor (TCR) rearr

104 ic leukemia (CLL) found to express unmutated Ig heavy chains (IgH) encoded by a 51p1 allele of IGHV1-

105 allows splenic B cells activated to undergo Ig heavy-chain (IgH) class-switch recombination (CSR) to

106 hemistry, EBV in situ hybridization, and for Ig heavy-chain (IgH) gene rearrangements, Clinically, we

107 kiss) EST gene index, we identified a unique Ig heavy-chain (IgH) isotype.

108 In mice, the Ig heavy-chain (IgH) locus contains, from 5' to 3', seve

109 SR may facilitate T(12;15): transposition of Ig heavy-chain (IgH) sequences to Myc.

110 (motif-1) or DPSFYSSSWTLFDY (motif-2) in the Ig heavy-chain (IgH) third complementarity-determining r

111 oping lymphocytes and during immunoglobulin (Ig) heavy chain (IgH) class switch recombination (CSR) i

112 and the region spanning the immunoglobulin (Ig) heavy chain (IgH) variable (V), diversity (D), and j

113 ne deaminase (AID) initiates immunoglobulin (Ig) heavy-chain (IgH) class switch recombination (CSR) a

114 and beta-catenin was different from that of Ig heavy chain in HCV-infected cells, suggesting two dif

115 good evidence for a signaling role played by Ig heavy chain in the developmental transition through t

116 s, GRP94 remained in stable association with Ig heavy chains in the presence of ATP or ADP.

117 Gene rearrangement of the Ig heavy chain indicated monoclonality or oligoclonality

118 ffects of adenosine nucleotides on chaperone-Ig heavy chain interactions were examined.

119 elease of BiP from both wild-type and mutant Ig heavy chain intermediates, GRP94 remained in stable a

120 ed to the B cell compartment using the mouse Ig heavy chain intron enhancer.

121 narily conserved, as mammalian Ig lambda and Ig heavy chain intron enhancers efficiently stimulate hy

122 the core E alpha element (E alpha C), or the Ig heavy chain intronic enhancer (iE mu), all of which p

123 th 5' and 3' in a fashion reminiscent of the Ig heavy chain intronic enhancer-associated MARs.

124 These B cells demonstrate Ig heavy chain isotype switching and autoimmune reactivi

125 Ig heavy chain isotype switching in B lymphocytes is kno

126 because they have a targeted deletion in the Ig heavy chain (J) locus, were more resistant to infecti

127 ow crossed the TCRMOG mice with MOG-specific Ig heavy-chain knock-in mice (IgHMOG mice; also referred

128 inding of the transcription factor Bright to Ig heavy chain loci after B cell activation is associate

129 Translocations involving both Ig heavy chain loci and clonal-like, dynamic IgA switchi

130 Germ-line transcripts from Ig heavy chain loci precede the occurrence of isotype sw

131 V(D)J is tightly controlled at the Ig heavy chain locus (IgH) at several different levels,

132 ween 9p13 and the switch micro region of the Ig heavy chain locus (IgH) on 14q32.

133 The 3' Ig heavy chain locus (Igh) regulatory region is the most

134 At the Ig heavy chain locus (IgH), a nucleosome in pro-B cells

135 rocess is independent of location within the Ig heavy chain locus and potentially AID-promoted.

136 The t(14;18) translocation involving the Ig heavy chain locus and the BCL-2 gene is the single mo

137 The Ig heavy chain locus contains a number of binding sites

138 Quantitative deep sequencing of the Ig heavy chain locus from B220(+)CD43(+) populations ide

139 important role in driving expression of the Ig heavy chain locus in a teleost fish.

140 appears to be greater than that found in the Ig heavy chain locus in the opossum, and light chains ar

141 The transcription of the murine Ig heavy chain locus is regulated not only by the intron

142 antisense germ-line transcription within the Ig heavy chain locus precedes V(D)J recombination and ha

143 gresses, RNA processing changes occur at the Ig heavy chain locus resulting in a switch from the memb

144 BLIN-2 has a clonal rearrangement of the Ig heavy chain locus, a dic(9;20) chromosomal abnormalit

145 train (H2dIgh-1b), which differs only in the Ig heavy chain locus, is resistant to HSK.

146 and can bind to regulatory sites within the Ig heavy chain locus.

147 rranged V(D)J segment at the immunoglobulin (Ig) heavy chain locus, the other allele being nonfunctio

148 and Rag1/2, which are critical for the IgH (Ig heavy-chain) locus contractions and rearrangement.

149 To further characterize the role of Ig heavy chain-mediated signaling in vivo, as well as in

150 IR gene segments by cross-breeding the human Ig heavy chain minilocus pHC1 transgenic mice and TdT-de

151 lls resulted in a decrease in the endogenous Ig heavy-chain mRNA secretory form-to-membrane ratio.

152 We have analyzed 543 Ig heavy chain nonproductive rearrangements, involving a

153 demonstrated surface expression of membrane Ig heavy chain on up to 40% of the cells from a transgen

154 on of polyadenylation of the immunoglobulin (Ig) heavy-chain pre-mRNA argued for trans-acting modifie

155 In homozygous knockouts, Ig heavy chain production is eliminated, and no antibody

156 with LMP1 expressed under the control of the Ig heavy chain promoter and enhancer.

157 ession was driven by the Emicro-enhancer and Ig heavy-chain promoter, and a 3' GFP tag was added to t

158 pment depends upon the surface expression of Ig heavy chain protein (mu) in a signaling complex known

159 uctures at the Igh locus that compact during Ig heavy chain rearrangement.

160 effect of age on the diversity of the murine Ig heavy chain repertoire has been studied in unimmunize

161 cells contributes to the suppression of the Ig heavy-chain secretory poly(A) site.

162 hypervariable, but not framework, regions of Ig heavy chain specifically stimulated CD4(+) and CD8(+)

163 LR1 also binds Ig heavy chain switch region sequences and may function

164 e carrying c-myc illegitimately joined to an Ig heavy chain switch region, ie, the t(12;15) chromosom

165 differ strikingly at the molecular level in Ig heavy chain third complementarity determining region

166 ocytes in association with Vpre-B and the mu Ig heavy chain to form the pre-B receptor.

167 Despite having more than one Ig heavy chain transcript, each sample was found to expr

168 ed a phylogenetic distance metric to analyze Ig heavy-chain transcript sequences in both young and el

169 The B cell regulator of Ig heavy chain transcription (Bright) is a DNA-binding p

170 'RR-deficient mice, whereas the simultaneous Ig heavy chain transcription rate is only partially redu

171 Thus, a recombined Ig heavy chain transgene prominently undergoes somatic d

172 TdT and an Ig heavy chain transgene were detected within a hormone-

173 a fide camelid IgG in which modifications of Ig heavy chain V (VH) sequences prevent dimer formation

174 The usage of >100 functional murine Ig heavy chain V(H) genes, when rearranged to D(H)J(H) g

175 s and GC B cells from infected mice revealed Ig heavy-chain V genes with significantly increased C-to

176 Unmutated CLLs, carrying Ig heavy chain variable (IGHV) genes in germline configu

177 Although Ig heavy chain variable region (V(H)) genes encode a sub

178 The Ig heavy chain variable region (V(H)) genes encode the a

179 To determine human Ig heavy chain variable region (VH) gene segment organiz

180 frozen tissue sections and their rearranged Ig heavy chain variable region (VH) genes of the V186.2/

181 phocytic leukemia (CLL) express a restricted Ig heavy chain variable region gene (VH gene) repertoire

182 Ig heavy-chain variable region exons are assembled devel

183 exclusively with rearrangements of a single Ig heavy-chain variable-region gene (V(H)3-30), despite

184 tribution of autoreactive antibodies between Ig heavy-chain variable-unmutated (IgV-unmutated) CLL (U

185 (BCLL) patients expresses an immunoglobulin (Ig) heavy chain variable (V(H)) region gene with some le

186 with sporadic B-CLL the same immunoglobulin (Ig) heavy chain variable region (VH) gene usage and occu

187 We examined the immunoglobulin (Ig) heavy chain variable region genes (V(H) genes) used

188 une repertoire sequencing of immunoglobulin (Ig) heavy chain variable regions (VH) from CSF and subso

189 expressed immunoglobulin (Ig) encoded by the Ig heavy-chain-variable-region gene (IGHV), IGHV3-21.

190 Using a simplified two-domain Ig heavy chain (VH-CH1), we have determined why BiP rema

191 A nearly identical CLL69C Ig heavy chain was identified from an MAA-enriched umbil

192 The binding of BiP to Ig heavy chains was ATP-sensitive.

193 Because 38B9 cells lack Ig heavy chains, we stably expressed mu heavy chain prot

194 coding for the membrane-bound form of the mu Ig heavy chain, which suggests a predominance of B lymph

195 by the association of incompletely assembled Ig heavy chains with the endoplasmic reticulum (ER) chap

196 n the negative selection of cells expressing Ig heavy chains with the potential to generate autoantib