ライフサイエンスコーパス: Ig light chain

1 , as well as that of WT CFTR and unassembled Ig light chain.

2 ple was found to express only one functional Ig light chain.

3 half-molecules of one Ig heavy chain and one Ig light chain.

4 f fibrillar, as well as partially denatured, Ig light chains.

5 age cells can express either kappa or lambda Ig light chains.

6 nic core of an amyloidogenic immunoglobulin (Ig) light chain.

7 Most renal amyloidosis cases are Ig light chain, AA, or leukocyte chemotactic factor 2 am

8 ereditary amyloidosis can be misdiagnosed as Ig light-chain (AL) amyloidosis because family history i

9 gly, the native conformations of insulin and Ig light chain also induced Congo red circular dichroism

10 CLU may play a pathogenetic role in TTR and Ig light chain amyloidoses and amyloidotic CMP.

11 asured in familial TTR, senile systemic, and Ig light chain amyloidosis patient groups and compared w

12 ents with familial TTR, senile systemic, and Ig light chain amyloidosis.

13 antitated by immunostaining for the relevant Ig light chain and by a quantitative polymerase chain re

14 nced multiple myeloma cell growth, decreased Ig light chain and HSPA5/BIP expression, activated ERK a

15 ified a 25 kDa protein that co-migrated with Ig light chain and was absent from RAG-1 or RAG-2 -/- br

16 gradation machinery, as well as secretion of Ig light chains and of cytokines and chemokines known to

17 from Xenopus genomic DNA that are related to Ig light chains and TCR.

18 hy characterized by deposition of monoclonal Ig light chains and/or heavy chains along the glomerular

19 BPB, and MYC and upregulated immunoglobulin (Ig) light chain and HSPA5/BIP Furthermore, pathway analy

20 ints (52%) joined to IgH, 12 (10%) joined to Ig light chains, and 46 (38%) joined to non-Ig partners.

21 as treatments had no effect on expression of Ig light chains, BCL-X, or actin.

22 to characterize monoclonal immunoglobulin (M-Ig) light chains before clinical presentation of AL amyl

23 rils from insulin and the variable domain of Ig light chain demonstrate induced CD spectra upon bindi

24 In addition, specific monoclonal Ig light chain deposition was evident within renal tubul

25 in vivo leads to the systemic deposition of Ig light chain domains in the form of either amyloid fib

26 To improve the analysis of surface Ig light chain expression and to increase the yield of i

27 B cells exhibited restricted immunoglobulin (Ig) light chain expression (either Igkappa or Iglambda),

28 eptor editing (substitution of an endogenous Ig light chain for the transgenic Ig light chain), so th

29 hich the secreted monoclonal immunoglobulin (Ig) light chains form amyloid fibrils.

30 ts composed of either transthyretin (TTR) or Ig light chain from nine patients with amyloidotic CMP w

31 a novel 3' regulatory region in the chicken Ig light chain gene containing not only a classical tran

32 In the absence of BCL6, DNA breaks during Ig light chain gene rearrangement lead to excessive up-r

33 c-Abl itself, in the regulated activation of Ig light chain gene rearrangement.

34 bility to activate secondary immunoglobulin (Ig) light chain gene rearrangement.

35 haracterized by induction of immunoglobulin (Ig) light chain gene rearrangement.

36 age-induced apoptosis during immunoglobulin (Ig) light chain gene recombination.

37 e-B lymphocytes, productive rearrangement of Ig light chain genes allows assembly of the B cell recep

38 the Ig heavy chain genes, the corresponding Ig light chain genes showed significant deviation from k

39 regulate the sequential rearrangement of the Ig light chain genes.

40 ave only detected secondary recombination of Ig light chain genes.

41 In cartilaginous fishes, the immunoglobulin (Ig) light chain genes are organized as multiple VJ-const

42 The phylogenetic relationships of Ig light chain (IGL) genes are difficult to resolve, bec

43 findings reveal a direct involvement of the Ig light chain (IgL) in B cell signaling and development

44 we have investigated the role of endogenous Ig light chain (IgL) transcriptional control elements in

45 -1 or motif-2, respectively, was paired with Ig light chains (IgL) encoded by IGLV3-21 or IGKV3-20, s

46 revealed nonstochastic pairing of disparate Ig light chains (IgL) with IgH that had restricted HCDR3

47 We conclude that maternally derived Ig light chain is present in the fetal murine CNS.

48 B cells will express either immunoglobulin (Ig) light chain k or , we designed a second-generation C

49 B cells will express either immunoglobulin (Ig) light chain kappa or lambda, we designed a second-ge

50 omes 4, 11, and 16, translocations involving Ig light chain-lambda (IgL-lambda, and Delta 13.

51 It has not been determined if the Ig light chain (LC) amyloid precursor protein in localiz

52 d epitope, recognizing both Abeta and lambda Ig light chain (LC) amyloids, which are associated with

53 aggregation of a destabilized amyloidogenic Ig light chain (LC) secreted from a clonally expanded pl

54 n of pre-B cells accompanied by the onset of Ig light chain (LC) variable region gene assembly.

55 Monoclonal Ig light chains (LC) can be responsible for pathologic c

56 In Ig light-chain (LC) amyloidosis (AL), the unique antibod

57 t the role of the monoclonal immunoglobulin (Ig) light chain (LC) is strongly suspected because of th

58 regation of an amyloidogenic immunoglobulin (Ig) light chain (LC) usually produced by a plasma cell c

59 isease in which a monoclonal immunoglobulin (Ig) light chain (LC) with a critically folded beta-confo

60 folding of a murine lambdaI immunoglobulin (Ig) light chain (LC).

61 the deposition of misfolded immunoglobulin (Ig) light chains (LC) in vital organs throughout the bod

62 on recombination machinery, the Ig heavy and Ig light chain loci rearrange in a stepwise manner.

63 trates that polymorphisms in immunoglobulin (IG) light chain loci dictate the composition of the Ab r

64 cluding unfolded light chains, a nonsecreted Ig light chain mutant, and the VSV-G ts045 mutant at the

65 h are most commonly caused by aggregation of Ig light chains or transthyretin (TTR) in the cardiac in

66 irmly establish the critical contribution of IG light chain polymorphism in Ab repertoire diversity,

67 gh interstitial amyloid fibril deposition of Ig light chain proteins is a major cause of cardiac dysf

68 results suggest that inherent reactivity of Ig light chains provides a natural mechanism for the rem

69 s indicate that VH replacement occurs before Ig light chain rearrangement and thus is not involved in

70 rgo cell-cycle arrest, a necessary event for Ig light chain rearrangement.

71 that IL-7-mediated suppression of premature Ig light-chain rearrangement is the most definitive func

72 enes, preventing the B cells from undergoing Ig light chain rearrangements.

73 in xenogeneic cultures led to an increase in Ig light-chain rearrangements in CD127(+) cells, but no

74 nexpectedly, CD127(-) cells showed extensive Ig light-chain rearrangements in the absence of IGH rear

75 which is consistent with their low level of Ig light-chain rearrangements.

76 ntibodies can be silenced by immunoglobulin (Ig) light chain receptor editing, we replaced the light

77 prompted to upregulate RAG1/2 and to undergo Ig light chain recombination.

78 l zones by cells showing the same pattern of Ig light chain restriction as the gastric lymphoma.

79 Ig light chain restriction was detected by flow cytometr

80 endogenous Ig light chain for the transgenic Ig light chain), so that their ability to bind HEL is de

81 minimized, permitting significant amounts of Ig light chains to be endocytosed into the proximal tubu

82 Aggregation of Ig light chains to form amyloid fibrils is a characteris

83 The relative paucity of N regions in Ig light chains, together with the down-regulation of Td

84 ce was obtained for ongoing rearrangement of IG light chain variable genes and expression of the surr

85 ete molecules of two Ig heavy chains and two Ig light chains, whereas the fourth isoform is predomina