ライフサイエンスコーパス: Ig light chain

1 , as well as that of WT CFTR and unassembled Ig light chain.

2 ple was found to express only one functional Ig light chain.

3 half-molecules of one Ig heavy chain and one Ig light chain.

4 f fibrillar, as well as partially denatured, Ig light chains.

5 age cells can express either kappa or lambda Ig light chains.

6 nic core of an amyloidogenic immunoglobulin (Ig) light chain.

7 Most renal amyloidosis cases are Ig light chain, AA, or leukocyte chemotactic factor 2 am

8 ereditary amyloidosis can be misdiagnosed as Ig light-chain (AL) amyloidosis because family history i

9 gly, the native conformations of insulin and Ig light chain also induced Congo red circular dichroism

10 CLU may play a pathogenetic role in TTR and Ig light chain amyloidoses and amyloidotic CMP.

11 asured in familial TTR, senile systemic, and Ig light chain amyloidosis patient groups and compared w

12 ents with familial TTR, senile systemic, and Ig light chain amyloidosis.

13 antitated by immunostaining for the relevant Ig light chain and by a quantitative polymerase chain re

14 nced multiple myeloma cell growth, decreased Ig light chain and HSPA5/BIP expression, activated ERK a

15 ified a 25 kDa protein that co-migrated with Ig light chain and was absent from RAG-1 or RAG-2 -/- br

16 from Xenopus genomic DNA that are related to Ig light chains and TCR.

17 hy characterized by deposition of monoclonal Ig light chains and/or heavy chains along the glomerular

18 BPB, and MYC and upregulated immunoglobulin (Ig) light chain and HSPA5/BIP Furthermore, pathway analy

19 ints (52%) joined to IgH, 12 (10%) joined to Ig light chains, and 46 (38%) joined to non-Ig partners.

20 as treatments had no effect on expression of Ig light chains, BCL-X, or actin.

21 to characterize monoclonal immunoglobulin (M-Ig) light chains before clinical presentation of AL amyl

22 rils from insulin and the variable domain of Ig light chain demonstrate induced CD spectra upon bindi

23 In addition, specific monoclonal Ig light chain deposition was evident within renal tubul

24 in vivo leads to the systemic deposition of Ig light chain domains in the form of either amyloid fib

25 To improve the analysis of surface Ig light chain expression and to increase the yield of i

26 eptor editing (substitution of an endogenous Ig light chain for the transgenic Ig light chain), so th

27 hich the secreted monoclonal immunoglobulin (Ig) light chains form amyloid fibrils.

28 ts composed of either transthyretin (TTR) or Ig light chain from nine patients with amyloidotic CMP w

29 a novel 3' regulatory region in the chicken Ig light chain gene containing not only a classical tran

30 In the absence of BCL6, DNA breaks during Ig light chain gene rearrangement lead to excessive up-r

31 c-Abl itself, in the regulated activation of Ig light chain gene rearrangement.

32 bility to activate secondary immunoglobulin (Ig) light chain gene rearrangement.

33 haracterized by induction of immunoglobulin (Ig) light chain gene rearrangement.

34 age-induced apoptosis during immunoglobulin (Ig) light chain gene recombination.

35 e-B lymphocytes, productive rearrangement of Ig light chain genes allows assembly of the B cell recep

36 the Ig heavy chain genes, the corresponding Ig light chain genes showed significant deviation from k

37 regulate the sequential rearrangement of the Ig light chain genes.

38 ave only detected secondary recombination of Ig light chain genes.

39 In cartilaginous fishes, the immunoglobulin (Ig) light chain genes are organized as multiple VJ-const

40 The phylogenetic relationships of Ig light chain (IGL) genes are difficult to resolve, bec

41 findings reveal a direct involvement of the Ig light chain (IgL) in B cell signaling and development

42 we have investigated the role of endogenous Ig light chain (IgL) transcriptional control elements in

43 -1 or motif-2, respectively, was paired with Ig light chains (IgL) encoded by IGLV3-21 or IGKV3-20, s

44 revealed nonstochastic pairing of disparate Ig light chains (IgL) with IgH that had restricted HCDR3

45 We conclude that maternally derived Ig light chain is present in the fetal murine CNS.

46 omes 4, 11, and 16, translocations involving Ig light chain-lambda (IgL-lambda, and Delta 13.

47 It has not been determined if the Ig light chain (LC) amyloid precursor protein in localiz

48 d epitope, recognizing both Abeta and lambda Ig light chain (LC) amyloids, which are associated with

49 aggregation of a destabilized amyloidogenic Ig light chain (LC) secreted from a clonally expanded pl

50 n of pre-B cells accompanied by the onset of Ig light chain (LC) variable region gene assembly.

51 Monoclonal Ig light chains (LC) can be responsible for pathologic c

52 regation of an amyloidogenic immunoglobulin (Ig) light chain (LC) usually produced by a plasma cell c

53 isease in which a monoclonal immunoglobulin (Ig) light chain (LC) with a critically folded beta-confo

54 folding of a murine lambdaI immunoglobulin (Ig) light chain (LC).

55 the deposition of misfolded immunoglobulin (Ig) light chains (LC) in vital organs throughout the bod

56 on recombination machinery, the Ig heavy and Ig light chain loci rearrange in a stepwise manner.

57 cluding unfolded light chains, a nonsecreted Ig light chain mutant, and the VSV-G ts045 mutant at the

58 h are most commonly caused by aggregation of Ig light chains or transthyretin (TTR) in the cardiac in

59 gh interstitial amyloid fibril deposition of Ig light chain proteins is a major cause of cardiac dysf

60 results suggest that inherent reactivity of Ig light chains provides a natural mechanism for the rem

61 s indicate that VH replacement occurs before Ig light chain rearrangement and thus is not involved in

62 rgo cell-cycle arrest, a necessary event for Ig light chain rearrangement.

63 that IL-7-mediated suppression of premature Ig light-chain rearrangement is the most definitive func

64 enes, preventing the B cells from undergoing Ig light chain rearrangements.

65 in xenogeneic cultures led to an increase in Ig light-chain rearrangements in CD127(+) cells, but no

66 nexpectedly, CD127(-) cells showed extensive Ig light-chain rearrangements in the absence of IGH rear

67 which is consistent with their low level of Ig light-chain rearrangements.

68 ntibodies can be silenced by immunoglobulin (Ig) light chain receptor editing, we replaced the light

69 l zones by cells showing the same pattern of Ig light chain restriction as the gastric lymphoma.

70 Ig light chain restriction was detected by flow cytometr

71 endogenous Ig light chain for the transgenic Ig light chain), so that their ability to bind HEL is de

72 minimized, permitting significant amounts of Ig light chains to be endocytosed into the proximal tubu

73 Aggregation of Ig light chains to form amyloid fibrils is a characteris

74 The relative paucity of N regions in Ig light chains, together with the down-regulation of Td

75 ce was obtained for ongoing rearrangement of IG light chain variable genes and expression of the surr

76 ete molecules of two Ig heavy chains and two Ig light chains, whereas the fourth isoform is predomina