ライフサイエンスコーパス: Ig

1 Ig heavy chain (IgH) isotypes (e.g., IgM, IgG, and IgE)

2 Ig heavy-chain variable region exons are assembled devel

3 Ig stripping combined with passive sensitization +/- oma

4 (cytotoxic T-lymphocyte-associated protein 4 Ig) is an emerging treatment in kidney transplantation.

5 The development of the fusion protein CTLA-4-Ig as an experimental and subsequent therapeutic tool is

6 Blockade of CD80/CD86 with CTLA-4-Ig markedly reduced the cycling and absolute numbers of

7 at was reversed upon cotreatment with CTLA-4-Ig.

8 cytotoxic T-lymphocyte-associated protein 4-Ig reducing disease symptoms and immunologic disturbance

9 cytotoxic T-lymphocyte-associated protein 4-Ig should be evaluated as a potential treatment of infla

10 In particular, abnormal Ig free light chains (LCs) may accumulate within epithel

11 IgE is the least abundant Ig isotype, yet it plays a critical role in allergic rea

12 tructural motifs located in the two adjacent Ig-like domains dictate the processing of CTDs by the T9

13 Here we define features of the AGM Ig loci and compare the proportion of Env-specific memor

14 cess of somatic hypermutation (SHM) and also Ig class switching, can have a potent mutator phenotype

15 y, we aimed to evaluate whether this altered Ig repertoire interferes with the inflammatory responsiv

16 Although Ig-containing and proline-rich receptor-1(IGPR-1) was re

17 rial subunits that makes them peculiar among Ig-like domain-containing proteins is a conserved disulf

18 n alpha-helical capsid-binding domain and an Ig-like domain exposed to the solvent.

19 cells in thymus were mature and displayed an Ig gene repertoire that was similar to pediatric bone ma

20 afted B-1 cells in humanized mice exhibit an Ig-usage pattern comparable to B-1 cells in cord blood.

21 erized NOD mice transgenically expressing an Ig molecule representative of a large proportion of natu

22 sulting from the structural properties of an Ig-like fold of DraE.

23 It shows an Ig-fold like architecture which consists of two antipara

24 e single-pass transmembrane proteins with an Ig-like domain, share the same subcellular distribution

25 ed a phylogenetic distance metric to analyze Ig heavy-chain transcript sequences in both young and el

26 reened a cohort of 141 patients with C3G and Ig-associated membranoproliferative GN (Ig-MPGN) for ant

27 profile, as indicated by increased CD57 and Ig-like transcript 2 and an inability to produce IFN-gam

28 tosis, Fc receptor function, complement, and Ig regulation are enhanced in PBS-treated Nrf2 null gene

29 B cell development and Ig rearrangement are governed by cell type- and developm

30 ing promotes plasma cell differentiation and Ig production, we investigated whether stromal expressio

31 also observed the codeposition of DNAJB9 and Ig-gamma Overall, these findings indicate that DNAJB9 is

32 on recombination machinery, the Ig heavy and Ig light chain loci rearrange in a stepwise manner.

33 l activation induces terminal maturation and Ig isotype class switch (class switch recombination [CSR

34 od marker for differentiating Ig-mutated and Ig-unmutated CLL and serve as prognostic marker.

35 nexpectedly that the leucine-rich repeat and Ig domain protein 1 (LINGO1) is expressed in over 90% of

36 ly demonstrated that leucine-rich repeat and Ig-like domain-containing Nogo receptor interacting prot

37 Leucine-rich repeat and Ig-like domain-containing Nogo receptor interacting prot

38 Mechanistically, injection of serum and Ig from CV mice into GF animals restored IgG deposition,

39 ol of the Fc-associated glycan structure and Ig subclass composition on the one hand and selective Fc

40 te and comprehensive repositories of TCR and Ig alleles.

41 with median survivals close to 25 years, and Ig-mutated CLL, where have more aggressive disease with

42 Most renal amyloidosis cases are Ig light chain, AA, or leukocyte chemotactic factor 2 am

43 s analysis of immunoglobulin (referred to as Ig-seq) coupled with high-throughput sequencing of trans

44 ibitory receptor called leukocyte-associated Ig-like receptor-1 (LAIR-1).

45 development of a novel flow cytometry-based Ig capture assay (ICA) for the identification and sortin

46 ped subset #4 (mutated IGHV4-34/IGKV2-30 BCR Ig) display a particularly indolent disease course.

47 Immunogenetic studies of the clonotypic BCR Ig of CLL subset #4 suggested a resemblance with B cells

48 The interaction between Ig-like transcript 3 (ILT3), a marker of tolerogenic den

49 A locus at SIGLEC5 (sialic acid binding Ig-like lectin 5) and a chromosomal region downstream of

50 ler (NK) cell inhibitory sialic acid-binding Ig-like lectin (Siglec) receptors, and enhanced binding

51 CD22 and sialic acid-binding Ig-like lectin (Siglec)-G are members of the Siglec fami

52 if ligand 18 (PARC), and sialic acid-binding Ig-like lectin 14 (SIG14) were significantly modulated i

53 CD22, a sialic acid-binding Ig-type lectin (Siglec) family member, is an inhibitory

54 Both Ig and TR rearrangements showed a significant decrease i

55 We found that both Ig loci were contracted in pro-B and pre-B cells.

56 and a stabilized version of mouse CCL1 (CCL1-Ig).

57 Administration of CCL1-Ig during EAE enhanced the in vivo proliferation of thes

58 the sulfotyrosine-binding pocket by CCR5mim2-Ig was sufficient for promoting CD4bs antibody binding t

59 D4bs antibodies were not as efficient as CD4-Ig at promoting E51 or 412d binding to Env trimer.

60 re more efficiently neutralized by human CD4-Ig (huCD4-Ig) than by the same molecule bearing rhesus C

61 without altering neutralization by human CD4-Ig, SIV neutralizing antibodies, or sera from SIV-infect

62 Consistent with these observations, CD4-Ig, but none of the CD4bs antibodies tested, substantial

63 its neutralization sensitivity to rhesus CD4-Ig without altering neutralization by human CD4-Ig, SIV

64 d by ILC2s were sufficient to enhance B cell Ig production.

65 ll analysis to interrogate the memory B cell Ig repertoires from two rhesus macaques after five seria

66 matic hypermutation (SHM) patterns in B cell Ig sequences have important basic science and clinical a

67 ons of activating members of the killer cell Ig-like receptor (KIR) family are not fully understood,

68 e C1-epitope motif recognized by killer cell Ig-like receptor.

69 ific and C2-specific lineage III killer cell Ig-like receptors (KIR).

70 Human NK cells carry inhibitory killer cell Ig-like receptors (KIRs), which recognize distinct HLAs.

71 ng the Bw4 epitope recognized by killer cell Ig-like receptors of NK cells, allotypes having the C1 e

72 arkers c-kit and IL-7Ralpha, nor killer cell Ig-like receptors or other late-differentiation markers.

73 he C1 epitope also recognized by killer cell Ig-like receptors, and allotypes having neither epitope.

74 ressing self-specific inhibitory killer cell Ig-like receptors.

75 T cell Ig and ITIM domain receptor (TIGIT), expressed on T, NK,

76 CTL-associated protein 4 (CTLA4), and T cell Ig and mucin domain protein-3 (TIM-3) coinhibitory signa

77 Although T cell Ig and mucin domain-containing molecule (TIM)-1 broadly

78 The enhanced expression of T cell Ig and mucin protein-3 (TIM-3) on tumor-associated dendr

79 udy, we identified elevated levels of T cell Ig and mucin-domain containing molecule-3 (Tim-3)-expres

80 In vivo blockade of T cell Ig mucin 3 signaling failed to enhance TCD8 function or

81 lymphocyte activation gene 3 (LAG-3), T cell Ig mucin 3, and 2B4.

82 used on Programmed Death 1 (PD-1) and T cell Ig- and mucin-domain molecule 3 (Tim-3), which are poten

83 wer levels of the inhibitory receptor T-cell Ig and ITIM domain (TIGIT), which results in resistance

84 ated with defective expression of the T-cell Ig mucin (TIM)-4 receptor.

85 In B cells, Ig class switch recombination (CSR) is initiated by acti

86 the frequency of CD4(+) and CD8(+) T cells, Ig(+) B cells, CD11b(+) myeloid-derived cells, and major

87 f the unrearranged human H chain and L chain Ig gene loci.

88 Both IgL 1 and 2 adopt the classical Ig domain conformation comprised of two layers of beta-s

89 of allergen-containing IgG immune complexes (Ig-ICs) by gut dendritic cells (DCs).

90 In contrast to CD80/86 antagonists (CTLA4-Ig), FR104 selectively blunts CD28 costimulation while s

91 otype, which was partially reversed by CTLA4-Ig therapy.

92 After treatment with low dose CTLA4-Ig, PI3Kgamma (-/-) , but not PI3Kappadelta (D910A/D910A

93 utophagosome formation, while DCs from CTLA4-Ig-treated rheumatoid arthritis patients displayed dimin

94 e presentation of chronic rejection in CTLA4-Ig-treated LysM(C)(re) Traf6 (fl/fl) mice was similar to

95 acy testing, we examined the effect of CTLA4-Ig and rapamycin on DSA-mediated cytolysis.

96 - and stability-engineered variants of CTLA4-Ig fusion molecules with enhanced pharmacokinetic profil

97 f6 (fl/fl) mice was similar to that of CTLA4-Ig-treated wild-type B6 recipients.

98 tive transplant survival outcomes post CTLA4-Ig treatment.

99 the T cell costimulatory signal by the CTLA4-Ig synthetic protein (abatacept) could prevent SEB-depen

100 l of T cell-dependent Ab response, the CTLA4-Ig variant MEDI5265 could be formulated at >100 mg/ml fo

101 as a correlate of clinical response to CTLA4-Ig therapy.

102 response of LRBA-deficient patients to CTLA4-Ig therapy.

103 so, blocking antigen presentation with CTLA4-Ig improves RBP4-induced insulin resistance and macropha

104 ysM(C)(re) Mtor(fl/fl) recipients with CTLA4-Ig induced long-term allograft survival (>100 days) with

105 TLA4 deficiency sharply decreased with CTLA4-Ig therapy in parallel with other markers of immune dysr

106 Human DCs treated with CTLA4-Ig, a fusion protein composed of the Fc region of IgG1 a

107 entation by treating RBP4-Ox mice with CTLA4-Ig, which blocks costimulation of T cells, is sufficient

108 tion of activated B cells and their cytokine/Ig production in vitro, and that pharmaceutically or gen

109 n cytokine/chemokine signaling and decreased Ig-mediated processes.

110 nced multiple myeloma cell growth, decreased Ig light chain and HSPA5/BIP expression, activated ERK a

111 tus and is a good marker for differentiating Ig-mutated and Ig-unmutated CLL and serve as prognostic

112 nflammation and that GF mice have a distinct Ig repertoire and B cell activity, we aimed to evaluate

113 le B cell responding to Ag, with diversified Ig receptors.

114 recently discovered NCRs is VISTA (V-domain Ig-containing Suppressor of T cell Activation).

115 Using dual variable domain Ig (DVD-Ig) technology, we constructed a molecule with a

116 GN cases also contained IgG1 as the dominant Ig and proteins of the classic complement pathway.

117 ystemic administration of the bispecific DVD-Ig or the TGF-beta mAb (1-10 mg/kg) but not the FnEDA mA

118 ction of the bispecific TGF-beta + FnEDA DVD-Ig or an FnEDA mAb, chemiluminescent detection and imagi

119 Using dual variable domain Ig (DVD-Ig) technology, we constructed a molecule with a moiety

120 s) represent a multigene family that encodes Ig superfamily proteins that mediate activating or inhib

121 t led to heightened expression of endogenous Ig H and L chains in splenic B cells, upregulation of RA

122 ich B cells develop can affect the expressed Ig repertoire by exerting influences on the distribution

123 NOD mice transgenically expressing Ig molecules recognizing antigens that are (insulin) or

124 Here we report novel feline Ig sequences, a technique to express antigen-specific fe

125 pa) and lambda (Iglambda) L chains of ferret Ig.

126 (DSBs) serve as obligatory intermediates for Ig heavy chain (Igh) class switch recombination (CSR).

127 ating receptor FcgammaRIII was necessary for Ig-mediated acquisition of Ags by isolated intestinal eo

128 lebsiella pneumoniae Transferring serum from Ig-deficient mice to GF animals did not alter their resp

129 As a master regulator of functional Ig heavy chain (IgH) expression, the IgH 3' regulatory r

130 ertions, whereas residues adjacent to the gD Ig-like V-type core tolerated shorter insertions (up to

131 and Ig-associated membranoproliferative GN (Ig-MPGN) for anti-FB and anti-C3b autoantibodies using E

132 Whereas variable gene segment of the H Ig chain (VH) gene usage in asthma reflected germline di

133 sion at the C-terminal end of the IgM heavy (Ig-mu) chains, termed the tailpiece, is necessary and su

134 In B6.Sle2(z)HEL(Ig).sHEL BCR-transgenic mice, Sle2(z) did not breach cen

135 d PCs with limited ER stress supporting high Ig secretion, but with a cost in terms of antigen-indepe

136 ac239, bound to and was neutralized by huCD4-Ig and rhCD4-Ig with nearly identical efficiencies.

137 ficiently neutralized by human CD4-Ig (huCD4-Ig) than by the same molecule bearing rhesus CD4 domains

138 to bind rhCD4-Ig more efficiently than huCD4-Ig.

139 Avelumab, a human Ig-G1 monoclonal antibody targeting PD-L1 and approved i

140 Neuraminidase treatment of coated CHIR-human Ig proteins reduced binding of trimeric H5 proteins to C

141 ablast expansions and increased VH3 idiotype Ig; however, the mechanisms for staphylococcal modificat

142 Immunoglobulin (Ig) class switch recombination (CSR) is initiated by the

143 NTHi expresses 4 immunoglobulin (Ig)A protease variants (A1, A2, B1, B2) with distinct cl

144 nic core of an amyloidogenic immunoglobulin (Ig) light chain.

145 eucine-rich repeat (LRR) and immunoglobulin (Ig) domains of Gpr124, and weakening this interaction by

146 ated by germline encoded and immunoglobulin (Ig) heavy-chain complementarity determining region 3 (HC

147 or necrosis factor (TNF) and immunoglobulin (Ig) superfamilies with diverse, and often opposing, outc

148 quantitative PCR (qPCR), and immunoglobulin (Ig)M trypomastigote excreted-secreted antigen (TESA)-blo

149 en manifests systemically as immunoglobulin (Ig)-related syndromes due to aberrant B-cell functions.

150 ollment were tested for DENV immunoglobulin (Ig) G and IgM to estimate incidence during the study per

151 interfaces of two different immunoglobulin (Ig) constant domain pairs are exchanged in part or fully

152 mmunity from OMVs comes from immunoglobulin (Ig), particularly IgG, in the milk of mucosally immunize

153 The germline immunoglobulin (Ig) variable heavy chain 4-34 (VH4-34) gene segment enco

154 to edit the mouse and human immunoglobulin (Ig) genes.

155 in mice transgenic for human immunoglobulin (Ig) loci.

156 eptor repertoire analysis of immunoglobulin (Ig) and T-cell receptor (TR) rearrangements, using next-

157 ntibody titer and avidity of immunoglobulin (Ig) G specific for diphtheria toxin, pertussis toxin, fi

158 The role of immunoglobulin (Ig)-E in occupational asthma (OA) due to low molecular w

159 lergen-specific serum/plasma immunoglobulin (Ig) E levels later in life.

160 For groups 1 and 2, plasma immunoglobulin (Ig) G, IgA, and neutralizing antibody responses at week

161 Anti-M. pneumoniae immunoglobulin (Ig) M antibodies were detected in GBS patients and healt

162 Aberrantly rearranged immunoglobulin (Ig) alleles are frequent.

163 f pollen) to determine serum immunoglobulin (Ig) E concentrations and Treg percentages.The probiotic

164 etin, IL-5 and IL-13), serum immunoglobulin (Ig)E and airway hyper-responsiveness (AHR).

165 fection elicited significant immunoglobulin (Ig)G and IgM antibody responses, indicating bacterial co

166 mbrane protein with a single immunoglobulin (Ig) domain, instructs the distinct, neuron-type-specific

167 LPS- and flagellin-specific immunoglobulin (Ig) concentrations were associated with poor growth in y

168 dical interview and specific immunoglobulin (Ig) E levels, and he consequently underwent an oral food

169 termine 6-month BCG-specific immunoglobulin (Ig) G and IgA levels.

170 Antigen-specific immunoglobulin (Ig) G targeting Duffy binding-like (DBL) domains from di

171 mutator enzyme that targets immunoglobulin (Ig) genes to initiate antibody somatic hypermutation (SH

172 nected to a carboxy-terminal immunoglobulin (Ig)-like domain through a beta-hairpin stabilized by dis

173 -switch recombination of the immunoglobulin (Ig) genes occur in germinal center (GC) B cells and are

174 itor-B cells recombine their immunoglobulin (Ig) loci to create unique antigen receptors.

175 Two immunoglobulin (Ig) diversification mechanisms collaborate to provide pr

176 Typically, immunoglobulin (Ig) domain-containing proteins control cell adhesion and

177 BPB, and MYC and upregulated immunoglobulin (Ig) light chain and HSPA5/BIP Furthermore, pathway analy

178 Results were correlated with immunoglobulin (Ig) G responses.

179 Immunoglobulins (Ig)-binding and the degranulation capacities of native a

180 Identification of the underlying defect in Ig-MPGN could lead to improved treatment.

181 This phenotype was not observed in Ig-treated Rag1(-/-) mice or wild-type mice treated with

182 bond-delimited polypeptide loops present in Ig-type CnaA domains.

183 alternative pathway activation is similar in Ig-MPGN and C3G, suggesting similar pathogenic mechanism

184 lobulins (Igs) and do not bind to the intact Ig counterpart.

185 ard of care (plasma exchange and intravenous Ig) at ten international centers.

186 ment, including plasma exchange, intravenous Ig, and rituximab.

187 ptimally required five tandem repeats of its Ig-binding domains.

188 ividuals, independently of activating killer Ig-like receptor expression.

189 ribution of other NK receptors (i.e., killer Ig-like receptor, LILRB1, or CD57) supported a sequentia

190 ptors, including NKG2A and inhibitory killer Ig-like receptors (KIRs), was negatively correlated with

191 TCL, except for the KIR family member killer Ig-like receptor 2DL4 (KIR2DL4; alias CD158D), which was

192 NK cells recognize self-HLA via killer Ig-like receptors (KIR).

193 Leukocyte Ig Like Receptors (LILR) are innate immune receptors pre

194 The human leukocyte Ig-like receptor family is part of the paired receptor s

195 ectively by taking advantage of B cell light Ig chain restriction.

196 Finally, a soluble Gpr124(LRR-Ig) probe binds to cells expressing Frizzled, Wnt7a or W

197 y was achieved by treating mice with LTbetaR-Ig, a therapeutic intervention currently being tested in

198 In B lymphocytes, Ig class switch recombination (CSR) is induced by activa

199 l features considered essential in mammalian Ig gene assembly and expression.

200 iglomerular basement membrane GN, monoclonal Ig GN, and C3 glomerulopathy.

201 red by the difficulty in identifying mutated Ig sequences in vivo in the absence of selection pressur

202 chain variable (IgVH) region may be mutated (Ig-mutated CLL) or unmutated (Ig-unmutated CLL); and the

203 The first component, Mycoplasma Ig binding protein (MIB), is an 83-kDa protein that is a

204 The second component, Mycoplasma Ig protease (MIP), is a 97-kDa serine protease that is a

205 tion and induction of bnAbs, and discuss new Ig KI methodologies to manipulate the production and/or

206 nal and nonclonal mutations arise within non-Ig AID target genes in the combined absence of UNG and M

207 ive analysis of productive and nonproductive Ig gene rearrangements from transgenic mice engineered t

208 y determines stage-specific accessibility of Ig loci.

209 decrease the actin polymerizing activity of Ig domain 3 of palladin (Palld-Ig3).

210 ing (NGS) technologies, a deeper analysis of Ig and/or TCR (IG/TR) gene rearrangements is now within

211 ted by polymerase chain reaction analysis of Ig/TCR gene rearrangements, and patients were assigned t

212 isplayed unique features in the third CDR of Ig H chains with minor alterations along the immunizatio

213 nonbranching fibrils (12-24 nm) composed of Ig and complement proteins.

214 Analysis and interpretation of Ig and TCR gene rearrangements in the conventional, low-

215 ing DeltaV-kappaLCs synthesize low levels of Ig and are mostly found among short-lived plasmablasts.

216 iller cell activity with ongoing lowering of Ig levels and CMV-specific antibody titers.

217 at some mammals can use an inverted order of Ig loci rearrangement.

218 receptors), heterodimers formed by pairs of Ig domains.

219 bination, however, sequential positioning of Ig loci away from the nuclear periphery determines stage

220 ncode the antigen-binding variable region of Ig heavy (H) and light (L) chains.

221 Variable regions of Ig chains provide the antigen recognition portion of B-c

222 n in Rag2:mCherry(+) cells and the timing of Ig H and L chain expression revealed simultaneous expres

223 Oligoclonal Ig bands (OCBs) of the cerebrospinal fluid are a hallmar

224 The influence of ovalbumin structure on Ig production upon sensitization and elicitation potency

225 cation and mutation frequency but not CSR or Ig switch region mutation.

226 t altering recognition of live, necrotic, or Ig-opsonized cells.

227 ndent and T-dependent mechanisms orchestrate Ig alpha class switching and SIgA responses against comm

228 Paired Ig-like receptor B is a cell surface immune-inhibitory r

229 These data identify paired Ig-like receptor B as a molecular checkpoint in IL-13-in

230 The polymeric Ig receptor (pIgR) transports polymeric Abs across epith

231 dants of the earliest vertebrates possessing Ig superfamily receptor-based adaptive immunity.

232 ecause of chance generation during preimmune Ig diversification.

233 exons from gene segments generates preimmune Ig repertoires, expressed as B cell receptors (BCRs).

234 e-9 and tissue factor production and promote Ig production in autologous B cells.

235 f the human pDC-specific inhibitory receptor Ig-like transcript 7.

236 ing based on immunoglobulin/T-cell receptor (Ig/TCR) gene rearrangements and with quantification of I

237 Sialic acid-recognizing Ig superfamily lectins or Siglecs are a family of cell s

238 nowledge afforded by analyses of recombinant Ig-based bnAb structures, it became apparent that key fu

239 le bearing rhesus CD4 domains 1 and 2 (rhCD4-Ig).

240 to and was neutralized by huCD4-Ig and rhCD4-Ig with nearly identical efficiencies.

241 ges also allowed SIVmac239 Env to bind rhCD4-Ig more efficiently than huCD4-Ig.

242 ngabey CD4 orthologs, largely restored rhCD4-Ig neutralization of SIVmac239 and other SIV isolates.

243 ally interacts predominantly with the second Ig-like polycystic kidney disease (PKD) repeat domain (P

244 hils were unable to acquire Ag in sensitized Ig-deficient mice, and passive immunization with immune

245 ic acid embedded within the core of a single Ig domain of the titin protein.

246 d functional convergence of the SOSIP-sorted Ig repertoire, with predominant VH4 or VH5 gene family u

247 Serum LPS- and flagellin-specific Ig concentrations (IgA and IgG) were measured with the u

248 elated with the quantity of EBOV GP-specific Ig produced but not with the production of neutralizing

249 (IgCAM) BT-IgSF (brain- and testis-specific Ig superfamily protein) plays a major role in male ferti

250 Surface Ig (sIg)kappa-expressing cells, isolated with mAb LK14 t

251 Its N-terminal Ig variable (IgV) domain has been suggested to be a prin

252 1 log) higher levels of BCR-ABL1 fusion than Ig/TCR rearrangements and/or IKZF1 deletion.

253 t for paracellular water permeation and that Ig-like domain containing receptor 1 (ILDR1) regulates i

254 Our results indicate that Ig genes in mouse and human cells can be edited to obtai

255 We provide novel information that Ig-like transcript 7 is rapidly internalized upon recept

256 The Ig superfamily member CD147 is upregulated following T c

257 The Ig-like cell adhesion molecule (IgCAM) BT-IgSF (brain- a

258 oach could be broadly implemented across the Ig constant domain family.

259 Class-switch recombination (CSR) alters the Ig isotype to diversify antibody effector functions.

260 At the Ig heavy chain locus (IgH), a nucleosome in pro-B cells

261 ared the role of pS38 in AID activity at the Ig switch region and off-target Myc gene.

262 , we demonstrate that cross-talk between the Ig-superfamily receptor CD300f and IL-5 is a key checkpo

263 d developmentally important in directing the Ig repertoire upon differentiation.

264 ngly inhibited by the splice insert B in the Ig domain region of LAR-RPTPs, and mediate SALM5-depende

265 cterized costimulatory pathways includes the Ig superfamily members CD28 and CTLA-4 and their ligands

266 espite a common recombination machinery, the Ig heavy and Ig light chain loci rearrange in a stepwise

267 y, and thereby on the total diversity of the Ig and TR repertoire.

268 oducts (RAGE) is a scavenger receptor of the Ig family that binds damage-associated molecular pattern

269 located at the most distal 3' region of the Ig H chain locus, has multiple regulatory functions that

270 Quantitative deep sequencing of the Ig heavy chain locus from B220(+)CD43(+) populations ide

271 15 days postinfection, and isotyping of the Ig subclass showed that the total IgG response switched

272 anobodies against complement receptor of the Ig superfamily (CRIg), found on tissue macrophages such

273 Neuroplastin (Nptn) is a member of the Ig superfamily and is expressed in two isoforms, Np55 an

274 udy shows that neuroplastin, a member of the Ig superfamily, which has previously been linked to the

275 llular domain of Axl at the interface of the Ig-1 ectodomain of Axl and the Lg-1 of Gas6.

276 We therefore studied the Ig gene repertoires and reactivity to autoantigens of si

277 We found that SALM5 interacts with the Ig domains of LAR family receptor protein tyrosine phosp

278 erotypes have discrete interactions with the Ig-like PKD domains of AAVR.

279 Thus, Ig locus contraction juxtaposes genomically distant elem

280 tivation-induced cytidine deaminase (AID) to Ig switch regions (S regions).

281 expression occurred upon differentiation to Ig secretion, as detected by alteration from membrane to

282 intrinsic toxic effects in PCs unrelated to Ig assembly, but mediated by ER stress-associated apopto

283 However, these transgenic Ig specificities were originally selected for their abil

284 This truncated Ig exclusion (TIE) checkpoint ablates PC clones with Del

285 rce measurements to reveal how the first two Ig-like domains of cMyPB-C (C0 and C1) interact with the

286 The data suggest that the two Ig-like subdomains of each Rel-homology region, which ar

287 rra and Jin (2016) characterize a small, two-Ig domain protein, ZIG-10, and its role in maintaining s

288 The CTD was found to possess a typical Ig-like fold encompassing seven antiparallel beta-strand

289 ay be mutated (Ig-mutated CLL) or unmutated (Ig-unmutated CLL); and the presence or absence of mutati

290 anti-inflammatory effects of large-dose i.v. Ig (IVIg) in autoimmunity.

291 effectively controlled tumors in K14-VEGFR3-Ig mice than in control mice.

292 t lacks dermal lymphatic vessels (K14-VEGFR3-Ig mice).

293 Ag acquisition was Ig-dependent; intestinal eosinophils were unable to acqu

294 Secondary diversification occurs when Ig V regions undergo somatic hypermutation (SHM) and aff

295 -/-) progenitor-B cells to determine whether Ig locus contraction or nuclear positioning is decisive

296 secrete Fab' fragments instead of the whole Ig.

297 CD79a and CD79b proteins associate with Ig receptors as integral signaling components of the B c

298 f these 15 patients, ten were diagnosed with Ig-MPGN.

299 patients with C3G and one [10%] patient with Ig-MPGN).

300 sicians to distinguish between patients with Ig-unmutated CLL, where typically have more indolent dis