ライフサイエンスコーパス: IgA2

1 of neutrophil granulocytes by both IgA1 and IgA2.

2 ly positive for anti-chlamydia IgG2, IgG4 or IgA2.

3 its native ligand as well as human IgA1 and IgA2.

4 uch a T-shape may be common to both IgA1 and IgA2.

5 rum levels of IgA1 are greater than those of IgA2.

6 re are two subclasses of human IgA, IgA1 and IgA2.

7 ere similar between wild-type and engineered IgA2.

8 (3 of 5), IgG2 (2 of 5), IgA1 (4 of 5), and IgA2 (1 of 5).

9 We used recombinant human IgA1 and human IgA2 Abs and domain swapped IgA/IgG chimeras to determin

10 The 2F5 IgG1 and IgA2 acted synergistically to fully block HIV-1 transfer

11 The major pathway for the clearance of all IgA2 allotypes is the liver.

12 G3 appears common, but IgG1, IgG2, IgA1, and IgA2 also arise, indicating a continuing influence of a

13 roup of urine samples, the prevalence of the IgA2 AMA was 6/18 (33%), significantly lower than in mat

14 lizing anti-HIV-1 2F5 IgG1, and compared 2F5 IgA2 and IgG binding affinity and functional activities.

15 tibodies of protease-insensitive subclasses (IgA2 and IgG) nor those directed against heterologous ca

16 IgG2, IgA2 and IgM were inert.

17 aride-specific immunoglobulin A (IgA), IgA1, IgA2 and secretory component, IgG antibodies, and total

18 enerated chimeric V gene-matched human IgA1, IgA2, and control IgG1 autoantibodies directed against t

19 It exists as two subclasses IgA1 and IgA2, and IgA2 is found in at least two allotypic forms,

20 e majority of stools contained both IgA1 and IgA2, and the relative proportions did not change follow

21 constructed from a hybrid comprised of human IgA2 bearing half of the human IgA1 hinge region.

22 We found that 2F5 IgA2 bound to the gp41 membrane proximal external region

23 The rapid clearance of IgA2 but not IgA1 through the liver may in part explain

24 her, our findings indicate that HDM-specific IgA2, but not IgA1, levels in serum and saliva are reduc

25 er and how the human IgA subclasses IgA1 and IgA2 contribute to the clinical status of house dust mit

26 Overall, our studies indicate that for IgA2 covalent assembly of the H and L chains requires th

27 onstrate that recombinant, chimeric IgA1 and IgA2 differ in their pharmacokinetic properties.

28 In contrast, the IgA2 epitope included a unique conformational motif on t

29 Increased IgG4-EW, IgA-EW, and IgA2-EW during eOIT are associated with clinical respons

30 Relative increases in IgG4-EW, IgA-EW, and IgA2-EW were observed in responders (P = 0.024, 0.024, a

31 e two subclasses of IgA, IgA1 and IgA2, with IgA2 existing as three allotypes, IgA2m(1), IgA2m(2) and

32 IgA2 exists as two known allotypes, IgA2 m(1) and IgA2 m

33 e the role of the CH1 domain, we constructed IgA2 from the broadly neutralizing anti-HIV-1 2F5 IgG1,

34 Compared to IgA1, IgA2 has a much shorter hinge region, which joins the tw

35 using molecular dynamics to generate random IgA2 hinge structures, to which homology models for the

36 and IgA2 m(2) with a recently reported novel IgA2 (IgA2(n)) possibly representing a third allotype.

37 IgG4/IgE, IgA/IgE, and IgA2/IgE ratios for EW and IgA/IgE ratio for OVA were fo

38 llergic controls, but HDM-specific levels of IgA2 in saliva were decreased in allergic subjects.

39 exists as two subclasses IgA1 and IgA2, and IgA2 is found in at least two allotypic forms, IgA2m(1)

40 Our previous studies indicated that in IgA2 lacking Cys(133), a disulfide bond forms between th

41 ected, and HDM-specific, IgE, IgG4, IgA1 and IgA2 levels were determined.

42 and eczema showed a significant decrease in IgA2-levels compared to patients who suffered from rhini

43 IgA2 exists as two known allotypes, IgA2 m(1) and IgA2 m(2) with a recently reported novel I

44 Only a small fraction of IgA2 m(1) assembles through disulfide-bonded HL.

45 ow some HL, H2L2, and H4L4J, suggesting that IgA2 m(1) can exist either as a form lacking H-L disulfi

46 IgA2 m(1) differs from IgA2 m(2) and the IgA2(n) at two

47 However, IgA2 m(2) and the IgA2(n) but not IgA2 m(1) form an H-L disulfide in the absence of Cys133

48 of the H chain with the L chains while human IgA2 m(1) has been reported to lack a covalent bond betw

49 (2) and the IgA2(n) at two positions in CH1; IgA2 m(1) has Pro212 and Pro221 whereas IgA2 m(2) and th

50 rotein purified from culture supernatants of IgA2 m(1) show some HL, H2L2, and H4L4J, suggesting that

51 nstrate that it is the presence of Pro221 in IgA2 m(1) that interferes with the H-L disulfide in the

52 In contrast, the major intermediate for IgA2 m(1) with Pro(221) assembly was H(2) even though bo

53 IgA2 m(1) differs from IgA2 m(2) and the IgA2(n) at two positions in CH1; IgA2

54 However, IgA2 m(2) and the IgA2(n) but not IgA2 m(1) form an H-L

55 CH1; IgA2 m(1) has Pro212 and Pro221 whereas IgA2 m(2) and the IgA2(n) have Ser212 and Arg221.

56 exists as two known allotypes, IgA2 m(1) and IgA2 m(2) with a recently reported novel IgA2 (IgA2(n))

57 lfide-bonding pattern; in IgA1, IgA2(n), and IgA2 m(2), a disulfide bond connects a cysteine residue

58 th previous scattering modelling of IgA1 and IgA2(m)1 suggests that the hinge of IgA1 and IgD are mor

59 solved analysis of IgE, IgG4, IgA, IgA1, and IgA2 may identify potential biomarkers of SU in OIT subj

60 o polarized macrophages mediated significant IgA2-mediated ADCC.

61 The IgA2 models show full steric access to the two FcalphaRI

62 Functionally, compared with IgG1, 2F5 IgA2 more efficiently blocked HIV-1 transcytosis across

63 and two IgA1 myeloma proteins but not to two IgA2 myeloma proteins.

64 IgA2 m(1) differs from IgA2 m(2) and the IgA2(n) at two positions in CH1; IgA2 m(1) has Pro212 an

65 However, IgA2 m(2) and the IgA2(n) but not IgA2 m(1) form an H-L disulfide in the a

66 Pro212 and Pro221 whereas IgA2 m(2) and the IgA2(n) have Ser212 and Arg221.

67 t covalent assembly of the H and L chains in IgA2(n) requires hinge-proximal Cys(241) and Cys(242) in

68 riments, we have demonstrated that wild-type IgA2(n) with Arg(221) and Cys(241) and Cys(242) assemble

69 A2 m(2) with a recently reported novel IgA2 (IgA2(n)) possibly representing a third allotype.

70 L chain disulfide-bonding pattern; in IgA1, IgA2(n), and IgA2 m(2), a disulfide bond connects a cyst

71 g as three allotypes, IgA2m(1), IgA2m(2) and IgA2(n).

72 the female genital tract secretions in which IgA2 occurs in slight excess, the distribution of IgA su

73 n blood as two isotypes, IgA1 and IgA2, with IgA2 present as three allotypes: IgA2m(1), IgA2m(2), and

74 Ricin bound to both human IgA1 and IgA2, primarily via N-linked oligosaccharide side chains

75 tive bacteria, but ZmpB had neither IgA1 nor IgA2 protease activity.

76 Furthermore, IgA2 proteins that lack the hinge region with O-linked g

77 ubclass profiles were IgG1 > IgG3 and IgA1 > IgA2, respectively.

78 However, only V-FP(imm) induced cervical IgA2-restricted Ab to the bacterial LPS vaccine componen

79 itis (AR) and controls, and assayed for IgA1/IgA2 synthesis, pIgR expression, production of secretory

80 IgA1 and IgA2 that are not rapidly eliminated by the ASGR are bot

81 human lactoferrin, secretory component, and IgA2 that were shown to be present on the surface of the

82 coid (OVM)-specific levels of IgA, IgA1, and IgA2 were quantified by ELISA.

83 s, there are two subclasses of IgA, IgA1 and IgA2, with IgA2 existing as three allotypes, IgA2m(1), I

84 )A exists in blood as two isotypes, IgA1 and IgA2, with IgA2 present as three allotypes: IgA2m(1), Ig