ライフサイエンスコーパス: IgE receptor

1 ctodomain shedding of CD23, the low affinity IgE receptor.

2 )CPX(2)CYX, for binding to the high-affinity IgE receptor.

3 ion of mast cells by the human high-affinity IgE receptor.

4 t not the gamma subunit of the high affinity IgE receptor.

5 in basophil expression of the high-affinity IgE receptor.

6 s, including tryptase, Kit, and a functional IgE receptor.

7 lls transfected with the human high-affinity IgE receptor.

8 r basophil by binding to their high affinity IgE receptors.

9 induction following aggregation of mast cell IgE receptors.

10 antigen-induced aggregation of high affinity IgE receptors.

11 Both FCER2 and FCER1A encode subunits of IgE receptors.

12 endocytic vesicles containing the clustered IgE receptors.

13 downstream signaling processes activated by IgE receptors.

14 nking of the high-affinity immunoglobulin E (IgE) receptor.

15 ressing a fully functional immunoglobulin E (IgE) receptor.

16 phorylated SHIP-Grb2-Dok that were lost upon IgE receptor activation but retained under conditions of

17 lls treated with chemoattractants, thrombin, IgE receptor agonists, or PMA.

18 but, upon activation via their high-affinity IgE receptor, alter their migratory kinetics to persist

19 wo genotypes showed comparable expression of IgE receptor and c-Kit.

20 e selectively endowed with the high-affinity IgE receptor and mediate a range of adaptive and innate

21 nstrate that IgE Abs can engage cell surface IgE receptors and activate effector cells against ovaria

22 very of IgE 50 y ago, followed by studies of IgE receptors and activation mechanisms, this review pro

23 allography interact differently with the two IgE receptors and suggest that temperature influences th

24 th factor, T cell, B cell, and high affinity IgE receptors and the receptor substrates IRS-1 (insulin

25 ecific IgE, nor the presence of a functional IgE receptor, and the clinical occurrence of some allerg

26 lergen exposure, decreases the expression of IgE receptors, and attenuates both immediate and delayed

27 MCs/Bs express high-affinity IgE receptors, and blocking their interactions with IgE

28 nteractions with both high- and low-affinity IgE receptors, and explains why omalizumab selectively b

29 required for interactions with two distinct IgE receptors, and the structure suggests strategies for

30 idate the effect of rfhSP-D on high-affinity IgE receptor- and CD23-mediated, grass pollen-induced al

31 Human high affinity IgE receptors are expressed as two different isoforms: t

32 ctors activated following stimulation of the IgE receptor as well as in ATP- and GTP-dependent intrac

33 emonstrated little or no cell surface IgE or IgE receptors as analyzed by immunofluorescence and flow

34 If they are present, are these IgE receptors associated with effector functions of eosi

35 By contrast, levels of IgE receptor-associated spleen tyrosine kinase, Syk, wer

36 of the antibody-binding domains of the human IgE receptor at 2.4 A resolution.

37 CD20, high-affinity IgE receptor beta chain (FcepsilonRIbeta), and HTm4 are

38 n-Barr virus gp350/220, and the low-affinity IgE receptor CD23) via the N-terminal two of fifteen or

39 ation of B cells expressing the low-affinity IgE receptor CD23, which mediates the clearance of IgE a

40 ation of B cells expressing the low-affinity IgE receptor CD23, which mediates the clearance of IgE a

41 The low affinity IgE receptor, CD23, is implicated in IgE regulation and

42 Additionally, cleavage of the low affinity IgE receptor, CD23, was profoundly impaired, but subsequ

43 ed IgE by direct binding to the low-affinity IgE receptor, CD23.

44 nd B cell surface levels of the low affinity IgE receptor, CD23.

45 The low-affinity immunoglobulin E (IgE) receptor, CD23 (FcepsilonRII), binds both IgE and C

46 and they inhibit endocytosis of crosslinked IgE receptor complexes, evidently by inhibiting pinching

47 Cross-linking of IgE-receptor complexes by antigen causes their coalescen

48 lency trigger degranulation by cross-linking IgE-receptor complexes, whereas smaller DNP-dendrimers a

49 ulation initiated by multivalent crossing of IgE-receptor complexes.

50 IL-5 and TNF-alpha production in response to IgE receptor cross-linkage, implying a positive feedback

51 ot stimulus specific but is evident for both IgE receptor cross-linking and direct calcium influx.

52 Stimulation or RBL-2H3 cells through IgE receptor cross-linking caused plasma membrane recrui

53 Activation of primary human mast cells by IgE receptor cross-linking or activation of HMC-1 cells

54 Signal transduction cascades following IgE receptor cross-linking were compared in bone marrow-

55 rived mast cells stimulated by high affinity IgE receptor cross-linking, direct influx of calcium, an

56 e bone marrow MC (BMMC) after stimulation by IgE receptor cross-linking.

57 well as the secretion of serotonin following IgE receptor cross-linking.

58 adapters that facilitate events initiated by IgE receptor-dependent activation of Src family protein

59 ulation of CD63 following stimulation of the IgE receptor, either specifically with peanut allergen o

60 In this study we show that IgE receptor engagement triggers activation of STAT6 in

61 After IgE receptor engagement, bone marrow mast cells from STA

62 Monocytes were essential IgE receptor-expressing effector cells that mediated the

63 sociated colitis was dependent on IgE, human IgE receptor-expressing effector cells, and the mediator

64 nt regulation of high-affinity (FcepsilonRI) IgE receptor expression on basophils.

65 iants of the beta-chain of the high affinity IgE receptor Fc epsilon RI, I181L-V183L and E237G, have

66 lls transfected with the human high-affinity IgE receptor Fc epsilon RI, we demonstrate that ligands

67 to occur primarily through the high-affinity IgE receptor Fc epsilon RI.

68 Cross-linking the high affinity IgE receptor Fc epsilonRI of basophils and mast cells ac

69 RII or the alpha-chain of the high-affinity IgE receptor Fc-epsilon RI, but did detect transcripts t

70 lysis showed the absence of the low-affinity IgE receptor Fc-epsilon RII (CD23) and Mac-2 and the abs

71 of the high affinity immunoglobulin-epsilon (IgE) receptor Fc(epsilon)RI is defective.

72 nstrate that engagement of the high affinity IgE receptor (Fc epsilon R1) leads to the tyrosine phosp

73 Ag stimulation of mast cells via the IgE receptor (Fc epsilon RI) elicits production and rele

74 Activation of the high affinity IgE receptor (Fc epsilon RI) of mast cells, a member of

75 her hand, cross-linking of the high affinity IgE receptor (Fc epsilon RI) on mast cells induces a set

76 tions this past year to our understanding of IgE receptor (Fc epsilon RI) signaling in mast cells inc

77 IgE and allergens through the high affinity IgE receptor (Fc epsilon RI), play a prominent role in a

78 has revealed a biochemical event proximal to IgE receptor (Fc epsilon RI)-stimulated tyrosine phospho

79 Stimulation of the high affinity IgE receptor (FC epsilonRI) as well as a variety of stre

80 Aggregation of the high affinity IgE receptor (Fc epsilonRI), a member of the immune rece

81 IgE is rapidly bound by the high affinity IgE receptor (Fc epsilonRI), thereby sensitizing Fc epsi

82 pivotal role in mediating the high-affinity IgE receptor (Fc epsilonRI)-induced degranulation of mas

83 by allergens through their highly expressed IgE receptor (Fc epsilonRI).

84 ation after stimulation of the high affinity IgE receptor (Fc epsilonRI).

85 ve identified the gene for the high-affinity IgE receptor (FC(epsilon)RI) beta subunit as a candidate

86 mast cells, cross-linking the high-affinity IgE receptor (Fc(epsilon)RI) initiates the Lyn-mediated

87 The high affinity IgE receptor (Fc(epsilon)RI) plays a central role in the

88 The binding of IgE to high-affinity IgE receptors (Fc epsilon RI) on the surface of mast cel

89 h antigen receptors, including high-affinity IgE receptors (Fc epsilon RI), is thought to be mediated

90 hrough the cross-linking of the low affinity IgE receptors (Fc epsilon RIIb or CD23) by IgE-allergen

91 , when activated through their high affinity IgE receptors (Fc epsilonRI), release various granule me

92 g of immunoglobulin E (IgE) to high affinity IgE receptors (Fc(epsilon)RI) expressed on the surface o

93 Following Ag stimulation, the IgE-receptor (Fc(epsilon)RI ) accumulates within these d

94 ved the structure of the human high affinity IgE receptor, Fc epsilon RI alpha, in six different crys

95 ity through activation via the high-affinity IgE receptor, Fc epsilon RI, although many other functio

96 tion of Fc gamma RIIB with the high-affinity IgE receptor, Fc epsilon RI, leads to inhibition of Ag-i

97 Antigen stimulation of mast cells via the IgE receptor, Fc epsilon RI, results in recruitment of t

98 express the high-affinity immunoglobulin E (IgE) receptor, Fc epsilon receptor 1 (Fc epsilon RI), ha

99 dependent of activation of the high-affinity IgE receptor (FcepsilonR1) by antigen, as adenosine is e

100 ated whether activation of the high-affinity IgE receptor FcepsilonRI elicits release of mast-cell re

101 orescence microscopy to demonstrate that the IgE receptor FcepsilonRI in the plasma membrane can sign

102 The high-affinity IgE receptor FcepsilonRI is constitutively expressed in

103 ll (MC) activation through the high-affinity IgE receptor FcepsilonRI leads to the release of mediato

104 IgE to prevent its binding to high-affinity IgE receptor FcepsilonRI on basophils and mast cells is

105 Signaling through the high affinity IgE receptor FcepsilonRI on human basophils and rodent m

106 inhibits the activation of the high affinity IgE receptor FcepsilonRI on mast cells and basophils by

107 igen-specific IgE bound to the high-affinity IgE receptor FcepsilonRI on mast cells and basophils.

108 For example, we find that the transmembrane IgE receptor FcepsilonRI preferentially segregates into

109 egranulation following DS, the high-affinity IgE receptor FcepsilonRI was still capable of transducin

110 , leading to activation of the high-affinity IgE receptor FcepsilonRI, and initiating a signaling cas

111 responses, IgE antibodies, the high-affinity IgE receptor FcepsilonRI, and mast cells can contribute

112 In signaling through the high affinity IgE receptor FcepsilonRI, the transmembrane adaptor call

113 c and asthmatic diseases is signaling by the IgE receptor FcepsilonRI, which depends on its interacti

114 E-dependent activation via the high-affinity IgE receptor FcepsilonRI.

115 hagocytosis, acting respectively through the IgE receptors FcepsilonRI and CD23.

116 nking of the high-affinity immunoglobulin E (IgE) receptor FcepsilonRI.

117 on of the alpha subunit of the high affinity IgE receptor (FcepsilonRI(-/-)) were exposed on 10 conse

118 tyrosine-phosphorylated after high affinity IgE receptor (FcepsilonRI) aggregation in rat basophilic

119 eets, CD9 colocalized with the high-affinity IgE receptor (FcepsilonRI) and NTAL but not with LAT.

120 ur aim was to evaluate whether high-affinity IgE receptor (FcepsilonRI) and the related basophil func

121 ls of FAK and was defective in high affinity IgE receptor (FcepsilonRI) but not Ca2+ ionophore-mediat

122 beta and gamma subunits of the high affinity IgE receptor (FcepsilonRI) contain a consensus sequence

123 High-affinity IgE receptor (FcepsilonRI) cross-linking on mast cells (

124 to determine whether increased high-affinity IgE receptor (FcepsilonRI) expression and cross-linking

125 onRIbeta) to eliminate surface high-affinity IgE receptor (FcepsilonRI) expression and function, rend

126 Aggregation of the high affinity IgE receptor (FcepsilonRI) in a mast cell line resulted

127 rly and downstream signaling mediated by the IgE receptor (FcepsilonRI) in RBL mast cells utilizing s

128 To define the role of the high affinity IgE receptor (FcepsilonRI) in the development of AHR, mi

129 PIR-B coligation with the IgE receptor (FcepsilonRI) inhibited IgE-mediated mast c

130 n intact mast cells, including high affinity IgE receptor (FcepsilonRI) internalization and endosome

131 The human high affinity IgE receptor (FcepsilonRI) is a central component of the

132 st cell activation through the high affinity IgE receptor (FcepsilonRI) is a critical component of at

133 The high affinity IgE receptor (FcepsilonRI) is a multisubunit complex com

134 Aggregation of the high-affinity IgE receptor (FcepsilonRI) on mast cells activates a tyr

135 Cross-linking of the high affinity IgE receptor (FcepsilonRI) on mast cells induces secreti

136 Aggregation of the high-affinity IgE receptor (FcepsilonRI) on mast cells initiates signa

137 Cross-linking of the IgE receptor (FcepsilonRI) on mast cells plays a critica

138 Cross-linking of the high-affinity IgE receptor (FcepsilonRI) on mast cells with IgE and mu

139 Ligation of the high-affinity IgE receptor (FcepsilonRI) or of c-Kit stimulates cytoki

140 ng chemokine, eotaxin, and the high-affinity IgE receptor (FcepsilonRI) were up-regulated >5-fold in

141 Engagement of the high affinity IgE receptor (FcepsilonRI) with a multimeric antigen lea

142 mast cells, cross-linking the high affinity IgE receptor (FcepsilonRI) with antigen activates cytoso

143 cell surface expression of the high affinity IgE receptor (FcepsilonRI), and eosinophilia.

144 In addition to the high-affinity IgE receptor (FcepsilonRI), MCs express numerous G prote

145 t the inflammatory response in high affinity IgE receptor (FcepsilonRI)-deficient mice.

146 strate Gab2 may play a role in high affinity IgE receptor (FcepsilonRI)-mediated mast cell activation

147 ed SH2 domains to investigate where and when IgE receptor (FcepsilonRI)-mediated tyrosine phosphoryla

148 ed as well as occupancy of the high affinity IgE receptor (FcepsilonRI).

149 st cell activation through the high-affinity IgE receptor (FcepsilonRI).

150 mulation of mast cells via the high affinity IgE receptor (FcepsilonRI).

151 h the mRNA and protein for the high affinity IgE receptor (FcepsilonRI); it is speculated that this r

152 that expresses both native rat high affinity IgE receptors (FcepsilonRI) and functional human Fcepsil

153 IgE and IgE receptors (FcepsilonRI) are well-known inducers of a

154 tial observation that antigen stimulation of IgE receptors (FcepsilonRI) causes a significant change

155 pG DNA favors Th1 responses but also possess IgE receptors (FcepsilonRI) implicated in allergen prese

156 receptors in B lymphocytes and high-affinity IgE receptors (FcepsilonRI) in mast cells.

157 tivation mediated through both high-affinity IgE receptors (FcepsilonRI) on mast cells and basophils

158 gic diseases via activation of high-affinity IgE receptors (FcepsilonRI) resulting in release of proi

159 Cross-linking of mast cell (MC) IgE receptors (FcepsilonRI) triggers degranulation of se

160 Besides high-affinity IgE receptors (FcepsilonRI), human basophils express act

161 ivated by the cross-linking of high-affinity IgE receptors (FcepsilonRI).

162 ne kinase has been shown to be necessary for IgE-receptor (FcepsilonRI)-mediated mast cell activation

163 1[EMR1](+)MPs), mast cell MPs (high-affinity IgE receptor [FcepsilonRI](+)c-kit(+)MPs), and basophil

164 Immunoreceptors such as the high affinity IgE receptor, FcepsilonRI, and T-cell receptor-associate

165 induced cross-linking of their high affinity IgE receptor, FcepsilonRI, by releasing histamine and ot

166 step in the activation of the high affinity IgE receptor, FcepsilonRI, is the tyrosine phosphorylati

167 Cross-linking the high-affinity IgE receptor, FcepsilonRI, on mast cells activates signa

168 Antigen stimulation of mast cells via the IgE receptor, FcepsilonRI, results in the recruitment of

169 te that IgE antibodies and the high affinity IgE receptor, FcepsilonRI, were essential for such acqui

170 ion including that through the high-affinity IgE receptor, FcepsilonRI.

171 dent mast cells expressing the high-affinity IgE receptor, FcepsilonRI.

172 th decreased expression of the high-affinity IgE receptor, FcepsilonRI.

173 y induced by activation of the high affinity IgE receptor, FcepsilonRI.

174 activated by engagement of the high-affinity IgE receptor, FcepsilonRI.

175 ide GM1, palmitoylated LAT, and cross-linked IgE receptors, FcepsilonRI.

176 s, and its enzymatic activity is enhanced by IgE receptor/FcepsilonRI cross-linking.

177 Thus, JAK3 plays a pivotal role in IgE receptor/FcepsilonRI-mediated mast cell responses, a

178 against the alpha-chain of the high-affinity IgE receptor (FcepsilonRIalpha) or IgE on mast cells in

179 ic cell (DC) expression of the high-affinity IgE receptor (FcepsilonRIalpha).

180 ing of the beta-subunit of the high-affinity IgE receptor (FcepsilonRIbeta) to eliminate surface high

181 CD23, also known as the low affinity IgE receptor (FcepsilonRII), has been hypothesized to ha

182 on mast cells and basophils and low-affinity IgE receptors (FcepsilonRII) on B cells.

183 The low affinity IgE receptor, FcepsilonRII (CD23), is both a positive an

184 the membrane topography of the high-affinity IgE receptor, FcstraightepsilonRI, and its associated ty

185 t cells are major effectors in high-affinity IgE receptor (FcvarepsilonRI)-dependent allergic reactio

186 nkage of the high-affinity immunoglobulin E (IgE) receptor (FcvarepsilonRI) on mast cells by antigen

187 stromal lymphopoietin and the high-affinity IgE receptor, FcvarepsilonRI, were required to attain ma

188 peptide receptor (FPR) and the high-affinity IgE receptor (FepsilonRI).

189 , signal transduction from the high affinity IgE receptor for the secretion of histamine was similar

190 lerate the dissociation of the high-affinity IgE receptor from IgE.

191 , reversing basopenia and improving basophil IgE receptor function, reducing activity of IgG autoanti

192 IgE receptors have been found on diverse inflammatory ce

193 xamine structural linkages between clustered IgE receptors (IgE-Fc epsilonRI) and the cytoskeleton in

194 e (BTK) is an emerging therapeutic target in IgE receptor (IgER)-cross-linked basophils.

195 hese mice express a tetrameric high affinity IgE receptor, in which the human alpha-chain associates

196 Aggregation of the high-affinity IgE receptor induces the tyrosine phosphorylation of sub

197 vation of mast cells by aggregation of their IgE receptors induces rapid and transient synthesis of c

198 Signaling through the high affinity IgE receptor is initiated by noncovalently associated Ly

199 CD23, the low affinity IgE receptor, is up-regulated on the surface of IL-4-tre

200 of allergen-specific IgE-bound high-affinity IgE receptors, leading to immediate mast cell degranulat

201 pic controls, upregulated TSLP receptor upon IgE receptor ligation.

202 ains selectively suppressed the induction of IgE receptor-mediated calcium signals as well as the bin

203 to determine the role of STAT6 activation in IgE receptor-mediated mast cell responses using STAT6 kn

204 investigation to determine whether TLR9- and IgE receptor-mediated responses oppose one another in pD

205 mediated BP blister formation in a humanized IgE receptor mouse model of BP.

206 showed that aggregation of the high affinity IgE receptor on mast cells, FcepsilonRI, causes this imm

207 on induced by cross-linking of high-affinity IgE receptor on mast cells.

208 mast cells, expression of the high-affinity IgE receptor on other innate immune cells, including mon

209 neutralizes almost all free IgE and reduces IgE receptors on basophils and mast cells.

210 more, the presence of trimeric high-affinity IgE receptors on leukocytes other than mast cells and ba

211 strate that perturbation of small numbers of IgE receptors on mast cells favors certain signals that

212 To investigate the expression of IgE receptors on murine eosinophils, they were purified

213 IgG autoantibody to IgE receptor or IgE itself causes urticarial lesions in

214 The affinity changes mediated by IgE receptor or interleukin-5 receptor persist longer.

215 nal transduction pathways, including EGF and IgE receptor pathways, have been proposed to be spatiall

216 eceptor tyrosine-based activation motif-free IgE receptor pool, which would fail to induce cell activ

217 The crystal structure of the IgE receptor provides a foundation for the development o

218 Syk SH2 domains selectively bind to Syk and IgE receptors, respectively.

219 tio-temporal dynamics of early events in the IgE receptor signal cascade.

220 CC-FCS data from studies of IgE receptor signaling challenge models of large stable

221 IgE receptor signaling events were also assessed in the

222 Our increasing understanding of IgE receptor signaling may lead to the development of no

223 0.22 +/- 0.01 at maximal association during IgE receptor signaling.

224 rafts," may act as functional platforms for IgE receptor signaling.

225 ts of btk mutant mast cells in high-affinity IgE receptor-stimulated wild-type mast cells without aff

226 Inhibition of IgE-receptor-stimulated, PLD-catalysed phosphatidate for

227 naling proteins (including the high-affinity IgE receptor subunits, spleen tyrosine kinase, and phosp

228 t of antigen activation of the high-affinity IgE receptor, supports an important role for this nucleo

229 with immune cells and in particular with the IgE receptor system, which has been valuable for develop

230 Human eosinophils express IgE receptors that participate in an IgE-dependent eosin

231 calcium ionophore or by their high affinity IgE receptors, they degranulated in a pattern similar to

232 plasma membrane signaling mechanism by which IgE receptors transiently associate with microdomains an

233 alpha and FcepsilonRIalpha (alpha subunit of IgE receptor type 1).

234 lonRIalpha (antibody to the alpha subunit of IgE receptor type I) stained for IL-13.

235 In studying the IgE receptor, we explored whether, in addition to their

236 caveolae microdomains, fluorescently labeled IgE receptors were found to be uniformly distributed in

237 ated reduced expression of the high affinity IgE receptor, which was restored to normal levels by the

238 ulation of RBL-2H3 m1 mast cells through the IgE receptor with antigen, or through a G protein-couple

239 s to characterize stimulated interactions of IgE receptors with several signaling proteins, including