ライフサイエンスコーパス: IgG4

1 with known concentrations for human IgE and IgG4 .

2 mulate somatic mutation of allergen-specific IgG4.

3 a significant increase in allergen-specific IgG4.

4 flammatory and blocking antibody function of IgG4.

5 , AIT is often associated with production of IgG4.

6 ligands without steric clashes, unlike human IgG4.

7 ted to the accumulation of anti-inflammatory IgG4.

8 IgG3 against the antigen panel and anti-C1q IgG4.

9 In these regards, it resembles human IgG4.

10 otal IgE, specific IgE, and Der p 1-specific IgG4.

11 nds favor half-molecule exchange in vivo for IgG4.

12 s tetrameric human hemoglobin (Hb) and human IgG4.

13 compared to those with anti-neurofascin-155 IgG4.

14 per high-power field that were positive for IgG4.

15 ficantly higher levels of alpha-gal-specific IgG4 Ab.

16 We found an association between levels of IgG4 above the upper reference limit and specific HLA ha

17 IgG4 Abs are dynamic molecules able to undergo a process

18 the anti-inflammatory activity attributed to IgG4 Abs.

19 ng, along with observed granular deposits of IgG4, abundant IgG4-containing plasma cells, and serum l

20 Thus IgG4 accumulation could be mediated by chronic activatio

21 is demonstrated for the first time how anti-IgG4 affinity chromatography can be used to prepare phys

22 ot nonallergic subjects, are able to produce IgG4 after cognate interactions with sTH2 clones and Fel

23 jective signs (objS) at any dose level, sIgE/IgG4 against Bet v 1 and Gly m 4.

24 LIT were assayed using ImmunoCAP for IgE and IgG4 against whole peanut, Ara h 1, Ara h 2, Ara h 3, Ar

25 All patients had antibodies (mainly IgG4) against IgLON5, a neuronal cell adhesion molecule.

26 ed to have a higher level of peanut-specific IgG4 and a higher peanut-specific IgG4:IgE ratio.

27 IgG4 and Ascaris spp.

28 nce of understanding the interaction between IgG4 and Fcgamma receptors.

29 ial implications for the interaction between IgG4 and FcgammaRs.

30 , Mal d 1 and Pru p 1 bound IgE from all and IgG4 and IgA from the majority of sera.

31 ncentrations of allergen-specific IgE, IgG1, IgG4 and IgA to seven Bet v 1-related food allergens wer

32 The mRNA levels of IgG4 and IgE, genes specific for Th2 cells, eosinophils,

33 Phleum pratense-specific IgG4 and IgE-blocking factor increased from baseline in

34 inity IgG1 and IgG3, and 1 had high-affinity IgG4 and later developed low-titer FVIII inhibitors.

35 ines to skew the immune response from IgE to IgG4 and regulation of dendritic cell, mast cell, basoph

36 t oral immunotherapy (POIT) were depleted of IgG4 and retested in inhibition assays.

37 d (iii) their capacity to produce inhibitory IgG4 and sialylated IgG able to mediate anti-inflammator

38 Interestingly, a strong increase in IgG4 and some increase in IgG2 were observed throughout

39 APT), skin testing, serum levels of specific IgG4 and specific IgE and safety were also evaluated.

40 detection of food allergen-specific IgE and IgG4 , and compared it with ImmunoCAP and ImmunoCAP ISAC

41 cant changes from baseline in cockroach IgE, IgG4, and blocking antibody levels.

42 ytometry of T cells, and measurement of IgE, IgG4, and facilitated antigen binding.

43 CD68, CD138, CD1a, and immunoglobulins Ig G, IgG4, and IgA.

44 Serum TMA-specific antibody (IgG, IgG4, and IgE) levels were estimated longitudinally (yea

45 -specific IgG, and casein-specific IgE, IgG, IgG4, and IgM levels, as well as immunoglobulin free lig

46 fore might affect the serum concentration of IgG4, and increased IgG4 might be a marker of a distinct

47 t some of the biological properties of human IgG4, and review the recent crystal structures of IgG4-F

48 r, HLA-B*08, than patients without increased IgG4, and significantly higher frequencies of HLA-B*07 a

49 ecreting lymphocytes and serum-specific IgE, IgG4, and total IgE levels were assessed.

50 tween the overall repertoires of circulating IgG4- and IgE-expressing cells.

51 respectively, but no increase with IgG2 and IgG4 anti-RhD Abs.

52 Serum levels of total IgG4, anti-Toxocara spp.

53 Although the role of IgG4 antibodies and OPA in protection is still unclear,

54 IgG4 antibodies are generally regarded as noninflammator

55 k of disease reveals that disease-associated IgG4 antibodies are self-reactive.

56 Human BR1 cells selectively upregulate IgG4 antibodies on differentiation to plasma cells.

57 Blocking IgG4 antibodies provide an additional explanation for th

58 py results in the production of blocking IgG/IgG4 antibodies that can inhibit IgE-dependent activatio

59 ver, children with transient CMA had IgE and IgG4 antibodies that more often recognized the same epit

60 IgG4 antibodies were infrequent (<5%) and contributed po

61 nd measurements of allergen-specific IgE and IgG4 antibodies were performed before and after treatmen

62 Four patients displayed predominantly IgG4 antibodies, and one patient presented IgG3 antibodi

63 mune parameters including augmented specific IgG4 antibodies, Th1 skewing and enhanced IL-10.

64 Human immunoglobulin G isotype 4 (IgG4) antibodies (Abs) are potential candidates for immu

65 ecently, a human monoclonal Phl p 7-specific IgG4 antibody (mAb102.1F10) was isolated from a patient

66 aimed to investigate differences in IgE and IgG4 antibody binding to CM epitopes between patients wi

67 Increases in levels of peanut-specific IgG4 antibody occurred predominantly in the consumption

68 The objective was to study the IgE and IgG4 antibody profiles to milk and milk proteins before

69 Human IgG4 antibody shows therapeutically useful properties co

70 rienced B cells with the capacity to produce IgG4 are present in allergic subjects and (2) cat allerg

71 0(-)CD38(hi) plasmablasts, which are largely IgG4(+), are increased in patients with active IgG4-RD.

72 nded to explore the use of allergen-specific IgG4 as a biomarker for compliance.

73 simultaneous detection of allergen-specific IgG4 , as a potential parameter for tolerance developmen

74 uencing accurately distinguish patients with IgG4-associated cholangitis/autoimmune pancreatitis (n =

75 ry T-cell (Treg) cytokines in IgG4-RD and in IgG4-associated MZL and IgG4-negative MZL using real-tim

76 Ocular IgG4-RD and IgG4-associated MZL exhibited significantly higher expre

77 it differs between ocular adnexal MZLs with (IgG4-associated MZL) and without (IgG4-negative MZL) num

78 ckground in IgG4-negative MZLs suggests that IgG4-associated MZLs may have a different pathogenesis.

79 that, in adults, eosinophilic esophagitis is IgG4-associated, and not an IgE-induced allergy.

80 idiopathic membranous nephropathy (IMN) have IgG4 autoantibodies against phospholipase A2 receptor (P

81 In all patients in this cohort, IgG4 autoantibodies were detected in the CSF.

82 nin G1 domains of CASPR2 and always included IgG4 autoantibodies.

83 g plays a substantial role in triggering the IgG4 autoantibody development in FS and provide new insi

84 In this investigation, we dissected the IgG4 autoantibody repertoires used by FS patients in res

85 fogo selvagem [FS]) in which the pathogenic IgG4 autoantibody response to the self-antigen desmoglei

86 be the initial antigenic stimulants for the IgG4 autoimmune responses in FS.

87 c gating strategy to reliably identify blood IgG4(+) B cells to study their cellular and molecular ch

88 We demonstrate that dominant IgG4(+) B-cell receptor (BCR) clones determined by next-

89 IgG4(+) BCR clones and IgG4/IgG RNA ratio markedly impro

90 r intensity and broader diversity of IgE and IgG4 binding have been found in children with persistent

91 time of tolerance development, both IgE and IgG4 binding intensity decreased significantly, particul

92 Interestingly, differences between IgE and IgG4 binding intensity to CM peptides decreased when the

93 IgE and IgG4 binding to sequential epitopes derived from five ma

94 ne protease-like proteins (Spls) as dominant IgG4-binding S aureus proteins.

95 has a half-life as long as that of IgG2 and IgG4, binds the FcgammaR receptor, and activates complem

96 veloped IMN with intense staining for PLA2R, IgG4, C3, C5b-9, factor B, and properdin and very weak s

97 Although allergen-specific IgG4 can block IgE-mediated allergen presentation and de

98 ange in allergen-specific immunoglobulin G4 (IgG4), change in asthma control or asthma quality-of-lif

99 I, FcgammaRIII and C1q binding properties of IgG4 compared with IgG1 and -3.

100 An increase in the IgG4 concentration to milk components during treatment i

101 IgE and IgG4 concentrations were determined for the major allerg

102 ement accompanied by swift declines in serum IgG4 concentrations.

103 observed granular deposits of IgG4, abundant IgG4-containing plasma cells, and serum levels of IgG4 r

104 Detectable allergen-specific IgG4 could be determined only for low concentrations, bu

105 glycoforms of IgG 2/3, and 19 glycoforms of IgG4) directly in unfractionated samples of human plasma

106 Increased IgG4-EW, IgA-EW, and IgA2-EW during eOIT are associated

107 Relative increases in IgG4-EW, IgA-EW, and IgA2-EW were observed in responders

108 cytometric analysis of peripheral blood for IgG4-expressing B cells and TH subsets.

109 ers and chemokine receptors was performed on IgG4-expressing B cells, and IgG4 transcripts were analy

110 obliterative phlebitis, and accumulation of IgG4-expressing plasma cells at disease sites.

111 IgG4 FAE is suggested to be an important biological mech

112 x conditions, the S228P mutation can prevent IgG4 FAE to undetectable levels both in vitro and in viv

113 ion crystal structures were not reported for IgG4-Fc until recently.

114 and review the recent crystal structures of IgG4-Fc.

115 lytical ultracentrifugation showed that both IgG4 forms were principally monomeric with sedimentation

116 Depletion of IgG4 from plasma of children with PS (and POIT) sensitiz

117 RT-PCR, we amplified, cloned, and sequenced IgG4 H chain transcripts of PBMCs from 10 children with

118 Increased serum levels of IgG4 have been reported in 9%-15% of patients with prima

119 IgG4 iDSA was associated with later allograft injury wit

120 en by IgG3 iDSA, whereas sABMR was driven by IgG4 iDSA.

121 Specific and total IgG1, IgG4, IgA, and IgE from plasma as well as culture supern

122 zed that component-resolved analysis of IgE, IgG4, IgA, IgA1, and IgA2 may identify potential biomark

123 mples were collected, and HDM-specific, IgE, IgG4, IgA1 and IgA2 levels were determined.

124 IgG4, IgE, and cell-specific signatures are regulated in

125 cutaneous reactions (P = .022) and enhanced IgG4/IgE ratios (P = .012).

126 Levels of IgG4 to egg proteins and IgG4/IgE ratios were higher in those randomized to egg (

127 Increases in peanut-specific IgG4 levels and IgG4/IgE ratios were observed in peanut EPIT-treated par

128 e dust mite-specific IgG/IgE ratios (but not IgG4/IgE ratios) were significantly lower in children wi

129 y to rMal d 1 nor enhanced rMal d 1-specific IgG4/IgE ratios.

130 IgG4/IgE, IgA/IgE, and IgA2/IgE ratios for EW and IgA/Ig

131 = 0.038), IgE-OVM (P = 0.032), and a higher IgG4/IgE-OVM ratio (P = 0.013) were associated with clin

132 t-specific IgG4 and a higher peanut-specific IgG4:IgE ratio.

133 ck test and a lower ratio of peanut-specific IgG4:IgE were associated with peanut allergy.

134 chain reaction (qPCR) protocol analyzing the IgG4/IgG RNA ratio in blood also achieves excellent diag

135 IgG4(+) BCR clones and IgG4/IgG RNA ratio markedly improve delineation, early d

136 propose a new diagnostic algorithm based on IgG4/IgG1 ratio that may be used in clinical practice to

137 ymptoms, total and allergen-specific IgE and IgG4, immune function, and inflammatory markers were obt

138 IgG4 in 17.5% and 8.0% of parents and offspring, respect

139 and casein-specific IgG and casein-specific IgG4 in patients with CM-FPIES versus those tolerating C

140 gths that were even weaker for IgG3 than for IgG4 in the case of allotype G3m(c3c5*/6,24*), whereas G

141 We evaluated the roles of IgE and IgG4 in the development of eosinophilic esophagitis.

142 ic IgE appears to determine the induction of IgG4 in the updosing phase.

143 , the specific T-cell response that leads to IgG4 induction during chronic allergen exposure remains

144 ific IgG1 promote OPA, and that CSP-specific IgG4 interferes with OPA, which we subsequently confirme

145 However, IgG4 is also known to undergo Fc-mediated aggregation an

146 wnership and the cellular mechanism by which IgG4 is produced.

147 ely devoid of effector function, whereas the IgG4 isotype can undergo in vivo Fab arm exchange leadin

148 by IgG1 and IgG3, whereas the Th2-associated IgG4 isotype was only detected at very low amounts.

149 tion status and only marginally involves the IgG4 isotype.

150 IgG2 and IgG4 isotypes have significantly lower binding affinity

151 Phl p 7 specific fully human IgE/lambda and IgG4/lambda antibodies.

152 The updosing phase induced a specific IgG4 level increase from a median of 0 ISU before treatm

153 fic IgE levels and increased peanut-specific IgG4 levels (all P < .001).

154 Increases in peanut-specific IgG4 levels and IgG4/IgE ratios were observed in peanut

155 of sTH2 cells, which correlates with higher IgG4 levels and low sensitization.

156 Serum IgG4 levels and serum inhibitory activity for IgE-allerg

157 Serum IgG4 levels correlated with the eosinophil and neutrophi

158 immunotherapy-induced grass pollen-specific IgG4 levels decreased to near pre-immunotherapy levels a

159 in allergen component-specific serum IgE and IgG4 levels during the updosing phase of subcutaneous im

160 , this qPCR test performed better than serum IgG4 levels in sensitivity (94% vs. 86%) and specificity

161 Specific IgG4 levels increased to 1.6-fold (70 mug), 3.1-fold (17

162 Specific IgG4 levels increased, while both CD203c+ and CD63+ baso

163 ped desensitization had a larger increase in IgG4 levels to alpha-lactalbumin (P = 0.034), beta-lacto

164 Specific serum IgG and IgG4 levels were dose dependently increased.

165 ls of memory B cells were reduced, and serum IgG4 levels were elevated.

166 kin test results and peanut-specific IgE and IgG4 levels were found, with overall greater effects wit

167 Egg-specific IgG4 levels were substantially higher in the egg group a

168 ant differences in allergen-specific IgE and IgG4 levels, cytokine production by PBMCs, or basophil a

169 sensitization to EW and induced egg-specific IgG4 levels.

170 ta collected for a pharmaceutically relevant IgG4 mAb being characterized to determine the effects of

171 tween these two responses, as all identified IgG4 mAbs cross-react to both Dsg1 and LJM11 Ags.

172 ion using passive transfer of human anti-Dsg IgG4 mAbs to neonatal mice.

173 in prick test, and specific IgE and specific IgG4 measurements.

174 Increasing somatic mutation of IgG4 members of a clone was seen in immunotherapy, where

175 analyses revealed increased numbers of blood IgG4(+) memory B cells in patients with IgG4-RD.

176 e serum concentration of IgG4, and increased IgG4 might be a marker of a distinct phenotype of PSC.

177 lts suggest that the overlap between IgE and IgG4 might be important in natural tolerance acquisition

178 c-Fc interactions are compatible with intact IgG4 molecules and may provide a model for the formation

179 ers to monitor and quantify FAE of their own IgG4 molecules in physiologically relevant matrices.

180 Using representative humanized WT IgG4 monoclonal Abs, namely, anti-IL-6 and anti-TNF, and

181 cterize biopharmaceutical samples, including IgG4 monoclonal antibodies (mAbs) and recombinant human

182 Dupilumab is a fully human IgG4 monoclonal antibody directed against the IL-4Ralpha

183 mab (CAT-354) is an IL-13-neutralising human IgG4 monoclonal antibody that has shown clinical benefit

184 ized serine 228 to proline (S228P) anti-IL-6 IgG4 mutant, it is demonstrated for the first time how a

185 y included skin test, serum specific IgE and IgG4, nasal allergen provocation test (NAPT), and advers

186 a1/beta-actin, and FOXP3/beta-actin than did IgG4-negative MZL (p < 0.05).

187 es in IgG4-RD and in IgG4-associated MZL and IgG4-negative MZL using real-time polymerase chain react

188 MZLs with (IgG4-associated MZL) and without (IgG4-negative MZL) numerous IgG4(+) plasma cells are unk

189 ce of a different inflammatory background in IgG4-negative MZLs suggests that IgG4-associated MZLs ma

190 nd increased or reduced levels of IgE, IgG1, IgG4 or IgA specific to most Bet v 1-related allergens.

191 of an IgE inhibitor, such as peanut-specific IgG4 (P-sIgG4), in PS patients.

192 Nivolumab, a fully human IgG4 PD-1 immune checkpoint inhibitor antibody, can resu

193 sed the activity of nivolumab, a fully human IgG4 PD-1 immune checkpoint inhibitor antibody, for pati

194 We assessed nivolumab, a fully human IgG4 PD-1 immune checkpoint inhibitor antibody, for safe

195 ZL) and without (IgG4-negative MZL) numerous IgG4(+) plasma cells are unknown.

196 Fibrosis and accumulation of IgG4(+) plasma cells in tissue are hallmarks of the dise

197 at the balance between milk-specific IgE and IgG4 plays a major role.

198 IgG4 plays a protective role in allergy by acting as a b

199 Panelists agreed that a maximum number of 30 IgG4-positive plasma cells per high-power field in the o

200 The presence of oligoclonally restricted IgG4-positive plasma cells within inflammatory meningeal

201 -RHP are a lymphoplasmacytic infiltration of IgG4-positive plasma cells, storiform fibrosis, and obli

202 s expressed by the podocyte, and both induce IgG4-predominant humoral immune responses that produce c

203 and B-cell responses, regulation of IgE and IgG4 production, and inhibition of responses from eosino

204 Nivolumab, a fully human IgG4 programmed death 1 (PD-1) immune-checkpoint-inhibit

205 icacy and safety of nivolumab, a fully human IgG4 programmed death 1 (PD-1) immune-checkpoint-inhibit

206 IgG4 purified from patients undergoing specific allergen

207 IgG-subclasses (sIgG1, sIgG4 including SIgE/IgG4 ratio), (iii) Serum inhibitory activity for IgE (Ig

208 Ocular IgG4-RD and IgG4-associated MZL exhibited significantly

209 h2 and regulatory T-cell (Treg) cytokines in IgG4-RD and in IgG4-associated MZL and IgG4-negative MZL

210 IgG4-RD can affect any organ and has a heterogeneous pre

211 A man in his mid-50s with multiorgan IgG4-RD developed progressive spastic hemiparesis and de

212 in tissue are hallmarks of the disease, and IgG4-RD is associated with increased IgG4 serum levels.

213 d IgE, suggesting that processes inherent to IgG4-RD itself rather than atopy per se contribute to th

214 Rituximab-induced B cell depletion in IgG4-RD leads to rapid clinical and histological improve

215 IgG4-RD lesions are infiltrated by T helper cells, which

216 ineation, early diagnosis, and monitoring of IgG4-RD of the biliary tree and pancreas.

217 The contribution of autoantibodies to IgG4-RD remains unclear.

218 cular immunoglobulin (Ig)G4-related disease (IgG4-RD) and marginal zone lymphomas (MZLs).

219 IgG4-related disease (IgG4-RD) is a fibroinflammatory disorder that can affect

220 IgG4-related disease (IgG4-RD) is a poorly understood, multiorgan, chronic inf

221 IgG4-related disease (IgG4-RD) is a systemic fibroinflammatory condition affec

222 Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) of the biliary tree and pancreas is difficult t

223 xteen patients with histologically confirmed IgG4-RD, 11 patients with sarcoidosis, and 30 healthy su

224 Furthermore, patients with IgG4-RD, but not patients with sarcoidosis, had increase

225 phocyte signature" observed in patients with IgG4-RD, could support diagnosis and treatment monitorin

226 dysregulated IgG4 response in patients with IgG4-RD.

227 bset of ocular MZLs arises in the setting of IgG4-RD.

228 been proposed that allergic mechanisms drive IgG4-RD.

229 38(hi) plasmablasts are a hallmark of active IgG4-RD.

230 G4(+), are increased in patients with active IgG4-RD.

231 common disease pathogenesis in patients with IgG4-RD.

232 lood IgG4(+) memory B cells in patients with IgG4-RD.

233 sensitive nor specific for the diagnosis of IgG4-RD.

234 containing plasma cells, and serum levels of IgG4 reactive to specific foods, indicate that, in adult

235 Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) of the biliary tree and

236 ormed, and a diagnosis of immunoglobulin G4 (IgG4)-related disease was made based on identification o

237 ay drive the generation of autoantibodies in IgG4-related autoimmune diseases.

238 IgG4-related disease (IgG4-RD) is a fibroinflammatory di

239 IgG4-related disease (IgG4-RD) is a poorly understood, m

240 IgG4-related disease (IgG4-RD) is a systemic fibroinflam

241 The three central pathology features of IgG4-related disease are lymphoplasmacytic infiltration,

242 IgG4-related disease generally responds to glucocorticoi

243 IgG4-related disease is a protean condition that mimics

244 Signs of systemic IgG4-related disease may concomitantly be present.

245 and effects from prednisone treatment among IgG4-related disease with salivary gland lesions (RD-SG)

246 rgans, is considered part of the spectrum of IgG4-related disease, and often arises in patients with

247 mbalance of immune and inflammatory cells in IgG4-related disease.

248 first steps to elucidate the pathogenesis of IgG4-related disease.

249 ormed, but the results were inconclusive for IgG4-related disease.

250 arged and given steroid therapy for presumed IgG4-related disease.

251 alists to develop alternative treatments for IgG4-related disease.

252 In cases of IgG4-related ocular disease, similar pathogens were dete

253 (RD-SG), without SG lesions (RD-nonSG), and IgG4-related retroperitoneal fibrosis (RF).

254 nephrotic syndromes and one patient with an IgG4-related retroperitoneal fibrosis.

255 cts and (2) cat allergen exposure induces an IgG4 response in a TH2 cell-dependent manner.

256 s provide new insights into the dysregulated IgG4 response in patients with IgG4-RD.

257 vels after therapy were linked to a specific IgG4 response, and production of blocking antibodies cor

258 SP-mediated OPA and an enhanced CSP-specific IgG4 response.

259 und significant differences in IgE, IgG, and IgG4 responses between both active groups and the placeb

260 IgG4 responses to recombinant A. fumigatus allergens wer

261 ignificantly decreased and allergen-specific IgG4 responses were significantly elevated (P < 0.001).

262 ular, hallmark histopathological features of IgG4-RHP are a lymphoplasmacytic infiltration of IgG4-po

263 Induced IgG4 seems to suppress IgE levels on ISAC, resulting in

264 revealed asymmetric solution structures for IgG4(Ser(222)) with extended hinge structures.

265 se, and IgG4-RD is associated with increased IgG4 serum levels.

266 ImmunoCAP ISAC and correlated with IgE- and IgG4 -specific fluorescence on silicon microarrays.

267 Using an IgG4-specific RT-PCR, we amplified, cloned, and sequence

268 IgG and IgG4 specificities and levels could not discriminate bet

269 The IgG4 subclass presents over a wider CCS range than the I

270 properties compared with the IgG2, IgG3, and IgG4 subclasses and is the most exploited subclass in th

271 Phospholipase A2-specific IgG4-switched memory B cells expanded after bee venom ex

272 associated with increased allergen-specific IgG4 synthesis early in therapy.

273 CDRH3 region was four nucleotides shorter in IgG4 than in IgE transcripts (p < 0.001).

274 nezumab is a humanized anti-Abeta monoclonal IgG4 that binds multiple forms of Abeta, with higher aff

275 e a model for the formation of aggregates of IgG4 that can cause disease pathology in the absence of

276 ic esophagitis had increased serum levels of IgG4 that reacted with milk, wheat, egg, and nuts-the 4

277 IgG4, the least represented human IgG subclass in serum,

278 ell frequency, cat allergen-specific IgE and IgG4 titers, and clinical status in adults with cat alle

279 Levels of IgG4 to egg proteins and IgG4/IgE ratios were higher in

280 after OIT regarding serum levels of IgE and IgG4 to milk and five milk allergen components evaluated

281 Levels of specific IgE and IgG4 to peanut and its components were determined.

282 th alpha-gal syndrome do not have detectable IgG4 to the oligosaccharide.

283 milk proteins with high- or very high-titer IgG4 to the same proteins.

284 IgE and IgG4 to these antigens were quantified using ImmunoCAP((

285 IgG4 transcripts in the circulation of children with all

286 as performed on IgG4-expressing B cells, and IgG4 transcripts were analyzed for somatic hypermutation

287 hieving SU, subjects achieving SU had higher IgG4 values (P = .001) and lower egg skin prick test sco

288 IgG4 was detected in 29.2% of parents and 10.3% of offsp

289 Granular extracellular IgG4 was detected in biopsy specimens from 21 of 24 pati

290 ique non-IgG2 anti-DNA deposit, and anti-C1q IgG4 was mainly detected in subepithelial membranous dep

291 s: rLinB-13 was the top performing molecule; IgG4 was the most predominant antibody subclass and anti

292 ication of internal calibrations for IgE and IgG4 were assessed.

293 in basophil activation and specific IgE and IgG4 were assessed.

294 Allergen-specific IgE and IgG4 were detected in parallel using two fluorescent dye

295 IgG4 were established by ELISA in 2 cohorts: parents bor

296 tracellular proteins targeted by human serum IgG4 were identified by means of immunoblotting to scree

297 The precise role of IgG4, whether it is protective or pathogenic, is still b

298 ith serum concentrations of Ves v 5-specific IgG4 which rose during AIT but almost reached pretreatme

299 by the presence and abundance of endogenous IgG4 wild-type (WT) Abs.

300 reactivity in RA was against pepsin-cleaved IgG4, with a 35% prevalence, >/=5.8-fold higher than in