ライフサイエンスコーパス: IgM

1 IgM AL amyloidosis is a distinct clinical entity.

2 IgM and IgD receptor downmodulation, HS1 and ERK activat

3 IgM antibody detection achieved 97.6% sensitivity and 96

4 IgM is the first antibody to be produced in immune respo

5 IgM levels are similarly suppressed in stroke patients.

6 IgM(+) MBCs also gave rise to T cell-dependent IgM(+) an

7 les collected during 1970-1999 (20% IgG, 19% IgM, and 16% both IgG and IgM), suggesting that the pres

8 of the contemporary specimens (18% IgG, 25% IgM, 30% both IgG and IgM).

9 IgG antibodies were detected in 87.5%, IgM antibodies in 67.5%, and IgG and/or IgM antibodies i

10 In U.S. states, 208 (27%) of 759 IgM-positive results were confirmed to be ZIKAV compared

11 These signals induced abundant IgM which, together with SIgM from clonally affiliated P

12 In contrast, allospecific IgM and IgG were significantly decreased in Akita mice a

13 xpanded clones were seen predominantly among IgM(+) memory B cells of all HCV-infected patients analy

14 iated lymphomas, was specifically seen among IgM(+) memory B cells of the patients.

15 An IgM antibody-capture enzyme-linked immunosorbent assay f

16 anscriptase-polymerase chain reaction and an IgM antibody-capture enzyme-linked immunosorbent assay.

17 ugamushi, three different PCR assays, and an IgM IFA.

18 ently observed in B cell lines expressing an IgM BCR and in some cell lines expressing an IgG BCR, bu

19 patients (both in treatment group B) had an IgM flare.

20 ctions are diagnosed serologically, using an IgM antibody capture enzyme-linked immunosorbent assay (

21 Waldenstrom macroglobulinemia (WM), an IgM-associated lymphoplasmacytic lymphoma, has witnessed

22 ntibodies are expressed as membrane-anchored IgM (mIgM) in 293F indicator cells.

23 CD79b protein but normal levels of CD79a and IgM protein.

24 licited significant immunoglobulin (Ig)G and IgM antibody responses, indicating bacterial colonizatio

25 receptor (pIgR) transports polymeric IgA and IgM across epithelia to mucosal secretions, where the cl

26 umulation of non-isotype-switched IgD(+) and IgM(+) B cells.

27 Total IgE and IgM, CM-specific IgG, and casein-specific IgE, IgG, IgG4

28 knockout mice, serum levels of IgG, IgE, and IgM were significantly attenuated, and local antibody de

29 ed system that qualitatively detects IgG and IgM antibodies against Treponema pallidum antigens in hu

30 sis and 373 controls were tested for IgG and IgM antibodies using the MVista anti-Coccidioides antibo

31 CNP-conjugates and immobilized human IgG and IgM antibodies were negligible.

32 re useful in detecting anti-Borrelia IgG and IgM antibodies, respectively.

33 As expected, IgG and IgM antibody signals to blood group antigens correlated

34 The level of IgG and IgM binding to these cells were compared using either fl

35 ctive inhibition of antigen-specific IgG and IgM formation after immunization with KLH.

36 of all specimens possessing anti-PEG IgG and IgM in excess of 500 ng/mL, respectively.

37 in 30% of human samples having less IgG and IgM RBC xenoreactivity than alloreactivity.

38 nd-tier tests are higher-specificity IgG and IgM Western blots.

39 1999 (20% IgG, 19% IgM, and 16% both IgG and IgM), suggesting that the presence of PEG-specific antib

40 pecimens (18% IgG, 25% IgM, 30% both IgG and IgM).

41 lence of anti-HEV immunoglobulin G (IgG) and IgM among 10,569 French blood donors living in mainland

42 specific molecular patterns such as IgG- and IgM-containing immune complexes.

43 IgG, and casein-specific IgE, IgG, IgG4, and IgM levels, as well as immunoglobulin free light chains,

44 n surface CD79B, immunoglobulin M (IgM), and IgM-induced signaling levels.

45 bow trout pIgR is known to transport IgT and IgM across epithelia.

46 umans, B cell IL-6 secretion was lowered and IgM levels were elevated upon ex vivo anti-BCR/TLR9 stim

47 ll interaction, whereas IL-10 production and IgM autoantibody formation were CD40L independent.

48 Patient plasma IgA RF and IgM RF showed a strong correlation.

49 er apoptotic depletion of class-switched and IgM memory cells was associated with phosphorylation of

50 Anti-IgM also increased mRNA translation in normal blood B ce

51 Anti-IgM significantly increased mRNA translation in primary

52 In addition, anti-IgM increased translation of mRNA-encoding MYC, a major

53 e activation markers was assessed after anti-IgM or CpG stimulation by using flow cytometry on B cell

54 on of healthy donor B cells with CD40L, anti-IgM, IL-21, CpG, IFN-alpha, IL-6 or BAFF induces miR-155

55 d other B-cell malignancies, to inhibit anti-IgM-induced signalling was reduced following IL-4 pretre

56 CHMFL-BTK-11 potently blocked the anti-IgM stimulated BCR signaling in the Ramos cell lines and

57 ical calcium (Ca(2+)) flux responses to anti-IgM as mCD22-expressing wild-type B cells.

58 Anti-GalC antibodies (IgM and/or IgG) were found in 4% of adults and 25% of ch

59 The human, neuropathy-associated IgM antibody is also shown to induce complement-independ

60 ut not IDEC-131 (2/9), completely attenuated IgM antidonor alloantibody (alloAb) production during tr

61 Anti-B19V IgM and IgG, avidity, and ETS assays were used to catego

62 onstrained transport of the IgM-isotype BCR (IgM-BCR) but not of the IgD-isotype BCR (IgD-BCR).

63 article, we discuss the association between IgM and human malaria parasites, building on several rec

64 e therefore investigated differences between IgM and IgD signaling in freshly isolated peripheral blo

65 We provide evidence that although both IgM and IgG BCRs reside in highly heterogeneous protein

66 Mature B cells coexpress both IgM and IgD B-cell antigen receptor (BCR) classes, which

67 In both IgM and antigen detection assays, the MagPix platform de

68 hibitor ibrutinib effectively inhibited both IgM and IgD isotype signaling.

69 lted in highly significant increases of both IgM (for anti-ATG and anti-Neu5Gc) and IgG (for anti-ATG

70 itro and that C1q binding was facilitated by IgM.

71 for detection of IgM antibodies with capture-IgM ELISA.

72 blasts or T cell-independent B220(-)CD138(+) IgM(+) plasma cells.

73 y; (4) there were lymphoid follicles (CD20(+)IgM(+)) with active B cells (phosphorylated nuclear fact

74 antibody clusters from CD19(+)CD20(+)CD27(-) IgM-naive B cells, >120,000 antibody clusters from CD19(

75 VDJ rearrangements of naive, mature CD5(+), IgM(+) memory, and class-switched memory B cells.

76 und over a 10-mo-period peritoneal B-1a cell IgM changed, showing the number of cells lacking N-regio

77 is initially low in fetal-derived B-1a cell IgM developing in the absence of TdT, increased in 7- to

78 had increased numbers of T-regulatory cells, IgM+CD21-/low-memory B cells, CD4+CXCR5+ interleukin 21+

79 faces from human IgA CH3, IgD CH3, IgG1 CH3, IgM CH4, T-cell receptor (TCR) alpha/beta, and TCR gamma

80 nesis of large and topologically challenging IgM complexes is dictated by a local conformational swit

81 borne antigen and suppression of circulating IgM.

82 tier EIAs in the United States, the combined IgM/IgG Vidas test (LYT).

83 ults suggest that clinicians should consider IgM antibody or polymerase chain reaction testing for Zi

84 Plasma and SF of RA patients contained IgM, IgG, and IgA RFs.

85 Reactivities to HSV-1 IgG, cytomegalovirus IgM, or cytomegalovirus IgG did not appear to increase g

86 At 7 days, IgM and macrophages were highly specific for NPIs (alpha

87 and IgG2c but not IgG3, as well as decreased IgM, associated with increased atherosclerosis and necro

88 lly, in nine HTBRF patients, we demonstrated IgM reactivity to Vsp1 in two and against Vlp15/16 in fo

89 s to detect DENV and one to detect anti-DENV IgM in a single serum specimen collected during the firs

90 Anti-DENV IgM RDT sensitivity and specificity ranged from 55.3 to

91 ctural protein 1 (NS1) antigen and anti-DENV IgM.

92 M(+) MBCs also gave rise to T cell-dependent IgM(+) and IgG(+)B220(+)CD138(+) plasmablasts or T cell-

93 t are only vulnerable to clearance via early IgM antibodies for a limited time.

94 a febrile illness characterized by anti-EBV IgM antibody positivity, high loads of circulating laten

95 (P < .01), local immunoglobulins (especially IgM, P < .0001), and anti-double-stranded DNA IgG (P < .

96 ve from this B-cell subset, this establishes IgM(+) memory B cells as a general target of lymphoproli

97 or treatment up-regulated B1 cell expansion, IgM production, phagocytic receptor expression, and phag

98 t majority of infected lymphocytes expressed IgM heavy chains with Iglambda light chains, recapitulat

99 For IgM detection in nonhuman primate samples, the MagPix pl

100 MagPix platform with a traditional ELISA for IgM and antigen detection of infections from Lassa and E

101 o trout IL-6 as a differentiation factor for IgM antibody-secreting cells (ASCs).

102 analysis for ZIKV had positive findings for IgM antibodies.

103 inally, we reveal an inhibitory function for IgM in the proliferation of T cells.

104 g and B-cell migration, whereas B cells from IgM-deficient mice are normal in this respect.

105 se by enabling mature B cells to switch from IgM expression to the expression of downstream isotypes.

106 Ig heavy chain (IgH) isotypes (e.g., IgM, IgG, and IgE) are generated as secreted/soluble ant

107 Anti-GalC IgM antibodies were not only found in GBS patients with

108 ilon mice, produce transcripts that generate IgM, IgG1, and IgE in an alternative splice form bias hi

109 s of serum IgM and enhanced renal glomerular IgM deposition.

110 We found that gut IgM(+) plasma cells (PCs) were more abundant in humans t

111 otein was detected in 86%; the remainder had IgM lambda or IgG kappa.

112 stimulation in presence of soluble anti-HEL IgM antibodies.

113 Subjects with a detectable anti-HEV IgM also underwent testing for HEV RNA.

114 The frequency of anti-HEV IgM was higher in donors living in a high anti-HEV IgG s

115 demonstrated repeatedly detectable anti-HEV IgM, but all were HEV-RNA negative and had other putativ

116 f 6 patients with positive reactivity on HEV IgM assays also revealed positive test results for cytom

117 ase levels showed positive reactivity on HEV IgM assays.

118 croglobulinaemia, especially those with high IgM concentrations.

119 One graft loss, mediated by non-HLA IgM and IgA antibodies, occurred.

120 Human IgM is heavily glycosylated, featuring five N-linked gly

121 X-linked hyper-IgM syndrome (XHIGM) is a primary immunodeficiency with

122 IgG, IgM, IgA, and specific antibody responses were normal.

123 Traditional Ab formats (IgG, IgM) are expensive and laborious to produce; however, th

124 ed region for simultaneous detection of IgG, IgM, and IgA antibodies against T. gondii in an approxim

125 s, we searched for vascular deposits of IgG, IgM, and the C5b-9 complement membrane attack complex.

126 lude, at least, detection of Toxoplasma IgG, IgM, and IgA and a comprehensive review of maternal hist

127 ritis, C5-b9 deposits co-localized with IgG, IgM, C1q, and C4d, consistent with immune complex depend

128 gene in DKO iRMEC further reduced human IgG/IgM binding.

129 nostic tests (RDTs) for the detection of IgG/IgM against a single pathogen have played a significant

130 mpatible with the multiplex detection of IgG/IgM to more than one pathogen.

131 labels for rapid multiplex detection of IgG/IgM.

132 the inflammatory factors such as IgG1, IgG2, IgM, IL-6 and PMPhi phagocytosis, stimulation of secreti

133 Upon immunization, IgM levels were reduced and, upon viral infection, germi

134 lycine, alanine) and mucosal immunoglobulin (IgM) and cytokine (IL-10, IL-4) production, thus providi

135 n reaction and/or CHIK virus immunoglobulin (IgM) after receiving consent.

136 n several recent publications that implicate IgM as a crucial molecule that determines both host and

137 A statistically significant decline in IgM signals with age was observed for many antibody subp

138 of high-quality complex molecules, including IgM antibodies.

139 feration, activation of NF-kappaB, increased IgM secretion, up-regulation of Blimp1 transcription and

140 Stimulated ILC2s also induced IgM, IgG, IgA, and IgE production by B cells.

141 Further, the TLR-induced IgM response is impaired in a type I and type II IFN-ind

142 tion of BLIMP-1 to cells rescues TLR-induced IgM response.

143 nonmuscle myosin heavy chain II may inhibit IgM binding and reduce injury in a preclinical model of

144 nt C57BL/6 or immunocompromised mice lacking IgM antibodies (Rag 2(-/-) and NOD-scid-gamma [NSG]).

145 sable for liver transduction in mice lacking IgM antibodies or complement, suggesting that alternativ

146 dissociated first-tier tests, the Vidas Lyme IgM II (LYM) and IgG II (LYG) EIAs, which use purified r

147 le spatial organization of immunoglobulin M (IgM) and IgG BCRs on the surfaces of resting and antigen

148 e responses, reduces total immunoglobulin M (IgM) and IgG levels, and leads to increased proliferatio

149 ZIKV-NS1 immunoglobulin M (IgM) and immunoglobulin G (IgG) ELISAs combined can dete

150 l DNA loads, (2) anti-B19V immunoglobulin M (IgM) and immunoglobulin G (IgG), (3) anti-VP1 IgG avidit

151 allizable fragment (Fc) of immunoglobulin M (IgM) can function as a cell-surface receptor for secrete

152 An immunoglobulin M (IgM) kappa paraprotein was detected in 86%; the remainde

153 r Epstein-Barr virus (EBV) immunoglobulin M (IgM) positivity, 94.7% (95% CI: 90.7-98.8%) for EBV IgG

154 Odds ratios for high immunoglobulin M (IgM) reactivity to EBV-viral capsid antigen and HSV-1 or

155 le out misleading positive immunoglobulin M (IgM) results in areas with various levels of past dengue

156 Mumps immunoglobulin M (IgM) testing was negative and reverse-transcription poly

157 a monoclonal expansion of immunoglobulin M (IgM)(+) autoreactive B cells, and also have an increased

158 hip between surface CD79B, immunoglobulin M (IgM), and IgM-induced signaling levels.

159 Immunoglobulin M (IgM)-related light chain (AL) amyloidosis, which account

160 omatically hypermutated immunoglobulin M(+) (IgM(+)) and IgG(+) MBC subsets and an unmutated IgD(+) M

161 orrelation between the reduction of anti-MAG IgM levels and clinical improvement, an immunological su

162 neuropathy producing high levels of anti-MAG IgM was developed.

163 onsidering the multivalent nature of the MAG-IgM interaction, polylysine polymers of different sizes

164 signature with memory IgA(+) B cells, memory IgM(+) B cells were related to some IgA(+) clonotypes an

165 ally related to a large repertoire of memory IgM(+) B cells disseminated throughout the intestine but

166 e peripheral neuropathy caused by monoclonal IgM autoantibodies that recognize the carbohydrate epito

167 44 (5%) cases tested by serology were mumps IgM positive, and 27 of the 40 (68%) tested by RT-PCR we

168 that after re-infection, somatically mutated IgM(+) memory B cells function as first responders by ra

169 ing memory rather than newly activated naive IgM(+) B cells and could help SIgA to anchor highly dive

170 Circulating natural IgM has been shown to play a significant role in mouse m

171 in increased serum concentrations of natural IgM and dysregulated homeostasis of B-2 cells; this caus

172 eritoneal cavity and that pathogenic natural IgM titers were reduced in the CD6(-/-) mice in associat

173 ablished that circulating pathogenic natural IgM, which is primarily produced by B1a cells outside of

174 a cell development and reduces serum natural IgM production; in particular, B1a cells that express au

175 Here we demonstrate that natural IgM-secreting B-1 cells in the spleen and bone marrow ar

176 Blimp-1(neg) IgM-secreting B-1 cells are not simply intermediates of

177 ropathic (28%) involvement compared with non-IgM AL.

178 iome, against which circulating IgD, but not IgM, was reactive.

179 ican Samoa and Puerto Rico, more than 80% of IgM-positive results were unspecified flavivirus infecti

180 Instead, they secrete similar amounts of IgM in wild-type and Blimp-1-deficient (PRDM-1(DeltaEx1A

181 in levels of IgG in 4 of 10 patients and of IgM in 6 of 10 patients at 6 months or later and in leve

182 We studied the binding of IgM to MNs, their complement-activating properties, and

183 n of Plvap results in a dramatic decrease of IgM(+)IgD(lo) B cells in both the spleen and the periton

184 ith quantitative RT-PCR and for detection of IgM antibodies with capture-IgM ELISA.

185 ristics of three ELISAs for the detection of IgM class antibodies to ZIKV, including the Centers for

186 n this study, we identify the Cmu4 domain of IgM as the target of hFCMR, and show that binding and in

187 ulinemia (MC) by driving clonal expansion of IgM(+)CD27(+) B cells.

188 absence of FcmuR, the surface expression of IgM-BCR was increased, which resulted in enhanced tonic

189 the transport and cell-surface expression of IgM-BCR.

190 was well tolerated, with a low incidence of IgM flare.

191 and show that binding and internalization of IgM by hFCMR is glycan-independent.

192 s of autoimmunity, increased serum levels of IgM anti-histone H2A autoantibodies significantly correl

193 eroprotective effects of increased levels of IgM antibodies have been suggested, including preventing

194 mice produced significantly higher levels of IgM than mice in the other groups before and after chall

195 ial cells is important in the maintenance of IgM(+) B cells in the spleen and peritoneal cavity.

196 is or ruled out infection in the majority of IgM-positive samples.

197 To decipher the mechanisms of IgM assembly, we investigated its biosynthesis in living

198 as a negative correlation between numbers of IgM+CD21-/low memory B cells and T-regulatory cells (P =

199 d differences in the spatial organization of IgM and IgG BCRs that may contribute to the characterist

200 ts, we demonstrate very distinct outcomes of IgM and IgD isotype activation in CLL cells, providing n

201 18% after therapy), decreased percentages of IgM+CD21-/low memory B cells (35.7% +/- 6.1% before ther

202 (equivalent to Asn-563 in the tail piece of IgM).

203 g of PTX3 promoted homeostatic production of IgM and class-switched IgG antibodies to microbial capsu

204 Along with selective production of IgM anti-phosphoryl choline, these data suggest that hum

205 -type B cells and promoted the production of IgM, IgG1, IgA, and IgE by these cells in vitro.

206 T cells (P < .01), but higher proportions of IgM+CD21-/low memory B cells (P < .05), CD4+IFNgamma+ ce

207 Screening of IgM B cell repertoires from one non-PV and three PV pati

208 No uptake of IgM and minimal endocytosis of IgG immune complexes by n

209 s known about the effect of glycosylation on IgM binding to the human Fcmu receptor (hFCMR).

210 males), 6 (8%) showed positive reactivity on IgM assays for HEV, indicating a possible acute HEV infe

211 testing method; providers should not rely on IgM testing alone.

212 .5%, IgM antibodies in 67.5%, and IgG and/or IgM antibodies in 88.8% of patients with acute pulmonary

213 unophenotype (CD19/CD20/CD40(+)), IgD and/or IgM expression (67%), and lack of programmed death-ligan

214 at they successfully drive human IgG1 CH3 or IgM CH4 heterodimerization to levels similar to or above

215 permutation in IgG (P = .003) but not IgA or IgM heavy chain sequences.

216 known variants associating with IgA, IgG or IgM levels or with composite immunoglobulin traits, acco

217 Surprisingly, high-titer anti-oxLDL IgM production and reduced atherosclerosis was dependent

218 ociated with increased protective anti-oxLDL IgM.

219 as been identified as a target of pathogenic IgM.

220 rall, these findings suggest that pathogenic IgM blockade represents a valid therapeutic strategy in

221 ocked the interaction of MAG with pathogenic IgM antibodies from patient sera but with only micromola

222 Additionally, passive anti-PC IgM Abs administered intratracheally with HDMs decreased

223 isting of 211 and 192 subjects with anti-PEG IgM and anti-PEG IgG, respectively, and 596 controls.

224 ndards, we quantified the levels of anti-PEG IgM and different subclasses of anti-PEG IgG (IgG1-4) in

225 genome-wide association studies for anti-PEG IgM and IgG responses in Han Chinese with 177 and 140 in

226 ndividuals, defined as positive for anti-PEG IgM and IgG responses, respectively, and with 492 subjec

227 nd with 492 subjects without either anti-PEG IgM or IgG as controls.

228 n (IGH) locus to be associated with anti-PEG IgM response at genome-wide significance (P = 2.23 x 10(

229 nd the IGH locus is associated with anti-PEG IgM.

230 Owing to their multivalency, polymeric IgM antibodies provide an efficient first-line of defens

231 se ofS. suisthat exclusively cleaves porcine IgM and represents the first virulence factor described,

232 events loss of splenic MZ B cells, preserves IgM levels, and reduces bacterial burden.

233 xpressing other switched isotypes and rarely IgM or IgD, suggesting that IgE is derived from previous

234 mice produced significantly more PC-reactive IgM and IgA.

235 Early studies revealed IgM and IgG responses to infection with various filoviru

236 tion as a cell-surface receptor for secreted IgM on a variety of cell types.

237 Mice lacking secreted IgM (sIgM (-/-)) antibodies display abnormal splenic B c

238 Previous studies with mice lacking secreted IgM (sIgM) due to a deletion of the mus splice region (m

239 RATIONALE: Deficiency of secreted IgM (sIgM(-/-)) accelerates atherosclerosis in Ldlr(-/-)

240 accumulation of endoglycosidase H-sensitive IgM intracellularly, resembling the trafficking block in

241 spleen, and led to elevated levels of serum IgM and enhanced renal glomerular IgM deposition.

242 However, since IgM does not cross the placenta, it may be a good marker

243 mice produce significantly less Ag-specific IgM Abs upon immunization with T cell-independent Ags, a

244 ent Ag, significantly suppressed Ag-specific IgM and IgG production in vivo, whereas splenic artery d

245 LCs, resulting in local and antigen-specific IgM production.

246 is the premembrane/envelope (prM/E)-specific IgM antibody-capture enzyme-linked immunosorbent assay (

247 Additionally, both HCMV specific IgM and IgG B-cell responses with the ability to neutral

248 Leptospira-specific IgM and IgG were detected at 15 days postinfection, and

249 ll and skin mucus, whereas F. major-specific IgM titers are only detected in serum.

250 ch usually entails the detection of specific IgM antibodies in either blood or cerebrospinal fluid th

251 CD138 and Blimp1 expression and PC-specific IgM, but did not affect proliferation.

252 In addition to increased PC-specific IgM, naive PD-L2(-/-) mice and irradiated chimeras recon

253 defined as detection of Zika virus-specific IgM or a positive RT-PCR result in neonates.

254 ll response, a modestly reduced WNV-specific IgM production, but more robust CD8(+) T cell recall res

255 ferentiation factor for B cells, stimulating IgM responses in the absence of follicular structures, a

256 strong immune response for inducing anti-STn IgM/IgG antibodies.

257 These results reveal that CD79B and surface IgM constitute a rate-limiting checkpoint against B cell

258 ls expressing MYD88(L265P) decreased surface IgM coupled with accumulation of endoglycosidase H-sensi

259 CD79B mutations alone increased surface IgM but did not enhance B cell survival, proliferation,

260 IgG BCRs are more clustered than IgM BCRs on resting cells and form larger protein island

261 Moreover, we demonstrated that IgM, but not IgG, bound to CC in vitro and that C1q bind

262 Finally, we show that IgM loses its ability to mediate trypanosome clearance a

263 providers and patients must understand that IgM results are preliminary.

264 The IgM ELISA for scrub typhus has high diagnostic accuracy

265 The IgM ELISA was performed for every sample at sample dilut

266 clonal, polyreactive natural antibodies, the IgM clone 9H4, revealed its ability to recognize the int

267 Furthermore, replacement of Cys-575 in the IgM tail piece of multimers resulted in monomers with en

268 ptide extension at the C-terminal end of the IgM heavy (Ig-mu) chains, termed the tailpiece, is neces

269 sized that CD20 Ab-induced clustering of the IgM or IgG BCR was involved in accessory CDC.

270 cells, where it constrained transport of the IgM-isotype BCR (IgM-BCR) but not of the IgD-isotype BCR

271 tic accuracy and is less subjective than the IgM IFA.

272 lated, cloned, and sequenced belonged to the IgM isotype of the innate immune system.

273 Despite this variability, the IgM binding function was retained across diverse sequenc

274 s during the neurological symptoms, with the IgM decrease paralleling the viral load after graft remo

275 However, these IgM plasma cells are probably not antigen-selected, as r

276 Cleaved AIM was unable to bind to IgM and was selectively filtered by the glomerulus, ther

277 Association of both CD79a and CD79b to IgM is markedly reduced.

278 In contrast to IgM cross-reactivity, IgG and IgA antibodies against ZIK

279 lood cells, binding of DBLMSP and DBLMSP2 to IgM inhibited the overall immunoreactivity of these prot

280 golipids changes the proportion of IgT(+) to IgM(+) B cells in trout HK.

281 ide-RNA (gRNA) with retro- or lenti-virus to IgM(+) mouse B cells and hybridomas, we induce class-swi

282 esting of cerebrospinal fluid for ZIKV using IgM antibody-capture enzyme-linked immunosorbent assay w

283 Hepatitis E virus IgM and IgG reactivity was determined.

284 Hepatitis E virus IgM and IgG reactivity.

285 MAC-ELISA, and the Euroimmun anti-Zika Virus IgM ELISA.

286 Guillain-Barre syndrome had anti-Zika virus IgM or IgG, and all (100%) had neutralising antibodies a

287 f ZIKV, dengue virus, and chikungunya virus; IgM enzyme-linked immunosorbent assays and plaque-reduct

288 obesity induced by a high fat diet, ex vivo IgM and IgG were elevated with unstimulated B cells.

289 blood, AIM is stabilized by association with IgM pentamers and maintains its high circulating levels.

290 imulations to show how this interaction with IgM may occur.

291 o-localized with C1q and C4d and rarely with IgM indicating activation of the classical complement pa

292 For this analysis, ZIKAV IgM was considered false positive for samples interprete

293 Almost a third of ZIKAV IgM-positive results were not confirmed; therefore, prov

294 y through 31 August 2016 with positive ZIKAV IgM results, and ZIKAV and DENV PRNTs were performed.

295 ncludes an initial screen using an anti-ZIKV IgM antibody capture enzyme-linked immunosorbent assay (

296 d serum was tested with the use of anti-ZIKV IgM enzyme-linked immunosorbent assay.

297 Therefore, we recommend testing for ZIKV IgM in neonates suspected of having congenital ZIKV infe

298 ng neonates, all 42 tested positive for ZIKV IgM: 38 of 42 serum specimens (90.5%) were positive, whe

299 enital ZIKV infection, and detection of ZIKV IgM in CSF is confirmatory of neurologic infection.

300 Among neonates, detection of ZIKV IgM in serum is confirmatory of congenital ZIKV infectio