ライフサイエンスコーパス: IkappaB kinase

1 al events lead to the activation of the IKK (IkappaB kinase).

2 manner, and is abolished upon inhibition of IkappaB kinase.

3 ogen synthase kinase 3 and two inhibitors of IkappaB kinase.

4 ine residues within the catalytic domains of IkappaB kinase.

5 heir spatial separation from the cytoplasmic IkappaB kinase.

6 effect of p53 on ubiquitin-related genes or IkappaB kinases.

7 factors RelA and IFN regulatory factor 3 and IkappaB kinases.

8 The molecular mechanism by which IkappaB kinase 1 (IKK1) regulates epidermal differentiat

9 This is triggered by IkappaB kinase 2 (IKK-2) phosphorylation of the p105 PES

10 IkappaB kinase 2 (IKK2) is the upstream kinase that is c

11 AK1) phosphorylation of NF-kappaB-activating IkappaB kinase 2 (IKK2), leading to increased NF-kappaB

12 ted NF-kappaB essential modulator (NEMO) and IkappaB kinase 2 (IKK2), two essential mediators of the

13 .1292dupG in exon 13 of IKBKB, which encodes IkappaB kinase 2 (IKK2, also known as IKKbeta)--leading

14 ed NF-kappaB by interfering with endothelial IkappaB kinase 2 activity in vitro and in vivo.

15 f NF-kappaB, or with SC 514, an inhibitor of IkappaB kinase 2 decreased GRK5.

16 e both inhibited by the NF-kappaB inhibitors IkappaB kinase 2 inhibitor and NF-kappaB essential modul

17 activation induced by overexpressed TRAF2 or IkappaB kinase 2.

18 o express either cyclooxygenase-2 (COX-2) or IkappaB kinase-2 (IKK2), and TP53(+/+) or TP53(f/f) spec

19 TNF-induced NF-kappaB signaling upstream of IkappaB kinase activation absolutely requires the influx

20 rom the nucleus to the cytosol, resulting in IkappaB kinase activation by mechanisms not yet fully un

21 , and 42, leading to attenuation of MAPK and IkappaB kinase activation in B cells during BCR signalin

22 The enhanced JNK and IkappaB kinase activation in DUSP14-deficient T cells wa

23 lammatory gene expression, increased JNK and IkappaB kinase activation, and increased polyubiquitinat

24 ng IkappaBalpha and IkappaBbeta cleavage and IkappaB kinase activation, DENV protease activates NF-ka

25 chanism of NF-kappaB induction not involving IkappaB kinase activation.

26 However, the induction of IkappaB kinase activity, IkappaB degradation, and DNA bi

27 a phosphorylation without affecting upstream IkappaB kinase activity.

28 concomitant increase in inhibitor of kappaB (IkappaB) kinase activity in cell lysates were observed.

29 these tumors and leads to activation of the IkappaB kinase, Akt, and extracellular signal-regulated

30 IkappaB kinase alpha (IKKalpha) activity is required for

31 We identified the two kinases IkappaB kinase alpha (IKKalpha) and IkappaB kinase beta

32 Despite their homology, IkappaB kinase alpha (IKKalpha) and IKKbeta have diverge

33 We investigated the role of IkappaB kinase alpha (IKKalpha) in pancreatic homeostasi

34 Here we report that IkappaB kinase alpha (IKKalpha) is a critical negative r

35 IkappaB kinase alpha (IKKalpha) is part of the cytoplasm

36 as independent of NIK's known function as an IkappaB kinase alpha (IKKalpha) kinase, because mice car

37 We previously reported that IkappaB kinase alpha (IKKalpha), a component of the kina

38 by producing lymphotoxin, which activates an IkappaB kinase alpha (IKKalpha)-BMI1 module in prostate

39 Coexpression of dominant-negative mutants of IkappaB kinase alpha (IKKalpha)/IKK1 or IKKbeta/IKK2 als

40 Breast milk appeared to suppress intestinal IkappaB kinase alpha and beta, resulting in inactivation

41 ced the complete degradation of both BTK and IkappaB kinase alpha in MCL lines and CD40-dependent B c

42 tivity was required for maintaining a stable IkappaB kinase alpha subunit (IKKalpha) level because tr

43 molecule to independently bind TRAF6, TAK1, IkappaB kinase alpha, and IkappaB kinase beta.

44 ished downstream mediators of NIK signaling, IkappaB kinase alpha/beta (IKKalpha/beta) and NF-kappaB,

45 nhibition of TGFbeta-associated kinase-1 and IkappaB kinase alpha/beta activities and reduced express

46 s associated with reductions in sMLA-induced IkappaB kinase alpha/beta and IFN regulatory factor 3 ac

47 1 significantly increased phosphorylation of IkappaB kinase alpha/beta and IkappaBalpha resulting in

48 d by increased abundance of RelB and phospho-IkappaB kinase alpha/beta, an indirect activator of NF-k

49 (phospho-nuclear factor-kappaB p65, phospho-IkappaB kinase alpha/beta, interleukin 1beta, and tumor

50 glycerophosphoinositol-dependent decrease in IkappaB kinase alpha/beta, p38, JNK, and Erk1/2 kinase p

51 miR-148a is an inhibitor of the IkappaB kinase alpha/NUMB/NOTCH pathway and an inducer o

52 sed differentiated phenotype and mediated by IkappaB kinase alpha/NUMB/NOTCH signaling.

53 t genome-wide siRNA screen demonstrated that IkappaB kinase-alpha (IKK-alpha) is a crucial host facto

54 IkappaB kinase-alpha (IKKalpha) is required for splenic

55 nes encoding IFN regulatory factor 6 (IRF6), IkappaB kinase-alpha (IKKalpha), and stratifin (SFN) exh

56 complex, NF-kappaB-inducing kinase-dependent IkappaB kinase-alpha activation, and p52/RelB nuclear tr

57 through inhibitor of nuclear factor-kappaB (IkappaB) kinase-alpha (IKK-alpha), a protein kinase that

58 gnaling pathways in mice with disruptions in IkappaB-kinase-alpha and IkappaB kinase-beta in the inte

59 uced activation of TAK-1 and ERK1/2, whereas IkappaB kinase and IkappaB were phosphorylated, even in

60 lyubiquitination of RIP1, phosphorylation of IkappaB kinase and IkappaBalpha, and IkappaBalpha degrad

61 hyper-proliferation and hyper-activation of IkappaB kinase and MAPKs (ERK, p38, and JNK) upon the li

62 ism by which the deubiquitinase A20 inhibits IkappaB kinase and NF-kappaB activation.

63 ignaling pathway that involves activation of IkappaB kinase and nuclear factor kappaB (NF-kappaB).

64 nitiated) cells (e.g. through suppression of IkappaB kinase and nuclear factor kappaB as well as othe

65 signal via the adaptor protein connection to IkappaB kinase and stress-activated protein kinases (CIK

66 phosphorylation, suggesting a suppression of IkappaB kinase and thus IkappaB-alpha activation.

67 ty and phosphorylation of p65, IkappaBalpha, IkappaB kinase, and Akt.

68 rming growth factor-beta activated kinase-1, IkappaB kinase, and NF-kappaB pathways.

69 hibitor of NF-kappaB (IkappaB) proteins, and IkappaB kinases are present in a variety of invertebrate

70 an inducible, constitutively active form of IkappaB kinase beta (CA-IKKbeta), a key kinase in the ca

71 capable of expressing constitutively active IkappaB kinase beta (CAIKKbeta) in airway epithelium wer

72 , IL-1 receptor-associated kinase 4 (IRAK4), IkappaB kinase beta (IKKB), IkappaB kinase iota (IKKI),

73 nvolves an increased nuclear accumulation of IkappaB kinase beta (IKKbeta) and an increased recruitme

74 anonical and noncanonical NF-kappaB pathways IkappaB kinase beta (IKKbeta) and IKKalpha to activate N

75 kinases IkappaB kinase alpha (IKKalpha) and IkappaB kinase beta (IKKbeta) as RelB interacting partne

76 sgenic mice expressing constitutively active IkappaB kinase beta (IKKbeta) in intestinal epithelial c

77 IkappaB kinase beta (IKKbeta) is a crucial kinase that r

78 Here, we report that IkappaB kinase beta (IKKbeta) is activated upon glutamin

79 Overexpression of IkappaB kinase beta (IKKbeta) or p65-RHD causes nuclear

80 pression enhances LPA-induced MEKK3-mediated IkappaB kinase beta (IKKbeta) phosphorylation and NF-kap

81 d that knockdown or blocking the activity of IkappaB kinase beta (IKKbeta) prevented the aggregation

82 IkappaB kinase beta (IKKbeta), a central coordinator of

83 IkappaB kinase beta (IKKbeta), a central coordinator of

84 teracts with and promotes the degradation of IkappaB kinase beta (IKKbeta), a component of the Ikappa

85 ownstream of the T-cell receptor (TCR) or of IkappaB kinase beta (IKKbeta), we demonstrate that NF-ka

86 We also demonstrate that IFN-gamma activates IkappaB kinase beta (IKKbeta)-dependent NF-kappaB to reg

87 hysiological basis of canonical or classical IkappaB kinase beta (IKKbeta)-nuclear factor kappaB (NF-

88 tively active form of the upstream activator IkappaB kinase beta (IKKbeta).

89 ften resulting from constitutive activity of IkappaB kinase beta (IKKbeta).

90 ced interleulin-8 production, and diminished IkappaB kinase beta (IKKbeta)/IKKgamma coimmunoprecipita

91 on loop that is essential for MEKK3-mediated IkappaB kinase beta (IKKbeta)/NF-kappaB activation.

92 We previously found that the IkappaB kinase beta (IKKbeta)/NF-kappaB pathway regulate

93 ritive and genetic inhibition of the central IkappaB kinase beta (IKKbeta)/nuclear factor-kappaB (NF-

94 ed LPS-dependent activation of NF-kappaB and IkappaB kinase beta activity, protected against LPS acti

95 sgenic mice expressing constitutively active IkappaB kinase beta in airway epithelium (IKTA (IKKbeta

96 ophagy in promoting obesity were reversed by IkappaB kinase beta inhibition in the brain.

97 Using brain-specific IkappaB kinase beta knockout mice, it was found that the

98 Expression of a constitutively active IkappaB kinase beta mutant not only decreased Fgf-10 pro

99 including the activation of proinflammatory IkappaB kinase beta pathway.

100 IkappaB kinase beta plays a critical role in TNFR1 phosp

101 Notably, NF-kappaB signaling through IkappaB kinase beta protected crypt IECs but did not pro

102 r-associated factor 6 (TRAF6) and attenuates IkappaB kinase beta-dependent (IKKbeta-dependent) phosph

103 bind TRAF6, TAK1, IkappaB kinase alpha, and IkappaB kinase beta.

104 [inhibitor of transcription factor NFkappaB (IkappaB) kinase beta; an upstream kinase responsible for

105 pression by decreasing the activation of the IkappaB-kinase beta-RelA NF-kappaB pathway.

106 s involves hypothalamic immunity mediated by IkappaB kinase-beta (IKK-beta), nuclear factor kappaB (N

107 appaB (NF-kappaB) and its upstream activator IkappaB kinase-beta (IKK-beta, encoded by Ikbkb) in the

108 IkappaB kinase-beta (IKKbeta) mediates activation of the

109 NEMO affects the activity of IkappaB kinase-beta (IKKbeta), which relieves the inhibi

110 d inhibits its phosphorylation on Ser-209 by IkappaB kinase-beta (IKKbeta).

111 reduced phosphorylative activation, reducing IkappaB kinase-beta activation and intrinsic activity, t

112 with disruptions in IkappaB-kinase-alpha and IkappaB kinase-beta in the intestinal epithelium.

113 uclear factor-kappaB-alpha level and reduced IkappaB kinase-beta phosphorylation, suggesting a suppre

114 Previously, we reported that IkappaB kinase-beta(IKKbeta) phosphorylates and stabiliz

115 was inhibited by dominant-negative AP-1 and IkappaB kinase-beta, but stimulated by WT AP-1 and Ikapp

116 B kinase-beta, but stimulated by WT AP-1 and IkappaB kinase-beta, suggesting that PKC-theta stimulate

117 ough the innate immune receptor MDA5 and the IkappaB kinase-beta-NF-kappaB pathway.

118 ing the activation and intrinsic activity of IkappaB kinase-beta.

119 ARD11)-TAK1 (MAP3K7)-inhibitor of NF-kappaB (IkappaB) kinase-beta (IKKbeta) module is a switch mechan

120 of ERK, but not Jun NH2-terminal kinase and IkappaB kinase, blocked the downregulation of Baf60c and

121 osphorylation and degradation, inhibition of IkappaB kinase complex (IKK) activation, suppression of

122 el pathway components functioned upstream of IkappaB kinase complex (IKK) activation.

123 Inhibition of the IkappaB kinase complex (IKK) has been implicated in the

124 The IkappaB kinase complex (IKK) is a key regulator of immun

125 pstream of NEMO, a regulatory subunit of the IkappaB kinase complex (IKK).

126 g NF-kappaB signaling via its effects on the IkappaB kinase complex and resulting in reduced IL2 gene

127 of exon 20 and a corresponding reduction in ikappaB kinase complex associated protein (IKAP) levels.

128 Inhibition of the IkappaB kinase complex essentially ablated all cytokine

129 Selective autophagic degradation of the IkappaB kinase complex prevents constitutive activation

130 re, digitization occurs well upstream of the IkappaB kinase complex, as protein kinase C translocatio

131 s process occurred through activation of the IkappaB kinase complex, which also led to activation of

132 cytoplasm through the kinase activity of the IkappaB kinase complex, which leads to translocation of

133 omozygous point mutation in IKBKAP, encoding IkappaB kinase complex-associated protein.

134 ppaB inhibitors, a process controlled by the IkappaB kinase complex.

135 actor kappaB (NF-kappaB) is activated by the IkappaB kinase complex.

136 ecifically suppressing the activation of the IkappaB kinase complex.

137 links PAR-1 activation to stimulation of the IkappaB kinase complex.

138 eceptor that mediates the degradation of the IkappaB kinase complex.

139 reduces the survival of pericytes through an IkappaB kinase-dependent pathway, mediates the low peric

140 These results suggest that the control of IkappaB kinase dephosphorylation by gamma(1)34.5 represe

141 tivation of TANK-binding kinase 1 (TBK1) and IkappaB kinase epsilon (IKKepsilon) and the subsequent a

142 manner that requires the kinase activity of IkappaB kinase epsilon (IKKepsilon) and the transactivat

143 we show that the phosphorylation of STAT1 by IkappaB kinase epsilon (IKKepsilon) inhibits STAT1 homod

144 to functionally and physically interact with IkappaB kinase epsilon (IKKepsilon), a known IRF3 kinase

145 f a number of cellular factors including the IkappaB kinase epsilon (IKKepsilon).

146 IkappaB kinase epsilon (IKKepsilon; IKKi, encoded by IKB

147 Here we show that the atypical IkappaB kinase epsilon and TANK-binding kinase 1 (IKKeps

148 1, which interacts with and acts upstream of IkappaB kinase epsilon to contribute to LPS-mediated ind

149 erminal "intrinsically disordered" region by IkappaB kinase epsilon.

150 support for a rationale to target IKBKE, an IkappaB kinase family member that activates the AKT and

151 ies have demonstrated that ubiquitination of IkappaB kinase gamma (IKKgamma), a regulatory subunit of

152 B essential modifier (NEMO), also designated IkappaB kinase gamma (IKKgamma), from the nucleus to the

153 paB essential modulator (NEMO; also known as IkappaB kinase gamma subunit [IKKgamma]).

154 binding to the NEMO/inhibitor of NF-kappaB (IkappaB) kinase gamma (IKKgamma) subunit of an IKK compl

155 presses NF-kappaB upstream of the regulatory IkappaB kinase-gamma protein subunit in the NF-kappaB si

156 Here we demonstrate that sumoylation of the IkappaB kinase homolog immune response-deficient 5 plays

157 (PP1), and Akt (SH-5) through inhibition of IkappaB kinase, IkappaBalpha phosphorylation, and inhibi

158 The noncanonical IkappaB kinases IKK-varepsilon and TANK-binding kinase 1

159 , by assessing the kinetics and amplitude of IkappaB kinase (IKK) activation, we report that TNF-alph

160 ium mobilization, as well as PI3K, MAPK, and IkappaB kinase (IKK) activation.

161 d by vorinostat in EOC cells is dependent on IkappaB kinase (IKK) activity and associated with a gene

162 art of a multicomponent complex that induces IkappaB kinase (IKK) activity and NF-kappaB activation.

163 ines with this deletion, exhibited increased IkappaB kinase (IKK) activity and production of proinfla

164 IkappaB kinase (IKK) activity was also reduced, which is

165 lecule that is an upstream regulator of both IkappaB kinase (IKK) and c-Jun N-terminal kinase (JNK),

166 was preceded by increased phosphorylation of IkappaB kinase (IKK) and IkappaBalpha as well as the nuc

167 on, and B56gamma silencing induced increased IkappaB kinase (IKK) and IkappaBalpha phosphorylation up

168 IkappaB kinase (IKK) and its downstream target NF-kappaB

169 Activation of IkappaB kinase (IKK) and NF-kappaB by genotoxic stresses

170 attern-independent agonist for activation of IkappaB kinase (IKK) and NF-kappaB in HM via activation

171 ibitor of kappaB (IkappaB)alpha degradation, IkappaB kinase (IKK) and p38 activation, RelA nuclear tr

172 In these cells, S1P, but not TNF, promotes IkappaB kinase (IKK) and p65 phosphorylation, IkappaBalp

173 ALT1-BCL10 (CBM) adapter complex to activate IkappaB kinase (IKK) and the classical NF-kappaB pathway

174 es with a novel ubiquitin-like domain in the IkappaB kinase (IKK) beta subunit of the IKK complex.

175 We now present evidence that IkappaB kinase (IKK) beta-mediated RelA Ser-536 phosphor

176 This is achieved through subversion of the IkappaB kinase (IKK) complex (or signalosome), which inv

177 Because CsA has the capability to impair IkappaB kinase (IKK) complex activation, the IKKalpha/be

178 IkappaB kinase (IKK) complex phosphorylation of the TPL-

179 aB kinase beta (IKKbeta), a component of the IkappaB kinase (IKK) complex that regulates nuclear fact

180 thesized that the MC159 protein targeted the IkappaB kinase (IKK) complex to inhibit these diverse si

181 MC005 inhibited NF-kappaB proximal to the IkappaB kinase (IKK) complex, and unbiased affinity puri

182 ulator (NEMO), a regulatory component of the IkappaB kinase (IKK) complex, controls NF-kappaB activat

183 ignaling pathway is under the control of the IkappaB kinase (IKK) complex, which consists of IKK-1, I

184 The IkappaB kinase (IKK) complex, which contains IKKalpha, I

185 aB essential modulator (NEMO) subunit of the IkappaB kinase (IKK) complex.

186 mplicated in the activation of the canonical IkappaB kinase (IKK) complex.

187 ctor TRAF2, the protein kinase TAK1, and the IkappaB kinase (IKK) complex.

188 cifically inhibit NF-kappaB by targeting the IkappaB kinase (IKK) complex: Compound A and NEMO bindin

189 factor-alpha (TNFalpha), TG2 did not require IkappaB kinase (IKK) for NF-kappaB activation.

190 F) 6, TGF-beta-activated kinase (TAK) 1, and IkappaB kinase (IKK) gamma is largely unknown.

191 NLRX1 interacts with TRAF6 or IkappaB kinase (IKK) in an activation signal-dependent f

192 and is sustained by constitutive activity of IkappaB kinase (IKK) in the cytoplasm.

193 hanges, we observed significant increases in IkappaB kinase (IKK) in the NAc after social defeat, a m

194 Activation of the IkappaB kinase (IKK) is central to NF-kappaB signaling.

195 degradation of NFkappaB-bound IkappaB by the IkappaB kinase (IKK) is required for activation in respo

196 a complex with the modulatory subunit of the IkappaB kinase (IKK) kinase, IKKgamma (or NEMO), resulti

197 f key inflammatory mediators such as JNK and IkappaB kinase (IKK) occurs rapidly upon consumption of

198 The IkappaB kinase (IKK) pathway is an essential mediator of

199 ion of the c-Jun N-terminal kinase (JNK) and IkappaB kinase (IKK) pathway.

200 ctivation through the TNF receptor 1 (TNFR1)/IkappaB kinase (IKK) pathway.

201 t of RIP1 to the receptor complex, impairing IkappaB kinase (IKK) recruitment and NF-kappaB activatio

202 n mice with sepsis and whether inhibition of IkappaB kinase (IKK) reduces the cardiac dysfunction in

203 crotic RIP1-RIP3 kinase complex, whereas the IkappaB Kinase (IKK) subunit NEMO appears to function do

204 tion of IkappaBalpha, and phosphorylation of IkappaB kinase (IKK) subunits IKKalpha and IKKbeta, indi

205 ear transcription factor kappaB (IkappaB) by IkappaB kinase (IKK) triggers the degradation of IkappaB

206 tors of c-Jun N-terminal kinase (JNK) and of IkappaB kinase (IKK) were used to investigate the involv

207 lex program is in operation, which activates IkappaB kinase (IKK), a key regulator of inflammatory cy

208 We found that DeltaNp63alpha interacts with IkappaB kinase (IKK), a multisubunit protein kinase that

209 TRE17 co-precipitates with IkappaB kinase (IKK), and IKK activity is augmented in s

210 phosphatidylinositol 3-kinase (PI 3-kinase), IkappaB kinase (IKK), IkappaB, NF-kappaB, and FGF-2 were

211 Nuclear factor (NF)-kappaB, activated by IkappaB kinase (IKK), is a key regulator of inflammation

212 Chemical inhibition of IkappaB kinase (IKK), mitogen-activated protein extracel

213 , transforming growth factor beta (TGFbeta), IkappaB kinase (IKK), Ras/mitogen-activated protein kina

214 ophagy factor ATG1/ULK1 and the noncanonical IkappaB kinase (IKK), TANK-binding kinase 1 (TBK1), whic

215 mans to yeast, was recently shown to require IkappaB kinase (IKK), the upstream regulator of the nucl

216 ion by nimbolide was caused by inhibition of IkappaB kinase (IKK), which led to suppression of Ikappa

217 nd activation of the pathway is dependent on IkappaB kinase (IKK), which phosphorylates IkappaB, targ

218 ppaB inhibitor, was depleted due to enhanced IkappaB kinase (IKK)-alpha activity.

219 tabilized NIK, and led to phosphorylation of IkappaB kinase (IKK)-alpha.

220 The inflammation-responsive IkappaB kinase (IKK)-beta and its target NF-kappaB have

221 acilitates ubiquitination and degradation of IkappaB kinase (IKK)-beta thus terminating IKK activity.

222 C, [Ca(2+)]i, protein kinase C) and requires IkappaB kinase (IKK)-beta.

223 The importance of IkappaB kinase (IKK)-induced proteolysis of NF-kappaB1 p

224 The role of IkappaB kinase (IKK)-induced proteolysis of NF-kappaB1 p

225 lammatory cytokines TNF and IL-17 stimulated IkappaB kinase (IKK)-NF-kappaB and impaired osteogenic d

226 IKKepsilon, an IkappaB kinase (IKK)-related kinase, is implicated in in

227 The IkappaB Kinase (IKK)-related kinases TBK1 and IKKvarepsi

228 a complex including BCL10, MALT1, and other IkappaB kinase (IKK)-signalosome components.

229 , which coordinates downstream activation of IkappaB kinase (IKK).

230 g homologs of NF-kappaB, IkappaB, Bcl-3, and IkappaB kinase (IKK).

231 ession of c-MYC via activation the canonical IkappaB kinase (IKK)/NF-kappaB pathway.

232 ligase TRAF6 is a key regulator of canonical IkappaB kinase (IKK)/NF-kappaB signaling in response to

233 Induction of TRAF3IP2 activates IkappaB kinase (IKK)/NF-kappaB, JNK/AP-1, and c/EBPbeta

234 ptic contacts may depend at least in part on IkappaB kinase (IKK)/NF-kappaB-related synapse-to-nucleu

235 ntial role in inflammation by activating the IkappaB kinase (IKK)/nuclear factor kappaB (NF-kappaB) a

236 inhibition induces a nuclear accumulation of IkappaB kinase (IKK)alpha, and inhibition of IKKalpha en

237 However, phosphorylated IkappaB kinase (IKK)alpha/beta expression and NF-kappaB

238 the TCR that activates the protein kinase C-IkappaB kinase (IKK)alpha/beta-NF-kappaB pathway, known

239 RP3-activated NF-kappaB in IkappaB kinase (IKK)beta(-/-) MEFs but not IKKalpha- or

240 activation of IRF5 was dependent on TAK1 and IkappaB kinase (IKK)beta, which thus reveals a physiolog

241 Inhibitor of IkappaB kinases (IKK) are key regulators of NF-kappaB si

242 The inhibitor of nuclear factor-kappaB (IkappaB) kinase (IKK) complex is the master regulator of

243 c process by activating inhibitor of kappaB (IkappaB) kinase (IKK) complex, which subsequently recrui

244 ly controlled by the inhibitor of NF-kappaB (IkappaB) kinase (IKK) complex.

245 , a component of the inhibitor of NF-kappaB (IkappaB) kinase (IKK) complex.

246 Mice lacking the inhibitor of NF-kappaB (IkappaB) kinase (IKK) kinase TAK1 underwent normal posit

247 Inhibitor of kappaB (IkappaB) kinase (IKK) phosphorylates IkappaB proteins, l

248 in the activation of inhibitor of NF-kappaB (IkappaB) kinase (IKK) through a proteasome-independent m

249 The IkappaB-Kinase (IKK) complex-consisting of the catalytic

250 Last, U(L)26 blocks TNF-alpha-induced IkappaB-kinase (IKK) phosphorylation, a key step in NF-k

251 ith MHC-I, MyD88-dependent TLR signals drive IkappaB-kinase (IKK)2-mediated phosphorylation of phagos

252 dulator (NEMO; the regulatory subunit of the IkappaB kinase [IKK] complex).

253 lacking the p65 subunit of NF-kappaB or the IkappaB kinases IKKalpha or IKKbeta, and in cells treate

254 macological inhibition of both the canonical IkappaB kinases (IKKalpha/beta) and the IKK-related kina

255 er demonstrated decreased phosphorylation of IkappaB kinase (IKKbeta) and IkappaBalpha in the presenc

256 Inhibition of IkappaB kinase (IKKbeta) and NF-kappaB leads to cell dea

257 T cells that lack the IkappaB kinase (IKKbeta) are unable to activate NF-kappa

258 in persistent elevation of the noncanonical IkappaB kinases IKKepsilon and TBK1.

259 cilitated the complex formation of CD91 with IkappaB kinases (IKKs) alpha and beta and increased the

260 While aspirin directly inhibits IkappaB kinases (IKKs) to phosphorylate IkappaBalpha for

261 st lethal challenge from wild-type virus via IkappaB kinase in dendritic cells (DCs), which sense vir

262 IkappaB kinase in turn phosphorylates IkappaB, leading t

263 utive noncanonical NF-kappaB activation, and IkappaB kinase inhibition reduced their proliferation to

264 S422D)SGK1-transfected MEG-01 cells with the IkappaB kinase inhibitor BMS-345541 (10muM) abolished SG

265 Experiments using an IkappaB kinase inhibitor support the conclusion that thi

266 nin (a PI3K inhibitor), and parthenolide (an IkappaB kinase inhibitor), inhibited pathogen-induced NF

267 Moreover, this synergy was blocked by an IkappaB kinase inhibitor, BAY 11-7082.

268 lls increased > 2-fold in the presence of an IkappaB-kinase inhibitor, indicating a protective effect

269 ha receptor-associated factor 6 and NEMO, by IkappaB kinase inhibitors, and by the IkappaBalpha super

270 inase 4 (IRAK4), IkappaB kinase beta (IKKB), IkappaB kinase iota (IKKI), interferon regulatory factor

271 amycin; DAF, decay-accelerating factor; IKK, IkappaB kinase; IRF, interferon regulatory factors; TBK1

272 platform for recruitment and stimulation of IkappaB kinase, leading to activation of the transcripti

273 ivation in tumor cells through inhibition of IkappaB kinase, leading to inhibition of phosphorylation

274 Hyperammonemia triggered activation of IkappaB kinase, NF-kappaB nuclear translocation, binding

275 romoted constitutive activation of PI3K/Akt, IkappaB kinase/NF-kappaB, mitogen-activated protein kina

276 ignature included "protein kinase cascade," "IkappaB kinase/NFkappaB cascade," and "regulation of pro

277 in cytosolic Ca(2+) levels or the classical IkappaB kinase/NFkappaB inflammatory response elicited b

278 injury by suppressing the activation of the IkappaB kinase-nuclear factor-kappaB pathway.

279 IkappaB kinase/nuclear [corrected] factor kappaB (IKK/NF

280 histone deacetylase activity and blockade of IkappaB kinase/nuclear factor-kappaB signaling during re

281 Gram-negative bacteria, Akt did not enhance IkappaB kinase or NF-kappaB p65 phosphorylation, but rat

282 ts activation of NF-kappaB by inhibiting the IkappaB kinase pathway and by promoting direct inhibitor

283 ies implicate Erb3 binding protein-1 and the IkappaB kinase pathway in the mechanism of action of WS6

284 phoma cells with inhibitors of the NF-kappaB/IkappaB kinase pathway or deletion of c-Rel or RelA resu

285 activated CaMKII in cardiomyocytes leads to IkappaB kinase phosphorylation and concomitant increases

286 NF-alpha activity was mediated by inhibiting IkappaB kinase phosphorylation, which attenuated the LPS

287 Analyses of NF-kappaB and IkappaB kinase proteins from Aiptasia suggest that non-c

288 cids via mammalian target of rapamycin 2 and IkappaB kinase regulate Akt activity and Akt association

289 Here, we found that inducible IkappaB kinase-related (IKK-related) kinase IKBKE expres

290 Genetic studies in mice have identified the IkappaB kinase-related kinase TANK-binding kinase 1 (TBK

291 demonstrated that kinetic considerations of IkappaB kinase-signaling input and IkappaBepsilon's inte

292 B (NF-kappaB) essential modulator (NEMO) and IkappaB kinase subunit beta (IKKbeta), an interaction th

293 Hippo kinases MST1, MST2, and the oncogenic IkappaB kinase TBK1 as the most enriched RASSF1A-interac

294 tment of TAX1BP1 and A20 to the noncanonical IkappaB kinases TBK1 and IKKi in response to poly(I:C) t

295 K Binding Kinase 1 (TBK1) is a non-canonical IkappaB kinase that contributes to KRAS-driven lung canc

296 Tid1 is an essential mediator that connects IkappaB kinases to the Beclin1-containing autophagy prot

297 a macrophage-specific constitutively active IkappaB Kinase transgenic model (IKFM), we demonstrated

298 y inhibiting the activation of non-canonical IkappaB kinase varepsilon and IkappaBalpha, and conseque

299 its downstream molecules, including JNK and IkappaB kinase, were enhanced in DUSP14-deficient T cell

300 more, the gamma(1)34.5 null mutant activates IkappaB kinase, which facilitates p65/RelA phosphorylati