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1 omoter after TNFalpha stimulation along with IkappaB kinase alpha.
2 complex, NF-kappaB-inducing kinase-dependent IkappaB kinase-alpha activation, and p52/RelB nuclear tr
3 ed Akt phosphorylation and the expression of IkappaB kinase alpha and beta (IKKalpha and beta) at bot
4 gulate the function of IkappaBalpha, such as IkappaB kinase alpha and beta and NF-kappaB-inducing kin
5 Breast milk appeared to suppress intestinal IkappaB kinase alpha and beta, resulting in inactivation
6 ngs point to constitutive phosphorylation of IkappaB kinase alpha and subsequent alterations in FANCD
8 gnaling pathways in mice with disruptions in IkappaB-kinase-alpha and IkappaB kinase-beta in the inte
12 ished downstream mediators of NIK signaling, IkappaB kinase alpha/beta (IKKalpha/beta) and NF-kappaB,
13 -regulated kinases (ERK; Thr(202)/Tyr(204)), IkappaB kinase alpha/beta (IKKalpha/beta; Ser(176)/(180)
14 nhibition of TGFbeta-associated kinase-1 and IkappaB kinase alpha/beta activities and reduced express
16 s associated with reductions in sMLA-induced IkappaB kinase alpha/beta and IFN regulatory factor 3 ac
17 1 significantly increased phosphorylation of IkappaB kinase alpha/beta and IkappaBalpha resulting in
18 appaB activation are mediated by a TRAF2-NIK-IkappaB kinase alpha/beta signaling cascade but is MEKK1
20 d by increased abundance of RelB and phospho-IkappaB kinase alpha/beta, an indirect activator of NF-k
21 d kinase 1/2, Jun N-terminal protein kinase, IkappaB kinase alpha/beta, and Akt were unaltered, const
22 (phospho-nuclear factor-kappaB p65, phospho-IkappaB kinase alpha/beta, interleukin 1beta, and tumor
23 glycerophosphoinositol-dependent decrease in IkappaB kinase alpha/beta, p38, JNK, and Erk1/2 kinase p
25 Of several kinases examined, inhibition of IkappaB kinase alpha blocked STG28-mediated cytoplasmic
27 1beta), as well as activation of the kinases IkappaB kinase alpha, IkappaB kinase beta, p38, Akt, and
28 uently, others have identified two proteins, IkappaB kinase alpha (IKK-alpha) and IkappaB kinase beta
31 t genome-wide siRNA screen demonstrated that IkappaB kinase-alpha (IKK-alpha) is a crucial host facto
33 through inhibitor of nuclear factor-kappaB (IkappaB) kinase-alpha (IKK-alpha), a protein kinase that
35 fashion, associated with phosphorylation of IkappaB kinase alpha (IKKalpha) and degradation of Ikapp
38 nt insolubilization of the upstream kinases, IkappaB kinase alpha (IKKalpha) and IkappaB kinase beta,
39 tion of NF-kappaB requires calcium-dependent IkappaB kinase alpha (IKKalpha) and IKKbeta activation a
41 d NEMO-binding domain from the C terminus of IkappaB kinase alpha (IKKalpha) and IKKbeta can disrupt
44 tes the recently identified cellular kinases IkappaB kinase alpha (IKKalpha) and IKKbeta, which norma
45 gers activation of cellular protein kinases, IkappaB kinase alpha (IKKalpha) and IKKbeta, which phosp
46 We reported recently a marked reduction in IkappaB kinase alpha (IKKalpha) expression in a large pr
50 AA/AA) "knockin" mice in which activation of IkappaB kinase alpha (IKKalpha) is prevented by replacem
51 of NF-kappaB activation, we demonstrate that IkappaB kinase alpha (IKKalpha) is recruited to chromati
52 as independent of NIK's known function as an IkappaB kinase alpha (IKKalpha) kinase, because mice car
53 B essential modifier-binding domain (NBD) of IkappaB kinase alpha (IKKalpha) or IKKbeta to prevent ni
56 ion of inhibitor kappaBalpha (IkappaBalpha), IkappaB kinase alpha (IKKalpha), and IkappaB kinase beta
57 asal epidermal keratinocytes require nuclear IkappaB kinase alpha (IKKalpha), but not its protein kin
58 ways of NF-kappaB activation, including p65, IkappaB kinase alpha (IKKalpha), IkappaB kinase beta (IK
59 We previously showed elevated activity of IkappaB kinase alpha (IKKalpha), IKKbeta, and protein ki
61 cing kinase (NIK) and its downstream kinase, IkappaB kinase alpha (IKKalpha), which requires the E3 l
62 by producing lymphotoxin, which activates an IkappaB kinase alpha (IKKalpha)-BMI1 module in prostate
65 Coexpression of dominant-negative mutants of IkappaB kinase alpha (IKKalpha)/IKK1 or IKKbeta/IKK2 als
67 nes encoding IFN regulatory factor 6 (IRF6), IkappaB kinase-alpha (IKKalpha), and stratifin (SFN) exh
68 Here, we show that the NF-kappaB activator, IkappaB kinase-alpha (IKKalpha), but not IKKbeta, promot
69 ced the complete degradation of both BTK and IkappaB kinase alpha in MCL lines and CD40-dependent B c
71 xpression of either dominant-negative AKT or IkappaB kinase alpha mutant, IKKalphaT23A, containing a
75 B essential modifier-binding domain (NBD) of IkappaB kinase alpha or IkappaB kinase beta specifically
76 ducing kinase or IkappaB kinase-beta but not IkappaB kinase-alpha significantly inhibited the TWEAK-i
77 tivity was required for maintaining a stable IkappaB kinase alpha subunit (IKKalpha) level because tr
79 trovirally transduced with dominant negative IkappaB kinase alpha, we demonstrate that CXCL12 express
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