ライフサイエンスコーパス: IkappaB kinase beta

1 nts of TRAF2, NIK, IkappaB kinase alpha, and IkappaB kinase beta.

2 bind TRAF6, TAK1, IkappaB kinase alpha, and IkappaB kinase beta.

3 wnstream kinases c-Jun N-terminal kinase and IkappaB kinase beta.

4 modulator (NEMO), and the catalytic subunit, IkappaB kinase beta.

5 ing the activation and intrinsic activity of IkappaB kinase-beta.

6 kappaB degradation) and was found to involve IkappaB-kinase beta.

7 reduced phosphorylative activation, reducing IkappaB kinase-beta activation and intrinsic activity, t

8 of RelA/p65 in a manner that is dependent on IkappaB kinase beta activity and on the mitogen-activate

9 ed LPS-dependent activation of NF-kappaB and IkappaB kinase beta activity, protected against LPS acti

10 [inhibitor of transcription factor NFkappaB (IkappaB) kinase beta; an upstream kinase responsible for

11 Additionally, IkappaB kinase beta and c-Jun N-terminal kinase 1 activa

12 r NF-kappaB due to spontaneous activation of IkappaB kinase beta and degradation of the NF-kappaB inh

13 ominant negative mutants of IkappaBalpha and IkappaB kinase beta and electrophoretic mobility shift a

14 FcepsilonRI-mediated activation of IkappaB kinase beta and IkappaBalpha phosphorylation and

15 plicating a possible link with the defective IkappaB kinase beta and IkappaBalpha phosphorylation in

16 splenic B cells are defective in BCR-induced IkappaB kinase beta and IkappaBalpha phosphorylation.

17 tracellular signal-regulated kinase 1/2, and IkappaB kinase beta appear to contribute to the anti-apo

18 -dead mutant of NF-kappaB-inducing kinase or IkappaB kinase-beta but not IkappaB kinase-alpha signifi

19 was inhibited by dominant-negative AP-1 and IkappaB kinase-beta, but stimulated by WT AP-1 and Ikapp

20 an inducible, constitutively active form of IkappaB kinase beta (CA-IKKbeta), a key kinase in the ca

21 capable of expressing constitutively active IkappaB kinase beta (CAIKKbeta) in airway epithelium wer

22 iciency also abrogated the formation of TAB1.IkappaB kinase beta complexes in 4T1 breast cancer cells

23 kinases, IkappaB kinase alpha (IKKalpha) and IkappaB kinase beta, components involved in IkappaBalpha

24 or of NF-kappaB expressed in C2C12 cells and IkappaB kinase beta-deficient embryonic mouse fibroblast

25 on of ABCA1 by TNFalpha is reduced by 65% in IkappaB kinase beta-deficient macrophages and by 30% in

26 r-associated factor 6 (TRAF6) and attenuates IkappaB kinase beta-dependent (IKKbeta-dependent) phosph

27 t pathway involves NF-kappaB-inducing kinase-IkappaB kinase beta/gamma-dependent phosphorylation and

28 on of CD28, which involves activation of the IkappaB-kinase beta/IkappaB/NF-kappaB-signaling cascade.

29 nsults activate a kinase complex composed of IkappaB kinase beta (IKK-beta), IKK-alpha, and IKK-gamma

30 oteins, IkappaB kinase alpha (IKK-alpha) and IkappaB kinase beta (IKK-beta), that are present in a tu

31 IkappaB kinase beta (IKK-beta, encoded by Ikbkb) is a ce

32 IkappaB kinase-beta (IKK-beta) activated NF-kappaB when

33 lective series of isoquinoline inhibitors of IkappaB kinase-beta (IKK-beta) are described.

34 s involves hypothalamic immunity mediated by IkappaB kinase-beta (IKK-beta), nuclear factor kappaB (N

35 appaB (NF-kappaB) and its upstream activator IkappaB kinase-beta (IKK-beta, encoded by Ikbkb) in the

36 nduces activation of inhibitor of NF-kappaB (IkappaB) kinase-beta (IKK-beta), a protein kinase that p

37 , IL-1 receptor-associated kinase 4 (IRAK4), IkappaB kinase beta (IKKB), IkappaB kinase iota (IKKI),

38 nvolves an increased nuclear accumulation of IkappaB kinase beta (IKKbeta) and an increased recruitme

39 anonical and noncanonical NF-kappaB pathways IkappaB kinase beta (IKKbeta) and IKKalpha to activate N

40 cross-linking resulted in phosphorylation of IkappaB kinase beta (IKKbeta) and the phosphorylation an

41 kinases IkappaB kinase alpha (IKKalpha) and IkappaB kinase beta (IKKbeta) as RelB interacting partne

42 Activation or overexpression of the IkappaB kinase beta (IKKbeta) attenuated insulin signali

43 The requirement of IkappaB kinase beta (IKKbeta) for cyclin D1 induction wa

44 sgenic mice expressing constitutively active IkappaB kinase beta (IKKbeta) in intestinal epithelial c

45 Here we examined the potential role of IkappaB kinase beta (IKKbeta) in mucus synthesis in vitr

46 -theta is mediated through the activation of IkappaB kinase beta (IKKbeta) in the absence of detectab

47 perrepressor and a dominant-negative form of IkappaB kinase beta (IKKbeta) inhibited NF-kappaB bindin

48 otein kinase C-theta (PKC-theta), Bcl10, and IkappaB kinase beta (IKKbeta) into lipid rafts of the im

49 IkappaB kinase beta (IKKbeta) is a crucial kinase that r

50 Here, we report that IkappaB kinase beta (IKKbeta) is activated upon glutamin

51 IkappaB kinase beta (IKKbeta) is an essential activator

52 IkappaB kinase beta (IKKbeta) is involved in tumor devel

53 IkappaB kinase beta (IKKbeta) is required for NF-kappaB

54 a) mice in which NF-kappaB signaling through IkappaB kinase beta (IKKbeta) is selectively ablated in

55 Overexpression of IkappaB kinase beta (IKKbeta) or p65-RHD causes nuclear

56 pression enhances LPA-induced MEKK3-mediated IkappaB kinase beta (IKKbeta) phosphorylation and NF-kap

57 via the alternate pathway is accompanied by IkappaB kinase beta (IKKbeta) phosphorylation, IkappaBal

58 We show that the IkappaB kinase beta (IKKbeta) plays a crucial role in pr

59 d that knockdown or blocking the activity of IkappaB kinase beta (IKKbeta) prevented the aggregation

60 t indomethacin, inhibited the activity of an IkappaB kinase beta (IKKbeta) that is required to activa

61 Tax expression increases the activity of IkappaB kinase beta (IKKbeta) to enhance phosphorylation

62 alpha), IkappaB kinase alpha (IKKalpha), and IkappaB kinase beta (IKKbeta) were measured.

63 IkappaB kinase beta (IKKbeta), a central coordinator of

64 IkappaB kinase beta (IKKbeta), a central coordinator of

65 teracts with and promotes the degradation of IkappaB kinase beta (IKKbeta), a component of the Ikappa

66 Small molecule inhibitors of IkappaB kinase beta (IKKbeta), a key regulator of the NF

67 beta(Deltahep) mice, which specifically lack IkappaB kinase beta (IKKbeta), an activator of NF-kappaB

68 hances TNFalpha-induced RIP1 ubiquitination, IkappaB kinase beta (IKKbeta), and NF-kappaB phosphoryla

69 luding p65, IkappaB kinase alpha (IKKalpha), IkappaB kinase beta (IKKbeta), and NF-kappaB-inducing ki

70 trast, the phosphorylation of ERK, p38 MAPK, IkappaB kinase beta (IKKbeta), and nuclear NFkappaB acti

71 complex, IkappaB kinase alpha (IKKalpha) and IkappaB kinase beta (IKKbeta), are required for NF-kappa

72 phosphorylation of IkappaBalpha by activated IkappaB kinase beta (IKKbeta), but the activities of oth

73 The majority of these proteins such as IkappaB kinase beta (IKKbeta), MKK3b, highly expressed i

74 fer marginally in their very poor binding to IkappaB kinase beta (IKKbeta), only wt NIK is able to bi

75 NF-kappaB pathway with UTC, an inhibitor of IkappaB kinase beta (IKKbeta), or transfection of CLL ce

76 IkappaB kinase beta (IKKbeta), required for NF-kappaB ac

77 lates sensitize insulin action by inhibiting IkappaB kinase beta (IKKbeta), the detailed mechanisms r

78 n of receptor-interaction proteins (RIP) and IkappaB kinase beta (IKKbeta), the key components of the

79 ownstream of the T-cell receptor (TCR) or of IkappaB kinase beta (IKKbeta), we demonstrate that NF-ka

80 We also demonstrate that IFN-gamma activates IkappaB kinase beta (IKKbeta)-dependent NF-kappaB to reg

81 a novel scenario of the proapoptotic role of IkappaB kinase beta (IKKbeta)-NF-kappaB, which can act a

82 hysiological basis of canonical or classical IkappaB kinase beta (IKKbeta)-nuclear factor kappaB (NF-

83 tively active form of the upstream activator IkappaB kinase beta (IKKbeta).

84 ften resulting from constitutive activity of IkappaB kinase beta (IKKbeta).

85 on of TAp63gamma, but not DeltaNp63gamma, by IkappaB kinase beta (IKKbeta).

86 ng activation of NF-kappaB, which depends on IkappaB kinase beta (IKKbeta).

87 ced interleulin-8 production, and diminished IkappaB kinase beta (IKKbeta)/IKKgamma coimmunoprecipita

88 on loop that is essential for MEKK3-mediated IkappaB kinase beta (IKKbeta)/NF-kappaB activation.

89 We previously found that the IkappaB kinase beta (IKKbeta)/NF-kappaB pathway regulate

90 ritive and genetic inhibition of the central IkappaB kinase beta (IKKbeta)/nuclear factor-kappaB (NF-

91 was abolished by a dominant-negative form of IkappaB kinase beta (IKKbeta, K44A) or a null mutation o

92 ells overexpressing a kinase-mutated form of IkappaB kinase beta (IKKbeta-KM), the activation of NF-k

93 ble transfection of a kinase-mutated form of IkappaB kinase beta (IKKbeta-KM).

94 We have previously shown that IkappaB kinase-beta (IKKbeta) interacts with the epithel

95 IkappaB kinase-beta (IKKbeta) mediates activation of the

96 IkappaB kinase-beta (IKKbeta) required for nuclear facto

97 f screening hits identified as inhibitors of IkappaB kinase-beta (IKKbeta), a key regulatory enzyme i

98 tween the carboxyl terminus of beta-ENaC and IkappaB kinase-beta (IKKbeta), the kinase that phosphory

99 ty of a recently identified cellular kinase, IkappaB kinase-beta (IKKbeta), was significantly elevate

100 NF-kappaB is regulated from the cytoplasm by IkappaB kinase-beta (IKKbeta), which earmarks inhibitors

101 NEMO affects the activity of IkappaB kinase-beta (IKKbeta), which relieves the inhibi

102 d inhibits its phosphorylation on Ser-209 by IkappaB kinase-beta (IKKbeta).

103 ARD11)-TAK1 (MAP3K7)-inhibitor of NF-kappaB (IkappaB) kinase-beta (IKKbeta) module is a switch mechan

104 conditional deficiency in those cells of the IkappaB-kinase beta (IKKbeta) subunit of IKK.

105 ty of a key kinase of the NF-kappaB cascade, IkappaB-kinase beta (IKKbeta) subunit, as a function of

106 The nuclear factor kappaB (NF-kappaB)/IkappaB-kinase-beta (IKKbeta) pathway has been shown to

107 Previously, we reported that IkappaB kinase-beta(IKKbeta) phosphorylates and stabiliz

108 sgenic mice expressing constitutively active IkappaB kinase beta in airway epithelium (IKTA (IKKbeta

109 r, ubiquitin-dependent mechanism to activate IkappaB kinase-beta in response to TNF-alpha and TLR3 li

110 with disruptions in IkappaB-kinase-alpha and IkappaB kinase-beta in the intestinal epithelium.

111 NIK (NF-kappaB-inducing kinase) or IKKbeta (IkappaB kinase beta) inhibited the activity of NF-kappaB

112 ophagy in promoting obesity were reversed by IkappaB kinase beta inhibition in the brain.

113 Using brain-specific IkappaB kinase beta knockout mice, it was found that the

114 essive "alternative" phenotype that requires IkappaB kinase beta-mediated NF-kappaB activation.

115 -specific transgenic expression of activated IkappaB kinase beta (MIKK), causes profound muscle wasti

116 Expression of a constitutively active IkappaB kinase beta mutant not only decreased Fgf-10 pro

117 ough the innate immune receptor MDA5 and the IkappaB kinase-beta-NF-kappaB pathway.

118 duced IL-32 was reduced by inhibition of the IkappaB kinase-beta/NF-kappaB and ERK pathways.

119 reporter was inhibited by dominant-negative IkappaB kinase beta or dominant-negative AP-1.

120 100 also requires IKKalpha, but not IKKbeta (IkappaB kinase beta) or IKKgamma (IkappaB kinase gamma).

121 ibitor of nuclear factor kappaB kinase beta (IkappaB kinase beta, or IKKbeta) has emerged as a key re

122 , PACAP, and VIP suppress phosphorylation of IkappaB kinase beta (P-IKKbeta), prevent degradation of

123 ivation of the kinases IkappaB kinase alpha, IkappaB kinase beta, p38, Akt, and extracellular recepto

124 including the activation of proinflammatory IkappaB kinase beta pathway.

125 uclear factor-kappaB-alpha level and reduced IkappaB kinase-beta phosphorylation, suggesting a suppre

126 IkappaB kinase beta plays a critical role in TNFR1 phosp

127 Notably, NF-kappaB signaling through IkappaB kinase beta protected crypt IECs but did not pro

128 pression by decreasing the activation of the IkappaB-kinase beta-RelA NF-kappaB pathway.

129 of CD4+ T cells with the NF-kappaB-inducing IkappaB kinase beta showed that NF-kappaB activation is

130 ding domain (NBD) of IkappaB kinase alpha or IkappaB kinase beta specifically inhibit the induction o

131 B kinase-beta, but stimulated by WT AP-1 and IkappaB kinase-beta, suggesting that PKC-theta stimulate

132 es between TAK1-binding protein 1 (TAB1) and IkappaB kinase beta that enabled TGF-beta to activate p6

133 ting protein, NF-kappaB-inducing kinase, and IkappaB kinase beta was abolished by simvastatin.