ライフサイエンスコーパス: IkappaB

1 IkappaB kinase (IKK) complex phosphorylation of the TPL-

2 IkappaB kinase 2 (IKK2) is the upstream kinase that is c

3 IkappaB kinase alpha (IKKalpha) activity is required for

4 IkappaB kinase beta (IKKbeta) is a crucial kinase that r

5 IkappaB kinase beta (IKKbeta), a central coordinator of

6 IkappaB kinase beta (IKKbeta), a central coordinator of

7 IkappaB kinase-beta (IKKbeta) mediates activation of the

8 IkappaB kinase/nuclear [corrected] factor kappaB (IKK/NF

9 IkappaB-alpha was able to counteract the effect of TCF4

10 rming growth factor-beta activated kinase-1, IkappaB kinase, and NF-kappaB pathways.

11 ALT1-BCL10 (CBM) adapter complex to activate IkappaB kinase (IKK) and the classical NF-kappaB pathway

12 mmatory chemokines by reducing TNF-activated IkappaB through p53 stabilization.

13 promoter activity and reduced TNF-activated IkappaB.

14 Induction of TRAF3IP2 activates IkappaB kinase (IKK)/NF-kappaB, JNK/AP-1, and c/EBPbeta

15 AK1) phosphorylation of NF-kappaB-activating IkappaB kinase 2 (IKK2), leading to increased NF-kappaB

16 Before activation, IkappaB proteins sequester NF-kappaB dimers in the cytop

17 In the case of NF-kappaB activation, IkappaB phosphorylation leads to its degradation, follow

18 tively active form of the upstream activator IkappaB kinase beta (IKKbeta).

19 capable of expressing constitutively active IkappaB kinase beta (CAIKKbeta) in airway epithelium wer

20 Expression of a constitutively active IkappaB kinase beta mutant not only decreased Fgf-10 pro

21 a macrophage-specific constitutively active IkappaB Kinase transgenic model (IKFM), we demonstrated

22 anced DNA binding affinity without affecting IkappaB degradation or p65 nuclear translocation.

23 Gene expression profiling after IkappaB-zeta knockdown demonstrated a significant downre

24 nhancer in B-cell inhibitor-alpha (PKC-alpha/IkappaB-alpha)-mediated or calcineurin/IkappaB-beta-depe

25 an essential role in AIAD via the PKC-alpha/IkappaB-alpha- and calcineurin/IkappaB-beta-dependent NF

26 by producing lymphotoxin, which activates an IkappaB kinase alpha (IKKalpha)-BMI1 module in prostate

27 as independent of NIK's known function as an IkappaB kinase alpha (IKKalpha) kinase, because mice car

28 support for a rationale to target IKBKE, an IkappaB kinase family member that activates the AKT and

29 IKKepsilon, an IkappaB kinase (IKK)-related kinase, is implicated in in

30 ling by BST2 was blocked by expression of an IkappaB-mutant that inhibits the canonical pathway of NF

31 nin (a PI3K inhibitor), and parthenolide (an IkappaB kinase inhibitor), inhibited pathogen-induced NF

32 reduces the survival of pericytes through an IkappaB kinase-dependent pathway, mediates the low peric

33 lly, PKCdelta activates NF-kappaB through an IkappaB-independent cytosolic interaction, which subsequ

34 Experiments using an IkappaB kinase inhibitor support the conclusion that thi

35 cids via mammalian target of rapamycin 2 and IkappaB kinase regulate Akt activity and Akt association

36 hat was associated with augmented ERK1/2 and IkappaB-alpha phosphorylation and increased levels of CC

37 duced mononuclear recruitment and ERK1/2 and IkappaB-alpha phosphorylation.

38 utive noncanonical NF-kappaB activation, and IkappaB kinase inhibition reduced their proliferation to

39 bind TRAF6, TAK1, IkappaB kinase alpha, and IkappaB kinase beta.

40 ation of proteasome substrates p27, Bax, and IkappaB-alpha, inhibits survival pathways and viability,

41 ced the complete degradation of both BTK and IkappaB kinase alpha in MCL lines and CD40-dependent B c

42 ng IkappaBalpha and IkappaBbeta cleavage and IkappaB kinase activation, DENV protease activates NF-ka

43 hate enabled its incorporation into DHFR and IkappaB-alpha using wild-type ribosomes, and the elabora

44 kinases IkappaB kinase alpha (IKKalpha) and IkappaB kinase beta (IKKbeta) as RelB interacting partne

45 f key inflammatory mediators such as JNK and IkappaB kinase (IKK) occurs rapidly upon consumption of

46 The enhanced JNK and IkappaB kinase activation in DUSP14-deficient T cells wa

47 its downstream molecules, including JNK and IkappaB kinase, were enhanced in DUSP14-deficient T cell

48 ion of the c-Jun N-terminal kinase (JNK) and IkappaB kinase (IKK) pathway.

49 ontaining other members of the NF-kappaB and IkappaB families.

50 ed LPS-dependent activation of NF-kappaB and IkappaB kinase beta activity, protected against LPS acti

51 Analyses of NF-kappaB and IkappaB kinase proteins from Aiptasia suggest that non-c

52 of ERK, but not Jun NH2-terminal kinase and IkappaB kinase, blocked the downregulation of Baf60c and

53 TAK-1 and ERK1/2, whereas IkappaB kinase and IkappaB were phosphorylated, even in basal conditions.

54 ium mobilization, as well as PI3K, MAPK, and IkappaB kinase (IKK) activation.

55 ted NF-kappaB essential modulator (NEMO) and IkappaB kinase 2 (IKK2), two essential mediators of the

56 B (NF-kappaB) essential modulator (NEMO) and IkappaB kinase subunit beta (IKKbeta), an interaction th

57 sults presented a novel mechanism of PKA and IkappaB pathway, which may be targeted for treating S. a

58 plex) are present in anucleate platelets and IkappaB is phosphorylated upon activation, suggesting th

59 y and also inhibits TNF-alpha production and IkappaB degradation in a dose-dependent manner.

60 in the interaction between DENV protease and IkappaB-alpha/beta, the enzymatic activity is critical t

61 activation of IRF5 was dependent on TAK1 and IkappaB kinase (IKK)beta, which thus reveals a physiolog

62 -induced NF-kappaB nuclear translocation and IkappaB degradation.

63 r-associated factor 6 (TRAF6) and attenuates IkappaB kinase beta-dependent (IKKbeta-dependent) phosph

64 d others found that IkappaBzeta, an atypical IkappaB family member and transcriptional coactivator of

65 We demonstrate that IkappaBzeta, an atypical IkappaB family member and transcriptional coactivator re

66 We found that expression of the atypical IkappaB member IkappaB (inhibitor of NF-kappaB) zeta, a

67 aB RelA, cRel, and RelB dimers, the atypical IkappaB protein Bcl3 is primarily a transcriptional core

68 ice with impaired expression of the atypical IkappaB protein IkappaBNS have markedly reduced frequenc

69 of-function studies reveal that the atypical IkappaB protein, Bcl3, is also required for induction of

70 lve the classical NF-kappaB pathway, because IkappaB-alpha degradation and p65 nuclear translocation

71 RE1A/beta-TrCP is substrate-specific because IkappaB, another substrate of SCF(beta-TrCP), is not sen

72 onstrated by reduction of phospho-IKK-beta, -IkappaB-alpha, and p65 nuclear translocation in ECs.

73 aNp63 expression through its ability to bind IkappaB and enhance nuclear Rel/A p65, a component of th

74 lecule that is an upstream regulator of both IkappaB kinase (IKK) and c-Jun N-terminal kinase (JNK),

75 kappaB system, degradation of NFkappaB-bound IkappaB by the IkappaB kinase (IKK) is required for acti

76 d inhibits its phosphorylation on Ser-209 by IkappaB kinase-beta (IKKbeta).

77 wing knockdown, we studied HIV activation by IkappaB knockdown, in comparison with those of known HIV

78 ear transcription factor kappaB (IkappaB) by IkappaB kinase (IKK) triggers the degradation of IkappaB

79 molecular stripping from the DNA induced by IkappaB.

80 sed differentiated phenotype and mediated by IkappaB kinase alpha/NUMB/NOTCH signaling.

81 s involves hypothalamic immunity mediated by IkappaB kinase-beta (IKK-beta), nuclear factor kappaB (N

82 nduction of PUMA by sorafenib is mediated by IkappaB-independent activation of nuclear factor (NF)-ka

83 of the differential NF-kappaB recognition by IkappaB subfamilies is discussed.

84 the PKC-alpha/IkappaBalpha- and calcineurin/IkappaB-beta-dependent NF-kappaB signaling pathways are

85 the PKC-alpha/IkappaB-alpha- and calcineurin/IkappaB-beta-dependent NF-kappaB signaling pathways, and

86 alpha/IkappaB-alpha)-mediated or calcineurin/IkappaB-beta-dependent, NF-kappaB-dependent allergen-ind

87 K Binding Kinase 1 (TBK1) is a non-canonical IkappaB kinase that contributes to KRAS-driven lung canc

88 y inhibiting the activation of non-canonical IkappaB kinase varepsilon and IkappaBalpha, and conseque

89 ligase TRAF6 is a key regulator of canonical IkappaB kinase (IKK)/NF-kappaB signaling in response to

90 mplicated in the activation of the canonical IkappaB kinase (IKK) complex.

91 Three canonical IkappaBs, IkappaBalpha, IkappaBbeta, and IkappaBepsilon,

92 ignature included "protein kinase cascade," "IkappaB kinase/NFkappaB cascade," and "regulation of pro

93 light polypeptide gene enhancer in B-cells (IkappaB) family.

94 ritive and genetic inhibition of the central IkappaB kinase beta (IKKbeta)/nuclear factor-kappaB (NF-

95 Unphosphorylated Bcl3 acts as a classical IkappaB-like inhibitor and removes p50 and p52 from boun

96 Tid1 is an essential mediator that connects IkappaB kinases to the Beclin1-containing autophagy prot

97 calization signals, and binding to cytosolic IkappaBs are conserved.

98 n and that its deficiency leads to decreased IkappaB turnover in humans, highlighting an important re

99 paired NF-kappaB activation due to decreased IkappaB ubiquitination and degradation.

100 ibited tumor necrosis factor-alpha-dependent IkappaB degradation and expression of proinflammatory me

101 can be triggered by targeting two different IkappaB proteins and that IkappaBepsilon may be an effec

102 ith MHC-I, MyD88-dependent TLR signals drive IkappaB-kinase (IKK)2-mediated phosphorylation of phagos

103 dentified as an interactor of the Drosophila IkappaB factor Cactus and shown to play a role in contro

104 egulates the transcription of the Drosophila IkappaB homolog, Cactus, in Toll receptor-mediated antim

105 ut NF-kappaB activation mechanism emphasizes IkappaB-tethered complex inactivation in the cytoplasm.

106 .1292dupG in exon 13 of IKBKB, which encodes IkappaB kinase 2 (IKK2, also known as IKKbeta)--leading

107 omozygous point mutation in IKBKAP, encoding IkappaB kinase complex-associated protein.

108 ed NF-kappaB by interfering with endothelial IkappaB kinase 2 activity in vitro and in vivo.

109 ndent actin depolymerization, which enhances IkappaB degradation, p65 nuclear translocation, nuclear

110 To further investigate how IkappaB-zeta mediates NF-kappaB activity, we performed i

111 ty and phosphorylation of p65, IkappaBalpha, IkappaB kinase, and Akt.

112 al events lead to the activation of the IKK (IkappaB kinase).

113 ed TGF-beta1-induced phosphorylation of IKK, IkappaB and RELA, degradation of IkappaBalpha, RELA nucl

114 t of RIP1 to the receptor complex, impairing IkappaB kinase (IKK) recruitment and NF-kappaB activatio

115 glycerophosphoinositol-dependent decrease in IkappaB kinase alpha/beta, p38, JNK, and Erk1/2 kinase p

116 is factor-alpha expression and a decrease in IkappaB-alpha degradation and nuclear factor-kappaB phos

117 This resulted in IkappaB levels significantly exceeding the basal, consti

118 ines with this deletion, exhibited increased IkappaB kinase (IKK) activity and production of proinfla

119 on, and B56gamma silencing induced increased IkappaB kinase (IKK) and IkappaBalpha phosphorylation up

120 coccus faecalis or CpG DNA, led to increased IkappaB cleavage, NF-kappaB nuclear localization, and IL

121 Last, U(L)26 blocks TNF-alpha-induced IkappaB-kinase (IKK) phosphorylation, a key step in NF-k

122 enced by the suppression of particle-induced IkappaB phosphorylation, NF-kappaB p65 nuclear transloca

123 art of a multicomponent complex that induces IkappaB kinase (IKK) activity and NF-kappaB activation.

124 Here, we found that inducible IkappaB kinase-related (IKK-related) kinase IKBKE expres

125 NF-alpha activity was mediated by inhibiting IkappaB kinase phosphorylation, which attenuated the LPS

126 t affecting the degradation of its inhibitor IkappaB-alpha.

127 eins, among which is the NF-kappaB inhibitor IkappaB.

128 ternary complexes with DNA and the inhibitor IkappaB.

129 equestered in the cytosol by their inhibitor IkappaB (inhibitor of NF-kappaB) proteins.

130 ing the controlled degradation of inhibitory IkappaB proteins.

131 F-kappaB dimer through binding to inhibitory IkappaB proteins.

132 While aspirin directly inhibits IkappaB kinases (IKKs) to phosphorylate IkappaBalpha for

133 ncorporated unprotected phosphotyrosine into IkappaB-alpha using a modified gene having a TAG codon i

134 calpains target vertebrate and invertebrate IkappaB proteins.

135 chanism of NF-kappaB induction not involving IkappaB kinase activation.

136 nes encoding IFN regulatory factor 6 (IRF6), IkappaB kinase-alpha (IKKalpha), and stratifin (SFN) exh

137 itor of nuclear transcription factor kappaB (IkappaB) by IkappaB kinase (IKK) triggers the degradatio

138 Mice lacking the inhibitor of NF-kappaB (IkappaB) kinase (IKK) kinase TAK1 underwent normal posit

139 binding to the NEMO/inhibitor of NF-kappaB (IkappaB) kinase gamma (IKKgamma) subunit of an IKK compl

140 ARD11)-TAK1 (MAP3K7)-inhibitor of NF-kappaB (IkappaB) kinase-beta (IKKbeta) module is a switch mechan

141 c process by activating inhibitor of kappaB (IkappaB) kinase (IKK) complex, which subsequently recrui

142 kappaB independently of inhibitor of kappaB (IkappaB) proteins.

143 ppaB inhibitor protein, inhibitor of kappaB (IkappaB)alpha, to study the roles of NF-kappaB in the de

144 Other elements of the nuclear factor kappaB/IkappaB cascade (ie, IKK-alpha,-beta,-gamma/NEMO and CAR

145 ter switches such as Nrf2/Keap1 or NF-kappaB/IkappaB is used for system-wide oxidative stress respons

146 phoma cells with inhibitors of the NF-kappaB/IkappaB kinase pathway or deletion of c-Rel or RelA resu

147 We identified the two kinases IkappaB kinase alpha (IKKalpha) and IkappaB kinase beta

148 otif protein similar to insect and mammalian IkappaB, an inhibitor of the transcription nuclear facto

149 additional effect to inhibit RANKL-mediated IkappaB degradation and NF-kappaB activation in osteocla

150 ain A (CalpA) on the Drosophila melanogaster IkappaB homologue Cactus in vivo.

151 at expression of the atypical IkappaB member IkappaB (inhibitor of NF-kappaB) zeta, a selective coact

152 silon), which form low-molecular-weight (MW) IkappaB:NF-kappaB complexes that are highly stable, and

153 Expression of a dominant-negative IkappaB, which blocks NF-kappaB nuclear translocation, p

154 lations of a realistic model of the NFkappaB/IkappaB network, we also illustrate the dephasing phenom

155 ophagy factor ATG1/ULK1 and the noncanonical IkappaB kinase (IKK), TANK-binding kinase 1 (TBK1), whic

156 The noncanonical IkappaB kinases IKK-varepsilon and TANK-binding kinase 1

157 in persistent elevation of the noncanonical IkappaB kinases IKKepsilon and TBK1.

158 Here, we show that the noncanonical IkappaB-related kinase, IKBKE, is a critical oncogenic e

159 We identified the atypical nuclear IkappaB protein IkappaB-zeta to be upregulated in ABC co

160 We describe Pickle, a Drosophila nuclear IkappaB that integrates signaling inputs from both the I

161 Surprisingly, the Bcl3-type nuclear IkappaB proteins functionally pair up only with NF-kappa

162 inhibition induces a nuclear accumulation of IkappaB kinase (IKK)alpha, and inhibition of IKKalpha en

163 nvolves an increased nuclear accumulation of IkappaB kinase beta (IKKbeta) and an increased recruitme

164 Activation of IkappaB kinase (IKK) and NF-kappaB by genotoxic stresses

165 ignaling pathway that involves activation of IkappaB kinase and nuclear factor kappaB (NF-kappaB).

166 Hyperammonemia triggered activation of IkappaB kinase, NF-kappaB nuclear translocation, binding

167 acetylation and suppressed the activation of IkappaB-alpha kinase.

168 and is sustained by constitutive activity of IkappaB kinase (IKK) in the cytoplasm.

169 d that knockdown or blocking the activity of IkappaB kinase beta (IKKbeta) prevented the aggregation

170 manner that requires the kinase activity of IkappaB kinase epsilon (IKKepsilon) and the transactivat

171 NEMO affects the activity of IkappaB kinase-beta (IKKbeta), which relieves the inhibi

172 ing the activation and intrinsic activity of IkappaB kinase-beta.

173 , by assessing the kinetics and amplitude of IkappaB kinase (IKK) activation, we report that TNF-alph

174 tors of c-Jun N-terminal kinase (JNK) and of IkappaB kinase (IKK) were used to investigate the involv

175 histone deacetylase activity and blockade of IkappaB kinase/nuclear factor-kappaB signaling during re

176 demonstrated that kinetic considerations of IkappaB kinase-signaling input and IkappaBepsilon's inte

177 2 blocked phosphorylation and degradation of IkappaB and enhanced inhibitory binding of PPARgamma to

178 paB kinase (IKK) triggers the degradation of IkappaB and migration of cytoplasmic kappaB to the nucle

179 IKKgamma, leads to increased degradation of IkappaB and subsequent nuclear translocation of RelA.

180 acilitates ubiquitination and degradation of IkappaB kinase (IKK)-beta thus terminating IKK activity.

181 teracts with and promotes the degradation of IkappaB kinase beta (IKKbeta), a component of the Ikappa

182 ion with CCDC22 to direct the degradation of IkappaB proteins.

183 e phosphorylation of IKK, the degradation of IkappaB, and augmented the expression of pro-inflammator

184 on of NF-kappaB by endogenous degradation of IkappaB-alpha was observed for HARE(N2280A) cells endocy

185 rase plasmids, as assessed by degradation of IkappaB-alpha.

186 cells by reducing proteasomal degradation of IkappaB.

187 Bcl-3 is an atypical member of the family of IkappaB proteins.

188 an inducible, constitutively active form of IkappaB kinase beta (CA-IKKbeta), a key kinase in the ca

189 The importance of IkappaB kinase (IKK)-induced proteolysis of NF-kappaB1 p

190 nhibition was associated with an increase of IkappaB.

191 n mice with sepsis and whether inhibition of IkappaB kinase (IKK) reduces the cardiac dysfunction in

192 Chemical inhibition of IkappaB kinase (IKK), mitogen-activated protein extracel

193 tions and detected a physical interaction of IkappaB-zeta with both p50 and p52 NF-kappaB subunits, i

194 ts held by the IkappaBs, and the kinetics of IkappaB degradation and resynthesis following knockdown,

195 Knockdown of IkappaB-zeta by RNA interference was toxic to ABC but no

196 exceeding the basal, constitutive levels of IkappaB.

197 Coexpression of dominant-negative mutants of IkappaB kinase alpha (IKKalpha)/IKK1 or IKKbeta/IKK2 als

198 tabilized NIK, and led to phosphorylation of IkappaB kinase (IKK)-alpha.

199 er demonstrated decreased phosphorylation of IkappaB kinase (IKKbeta) and IkappaBalpha in the presenc

200 The cNOS-mediated reduction of IkappaB is likely due to the imbalance of nitric oxide/p

201 oxide synthase plays a role in regulation of IkappaB reduction and NF-kappaB activation in human kera

202 -kappaB p65 by preventing the resynthesis of IkappaB and increased transcription of KC and IL-6 genes

203 We investigated the role of IkappaB kinase alpha (IKKalpha) in pancreatic homeostasi

204 arget genes, indicating an essential role of IkappaB-zeta in regulating a specific set of NF-kappaB t

205 proteasome activity followed by stability of IkappaB.

206 clear translocation via the stabilization of IkappaB is an important mechanism of PI-induced apoptosi

207 ired either for mitochondrial suppression of IkappaB degradation.

208 There are two types of IkappaB inhibitors: the prototypical IkappaBs (IkappaBal

209 ies have demonstrated that ubiquitination of IkappaB kinase gamma (IKKgamma), a regulatory subunit of

210 storation of p53 increased ubiquitination of IkappaB, resulting from concurrently reduced proteasome

211 beta-mediated signaling pathways upstream of IkappaB and MAPK activation.

212 TNF-induced NF-kappaB signaling upstream of IkappaB kinase activation absolutely requires the influx

213 Phosphorylation of IkappaBs results in their proteasomal degradation and th

214 d by vorinostat in EOC cells is dependent on IkappaB kinase (IKK) activity and associated with a gene

215 Hippo kinases MST1, MST2, and the oncogenic IkappaB kinase TBK1 as the most enriched RASSF1A-interac

216 o express either cyclooxygenase-2 (COX-2) or IkappaB kinase-2 (IKK2), and TP53(+/+) or TP53(f/f) spec

217 effect of p53 on ubiquitin-related genes or IkappaB kinases.

218 a complex including BCL10, MALT1, and other IkappaB kinase (IKK)-signalosome components.

219 nd shares low sequence similarity with other IkappaB proteins.

220 anonical and noncanonical NF-kappaB pathways IkappaB kinase beta (IKKbeta) and IKKalpha to activate N

221 d by increased abundance of RelB and phospho-IkappaB kinase alpha/beta, an indirect activator of NF-k

222 (phospho-nuclear factor-kappaB p65, phospho-IkappaB kinase alpha/beta, interleukin 1beta, and tumor

223 phosphorylated NF-kappaB and phosphorylated IkappaB levels in osteoclasts.

224 vels of Nur77, CD5, GITR, and phosphorylated IkappaB-alpha in thymocytes from NODBim(-/-) mice sugges

225 d increased NF-kappaB-p65 and phosphorylated IkappaB-alpha levels along with higher serum levels of T

226 However, phosphorylated IkappaB kinase (IKK)alpha/beta expression and NF-kappaB

227 Unexpectedly, phosphorylated IkappaB-alpha also mediated the exchange of exogenous DN

228 canonical role of IKKbeta in phosphorylating IkappaB to allow NFkappaB activation.

229 equired for TNF-induced IKK phosphorylation, IkappaB degradation, nuclear translocation of NF-kappaB

230 es that are highly stable, and the precursor IkappaBs (p105/IkappaBgamma and p100/IkappaBdelta), whic

231 In these cells, S1P, but not TNF, promotes IkappaB kinase (IKK) and p65 phosphorylation, IkappaBalp

232 ntified the atypical nuclear IkappaB protein IkappaB-zeta to be upregulated in ABC compared with germ

233 overexpressing NF-kappaB inhibitory protein IkappaB expression, we demonstrate that LPS-induced ET-1

234 specific isoforms of the inhibitory protein IkappaB mediated these diverse responses; NF-kappaB sign

235 Unlike prototypical IkappaB proteins, which are inhibitors of NF-kappaB RelA

236 ypes of IkappaB inhibitors: the prototypical IkappaBs (IkappaBalpha, IkappaBbeta, and IkappaBepsilon)

237 glycogen synthase kinase 3 activity, reduces IkappaB phosphorylation and p65 NF-kappaB translocation,

238 reduced phosphorylative activation, reducing IkappaB kinase-beta activation and intrinsic activity, t

239 onse, highlight the importance of regulating IkappaB/Cactus transcription in innate immunity, and ide

240 C, [Ca(2+)]i, protein kinase C) and requires IkappaB kinase (IKK)-beta.

241 erse the effect of l-NAME in partial restore IkappaB level post-UVB.

242 ished downstream mediators of NIK signaling, IkappaB kinase alpha/beta (IKKalpha/beta) and NF-kappaB,

243 ated very low TNF release and no significant IkappaB degradation or NF-kappaB nuclear translocation,

244 tivity was required for maintaining a stable IkappaB kinase alpha subunit (IKKalpha) level because tr

245 lammatory cytokines TNF and IL-17 stimulated IkappaB kinase (IKK)-NF-kappaB and impaired osteogenic d

246 IRAK2-TRAF6 interaction is needed to sustain IkappaB-inducing kinase beta activity during prolonged a

247 molecule to independently bind TRAF6, TAK1, IkappaB kinase alpha, and IkappaB kinase beta.

248 r cells and for regulation of its key target IkappaB and hence NF-kappaB.

249 d the effects on HIV activation of targeting IkappaBs by single and pairwise small interfering RNA (s

250 , transforming growth factor beta (TGFbeta), IkappaB kinase (IKK), Ras/mitogen-activated protein kina

251 Collectively, our data demonstrate that IkappaB-zeta is essential for nuclear NF-kappaB activity

252 t genome-wide siRNA screen demonstrated that IkappaB kinase-alpha (IKK-alpha) is a crucial host facto

253 and p52 NF-kappaB subunits, indicating that IkappaB-zeta interacts with components of both the canon

254 Here we report that IkappaB kinase alpha (IKKalpha) is a critical negative r

255 Here, we report that IkappaB kinase beta (IKKbeta) is activated upon glutamin

256 We previously reported that IkappaB kinase alpha (IKKalpha), a component of the kina

257 Previously, we reported that IkappaB kinase-beta(IKKbeta) phosphorylates and stabiliz

258 The IkappaB family protein BCL-3 stabilizes a NF-kappaB p50

259 The IkappaB kinase complex (IKK) is a key regulator of immun

260 The IkappaB-Kinase (IKK) complex-consisting of the catalytic

261 ntial role in inflammation by activating the IkappaB kinase (IKK)/nuclear factor kappaB (NF-kappaB) a

262 ies implicate Erb3 binding protein-1 and the IkappaB kinase pathway in the mechanism of action of WS6

263 ough the innate immune receptor MDA5 and the IkappaB kinase-beta-NF-kappaB pathway.

264 ppaBbeta, and IkappaBepsilon, exist, but the IkappaB proteins' role in HIV activation regulation is n

265 al is sequestered outside the nucleus by the IkappaB homolog Cactus.

266 degradation of NFkappaB-bound IkappaB by the IkappaB kinase (IKK) is required for activation in respo

267 f a number of cellular factors including the IkappaB kinase epsilon (IKKepsilon).

268 ts activation of NF-kappaB by inhibiting the IkappaB kinase pathway and by promoting direct inhibitor

269 Bcl-3 is an atypical member of the IkappaB family and modulates gene expression via interac

270 xposure to oxidative stress, the role of the IkappaB family of inhibitory proteins in modulating this

271 Bcl-3 is an atypical member of the IkappaB family that modulates transcription in the nucle

272 athway activation induces degradation of the IkappaB inhibitor Cactus, resulting in a ventral-to-dors

273 This is achieved through subversion of the IkappaB kinase (IKK) complex (or signalosome), which inv

274 aB kinase beta (IKKbeta), a component of the IkappaB kinase (IKK) complex that regulates nuclear fact

275 ulator (NEMO), a regulatory component of the IkappaB kinase (IKK) complex, controls NF-kappaB activat

276 aB essential modulator (NEMO) subunit of the IkappaB kinase (IKK) complex.

277 Activation of the IkappaB kinase (IKK) is central to NF-kappaB signaling.

278 a complex with the modulatory subunit of the IkappaB kinase (IKK) kinase, IKKgamma (or NEMO), resulti

279 dulator (NEMO; the regulatory subunit of the IkappaB kinase [IKK] complex).

280 miR-148a is an inhibitor of the IkappaB kinase alpha/NUMB/NOTCH pathway and an inducer o

281 Inhibition of the IkappaB kinase complex (IKK) has been implicated in the

282 Selective autophagic degradation of the IkappaB kinase complex prevents constitutive activation

283 s process occurred through activation of the IkappaB kinase complex, which also led to activation of

284 cytoplasm through the kinase activity of the IkappaB kinase complex, which leads to translocation of

285 eceptor that mediates the degradation of the IkappaB kinase complex.

286 ecifically suppressing the activation of the IkappaB kinase complex.

287 Here we demonstrate that sumoylation of the IkappaB kinase homolog immune response-deficient 5 plays

288 pression by decreasing the activation of the IkappaB-kinase beta-RelA NF-kappaB pathway.

289 g NF-kappaB signaling via its effects on the IkappaB kinase complex and resulting in reduced IL2 gene

290 e synthase (cNOS), can partially reverse the IkappaB reduction and inhibit the DNA binding activity a

291 We previously found that the IkappaB kinase beta (IKKbeta)/NF-kappaB pathway regulate

292 MC005 inhibited NF-kappaB proximal to the IkappaB kinase (IKK) complex, and unbiased affinity puri

293 abundance of NF-kappaB subunits held by the IkappaBs, and the kinetics of IkappaB degradation and re

294 er determining the relative abundance of the IkappaBs, the relative abundance of NF-kappaB subunits h

295 Notably, NF-kappaB signaling through IkappaB kinase beta protected crypt IECs but did not pro

296 rculosis demonstrated robust release of TNF, IkappaB degradation, and NF-kappaB nuclear translocation

297 at serine 428, which promoted its binding to IkappaB kinasebeta (IKKbeta), resulting in the inhibitio

298 activated CaMKII in cardiomyocytes leads to IkappaB kinase phosphorylation and concomitant increases

299 uced activation of TAK-1 and ERK1/2, whereas IkappaB kinase and IkappaB were phosphorylated, even in

300 cilitated the complex formation of CD91 with IkappaB kinases (IKKs) alpha and beta and increased the