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1 Ile-Pro-Ile-Gln-Tyr, Tyr-Pro-Tyr-Tyr and Leu-Pro-Tyr-Pro
2 effect, we find that the actions of [Sar(1),Ile(4), Ile(8)]-AngII require the AT1 receptor and resul
5 copy-based analysis demonstrate that [Sar(1),Ile(4),Ile(8)]-AngII promotes internalization of AT1-B2
7 e arrestin pathway-selective agonist [Sar(1)-Ile(4)-Ile(8)]AngII (SII), is blocked by shRNA silencing
8 , three, or four replacements at (5)Ile, (12)Ile, and (15)Glu reduced AMA reactivity even further.
10 f TM3 to extracellular loop 2, ECL2 (Thr-141/Ile-142) and ECL2 (Asn-148/Asp-149, Leu-150/Thr-151, Arg
11 e N-Cap amphipathic helix identified Leu-15, Ile-18, and Ile-19 as residues critical for the stabiliz
12 mogens, pro-uPA (at consensus sites Lys(158)-Ile(159) and Lys(135)-Lys(136)) and plasminogen, yieldin
13 d conformation was induced by [Sar(1),Gln(2),Ile(8)] AngII, a specific analog that binds to the D281A
17 Specifically, Candida intermedia gxs1 Phe(38)Ile(39)Met(40), Scheffersomyces stipitis rgt2 Phe(38) an
18 we find that the actions of [Sar(1),Ile(4), Ile(8)]-AngII require the AT1 receptor and result from a
21 sed analysis demonstrate that [Sar(1),Ile(4),Ile(8)]-AngII promotes internalization of AT1-B2 heterod
22 tin pathway-selective agonist [Sar(1)-Ile(4)-Ile(8)]AngII (SII), is blocked by shRNA silencing of bet
23 with two, three, or four replacements at (5)Ile, (12)Ile, and (15)Glu reduced AMA reactivity even fu
27 Mutating SM residues Phe-35/Ser-37/Leu-65/Ile-69 into alanine, based on the key residues in Deg1,
29 1 (Phe-40), helix 3 (Leu-63, Arg-68, Gln-69, Ile-72, Tyr-76), and C-terminal segment (Leu-81, Glu-84)
30 idues at gp120 positions 23, 45, 47, and 70 (Ile-Ala-Lys-Asn [I-A-K-N]) emerged as signatures of muco
31 revealed also a key role of residues Lys-74/Ile-76 at the N-terminal of FGF14 in the FGF14.Nav1.6 co
33 ned in this study harbored the single Thr-86-Ile mutation in GyrA, FQ(R) C. jejuni isolates had other
34 ds Gly and Glu, and the essential amino acid Ile were more abundant in the scalp hair of diabetic pat
35 nel-based homology models predict amino acid Ile-1575 in domain IV segment 6 to be in close proximity
36 I finger domain located between amino acids Ile(5) and Asn(37) and a VDAC region including amino aci
37 es whereas those of hydrophobic amino acids (Ile, Phe) deviate positively from the isotropic trend li
38 -TM3 loop, exerts a steric repulsion against Ile-225 at the top of TM1 in the neighboring subunit.
39 protein (65-74) fragment (H-Val-Gln-Ala-Ala-Ile-Asp-Tyr-Ile-Asn-Gly-OH), following the solid-phase p
40 nt (with a C-terminal Gly, H-Asn-Phe-Gly-Ala-Ile-Leu-Gly-NH2) and acyl carrier protein (65-74) fragme
43 Ile and Thr residues, i.e. containing d-allo-Ile and d-allo-Thr along with d-amino acids and glycine.
47 ipathic helix identified Leu-15, Ile-18, and Ile-19 as residues critical for the stabilization of ful
49 th the scaffold proteins beta-arrestin 2 and Ile Gln motif containing GTPase Activating Protein 1, a
50 g the idea, mutations in residues Ile-24 and Ile-25 of the MinD-interacting domain affect fibril form
52 ophobic core residues, Leu-331, Val-338, and Ile-345, of Hec1 with alanine completely eliminated Nuf2
56 ), Ala(16), Met(17), Gly(475), Val(477), and Ile(485) are more important for kinase domain closure an
58 gest that an interaction between Val(48) and Ile(328) stabilizes the closed channel and that this is
60 ral side chains, such as Phe-57, Tyr-60, and Ile-77, that change their orientations to accommodate th
61 Additional mutations in residues Ile-72 and Ile-74 suggest a role of the C-terminal domain of MinE i
62 obic patch of ubiquitin comprising Leu-8 and Ile-44 is important for E6AP-mediated ubiquitination, wh
63 idA proteins can preempt damage to BCAT3 and Ile biosynthesis by hydrolyzing the Ser-derived enamine/
64 ith the APC/C through their common C-box and Ile-Arg tail motifs, the mechanism underlying this diffe
66 ntally verified contact of Ser-281 (ECD) and Ile-486 (TMD) was subsequently utilized in docking homol
67 fied to homogeneity functional Asn, Glu, and Ile tRNAs from the native E. coli tRNA mixture, and by c
68 exception of isoacceptors for Asn, Glu, and Ile, the majority of 48 synthetic Escherichia coli tRNAs
69 vealed that BCAT6 transaminates Val, Leu and Ile as well as the corresponding 2-oxo acids but also tr
70 (MS) for de novo protein sequencing, Leu and Ile have been generally considered to be indistinguishab
72 cid sequences, including identity of Leu and Ile residues, can be accurately obtained solely by means
73 by supplementation of LNAAs, such as Leu and Ile, with a strong affinity for the LNAA transporter typ
78 eu, Tyr-Pro-Tyr-Tyr, Leu-Pro-Tyr-Pro-Tyr and Ile-Pro-Ile) and a casein (CasH), whey (WPH) and lactofe
80 f 7 and NOP ligands (e.g., H-Arg-Tyr-Tyr-Arg-Ile-Lys-NH2) led to binding affinities in the low nanomo
81 3a (H-Dmt-d-Arg-Aba-beta-Ala-Arg-Tyr-Tyr-Arg-Ile-Lys-NH2) to mice resulted in potent and long lasting
82 hat tryptophan-containing dipeptides such as Ile-Trp or Val-Trp, which were recently found in food pr
84 e hydrogen-bonded coassemblies formed by BTA Ile and the intrinsically achiral catalytic rhodium cata
85 BTA(PPh2) and the enantiopure comonomer BTA Ile as confirmed by various spectroscopic and scattering
90 e quantum coherence (HMQC) spectrum of (13)C-Ile-labeled enzyme resembles the glucose-bound state.
92 inge enables conserved nonpolar side chains (Ile(A2), Val(A3), Val(B12), Phe(B24), and Phe(B25)) to e
93 ctures of dimers of unliganded CodY and CodY-Ile derived from the tetramers showed a splaying of the
94 wolowo University Teaching Hospital Complex, Ile-Ife, Osun State, Nigeria from January 2007 to Decemb
96 Our analysis highlighted highly conserved Ile and Phe residues at the RfaH interdomain interface.
98 siological conditions and that the conserved Ile-Met motif is mainly used to recover mistargeted rece
100 he pentapeptides Cys-Ile-His-Asn-Pro and Cys-Ile-Gln-Pro-Val while low response was achieved for the
101 peptides (cysteinylglycine, glutathione, Cys-Ile-His-Asn-Pro, Cys-Ile-Gln-Pro-Val, Cys-Arg-Gln-Val-Ph
102 ponse was obtained for the pentapeptides Cys-Ile-His-Asn-Pro and Cys-Ile-Gln-Pro-Val while low respon
103 ycine, glutathione, Cys-Ile-His-Asn-Pro, Cys-Ile-Gln-Pro-Val, Cys-Arg-Gln-Val-Phe) vs. 14 volatile co
106 ved in SR-KO mice and are also enhanced by D-Ile, indicating that glycine overlaps with D-serine bind
108 rter activity is enhanced by D-isoleucine (D-Ile), which releases D-serine and glycine from Asc-1-tra
109 n target of rapamycin signaling and decrease Ile Gln motif containing GTPase Activating Protein 1 pho
110 s show that Met(73) and, to a lesser extent, Ile(75) suppress excision activity when TAMs are present
111 By comparison, substitutions of Asn for Ile-136 (I136N) and Thr for Ile-142 (I142T) in a subdoma
115 tions of Asn for Ile-136 (I136N) and Thr for Ile-142 (I142T) in a subdomain previously named the heli
116 g a proline scan of the inner S6 helix, from Ile(655) to Tyr(667) revealed that gate perturbation occ
117 her generation of a signature 69 Da ion from Ile or formation of unique w-ions employing MS(3) (ETD-H
121 peptides of the sequence EGAAXAASS (X = Gly, Ile, Tyr, Trp) through comparison of molecular dynamics
122 acetyltransferase uses a similar Gly-Asp-Gly-Ile motif to form the "cysteine synthase" complex with C
123 ositive bacteria lack C-terminal Gly-Tyr-Gly-Ile motifs, suggesting that they do not interact with Cy
124 CT(EC536) inserts its C-terminal Gly-Tyr-Gly-Ile peptide tail into the active-site cleft of CysK to a
125 ing to AA was: Trp > norleucine > Phe, Leu > Ile > His >3,4-dihydroxyphenylalanine, Arg > Val > Lys,
127 ate, thereby establishing the alpha-70(Val-->Ile) intermediate as a reliable guide to mechanism.
128 e-trapped intermediate of the alpha-70(Val-->Ile) MoFe protein as the Janus intermediate that stores
130 s containing amino acids Ala, Asn, Gln, His, Ile, and Lys at positions equivalent to 782 and/or 786 i
131 Leu-Leu-Ala-Pro and Met-Ala-Gly-Val-Asp-His-Ile, with IC50 values in the range 43-159 muM were ident
132 UT1), reveal that Ile-335 (or the homologous Ile-296 in hSLC2A5) is a key component for protein confo
133 similarly to the wild type hSLC2A9; however, Ile-335 is necessary for urate/fructose trans-accelerati
139 (IC2 and IC3) of the CB1 receptor, including Ile-218(3.54), Tyr-224(IC2), Asp-338(6.30), Arg-340(6.32
140 28~Gln653, named CP), but with an innovative Ile-Asp-Leu tail (IDL) that dramatically increased the i
142 ain amino acids (BCAAs) leucine, isoleucine (Ile), and valine (Val) in the mitochondria efficiently a
143 Asp, as well as racemization of isoleucine (Ile) and phenylalanine (Phe) after 100 s of irradiation
144 f growth regulators includes the isoleucine (Ile) conjugate of jasmonic acid (JA-Ile) and its biosynt
146 coronatine (COR), we demonstrate that (1) JA-Ile/COR-based signaling regulates corolla limb opening a
147 leucine (Ile) conjugate of jasmonic acid (JA-Ile) and its biosynthetic precursor 12-oxophytodienoic a
148 eracted by a combination of the bacterial JA-Ile mimic coronatine and type III virulence-associated e
149 ) the jasmonic acid-isoleucine conjugate (JA-Ile) and (2) other octadecanoids are suppressed by micro
150 nd ILL6, that define a second pathway for JA-Ile turnover during the wound response in Arabidopsis le
151 ugh COI1; and (3) limb expansion involves JA-Ile-induced changes in limb fresh mass and carbohydrate
152 nd that the COR and jasmonate isoleucine (JA-Ile) co-receptor JAZ2 is constitutively expressed in gua
153 The binding of jasmonoyl-L-isoleucine (JA-Ile) to the F-box of CORONATINE INSENSITIVE1 (COI1) is r
154 hormonal signal, jasmonoyl-L-isoleucine (JA-Ile), has been found recently to undergo catabolic inact
157 To assess the relative contribution of JA/JA-Ile and OPDA to insect resistance in tomato (Solanum lyc
159 we found that OPDA can substitute for JA/JA-Ile in the local induction of defense gene expression, b
162 g the signaling activities of OPDA and JA/JA-Ile, we found that OPDA can substitute for JA/JA-Ile in
163 were complemented with methyl jasmonate, JA-Ile, and its functional homolog, coronatine (COR), we de
164 ate pathway highlight novel mechanisms of JA-Ile hormone turnover and redefine the dynamic metabolic
167 Flower opening, by contrast, requires JA-Ile signaling-dependent changes in primary metabolism, w
168 ons of benzylacetone) and nectar requires JA-Ile/COR perception through COI1; and (3) limb expansion
169 ation of JA to Ile, (ii) oxidation of the JA-Ile conjugate, and (iii) cleavage under the action of th
170 trate a master regulatory function of the JA-Ile/COI1 duet for the main function of a sympetalous cor
172 e conjugating jasmonic acid (JA) to at least Ile, Leu, Met, Phe, Trp and Val and both osjar1 alleles
173 Branched-chained amino acids (BCAAs) (Leu, Ile, and Val) and their catabolites, propionylcarnitine
174 The branched-chain amino acids (BCAAs) Leu, Ile, and Val are among nine essential amino acids that m
179 elines we unambiguously identified every Leu/Ile residue in peptides containing up to five Leu/Ile re
180 nstrated, for the first time, that every Leu/Ile residue in the variable regions of a monoclonal anti
182 is integrated, online LC-MS approach for Leu/Ile assignment can be applied to de novo sequencing of a
183 s and oligomers through its hydrophobic (Leu/Ile/Phe-rich) domain, which has been shown to play essen
188 55 where Lys23 to Phe39 encompassing the Leu/Ile/Phe-rich domain forms an amphipathic alpha-helix.
192 5)N-labeled Ras as well as [(13)C]methyl-Met,Ile-labeled Sos for observing site-specific details of R
195 de, whereas the strong positive deviation of Ile leads to prediction or fibril formation for the NINI
198 e same extent as ZnTerp upon Ala mutation of Ile-116(III:16/3.40), a residue that constrains the Trp-
199 revertants of K377C reveals that mutation of Ile-22 (in helix I) preserves Na(+) binding, whereas tha
200 for external QX-222 created by mutations of Ile-1575 was abolished by the additional mutation K1237E
202 from the 4-fold channel axis and twisting of Ile-4937 at the channel constriction site out of the cha
205 n this model, OMR1 exerts primary control on Ile accumulation and functions independently of AHAS and
207 ta-ketosulfonamides derived from Val, Leu or Ile gave the expected beta-keto-alpha,alpha-difluorosulf
208 obic character; (3) ISDs tend to have Leu or Ile residues at their core; (4) ISDs are approximately e
209 complex with ligands containing P(0) Leu or Ile residues reveals two distinct modes of accommodation
210 X is any amino acid and Phi is Val, Leu, or Ile) endocytic motif that, when transferred to CD4, resu
213 For steric reasons, epoxyketones with Val or Ile at the P1 position are weak inhibitors of all active
216 3)-Lys(350)) and extracellular FPR1 peptide (Ile(191)-Arg(201)) as well as three similarly placed FPR
217 Five casein-derived synthetic peptides (Ile-Pro-Ile-Gln-Tyr, Leu-Pro-Leu-Pro-Leu, Tyr-Pro-Tyr-Ty
218 interaction between milk bioactive peptides, Ile-Asn-Tyr-Trp, Leu-Asp-Gln-Trp, and Leu-Gln-Lys-Trp, a
219 Three novel DPP-IV inhibitory peptides, Ile-Leu-Ala-Pro, Leu-Leu-Ala-Pro and Met-Ala-Gly-Val-Asp
220 residues with Ile, one by one, and prepared Ile-1-(13)C amyloid of each mutant, seeding with amyloid
221 variation surrounding the C-terminal Glu-Pro-Ile-Tyr-Ala (EPIYA) motifs as well as the number of EPIY
222 Pro-Tyr-Tyr, Leu-Pro-Tyr-Pro-Tyr and Ile-Pro-Ile) and a casein (CasH), whey (WPH) and lactoferrin hyd
223 e casein-derived synthetic peptides (Ile-Pro-Ile-Gln-Tyr, Leu-Pro-Leu-Pro-Leu, Tyr-Pro-Tyr-Tyr, Leu-P
226 ed non-Hispanic white patients with the rare Ile 164 allele compared with non-Hispanic white patients
227 rimary and replication cohorts with the rare Ile 164 allele were more than twice as likely as Thr 164
228 anic white patients with or without the rare Ile 164 allele, 2.6 [SD 3.5] vs 1.1 [2.1] visits, p<0.00
229 e binding, although the MinD-binding residue Ile-25 is critical for this conformational transition.
233 g hydrophobic contacts between FtsZ residues Ile-374, Pro-375, and Leu-378 with ZapD residues Leu-74,
234 Supporting the idea, mutations in residues Ile-24 and Ile-25 of the MinD-interacting domain affect
236 and binding studies indicated that residues Ile-701, Phe-705, and Trp-708 of the MyoB IQ motif are c
237 nce of three relay loop amino acid residues (Ile(508), Asn(509), and Asp(511)) in communicating with
238 2 peptides which possess two extra residues (Ile 41 &Ala 42) that the non-pathological strain (Abeta4
239 onal roles of two form II-specific residues (Ile(165) and Met(331)) near the active site were examine
242 Both peptides contain a putative 'SIP' (Ser-Ile-Pro) domain that is important for interactions with
245 g involves the hydrophobic patch surrounding Ile-44 in the parkin Ubl, a region that is highly conser
248 C-terminal domain of primase, we found that Ile-85 is located at the interface in the NTD of DnaB th
249 al structure of hSLC2A1 (GLUT1), reveal that Ile-335 (or the homologous Ile-296 in hSLC2A5) is a key
250 tutions at positions 80 and 83 revealed that Ile(80) and Arg(83) within the Bw4 motif constrain the c
253 ), and the association was reinforced in the Ile-de-France region when this indicator was combined wi
254 onserved hydrophobic residues, including the Ile at position 181 which was highly correlated with vac
255 eochemistry of the chiral side chains of the Ile and Thr residues, i.e. containing d-allo-Ile and d-a
257 ion measurements of the methyl groups of the Ile, Leu, and Val residues at two static magnetic fields
259 olymorphism is functional in vitro, with the Ile allele leading to increased monoamine transport into
261 actions revealed that mutation of Val-434 to Ile significantly reduces inhibition by meloxicam due to
263 fect can almost exclusively be attributed to Ile-Trp, the ACE inhibition by plant protein hydrolysate
265 l pathway involving (i) conjugation of JA to Ile, (ii) oxidation of the JA-Ile conjugate, and (iii) c
266 sn-348, the latter of which, when mutated to Ile, is implicated in resistance to both nucleoside and
269 mutant of Bacillus subtilis that allows tRNA(Ile) mischarging while retaining wild-type Ile-tRNA(Ile)
271 ic binding to the cognate tRNA(Ile) and tRNA(Ile)-dependent structural rearrangements consistent with
272 ty exists in the recognition of certain tRNA(Ile) isoacceptors that are initially transcribed with th
273 strated specific binding to the cognate tRNA(Ile) and tRNA(Ile)-dependent structural rearrangements c
274 ed in which the essential gene encoding tRNA(Ile)-lysidine synthetase was deleted for the first time.
280 l-tRNA synthetases, IleRS can mischarge tRNA(Ile) and correct this misacylation through a separate po
281 A(Leu(UUR)) or with mutations in the mt-tRNA(Ile), both of which are aminoacylated by Class I mt-amin
284 nisms, the C34 wobble position in these tRNA(Ile) precursors is rapidly modified to lysidine to preve
286 ever, the molecular mechanisms by which tRNA(Ile) organizes the synthetic site to enhance pre-transfe
288 strain, C34 at the wobble position of tRNA2(Ile) is expected to remain unmodified and cells depend o
289 agmatidine) at the wobble position of tRNA2(Ile) to base pair specifically with the A of the AUA cod
291 -74) fragment (H-Val-Gln-Ala-Ala-Ile-Asp-Tyr-Ile-Asn-Gly-OH), following the solid-phase peptide synth
293 ruct an alpha1-proteinase inhibitor variant (Ile-Lys-Pro-Arg-/-Ser-Ile-Pro) with high specificity for
294 The most potent inhibitory peptides were Ile-Gln-Ala (beta-CN f187-189) and Val-Glu-Pro (beta-CN
295 s showed a splaying of the wHTH domains when Ile was bound; splaying is likely to account for the inc
298 eu and then replaced 16 single residues with Ile, one by one, and prepared Ile-1-(13)C amyloid of eac
299 Ca(2+) -dependent complex with EB3 via Ser-x-Ile-Pro aminoacid motif and that disruption of STIM2-EB3
300 species, as well as a peptide-based probe, z-Ile-Glu-ThrAsp-D-Cys (IETDC), which releases D-cysteine
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