ライフサイエンスコーパス: Indian hedgehog

1 separate requirements for Sonic hedgehog and Indian hedgehog.

2 tion in a similar manner as misexpression of Indian hedgehog.

3 ranscribed near cells making either Sonic or Indian hedgehog.

4 nic hedgehog a (Shha) rather than Ob-derived Indian hedgehog a (Ihha), which nevertheless functions a

5 We show that Indian Hedgehog, a bone-derived signaling molecule, part

6 iately descended from their progenitors upon Indian hedgehog action and Runx2 expression.

7 (PTH)-related protein (PTHrP), regulated by Indian hedgehog and acting through the PTH/PTHrP recepto

8 zed, lacked maturing chondrocytes expressing Indian hedgehog and collagen X, and failed to undergo en

9 Two signalling molecules-Indian hedgehog and parathyroid hormone-related peptide-

10 e PTH/PTHrP receptor mediates the effects of Indian Hedgehog and PTHrP on chondrocyte differentiation

11 orter mice, we show that the two Hh ligands (Indian hedgehog and sonic hedgehog ligands) are expresse

12 Expression of col10a1, indian hedgehog, and patched was disrupted in mutants, r

13 cytochrome P450, glutathione S-transferase, Indian hedgehog, and solute carrier family genes.

14 We further demonstrate that misexpression of Indian hedgehog appears to directly upregulate BMP2 and

15 ), its receptor, the PTH/PTHrP receptor, and Indian hedgehog are implicated in the regulation of chon

16 We show that expression of Fibronectin and Indian Hedgehog are reduced in chato mutant yolk sacs.

17 parathyroid hormone-related peptide (PTHrP), Indian hedgehog, bone morphogenetic proteins and transfo

18 F9 cell lines expressing a full length Indian hedgehog cDNA express a number of characteristics

19 aturation and hypertrophy markers, including Indian hedgehog, collagen X and MMP-13.

20 Indian hedgehog (encoded by Ihh) has been shown to be ex

21 d Ihh expression domains that the borders of Indian hedgehog expression in the chondrocytes are refle

22 is of Day 7.5 and 8.5 embryos indicates that Indian hedgehog expression is highest in the visceral yo

23 h plates adjacent to interphalangeal joints, Indian hedgehog expression is increased, whereas Collage

24 dition of retinoic acid and also upregulates Indian hedgehog expression.

25 of the parathyroid hormone-related protein, Indian hedgehog, fibroblast growth factor, bone morphoge

26 assessed the function of Sonic hedgehog and Indian hedgehog genes, which encode members of the Hedge

27 aled a significant increase in expression of Indian Hedgehog, glioma-associated oncogene homolog 1, W

28 Analysis of Indian hedgehog homolog a (ihha) mutants shows that the

29 We find that Runx2 directly up-regulates Indian Hedgehog (IHH) and colocalizes with Gli2, a Hedge

30 mice, accompanied by increased expression of Indian Hedgehog (Ihh) and hyperproliferation of surface

31 of Shh is accompanied by an up-regulation of Indian Hedgehog (Ihh) and maintenance of Hh pathway acti

32 ncrease in cell volume, and up-regulation of Indian hedgehog (Ihh) and of collagen type X--all indica

33 A signaling cascade involving Indian hedgehog (Ihh) and parathyroid hormone related pe

34 Indian hedgehog (Ihh) and Parathyroid Hormone-related Pr

35 d kinase (ERK) pathway activation, increased Indian hedgehog (Ihh) and parathyroid hormone-related pr

36 mmit to the osteogenic pathway and that both Indian hedgehog (IHH) and parathyroid hormone-related pr

37 ulted in downregulation of expression of the Indian hedgehog (IHH) and parathyroid hormone-related pr

38 Indian hedgehog (Ihh) and PTHrP signaling play crucial r

39 seal prehypertrophic chondrocytes expressing Indian hedgehog (Ihh) and were followed by mineralizing

40 velopmental stages, sonic hedgehog (Shh) and indian hedgehog (Ihh) are secreted by the endoderm of th

41 We identify Indian hedgehog (Ihh) as a novel downstream target of AR

42 The full-length mouse Indian hedgehog (Ihh) cDNA was cloned from an embryonic

43 Overexpression of Hip in cartilage, where Indian hedgehog (Ihh) controls growth, leads to a shorte

44 Indian hedgehog (Ihh) controls multiple aspects of endoc

45 Indian hedgehog (Ihh) controls multiple aspects of endoc

46 Indian hedgehog (Ihh) critically regulates multiple aspe

47 entally regulated and enhanced expression of Indian hedgehog (Ihh) during pregnancy and lactation.

48 Reduced Indian hedgehog (Ihh) expression was observed in prehype

49 skeletal tissue also demonstrated increased Indian hedgehog (IHH) expression.

50 paracrine signals Desert hedgehog (Dhh) and Indian hedgehog (Ihh) from granulosa cells.

51 tiation, serving as a downstream mediator of Indian Hedgehog (IHH) function in both a local signaling

52 We identified the Indian hedgehog (Ihh) gene as a target of BMP signaling.

53 findings, we detected mRNA encoding SHH and Indian hedgehog (IHH) in both Nkx2.1(-/-) basal forebrai

54 tivates osteocalcin (Ocn) in osteoblasts and indian hedgehog (Ihh) in chondrocytes.

55 We examined the role of Indian hedgehog (Ihh) in mesenchymal organization and th

56 roRNA in parallel to mechanical induction of Indian hedgehog (Ihh) in primary chicken chondrocytes cu

57 ning revealed a visceral endoderm pattern of Indian hedgehog (Ihh) in wild-type E6.5 embryos.

58 We now show that Indian hedgehog (Ihh) is a primitive endoderm-secreted s

59 Indian hedgehog (IHH) is an epithelial-derived signal in

60 Indian hedgehog (Ihh) is essential for chondrocyte and o

61 Indian hedgehog (Ihh) is essential for embryonic mandibu

62 g retina, albeit at very low levels, whereas Indian hedgehog (Ihh) is expressed in the developing and

63 Our previous studies have shown that Indian hedgehog (Ihh) is expressed in the visceral endod

64 Indian hedgehog (Ihh) is expressed normally in the growt

65 Indian hedgehog (Ihh) is indispensable for development o

66 Indian hedgehog (Ihh) is indispensable for osteoblast di

67 The expression of Indian hedgehog (Ihh) is markedly decreased, whereas the

68 olving endodermally secreted Sonic (Shh) and Indian hedgehog (Ihh) proteins that directly signal to a

69 aturing chondrocytes that also expressed the Indian hedgehog (Ihh) receptor and transcriptional targe

70 ing molecules in cartilage, most notably the Indian hedgehog (Ihh) receptor patched (Ptch), was lower

71 Indian Hedgehog (Ihh) regulates chondrocyte and osteobla

72 Indian hedgehog (Ihh) regulates endochondral ossificatio

73 Here we asked whether Indian hedgehog (Ihh) regulates symphyseal cartilage dev

74 Indian Hedgehog (Ihh) regulates tissue morphogenesis.

75 A null mutation in the morphogen Indian hedgehog (IHH) results in an embryonic lethal phe

76 Loss of Indian hedgehog (Ihh) results in reduction in pancreas s

77 s of bm limb growth plates showed diminished Indian hedgehog (Ihh) signaling and abnormal Ihh protein

78 Indian hedgehog (Ihh) signaling from prehypertrophic cho

79 We investigated the role of Disp1 in Indian hedgehog (Ihh) signaling in the developing bone b

80 Indian hedgehog (Ihh) signaling is indispensable for ost

81 of the spinal cord that most likely reflects Indian hedgehog (Ihh) signaling originating from the und

82 Significantly, FGFR3 downregulated the Indian hedgehog (Ihh) signaling pathway and Bmp4 express

83 athyroid hormone-related peptide (PTHrP) and Indian hedgehog (Ihh) signaling tightly regulates chondr

84 e associated with reduced Ihh expression and Indian hedgehog (Ihh) signaling.

85 , and the endochondral skeleton, a target of Indian hedgehog (Ihh) signaling.

86 ment via expression of either Sonic (Shh) or Indian Hedgehog (Ihh) under control of the human Pax4-pr

87 In contrast, a second Hh family member, Indian hedgehog (Ihh) which maps close to Dbf, is ectopi

88 expression of chondrogenic genes, including Indian hedgehog (Ihh), a critical mediator of mechanotra

89 n by IGFs interacts genetically with that by Indian hedgehog (Ihh), a locally produced growth signal

90 A chicken homolog of Indian hedgehog (Ihh), a member of the conserved Hedgeho

91 Indian hedgehog (Ihh), a member of the hedgehog (Hh) fam

92 Indian hedgehog (Ihh), a member of the vertebrate hedgeh

93 endoderm survival and production of VEGF-A, Indian hedgehog (IHH), and bFGF.

94 Mammalian Hhs include Sonic hedgehog (Shh), Indian hedgehog (Ihh), and Desert hedgehog (Dhh).

95 the hedgehog ligands Sonic hedgehog (SHH) or Indian hedgehog (IHH), and with upregulation of the tran

96 Here we show that Indian hedgehog (Ihh), another hedgehog family member, a

97 pression but barely detectable expression of Indian hedgehog (Ihh), collagen X (Col10a1), Vegf (Vegfa

98 P normally functions in a feedback loop with Indian hedgehog (IHH), in which a reduction in one signa

99 Indian hedgehog (Ihh), one of the three mammalian hedgeh

100 ted with RNAs encoding Sonic hedgehog (Shh), Indian hedgehog (Ihh), or a dominant-negative regulatory

101 Indian hedgehog (Ihh), patched (Ptc), and Gli3 are expre

102 By contrast, the expression domains of Indian hedgehog (Ihh), patched, and noggin become restri

103 (PTH-related) protein (PTHrP), regulated by Indian hedgehog (Ihh), prevents premature hypertrophic d

104 meric mice, we provide in vivo evidence that Indian hedgehog (IHH), synthesized by prehypertrophic an

105 patched 1 (Ptch1), sonic hedgehog (Shh) and Indian hedgehog (Ihh), we demonstrate that Disp1 genetic

106 Indian hedgehog (Ihh), which is predominantly expressed

107 epiphyseal growth zone are regulated by the Indian hedgehog (IHH)-parathyroid hormone-related protei

108 largement accompanied by early activation of Indian hedgehog (Ihh).

109 a skeletogenic domain typically occupied by Indian hedgehog (Ihh).

110 mors and is accompanied by overexpression of Indian hedgehog (IHH).

111 erent chondrocyte zones independently of the Indian hedgehog (Ihh)/parathyroid hormone-related peptid

112 hormone-related peptide (PTHrP) receptor and Indian Hedgehog (IHH:), suggesting a new regulatory role

113 hedgehog proteins (sonic hedgehog [SHH] and Indian hedgehog [IHH]), Wnt proteins (Wnt-3a, Wnt-5a, an

114 the previous characterization of the role of Indian Hedgehog in bone morphogenesis, lead us to propos

115 s of the hedgehog pathway (purmorphamine and Indian hedgehog) in MC3T3 osteoblasts led to increased B

116 ng stimulates the expression and activity of Indian hedgehog, increases the expression of beta-cateni

117 Taken together, these data suggest that Indian hedgehog is involved in mediating differentiation

118 tures demonstrates that whereas little or no Indian hedgehog message is present in blastocysts, signi

119 We demonstrate here that the expression of Indian hedgehog mRNA and protein is upregulated dramatic

120 In situ hybridization analysis for Indian hedgehog mRNA expression demonstrates the presenc

121 Both Sonic hedgehog and Indian hedgehog mutant mice show reduced smooth muscle,

122 Indian hedgehog mutants show reduced epithelial stem cel

123 m the perichondrium, which is not typical of Indian hedgehog mutants.

124 hat synchondrosis development is abnormal in Indian hedgehog-null mice.

125 receptor gamma, matrix metalloproteinase 13, Indian hedgehog, osteocalcin, and the proapoptotic gene

126 Expression of Indian hedgehog, Patched-1, collagen X, and MMP-13 was r

127 Although Indian hedgehog, Patched1, parathyroid hormone-related p

128 esterone receptor target genes including the Indian Hedgehog pathway genes are significantly down-reg

129 tical mediator of progesterone action in the Indian Hedgehog pathway, by ChIP analysis.

130 nd 5 proteins that also affect the so-called Indian Hedgehog pathway, whose physical and functional t

131 u hybridization showed reduced expression of Indian hedgehog, PTH/PTH-related peptide receptor (PTH,

132 erentiated mutant chondrocytes activates the Indian hedgehog/PTHrP axis and slows differentiation of

133 In vivo, mutating Indian Hedgehog results in a sex ratio bias against fema

134 hic cell zones, a much wider distribution of Indian hedgehog signaling activity, and ectopic ossifica

135 ze the role of BMPs as possible mediators of Indian hedgehog signaling and use Noggin misexpression t

136 l ossification even though Runx2 expression, Indian hedgehog signaling, and osteoblastogenesis is int

137 eased Runx2 and Ihh expression and increased Indian hedgehog signaling.

138 ndrocyte proliferation, differentiation, and Indian hedgehog signaling.

139 attributable to abnormal sonic hedgehog and Indian hedgehog signalling, respectively.

140 Evidence is presented that Sonic and Indian hedgehog signals act together, through a Foxf1/Bm

141 ntiation (&agr; 1(II) collagen, Fgfr3, Osf2, Indian hedgehog, Sox9), as well as a chondrocyte-specifi

142 ression of dnPKA, but not by coexpression of Indian Hedgehog, suggesting that GiPs act upstream of PK

143 a signaling network with Sonic hedgehog and Indian hedgehog that are essential to anterior-posterior

144 ce suggests that the signaling is induced by Indian hedgehog that is produced by distal (ectoplacenta

145 ption-polymerase chain reaction experiments, Indian hedgehog transcript was first detected in the mou

146 icated by the presence of Sonic hedgehog and Indian hedgehog transcripts, by the pathway- and growth-

147 ng the regulatory landscape of IHH (encoding Indian hedgehog), which cause multiple, highly localized