ライフサイエンスコーパス: Ir gene

1 ups of children for abnormalities in the IGF-IR gene.

2 T antigen to transform MEFs with deleted IGF-IR genes.

3 nate the effects of the class II and class I Ir genes.

4 hat the TCR locus can be an Immune response (Ir) gene.

5 e 1 insulin-like growth factor receptor (IGF-IR) genes.

6 ivo expression of heritable inverted-repeat (IR) genes.

7 reported immune-responsive regulation of IGF-IR genes adds to an emerging body of evidence that suppo

8 Non-MHC Ir genes also contribute to the control of in vitro CTL

9 mice exhibited complete rearrangement of the IR gene and a more than 95% decrease in IR mRNA.

10 s including exon 11 of the Insulin Receptor (IR) gene and exon 5 of the cardiac Troponin T (cTNT) gen

11 e insulin-like growth factor I receptor (IGF-IR) genes) and R508 cells (derived from R- and with 15 x

12 inhibit transcription elongation of the IGF-IR gene, and emphasize the efficacy of triplex-mediated

13 The former two IR genes are expressed in several neurons per sensillum,

14 arly establish that there are effects of the Ir gene associated with both biotypes of TcpA.

15 we have identified a novel mechanism of IGF-IR gene autoregulation in breast cancer cells.

16 Regulation of the IGF-IR gene by IGF-IR protein is mediated at the level of tr

17 ition to the effects of the classic class II Ir gene, class I (D, L) or nonclassical class I (Qa-2) m

18 We report that heritable IR genes confer potent and specific gene inactivation fo

19 ructure of insulin to study the mechanism of Ir gene control in H-2b mice, which respond to beef insu

20 Two ird genes encode components of the signaling pathways th

21 ith endothelial-specific inactivation of the IR gene (EndoIRKO), we find that in response to systemic

22 may provide for intricate regulation of IGF-IR gene expression at the translational level.

23 e a novel mechanism of autoregulation of IGF-IR gene expression by cellular IGF-IR, which is seemingl

24 Thus, whereas IGF-IR stimulated IGF-IR gene expression, IR inhibited IGF-IR promoter activit

25 ossible mechanisms by which p53 may regulate IR gene expression, we show that p53 can repress the IR

26 fibroblast growth factor (bFGF) regulate IGF-IR gene expression.

27 Insulin-like growth factor-I receptor (IGF-IR) gene expression is regulated by various stimuli, inc

28 ase domains from six distinct members of the IR gene family were obtained, and sequence comparisons r

29 e conclude that there are at least two human Ir genes, HLA-DRB1*01 and HLA-DRB1*03, that confer a hig

30 We discovered a non-MHC-linked Ir gene in a T cell receptor (TCR) locus that was requir

31 We also examined the regulation of each IGF-IR gene in fish challenged by bacterial and viral infect

32 re/lox system to specifically inactivate the IR gene in rod photoreceptors.

33 nt was revealed by genetic disruption of the IR gene in the oncogene-expressing pancreatic beta cells

34 prominently express two Ionotropic Receptor (IR) genes, IR76b and IR25a, and we show that both these

35 ys a key role in epitope immunodominance and Ir gene-linked unresponsiveness.

36 Immune response (Ir) gene-linked low responsiveness to protein Ags can be

37 es to H-Y are controlled by immune response (Ir) genes mapping to the MHC.

38 To overcome the effects of the class II Ir gene, multiple TcpA peptides similar to peptides 4, 5

39 Immune response (Ir) genes, originally proposed by Baruj Benacerraf to ex

40 cells with a targeted disruption of the IGF-IR genes, R- cells, are refractory to transformation by

41 ived from well-characterized model Ags under Ir gene regulation has been very limited.

42 ly opposite activities in the context of IGF-IR gene regulation.

43 ole of IGF-IR in the specific context of IGF-IR gene regulation.

44 ental transcriptional regulation of each IGF-IR gene, revealing tight co-expression between the IGF-I

45 We disrupted the insulin receptor (IR) gene specifically in the theca-interstitial (TI) cel

46 n rates are, on average, 3.7 times slower in IR genes than in SC genes.

47 ote for point mutations in exon 2 of the IGF-IR gene that altered the amino acid sequence to Arg108Gl

48 Mutations in the IGF-IR gene that lead to abnormalities in the function or nu

49 demonstrated that Vbeta8.1 functioned as an Ir gene that was indispensable for immune reactivity aga

50 otential for effects of the immune response (Ir) gene that could complicate a peptide-based vaccine.

51 define 14 genes [immune response deficient (ird) genes] that have distinct roles in the immune respo

52 F and IGF-I have differential effects on IGF-IR gene transcription, with the IGF-I response region as

53 structural gene can efficiently suppress IGF-IR gene transcription.

54 Complete sequencing of the IGF-IR gene was performed with DNA from nine children.

55 to H-Y are controlled by MHC class I and II Ir genes, which-respectively, restrict CD8 and CD4 T cel

56 lower synonymous rates consistent with other IR genes, while genes moved from the IR into the SC exhi