ライフサイエンスコーパス: J chain

1 creted IgM, polymeric Ig receptor (pIgR), or J chain.

2 avy) chain and one glycosylation site on the J chain.

3 with recombinant baculovirus containing the J chain.

4 is present as high order polymers containing J chain.

5 (alpha)2 is also present; the dimers contain J chain.

6 pentamers with J chain and hexamers lacking J chain.

7 , polymeric IgA exists mostly as dimers with J chain.

8 glycan sites on the mu chain and one on the J-chain.

9 J chain also is required for poly-Ig receptor-mediated t

10 hat approximately 15% of plasma pIgA carried J chain and displayed selective SC binding capacity eith

11 IgM is assembled into pentamers with J chain and hexamers lacking J chain.

12 sufficient to regulate BSAP targets CD19 and J chain and is necessary but not sufficient to induce XB

13 upregulates the expression of syndecan-1 and J chain and represses that of c-myc.

14 s contain IgM multimers that incorporate the J chain and resist degradation by endoglycosidase H, arg

15 Expression of the Ig J chain and the secreted form of Ig mu, which are both k

16 lphatp is present mainly as hexamers lacking J chain, and mumugammamu-utp forms tetramers and hexamer

17 ged mice, associated with elevated levels of J chain, and secretion of IgM.

18 xtinguished genes include those encoding Ig, J chain, and the transcription factors Oct-2, PU.1, and

19 mine the allergic diarrhea susceptibility of J chain- and polymeric immunoglobulin receptor-deficient

20 stent with this, chicken ovalbumin-immunized J chain- and polymeric immunoglobulin receptor-deficient

21 In mice and chickens, J chain appears to be expressed only in activated B cell

22 munoglobulin gene products such as mu(s) and J chain as well as the loss of the transcriptional regul

23 eposited IgA has been reported as polymeric, J chain associated, and often, hypogalactosylated but wi

24 for their transport into the lumen, pIgR or J chain, cleared C. rodentium normally.

25 t chains in monomeric as well as in joining (J)-chain containing dimeric IgA.

26 reported to be required for binding of human J chain-containing IgA to secretory component.

27 f undergalactosylated, mostly polymeric, and J chain-containing IgA1 and IgG antibodies specific for

28 Following nonmucosal VRP delivery, J chain-containing, polymeric IgA Abs were detected in t

29 lveolar lavage IgA levels were higher in the J chain-deficient animals.

30 Further, we suggest that J chain-deficient IgA is transported into secretions by

31 etions was polymeric while the secretions of J chain-deficient mice contained IgA monomers and other

32 Notably, wild-type, alpha1KI, and even J chain-deficient mice showed increased polymeric serum

33 e have previously reported the generation of J chain-deficient mice.

34 d glandular secretions were not depressed in J chain-deficient mice.

35 was associated with SC in wild-type but not J chain-deficient mice.

36 des the demonstration that binding of IgM is J chain dependent, and that pIg-precipitated receptor ha

37 cantly decrease J chain promoter activity in J chain expressing B cell lines.

38 At the low levels present in J chain-expressing plasma cells, BSAP repression could b

39 sorting and examined each subpopulation for J chain expression by reverse transcriptase-PCR.

40 sed mainly on transformed cells suggest that J chain expression may initiate during earlier stages in

41 J chain expression occurred in most cells irrespective o

42 Conservation with J chains from other species is relatively poor, especial

43 leukin-2 (IL-2)-induced transcription of the J chain gene as a model system.

44 owed that BSAP mediates the silencing of the J chain gene during the early stages of B cell developme

45 rmine whether IL-2 signals are targeted to a J chain gene enhancer as well as to its promoter, the se

46 anscription factor PU.1 positively regulates J chain gene expression by binding to one of the control

47 ts as a stage-specific positive regulator of J chain gene expression in the B cell lineage.

48 Immunoglobulin J chain gene expression is induced by the delivery of a

49 e BCL1 with IL-2 or IL-5 (which up-regulates J chain gene expression) resulted in an increased expres

50 stent with its role as positive regulator of J chain gene expression, B-MEF2 levels were enhanced in

51 The immunoglobulin J chain gene is inducibly transcribed in mature B cells

52 These results suggest that the J chain gene is transcriptionally active during early st

53 ctor, named B-MEF2, positively regulates the J chain gene promoter activity via the second control el

54 versed the positive regulation and inhibited J chain gene transcription.

55 leukin-2 (IL-2)-induced transcription of the J chain gene was used as a model for analyzing cytokine

56 to its promoter, the sequences flanking the J chain gene were first examined for DNase I hypersensit

57 ied, two strong ones, 7.5 kb upstream of the J chain gene, were found to be associated with an enhanc

58 The putative orthologue of mammalian J chain has been identified in the nurse shark by sequen

59 J chain has been proposed to play a role in the mucosal

60 Compared with most other immune molecules, J chain has not been studied extensively, in part becaus

61 rm, suggesting that the reported presence of J chain in invertebrates should be reassessed.

62 In this short review, we discuss J chain in light of the various proposed models of its e

63 in the spiral valve (intestine) suggest that J chain in nurse sharks may not have a role in Ig secret

64 omains are critical for polymer assembly and J chain incorporation.

65 J chain is a small polypeptide covalently attached to po

66 Thus, J chain is not essential for IgA transport by intestinal

67 e only highly conserved segment in all known J chains is a block of residues surrounding an N-linked

68 Joining chain (J chain) is a small polypeptide that regulates multimeri

69 J chain knockout mice were readily protected by heterosu

70 Even the reported phenotype of the J chain-knockout mouse is often misunderstood or underap

71 her, these data suggest that while the VH6-D-J chain may be important in the binding to beta 2GP-1, p

72 The J chain message was not detected in peripheral CD3+ T ce

73 J chain mRNA was also detected during fetal thymocyte de

74 ly reported sequence of functionally spliced J chain mRNA.

75 tly induce Blimp-1, X box-binding protein-1, J chain, or secretory Ig mu transcripts but express IFN-

76 The nucleotide sequence of J chain PCR products from CD34+/CD19- bone marrow progen

77 isotype, despite the documented presence of J chain(-) plasma cells in mammals, specifically in all

78 relationship exists between USF and a second J chain positive-regulating factor, B-MEF2, using co-imm

79 different cell types with heavy, light, and J chains produced by the plasma cells, whereas secretory

80 the USF binding motif significantly decrease J chain promoter activity in J chain expressing B cell l

81 nts USF and B-MEF2 from interacting with the J chain promoter during the antigen-independent stages o

82 sitive-acting factors binding to down-stream J chain promoter elements.

83 mediately upstream from the BSAP site on the J chain promoter.

84 g to one of the control elements (JB) in the J chain promoter.

85 ntrol elements (JA and JB) exists within the J chain promoter.

86 nt of MEF2C blocked B-MEF2 regulation of the J chain promoter.

87 ecognizes a negative regulatory motif in the J chain promoter.

88 erally assumed that all plasma cells express J chain regardless of expressed isotype, despite the doc

89 Formation of pentamers containing J chain requires C(mu)3, C(mu)4, and the mutp.

90 Analysis of J chain sequences in diverse species is in agreement wit

91 carboxyl-terminal portion, and, unlike other J chains, the shark protein is not acidic.

92 ine residues that are conserved in mammalian J chains, three are lacking in the nurse shark, includin

93 (BSAP), a transcription factor that silences J chain transcription, has been identified as a nuclear

94 ir respective promoter elements and activate J chain transcription.

95 r with these data, the relative abundance of J chain transcripts in the spleen and their absence in t

96 In fetal and adult bone marrow, J chain transcripts were detected at all stages of B lin

97 amu-utp forms tetramers and hexamers lacking J chain, whereas IgA-mutp is present as high order polym

98 e observations were made in mice lacking the J chain, which is required for pIgR-dependent transepith

99 been suggested, we studied dependence on the J chain, which is required for polymeric Ig receptor-med