ライフサイエンスコーパス: JAK-STAT pathway

1 restricts WNV infection by activation of the Jak-STAT pathway.

2 y reduced SOCS5 levels, leading to activated JAK-STAT pathway.

3 addition, LOS-induced IFN-beta activated the JAK-STAT pathway.

4 t, blocking type I IFN signaling through the JAK-STAT pathway.

5 e originally identified as inhibitors of the JAK-STAT pathway.

6 ogical pathways, such as IL-6 signalling via JAK-STAT pathway.

7 e originally identified as inhibitors of the JAK-STAT pathway.

8 fied as transcriptional co-regulators of the JAK-STAT pathway.

9 d), which encodes the secreted ligand of the JAK-STAT pathway.

10 protein ISGylation in the regulation of the JAK-STAT pathway.

11 nic in activated HSCs and can signal via the Jak-Stat pathway.

12 was independent of the classical IFN-induced JAK-STAT pathway.

13 used in leukocytes: the ITAM pathway and the Jak-STAT pathway.

14 r of IFN-alpha-induced signaling through the Jak-STAT pathway.

15 nd negatively regulate signaling through the JAK-STAT pathway.

16 OCS) proteins are feedback inhibitors of the JAK/STAT pathway.

17 hat IL-6 induces IDO1 expression through the JAK/STAT pathway.

18 demonstrate a new neuronal function for the JAK/STAT pathway.

19 al signaling, but not the interferon-induced JAK/STAT pathway.

20 of multiple signaling pathways including the JAK/STAT pathway.

21 regulating the innate immune response is the JAK/STAT pathway.

22 nti-STAT3, suggesting the involvement of the JAK/STAT pathway.

23 pinal NMDA receptor and IL-1beta through the JAK/STAT pathway.

24 xpression or number and does not involve the JAK/STAT pathway.

25 o gain-of-function mutants in the Drosophila JAK/STAT pathway.

26 pregulating Claudin-2 expression through the JAK/STAT pathway.

27 he Stat family of signal transducers via the Jak/Stat pathway.

28 or to the furrow, indicating function of the Jak/STAT pathway.

29 ated by the leukemia inhibitory factor (LIF)/JAK/STAT pathway.

30 tosolic phospholipase A(2) (cPLA(2)) and the Jak/STAT pathway.

31 or some vertebrate cytokine receptors of the JAK/STAT pathway.

32 down-regulate immediate early genes via the Jak/Stat pathway.

33 in genes encoding PAX5 and components of the JAK/STAT pathway.

34 its endocytosis, whereas JAK2 initiates the JAK/STAT pathway.

35 ia into MGPCs in the zebrafish retina is the Jak/Stat-pathway.

36 constitutive activation of the Janus kinase (JAK)/STAT pathway.

37 these genes are linked to the Janus kinase (JAK)/STAT pathway.

38 dent mechanisms and the MAPK, NF-kappaB, and JAK-STAT pathways.

39 nes are distinct from those regulated by the JAK-STAT pathways.

40 hogenetic protein (BMP) and the inflammatory JAK-STAT pathways.

41 l transducer and activator of transcription (JAK-STAT) pathway.

42 l transducer and activator of transcription (JAK-STAT) pathway.

43 transducers and activators of transcription (JAK-STAT) pathway.

44 l transducer and activator of transcription (JAK-STAT) pathway.

45 ctive downregulation mechanism in EOS(A) for JAK/STAT pathways.

46 ediated sequential activation of the Src and JAK/STAT pathways.

47 transducers and activators of transcription (JAK/STAT) pathway.

48 ired (upd) encodes a secreted ligand for the JAK/STAT pathway [5-7].

49 te these critical upstream components of the Jak-Stat pathway, achieving inhibition of Stat phosphory

50 The Hh and JAK/STAT pathways act independently and non-redundantly

51 OCS) proteins are negative regulators of the JAK/STAT pathway activated by proinflammatory cytokines,

52 However, the role of JAK-STAT pathway activation in different MPNs, and in pa

53 These results suggested that JAK-STAT pathway activation might contribute to the path

54 Surprisingly, both JAK/STAT pathway activation and ruxolitinib efficacy wer

55 ed (IKK-related) kinase IKBKE expression and JAK/STAT pathway activation compose a cytokine signaling

56 pegIFN-alpha is not the result of prolonged Jak/STAT pathway activation in hepatocytes, but rather i

57 The HEL cell line, in which constitutive JAK/STAT pathway activation is caused by JAK2V617F, was

58 L1 expression in HNC cells in the context of JAK/STAT pathway activation, Th1 inflammation, and HPV s

59 bitor SOCS3 cooperates with IL-6 to maintain JAK/STAT pathway activation, thus contributing to leukem

60 herd's crook shape is dependent on localised JAK/STAT pathway activation.

61 ry of 2000 small molecules for modulators of JAK/STAT pathway activation.

62 lasms by identifying compounds that suppress JAK/STAT pathway activation.

63 ells (ISCs) by stimulating Wingless (Wg) and JAK/STAT pathway activities, whereas cytokine production

64 nstrate that Et/Lat negatively regulates the JAK/STAT pathway activity and can bind to Dome, thus red

65 lass II receptor families and the downstream JAK-STAT pathway along with its key negative regulators.

66 Manipulations of the JAK/STAT pathway also disrupt circadian rhythms.

67 To understand whether the JAK/Stat pathway also regulates cardiogenesis, we perfor

68 The Wnt/beta-catenin and JAK/STAT pathways, altered in 62.5% and 45.5% of cases,

69 The G-CSF receptor (G-CSFR) activates the Jak/STAT pathway, although little is understood about ho

70 ified as strong inhibitors of the Drosophila JAK/STAT pathway, an effect conserved to human cells.

71 o leptin with activation of an intracellular JAK-STAT pathway and a reduction in firing rate.

72 g new evidence supporting a link between the JAK-STAT pathway and cadherin-based cell-cell interactio

73 terferon receptors, interferon activates the JAK-STAT pathway and results in the positive feedback of

74 emonstrate a dichotomy between the classical JAK-STAT pathway and the NF-kappaB signaling pathway.

75 IFN receptor (IFNAR), there is activation of Jak-Stat pathways and also engagement of Mnk kinases.

76 lements both the transcriptional activity of Jak-STAT pathways and controls initiation of mRNA transl

77 that is down-regulated by inhibitors of the JAK/STAT pathway and enhanced by inhibitors of the Src k

78 he polycystin-1/2 complex is to regulate the JAK/STAT pathway and explain how mutations of either gen

79 ting form of SOCS3 (CP-SOCS3) to inhibit the JAK/STAT pathway and prevent cytokine-mediated lethal in

80 (Ship-1, CD72) as well as inhibitors of the Jak/Stat pathway and signaling by means of Toll-like rec

81 Although the Jak/Stat pathway and specifically Stat5 transcription fa

82 1 gene may impair negative regulation of the Jak/STAT pathway and therefore result in greater respons

83 of lens cell proliferation by inhibitors of JAK/STAT pathways and by the aberrant proliferation of l

84 These tumors have activated JAK/STAT pathways and expression of interferon-stimulate

85 red independently of the IL-15/IL-2Rbeta and Jak/STAT pathways and instead required IL-15Ralpha signa

86 fects of IL-21R arose from signaling through JAK/STAT pathways and upregulation of caspase 3.

87 transducers and activators of transcription (Jak/STAT) pathway and cytosolic phospholipase A(2) (cPLA

88 l transducer and activator of transcription (JAK/STAT) pathway and enhanced the expression of IFN reg

89 transducers and activators of transcription (JAK/STAT) pathways and whether they induce expression of

90 e effect of PDGF-BB on the activation of the Jak STAT pathway, and this event was correlated with inh

91 ype I, II, and III IFNs, signals through the JAK-STAT pathway, and plays central roles in host defens

92 eins are negative-feedback regulators of the JAK/STAT pathway, and SOCS3 contributes to host immunity

93 ading to apoptotic cell death, NF-kappaB and JAK/STAT pathways, and inflammasome-assembly mediating i

94 iviral responses, components of the Toll and JAK/STAT pathways, and serine protease inhibitors in bot

95 The JAK-STAT pathway appears to be activated in all myelopro

96 contrast, the antiviral contribution of the JAK-STAT pathway appears to be virus specific.

97 It is known that the BMP and JAK-STAT pathways are necessary for the maintenance of G

98 Cell-cycle and JAK-STAT pathways are significantly altered in lung canc

99 Abnormalities of the JAK/STAT pathway are associated with cancer.

100 d, but mutations affecting the NF-kappaB and JAK/STAT pathways are frequent.

101 ted over the past decade have shown that the JAK/STAT pathways are involved in GH signaling to the nu

102 We also found that TGFbeta and Jak/Stat pathways are necessary but not sufficient for t

103 e, as potent Jak2 inhibitors to modulate the Jak/STAT pathway, are described.

104 nvasiveness, and migration and implicate the JAK/STAT pathway as a critical mediator of leptin action

105 is suggests the feasibility of targeting the JAK/STAT pathway as a neuroprotective therapy for neurod

106 els of MS, suggesting the feasibility of the JAK/STAT pathway as a target for neuroinflammatory disea

107 entified components of the TGFbeta (Dpp) and JAK/STAT pathways as being required for Tor(GOF) signali

108 fferentiation through convergence on the LIF/JAK-STAT pathway at the level of STAT3.

109 r type I IFN signaling by downregulating the JAK-STAT pathway at the level of the IFN receptor.

110 eral small-molecule inhibitors targeting the JAK/STAT pathway blocked proliferation elicited by IL-2

111 on of genes involved in RNAi, Toll, Imd, and JAK-STAT pathways, but the majority of differentially ex

112 , SOCS proteins are not only induced via the JAK/STAT pathway, but are also transcribed on triggering

113 eins introduce additional diversity into the JAK-STAT pathway by adjusting the output of activated ST

114 intron, and is induced by the IFN-triggered Jak-STAT pathway by binding of the IFN-stimulated gene f

115 PN significantly decreases the JAK-STAT pathway by reducing levels of phosphorylated ST

116 ese changes result from a disturbance of the JAK/STAT pathway by hypoxia, and (3) identify JAK/STAT s

117 Here, we pursue STRA13 involvement in the JAK/STAT pathway by studying its role in STAT1 expressio

118 Activation of the JAK/STAT pathway by the IL-6 family of cytokines is the

119 rs complements the function of IFN-activated JAK-STAT pathways, by allowing mRNA translation of IFN-s

120 o These results indicate that inhibiting the JAK/STAT pathway can prevent neuroinflammation and neuro

121 whether DOME, the Drosophila receptor of the JAK/STAT pathway, can dimerise and if the dimerisation i

122 ization was accompanied by activation of the JAK/STAT pathway, commonly seen in megakaryocytic malign

123 bit enhanced and prolonged activation of the JAK/STAT pathway compared with macrophages from SOCS3(fl

124 oss causes phenotypes similar to the loss of JAK/STAT pathway components.

125 ese included components of the Toll, Imd and JAK/STAT pathways, consistent with interactions between

126 e controlled by the evolutionarily conserved JAK-STAT pathway contributes to the antiviral host defen

127 how cross-coupling between the CREB/CRTC and JAK/STAT pathways contributes to BM homeostasis.

128 ervations suggest that autoregulation of the Jak-STAT pathway controls the onset of astrogliogenesis.

129 The JAK/STAT pathway controls many developmental events, inc

130 of autocrine interleukin-10, which activates JAK/STAT pathway-dependent tyrosine phosphorylation of S

131 transducers and activators of transcription (JAK/STAT) pathway determines cell fates by regulating ge

132 first documentation that suppression of the JAK/STAT pathway disrupts the circuitry of neuroinflamma

133 NTF receptor) and AG490 (an inhibitor of the JAK/STAT pathway downstream of CNTF signalling).

134 s, suggesting that PIV-3 interferes with the JAK/STAT pathway downstream of the IFN-lambdaR1/IL-10R2

135 Constitutive activation of the JAK/STAT pathway downstream of Unpaired partially rescue

136 is the first to characterize a role for the JAK/Stat pathway during cardiogenesis and identifies an

137 ss, advances continue to be made in defining Jak-Stat pathway effects on different cellular processes

138 The JAK-STAT pathway exerts its anti-Anaplasma activity pres

139 The JAK-STAT pathway exerts its anti-dengue activity presuma

140 The JAK/STAT pathway exerts pleiotropic effects on a wide ra

141 We have investigated the requirement of the JAK/STAT pathway for signaling by wild-type and mutant f

142 landscape of SS and a role for inhibition of JAK/STAT pathways for the treatment of SS.

143 function of CySCs is solely attributable to JAK/STAT pathway function.

144 ly understood, although the cytokine-induced Jak-STAT pathway has been postulated to regulate astrogl

145 Although the affect of SOCS proteins on the Jak-STAT pathway has been well characterized, their role

146 Inhibition of the JAK/STAT pathway has clinical efficacy in multiple precl

147 Dysregulation of the JAK/STAT pathway has pathological implications in autoim

148 The JAK/STAT pathway has pleiotropic roles in animal develop

149 2V617F mutation, additional mutations in the JAK-STAT pathway have been discovered including a series

150 s that control their actions, members of the Jak-Stat pathway, ideal targets for pharmacological inte

151 rmine the role of the Janus tyrosine kinase (JAK)-STAT pathway in NF-kappaB activation by IFN, we exa

152 cretion of one or more factors activates the JAK-STAT pathway in an auto/paracrine manner.

153 s BCR-ABL, underscores the importance of the JAK-STAT pathway in both normal cellular development and

154 demonstrating the central importance of the JAK-STAT pathway in MPN pathogenesis.

155 In contrast, IL-21 failed to activate the JAK-STAT pathway in nonreconstituted JT cells.

156 udies identified additional mutations in the JAK-STAT pathway in some patients with JAK2V617F(-) MPD,

157 results implicate the inflammatory IFN-alpha/Jak-Stat pathway in the developmental maturation of embr

158 li cell co-cultures, and direct study of the JAK-STAT pathway in these models and in L cells transfec

159 e decreases and demonstrated the role of the JAK-STAT pathway in vivo during PN.

160 We summarize how the Jak-Stat pathways in these cells are negatively regulate

161 Although the roles of Jak-Stat pathways in type I and II interferon (IFN)-depe

162 l Transducer and Activator of Transcription (JAK-STAT) pathway in two adjacent types of stem cells: g

163 that GPR45 regulates POMC expression via the JAK/STAT pathway in a cell-autonomous manner.

164 okine signaling (SOCS) which can inhibit the JAK/STAT pathway in a classical negative-feedback manner

165 Given the importance of the JAK/STAT pathway in activating microglia and inducing cy

166 mechanisms of constitutive activation of the JAK/STAT pathway in cancer pathogenesis.

167 ndered whether BCR stimulation activates the JAK/STAT pathway in CLL cells.

168 a new valuable tool to study the role of the JAK/STAT pathway in disease development.

169 by deregulation of several components of the Jak/STAT pathway in early carcinogenesis, then upregulat

170 re we demonstrate aberrant activation of the JAK/STAT pathway in ETP-ALL blasts relative to non-ETP T

171 potential therapeutic value of targeting the JAK/STAT pathway in lymphoma in the clinical setting.

172 in a male-specific manner, and activates the JAK/STAT pathway in male germ cells at the time of gonad

173 In vitro, alpha-SYN exposure activated the JAK/STAT pathway in microglia and macrophages, and treat

174 the therapeutic potential of inhibiting the JAK/STAT pathway in models of EAE.

175 y is the first to demonstrate a role for the JAK/STAT pathway in regional specification by acting ant

176 fied totA as a gene that is regulated by the JAK/STAT pathway in response to septic injury.

177 The findings implicate the JAK/STAT pathway in the pathogenesis of APL and illustra

178 ast 5 wpi, revealing active signaling of the Jak/STAT pathway in these cells.

179 nstrate the ubiquitous activation of Ras and Jak/Stat pathways in HCC and suggest the potential use o

180 Suppression of Ras and Jak/Stat pathways in HCC cell lines was evaluated by via

181 l Transducer and Activator of Transcription (Jak/STAT) pathway in the stem cells.

182 l transducer and activator of transcription (JAK/STAT) pathways in MMP induction by B. burgdorferi.

183 transducers and activators of transcription (JAK/STAT) pathway, in adult retinal ganglion cells (RGCs

184 Such indirect activation of the Jak-Stat pathway induced by the interaction between an R

185 MTC cells, specifically required for the LIF/JAK/STAT pathway-induced growth inhibition in these cell

186 Our findings document that inhibition of the JAK/STAT pathway influences both innate and adaptive imm

187 Our findings suggest that JAK-STAT pathway inhibition may represent a therapeutic

188 Methotrexate might bring the benefits of JAK/STAT pathway inhibition at a lower cost.

189 However, unlike common JAK-STAT pathway inhibitors, BRD0476 inhibits JAK-STAT s

190 In addition, mutations in the Jak/STAT pathway interact genetically with the Notch pat

191 ding the crucial components of the gliogenic JAK-STAT pathway is accelerated in Dnmt1-/- NPCs.

192 Notably, the JAK-STAT pathway is altered by KLF4, with increased phos

193 The JAK-STAT pathway is critical in mediating signaling of a

194 Although the discovery of mutations in the JAK-STAT pathway is important from a pathogenetic and di

195 ssential to cytokine receptor signaling, the JAK-STAT pathway is one of the best understood signal tr

196 Our data suggest that the JAK-STAT pathway is part of the A. aegypti mosquito's an

197 The JAK-STAT pathway is proposed to be regulated through dir

198 Previous genetic studies showed that the JAK-STAT pathway is required for full activation of the

199 The mitogenic JAK-STAT pathway is strongly and specifically activated

200 Cytokine signaling by the Jak-STAT pathway is subject to complex negative regulati

201 es in salivary glands and hemolymph when the JAK-STAT pathway is suppressed by RNA interference.

202 to dengue virus infection increases when the JAK-STAT pathway is suppressed through RNAi depletion of

203 The JAK-STAT pathway is the major mediator of these biologic

204 tors discovered in cytokine signaling of the JAK-STAT pathway is the suppressor of cytokine signaling

205 The JAK/STAT pathway is a highly conserved regulatory module

206 The JAK/STAT pathway is activated by cytokines that induce r

207 rosophila, and zebrafish have shown that the JAK/STAT pathway is also required in an unusually broad

208 The JAK/STAT pathway is altered in T-cell large granular lym

209 The JAK/STAT pathway is critical for development, regulation

210 vation in a gradient of the highly conserved JAK/STAT pathway is essential for orienting the cell rea

211 The JAK/STAT pathway is important for several functions in h

212 established roles in cytokine signaling, the JAK/STAT pathway is involved in synaptic plasticity in t

213 Furthermore, the JAK/STAT pathway is necessary for male-specific germ cel

214 uction of IFN-beta mRNA or activation of the Jak/STAT pathway is not seen.

215 We conclude that activation of the Jak/Stat pathway is the primary mechanism for IFN-gamma-

216 The JAK/STAT pathway is used by numerous cytokines for signa

217 nversely, cytokine signaling through cognate Jak/STAT pathways is reportedly unaffected or even stimu

218 l transducer and activator of transcription (JAK/STAT) pathway is one of the key signaling cascades i

219 SOCS2, a feedback inhibitor of JAK-STAT pathways, is expressed in most primitive HSC an

220 ncomitant genomic alterations activating the JAK-STAT pathway (JAK1, JAK2, IL7R) identified in 63 pat

221 e showed an increased activation of the IL-6-JAK-STAT pathway leading to a systemic lupus erythematos

222 utocrine and paracrine signaling through the JAK-STAT pathway, leading to the transcriptional inducti

223 transducers and activators of transcription (JAK/STAT) pathway, leading to elevated transcription of

224 eling process, demethylation of genes in the JAK-STAT pathway leads to an enhanced activation of STAT

225 This initial description of the JAK-STAT pathway led quickly to additional discoveries t

226 leads to ectopic production of the mitogenic JAK-STAT pathway ligand Unpaired, which is secreted from

227 division by repressing the expression of the JAK-STAT pathway ligand Upd3 in differentiating enterobl

228 ions for FSCs depends on gradients of Hh and JAK-STAT pathway ligands, which emanate from opposite, d

229 ed stem cell proliferation and expression of Jak/Stat pathway ligands.

230 l transducer and activator of transcription (Jak-STAT) pathway maintains stem cells; germline stem ce

231 Interestingly, the JAK/STAT pathway maintains the niche required for germli

232 suggest that this direct interference in the JAK-STAT pathway may play a role in arsenic-associated p

233 ur findings provide direct evidence that the JAK/STAT pathway mediates a key signal from the somatic

234 Although the JAK/STAT pathway mediates lymphokine-induced transcripti

235 se activity and increased phosphorylation of JAK-STAT pathway members.

236 efficacy were independent of the presence of JAK/STAT pathway mutations, raising the possibility that

237 The action of neither the Jak-STAT pathway nor the NF-kappaB pathway was required

238 so revealed that arsenic inactivation of the JAK-STAT pathway occurred independent of arsenic activat

239 vestigate the possible role of TNF-alpha and JAK/STAT pathway on de novo lipogenesis and PCSK9 expres

240 ited by blockade of the NF-kappaB, PI3K, and JAK-STAT pathways or the presence of neutralizing anti-I

241 om treatment with specific inhibitors of the Jaks/Stat pathway or the Brc-Abl kinase.

242 l transducer and activator of transcription (JAK-STAT) pathways, or indirectly via changes in the tum

243 g but when overactivated can also induce the JAK/STAT pathway, originally identified as the signaling

244 the virus when the negative regulator of the JAK-STAT pathway, PIAS, is silenced.

245 gamma receptor-dependent cytokines and their JAK/STAT pathways play pivotal roles in T cell immunity.

246 These data suggest that the Jak/STAT pathway plays a prominent role in PSC prolifera

247 f complementary approaches, we show that the JAK/STAT pathway plays an essential role in the inductio

248 However, we show that the JAK/STAT pathway plays an important role in patterning t

249 in DROSOPHILA: Our results indicate that the JAK/STAT pathway plays little or no role in signaling by

250 ytokine signaling via a restricted number of Jak-Stat pathways positively and negatively regulates al

251 Importantly, inhibition of the JAK/STAT pathway prevented the degeneration of dopaminer

252 ics of GSCs, while ectopic activation of the Jak-STAT pathway prevents differentiation.

253 receptor (IL-7R), via its activation of the JAK-STAT pathway, promotes gene programs that change dyn

254 l transducer and activator of transcription (JAK/STAT) pathway provides a sex-specific signal from th

255 In addition, inhibition of the JAK/STAT pathway reduces IVNV.

256 identified, and partially characterized, two JAK-STAT pathway-regulated and infection-responsive deng

257 Furthermore, we show that the JAK/STAT pathway regulates a small enhancer in the wg 3'

258 These results demonstrate that the JAK/STAT pathway regulates cellular epigenetic status an

259 E loss-of-function alleles, we show that the JAK/Stat pathway regulates tin expression prior to heart

260 We characterize the Drosophila JAK/STAT pathway regulator SOCS36E and show that it func

261 mphoma (DLBCL), we observed higher levels of JAK/STAT pathway-related serum cytokines (ie, IL-6, IL-1

262 highlights some of the most active areas of Jak-Stat pathway research.

263 or STAT transcription factors of the Imd and Jak-STAT pathways, respectively.

264 , IRF3, Tbk1, extracellular IFNbeta, and the Jak-Stat pathway resulted in reduced activity of GCV and

265 e culture sections through activation of the JAK/STAT pathway, resulting in increased activity of iNO

266 , whereby IFN-alpha/beta signals through the Jak/STAT pathway, resulting in the establishment of the

267 Pharmacologic inhibition of ERK and JAK/STAT pathways reversed miR-194-driven phenotypes.

268 rved molecular mechanism that directly links JAK/STAT pathway signalling to intercellular adhesion an

269 vo, to identify ligands and mediators of the JAK-STAT pathway that accompany glial activation.

270 f IFN-alpha therapy are likely to act at the JAK-STAT pathway that controls transcription of downstre

271 aling 3 (Socs3), a feedback inhibitor of the Jak-Stat pathway that prevents Stat3 activation.

272 ne signaling-3 (SOCS3), 2 key factors of the JAK/STAT pathway that induce and inhibit STAT3 activatio

273 K)1/2, but not induction of apoptosis or the JAK/STAT pathway that is necessary for the antiviral eff

274 f immune responses, and dysregulation of the JAK/STAT pathway, that is, hyperactivation, has patholog

275 presses the activation of the astrogliogenic Jak-Stat pathway, the underlying molecular mechanism was

276 hat expression of polycystin-1 activates the JAK-STAT pathway, thereby upregulating p21(waf1) and ind

277 or mosquito vector for dengue virus uses the JAK-STAT pathway to control virus infection.

278 the production of Upd2, which activated the JAK-STAT pathway to promote ISC proliferation.

279 the expression of various components of the Jak-STAT pathway to strengthen STAT signaling and trigge

280 ontribution of the small interfering RNA and JAK-STAT pathways to the control of viral infections, we

281 find that the microRNA miR-279 regulates the JAK/STAT pathway to drive rest:activity rhythms in Droso

282 Both types of IFN signal through the Jak/STAT pathway to elicit antiviral activity, yet IFN-g

283 IL-12, IL-23, IFN-gamma, and GM-CSF, use the JAK/STAT pathway to induce biological responses.

284 the anterior polar cells signal through the JAK/STAT pathway to induce the formation of the stalk be

285 l transducer and activator of transcription (JAK-STAT) pathway transmits information received from ex

286 ediated through the diffusible ligand of the Jak/STAT pathway, Unpaired (Upd), which was recently ide

287 the therapeutic potential of inhibiting the JAK/STAT pathway using the JAK1/2 inhibitor, AZD1480.

288 This process appears to be mediated by the JAK/STAT pathway via the leptin receptor long form and t

289 concentrations of pegIFN-alpha in serum, the Jak/STAT pathway was activated in hepatocytes only on th

290 Activation of Ras and Jak/Stat pathways was enhanced in all HCCs when compared

291 l transducer and activator of transcription (Jak/Stat) pathway was discovered 20 years ago as a media

292 aling 3 (SOCS3), a protein suppressor of the JAK-STAT pathway, was constitutively highly expressed an

293 acts on interferon-stimulated genes via the JAK-STAT pathway, which has been implicated in developme

294 es 24p3 expression through activation of the JAK/STAT pathway, which culminates in binding of Stat5 t

295 entricles of adult rats did not activate the JAK/STAT pathway, which is potentially due to increased

296 ale soma signals to the germline through the JAK/STAT pathway, while the nature of the signal from th

297 Blockade of the JAK-STAT pathway with a small molecule has been shown to

298 l transducer and activator of transcription (JAK/STAT) pathway with activation of STAT1 and STAT2.

299 IL-7 activated the JAK/STAT pathway, with increased phosphorylation of JAK-

300 pothesis that using these drugs to block the JAK-STAT pathway would prevent autoimmune diabetes.