ライフサイエンスコーパス: Jakob

1 In this issue of Blood, Jakob et al report that hematopoietic progenitor kinase

2 actors in response to the foreign Creutzfeld-Jakob disease agent, it is likely that innate immunity u

3 on of the attenuated SY strain of Creutzfeld-Jakob disease in mice could delay clinical signs and wid

4 studying transmission of variant Creutzfeld-Jakob disease by blood products in humans.

5 The emergence of variant Creutzfeld-Jakob disease, following on from the bovine spongiform e

6 to humans in the form of variant Creutzfeldt Jakob disease, have raised concerns about the zoonotic p

7 Creutzfeldt-Jakob disease (CJD) and autoimmune encephalitis with ant

8 Creutzfeldt-Jakob disease (CJD) has been accidentally transmitted by

9 Creutzfeldt-Jakob disease (CJD) in humans has been shown to be trans

10 Creutzfeldt-Jakob disease (CJD) is a neurodegenerative disorder caus

11 Creutzfeldt-Jakob disease (CJD) is a rare but invariably fatal neuro

12 Creutzfeldt-Jakob disease (CJD) is a rare progressive neurodegenerat

13 Creutzfeldt-Jakob disease (CJD), the most common human prion disease

14 were Alzheimer's disease (18%), Creutzfeldt-Jakob disease (12%) and inflammatory disorders (9%).

15 al sclerosis (FTD/ALS, n = 252), Creutzfeldt-Jakob disease (CJD, n = 239), Parkinson's disease (PD, n

16 neity, including patients with a Creutzfeldt-Jakob disease (CJD) phenotype.

17 disease with this feature after Creutzfeldt-Jakob disease, originally reported in 1920.

18 hallenge with the human kuru and Creutzfeldt-Jakob agents as well as with scrapie agent isolated from

19 ms of Alzheimer disease (AD) and Creutzfeldt-Jakob disease (CJD) are clinically distinguishable, atyp

20 (BSE) and scrapie in animals and Creutzfeldt-Jakob disease (CJD) in humans.

21 e spongiform encephalopathy, and Creutzfeldt-Jakob disease in humans.

22 eases, and arguably, scrapie and Creutzfeldt-Jakob disease prions represent the best therapeutic targ

23 as Alzheimer's, Parkinson's, and Creutzfeldt-Jakob disease share a common pathogenetic mechanism invo

24 ne spongiform encephalopathy and Creutzfeldt-Jakob disease, are usually characterized by the accumula

25 hrogenic diabetes insipidus, and Creutzfeldt-Jakob disease.

26 isease, motor neuron disease and Creutzfeldt-Jakob disease.

27 ne spongiform encephalopathy and Creutzfeldt-Jakob disease.

28 tions, including Alzheimer's and Creutzfeldt-Jakob diseases and type II diabetes.

29 itions including Alzheimer's and Creutzfeldt-Jakob diseases represent, on this basis, pathological ca

30 ng Alzheimer's, Parkinson's, and Creutzfeldt-Jakob diseases.

31 s, ataxia, dystonia, chorea, and Creutzfeldt-Jakob with and Jewish.

32 ementias such as Alzheimer's and Creutzfeldt-Jakob's disease and other central nervous system disease

33 thy (BSE; "mad cow" disease) and Creutzfeldt-Jakob's disease, appears to be a beta-sheet-rich amyloid

34 zheimer's (AD), Parkinson's, and Creutzfeldt-Jakob, and in animal diseases such as BSE.

35 Prion diseases such as Creutzfeldt-Jakob disease (CJD) are fatal, neuro-degenerative disord

36 Prion diseases such as Creutzfeldt-Jakob disease (CJD) are incurable and rapidly fatal neur

37 urodegenerative diseases such as Creutzfeldt-Jakob disease (CJD).

38 ions were initially diagnosed as Creutzfeldt-Jakob disease (CJD).

39 o various human diseases such as Creutzfeldt-Jakob disease and Gerstmann-Straussler-Scheinker syndrom

40 enesis of prion diseases such as Creutzfeldt-Jakob disease and scrapie.

41 Prion diseases such as Creutzfeldt-Jakob disease are possibly caused by the conversion of a

42 Human prion diseases such as Creutzfeldt-Jakob disease are transmissible brain proteinopathies, c

43 d both in prion diseases such as Creutzfeldt-Jakob disease, where its monomeric cellular isoform (PrP

44 ction of mice with an attenuated Creutzfeldt-Jakob disease agent (SY-CJD) interferes with superinfect

45 ents, dementia with Lewy bodies, Creutzfeldt-Jakob disease, vascular or unclassified dementia.

46 of the infectious agents causing Creutzfeldt-Jakob disease (CJD), scrapie, and bovine spongiform ence

47 stant to both kuru and classical Creutzfeldt-Jakob disease (CJD) prions (which are closely similar) b

48 o date, 1,147 cases of confirmed Creutzfeldt-Jakob disease deaths in the United Kingdom since 1990 ha

49 wo hundred individuals developed Creutzfeldt-Jakob disease (CJD) worldwide as a result of treatment,

50 cedures were applied to diagnose Creutzfeldt-Jakob disease (CJD).

51 hings was accurate in diagnosing Creutzfeldt-Jakob disease and indicated substantial prion seeding ac

52 invariably lethal prion disease Creutzfeldt-Jakob disease (CJD) and nonprion rapidly progressive dem

53 deer and elk, and Kuru disease, Creutzfeldt-Jakob disease (CJD) and variant CJD in humans.

54 ated with one of these diseases [Creutzfeldt-Jakob disease (CJD)] that was exactly analogous to a pre

55 n causes the rare human disorder Creutzfeldt-Jakob disease (CJD).

56 Familial Creutzfeldt-Jakob disease and cerebrotendinous xanthomatosis tend to

57 al familial insomnia or familial Creutzfeldt-Jakob disease, depending upon the presence of Met or Val

58 variant, sporadic, and familial Creutzfeldt-Jakob disease, in the presence of blood components.

59 pinal fluid (CSF) biomarkers for Creutzfeldt-Jakob disease (CJD) are established and partly included

60 e shorter incubation periods for Creutzfeldt-Jakob disease (CJD) prions than mice expressing full-len

61 detects the specific marker for Creutzfeldt-Jakob disease, the prion protein (PrP(CJD)), by means of

62 rains of patients suffering from Creutzfeldt-Jakob disease and related conditions, such as Gerstmann-

63 olymorphism protects people from Creutzfeldt-Jakob disease, the Sup35p polymorphisms were selected to

64 poral lobar degeneration (FTLD), Creutzfeldt-Jakob disease (CJD), Alzheimer's disease (AD), Parkinson

65 ic GT cells infected with the FU Creutzfeldt-Jakob disease agent, but not parallel mock controls, dis

66 Human Creutzfeldt-Jakob disease (CJD) and similar neurodegenerative diseas

67 rently less susceptible to human Creutzfeldt-Jakob disease prions.

68 , including sheep scrapie, human Creutzfeldt-Jakob disease, and cervid chronic wasting disease.

69 dotoxemia, sepsis, or iatrogenic Creutzfeldt-Jakob disease (to date, 1,147 cases of confirmed Creutzf

70 ease and in a case of iatrogenic Creutzfeldt-Jakob disease associated with growth hormone therapy.

71 Patients with iatrogenic Creutzfeldt-Jakob disease due to administration of cadaver-sourced g

72 ts who have developed iatrogenic Creutzfeldt-Jakob disease in the UK since 2003.

73 hort of patients with iatrogenic Creutzfeldt-Jakob disease in the UK suggests that there was a point

74 incubation period of iatrogenic Creutzfeldt-Jakob disease is significantly different between all thr

75 ts who have developed iatrogenic Creutzfeldt-Jakob disease, 56 have been genotyped.

76 Importance: Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disorde

77 in (PrP) plays a central role in Creutzfeldt-Jakob Disease (CJD) and other transmissible spongiform e

78 xtracts demonstrated that PrP in Creutzfeldt-Jakob disease (CJD) brains is cleaved by a cellular prot

79 rts have claimed anticipation in Creutzfeldt-Jakob disease (CJD) caused by the c.598G > A mutation in

80 Previous studies in Creutzfeldt-Jakob disease (CJD) have shown that myeloid cells in the

81 (BSE) in cattle and PrP(CJD) in Creutzfeldt-Jakob disease (CJD) in humans.

82 athological diversity evident in Creutzfeldt-Jakob disease and whether different prion protein types

83 rions, such as those involved in Creutzfeldt-Jakob disease.

84 enerative diseases which include Creutzfeldt-Jakob disease (CJD) in humans and bovine spongiform ence

85 nerative conditions that include Creutzfeldt-Jakob disease (CJD) in humans and bovine spongiform ence

86 enerative disorders that include Creutzfeldt-Jakob disease in humans, scrapie in sheep and goats, and

87 ommon in the T/BG group included Creutzfeldt-Jakob disease, arbovirus, and Mycobacterium tuberculosis

88 degenerative disorders including Creutzfeldt-Jakob disease (CJD) in humans, is the conversion of the

89 neurological diseases including Creutzfeldt-Jakob disease (CJD), but the aggregation mechanisms rema

90 ion disease in humans, including Creutzfeldt-Jakob disease (CJD).

91 ans and other animals, including Creutzfeldt-Jakob disease and bovine spongiform encephalopathy.

92 egenerative conditions including Creutzfeldt-Jakob disease in humans and scrapie and bovine spongifor

93 degenerative diseases, including Creutzfeldt-Jakob disease in humans, scrapie in sheep and bovine spo

94 odegenerative diseases including Creutzfeldt-Jakob disease, motor neuron disease and Alzheimer's dise

95 sease, and 2 of 2 with inherited Creutzfeldt-Jakob disease) but were negative in 43 of 43 patients wi

96 st common human prion disease is Creutzfeldt-Jakob disease (CJD).

97 ive disorders that include Kuru, Creutzfeldt-Jakob disease, Gerstmann-Straussler-Scheinker syndrome (

98 ort from the Australian National Creutzfeldt-Jakob Disease Registry concerns a 61-year-old British-bo

99 atients referred to the National Creutzfeldt-Jakob Disease Research & Surveillance Unit during the pe

100 Heightened awareness of Creutzfeldt-Jakob disease (CJD) among physicians and the lay public

101 lthough surgical transmission of Creutzfeldt-Jakob disease (CJD) has been demonstrated, these iatroge

102 nd accurate in vivo diagnosis of Creutzfeldt-Jakob disease (CJD) is necessary for quickly distinguish

103 The sporadic form of Creutzfeldt-Jakob disease (sCJD) has been classified on the basis of

104 ince developed a variant form of Creutzfeldt-Jakob disease (vCJD), also mostly in the United Kingdom,

105 prions, the causative agents of Creutzfeldt-Jakob disease and other human prion diseases, requires p

106 candidates for the treatment of Creutzfeldt-Jakob disease and other prion diseases.

107 ective in slowing propagation of Creutzfeldt-Jakob disease prions in transgenic mice.

108 s with the E200K genetic form of Creutzfeldt-Jakob Disease, 20 healthy carriers of this mutation that

109 involved in the pathogenesis of Creutzfeldt-Jakob Disease, and its anatomical connections are suffic

110 detected early in the course of Creutzfeldt-Jakob Disease, and years before symptomatic onset in mut

111 appearance of a variant form of Creutzfeldt-Jakob disease, which has been linked to consumption of p

112 ecognized phenotypic spectrum of Creutzfeldt-Jakob disease.

113 90 to 100) for the detection of Creutzfeldt-Jakob disease.

114 owed early diagnosis of probable Creutzfeldt-Jakob disease before the characteristic clinical picture

115 luding Alzheimer's, Parkinson's, Creutzfeldt-Jakob, and Lou Gehrig's diseases, as well as the tauopat

116 uch as Alzheimer's, Parkinson's, Creutzfeldt-Jakob, and others display remarkable phenotypic heteroge

117 gates extracted from 60 sporadic Creutzfeldt-Jakob disease (CJD) and 6 variant CJD brains.

118 brains of patients with sporadic Creutzfeldt-Jakob disease (CJD) bind to very low-density (VLDL) and

119 from a large number of sporadic Creutzfeldt-Jakob disease (CJD) cases.

120 Sporadic Creutzfeldt-Jakob disease (CJD) is the most prevalent manifestation

121 those in subjects with sporadic Creutzfeldt-Jakob disease (CJD), as well as CJD-affected subjects wh

122 n human prion disorder, sporadic Creutzfeldt-Jakob disease (CJD), in which prions are formed spontane

123 n a pregnant woman with sporadic Creutzfeldt-Jakob disease (CJD).

124 d as either familial or sporadic Creutzfeldt-Jakob disease (CJD); there was no case of variant CJD.

125 enotypes, identified as sporadic Creutzfeldt-Jakob disease (M/M2 sCJD) and sporadic fatal insomnia (s

126 are these with cases of sporadic Creutzfeldt-Jakob disease (n = 170) in the United Kingdom over the p

127 onfer susceptibility to sporadic Creutzfeldt-Jakob disease (rs1029273), all patients were homozygous

128 were suspected to have sporadic Creutzfeldt-Jakob disease (sCJD) and yet were found to have an alter

129 l fluid (CSF) tests for sporadic Creutzfeldt-Jakob disease (sCJD) are based on the detection of surro

130 (sFI) and a subtype of sporadic Creutzfeldt-Jakob disease (sCJD) identified as sCJDMM2, which share

131 A case of sporadic Creutzfeldt-Jakob disease (sCJD) is described in a young Dutch prote

132 ntiated 94% of cases of sporadic Creutzfeldt-Jakob disease (sCJD) MM1 from the sCJD MM2 phenotype, an

133 firmed the diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) MM1 subtype.

134 Sc237 prions and human sporadic Creutzfeldt-Jakob disease (sCJD) prions.

135 st common subtype being sporadic Creutzfeldt-Jakob disease (sCJD), a rapidly progressive dementia.

136 st common subtype being sporadic Creutzfeldt-Jakob disease (sCJD), a rapidly progressive dementia.

137 have been identified in sporadic Creutzfeldt-Jakob disease (sCJD), based on the methionine/valine pol

138 o patients, who died of sporadic Creutzfeldt-Jakob disease (sCJD), contained either sCJD(MM1) or sCJD

139 Human sporadic Creutzfeldt-Jakob disease (sCJD), endemic sheep scrapie, and epidemi

140 ies present in control, sporadic Creutzfeldt-Jakob disease (sCJD), or variant CJD (vCJD) brains.

141 issue of a patient with sporadic Creutzfeldt-Jakob Disease (sCJD), the most common form of human prio

142 ces in individuals with sporadic Creutzfeldt-Jakob disease (sCJD).

143 ions from patients with sporadic Creutzfeldt-Jakob disease (sCJD).

144 ntigens misdiagnosed as sporadic Creutzfeldt-Jakob disease (sCJD).

145 as been also claimed in sporadic Creutzfeldt-Jakob disease (sCJD).

146 levels in some cases of sporadic Creutzfeldt-Jakob disease and conversely, that the form of abnormal

147 alopathies (variant and sporadic Creutzfeldt-Jakob disease and genetic forms of prion disease), patie

148 f the major subtypes of sporadic Creutzfeldt-Jakob disease and in a case of iatrogenic Creutzfeldt-Ja

149 wenty-six patients with sporadic Creutzfeldt-Jakob disease and nine age- and gender-matched healthy c

150 th and patients without sporadic Creutzfeldt-Jakob disease and tested them using RT-QuIC, an ultrasen

151 ived from patients with sporadic Creutzfeldt-Jakob disease are taken up and degraded by immortalized

152 clinically mistaken for sporadic Creutzfeldt-Jakob disease because of a negative family history.

153 tein that characterizes sporadic Creutzfeldt-Jakob disease can be found in certain brain regions of c

154 udy the white matter in sporadic Creutzfeldt-Jakob disease compared to healthy control subjects and t

155 Definite diagnosis of sporadic Creutzfeldt-Jakob disease in living patients remains a challenge.

156 pithelium in diagnosing sporadic Creutzfeldt-Jakob disease in living patients.

157 Sporadic Creutzfeldt-Jakob disease is considered primarily a disease of grey

158 Sporadic Creutzfeldt-Jakob disease is the most common of the human prion dise

159 ely, the data show that sporadic Creutzfeldt-Jakob disease PrP(Sc) is not a single conformational ent

160 Cases diagnosed as sporadic Creutzfeldt-Jakob disease with atypical neuropathology were also rev

161 an idiopathic disorder (sporadic Creutzfeldt-Jakob disease) or can be acquired, as is the case for va

162 (15 of 15 with definite sporadic Creutzfeldt-Jakob disease, 13 of 14 with probable sporadic Creutzfel

163 13 of 14 with probable sporadic Creutzfeldt-Jakob disease, and 2 of 2 with inherited Creutzfeldt-Jak

164 amples from humans with sporadic Creutzfeldt-Jakob disease, as well as in rodents with experimental p

165 In sporadic Creutzfeldt-Jakob disease, disease-associated PrP(Sc) is present not

166 ALS, Alzheimer disease, sporadic Creutzfeldt-Jakob disease, Huntington disease-like syndrome, and oth

167 matter of patients with sporadic Creutzfeldt-Jakob disease, mainly in the left hemisphere, with a str

168 hin the white matter in sporadic Creutzfeldt-Jakob disease, suggesting possible primary involvement o

169 stological diagnosis of sporadic Creutzfeldt-Jakob disease.

170 on human prion disease, sporadic Creutzfeldt-Jakob disease.

171 e encephalopathies from sporadic Creutzfeldt-Jakob disease.

172 diagnostic criteria of sporadic Creutzfeldt-Jakob disease.

173 s that closely resemble sporadic Creutzfeldt-Jakob disease.

174 erited prion disease or sporadic Creutzfeldt-Jakob disease.

175 diagnostic criteria for sporadic Creutzfeldt-Jakob disease.

176 bled those of classical sporadic Creutzfeldt-Jakob disease.

177 een and within cases of sporadic Creutzfeldt-Jakob disease.

178 0% for the diagnosis of sporadic Creutzfeldt-Jakob disease.

179 ttern of involvement in sporadic Creutzfeldt-Jakob disease.

180 e total white matter in sporadic Creutzfeldt-Jakob disease.

181 sed in the diagnosis of sporadic Creutzfeldt-Jakob disease; however, the characteristic waveforms do

182 rimental, acquired, and sporadic Creutzfeldt-Jakob diseases.

183 y for PrP(TSE) after exposure to Creutzfeldt-Jakob disease brain homogenate.

184 e sheep to scrapie and humans to Creutzfeldt-Jakob disease.

185 h a mouse model of transmissible Creutzfeldt-Jakob disease (CJD), the ataxia of Tg(A116V) mice is mor

186 pathy (BSE) to humans as variant Creutzfeldt-Jakob disease (CJD) has affected over 100 individuals, a

187 Variant Creutzfeldt-Jakob disease (CJD) is thought to be caused by dietary o

188 halopathy to people as a variant Creutzfeldt-Jakob disease (CJD), it becomes critical to identify cel

189 e from a small sample of variant Creutzfeldt-Jakob disease (CJD).

190 prions from humans with variant Creutzfeldt-Jakob disease (CJD); on second passage in Tg(BoPrP) mice

191 autopsy-proved cases of variant Creutzfeldt-Jakob disease (n = 59) and compare these with cases of s

192 rP(Sc) molecular type in variant Creutzfeldt-Jakob disease (termed type 2B), presumably resulting fro

193 Variant Creutzfeldt-Jakob disease (vCJD) and bovine spongiform encephalopath

194 rodegenerative condition variant Creutzfeldt-Jakob disease (vCJD) and, based on recent human prevalen

195 a prototype blood-based variant Creutzfeldt-Jakob disease (vCJD) assay has sufficient sensitivity an

196 m, a deceased carrier of variant Creutzfeldt-Jakob disease (vCJD) can be followed up to quantify tran

197 of the rising number of variant Creutzfeldt-Jakob disease (vCJD) cases.

198 Variant Creutzfeldt-Jakob disease (vCJD) differs from other human prion dise

199 Variant Creutzfeldt-Jakob disease (vCJD) has a pathogenesis distinct from ot

200 Variant Creutzfeldt-Jakob disease (vCJD) has been recognized to date only in

201 o-person transmission of variant Creutzfeldt-Jakob disease (vCJD) has occurred through blood transfus

202 Infections with variant Creutzfeldt-Jakob disease (vCJD) have almost exclusively occurred in

203 number of patients with variant Creutzfeldt-Jakob disease (vCJD) have been treated with intraventicu

204 rt a case of preclinical variant Creutzfeldt-Jakob disease (vCJD) in a patient who died from a non-ne

205 to be zoonotic, causing variant Creutzfeldt-Jakob disease (vCJD) in humans and having guided protect

206 the current outbreak of variant Creutzfeldt-Jakob disease (vCJD) in the United Kingdom, because all

207 The development of variant Creutzfeldt-Jakob disease (vCJD) in three recipients of non-leukored

208 uman exposure levels and variant Creutzfeldt-Jakob disease (vCJD) incidence.

209 Variant Creutzfeldt-Jakob disease (vCJD) is a fatal neurodegenerative disord

210 Variant Creutzfeldt-Jakob disease (vCJD) is a fatal neurodegenerative disord

211 Variant Creutzfeldt-Jakob disease (vCJD) is a novel human prion disease caus

212 Variant Creutzfeldt-Jakob disease (vCJD) is a unique and highly distinctive

213 clinical expression of, variant Creutzfeldt-Jakob disease (vCJD) is essential for future management

214 ns have been raised that variant Creutzfeldt-Jakob disease (vCJD) might be transmissible by blood tra

215 n in the distribution of variant Creutzfeldt-Jakob disease (vCJD) might indicate the transmission rou

216 prion-affected patients (variant Creutzfeldt-Jakob disease (vCJD) n = 20, iatrogenic CJD (iCJD) n = 1

217 encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (vCJD) prions are faithfully maintained up

218 The transmission of variant Creutzfeldt-Jakob disease (vCJD) through blood transfusions has crea

219 voir for transmission of variant Creutzfeldt-Jakob disease (vCJD) to humans.

220 Interindividual variant Creutzfeldt-Jakob disease (vCJD) transmission through blood and bloo

221 ern since the reports of variant Creutzfeldt-Jakob disease (vCJD) transmission through blood transfus

222 possible transmission of variant Creutzfeldt-Jakob disease (vCJD) via blood transfusion has caused co

223 the risk of transmitting variant Creutzfeldt-Jakob disease (vCJD) via blood transfusion have relied l

224 Variant Creutzfeldt-Jakob disease (vCJD) was first described in the United K

225 Variant Creutzfeldt-Jakob Disease (vCJD) was first reported in 1996; the you

226 Variant Creutzfeldt-Jakob disease (vCJD), a novel form of human prion diseas

227 The onset of variant Creutzfeldt-Jakob disease (vCJD), and the unknown prevalence of infe

228 nd its human equivalent, variant Creutzfeldt-Jakob disease (vCJD), are caused by the same strain of i

229 cribed in cases of human variant Creutzfeldt-Jakob disease (vCJD), experimental ovine bovine spongifo

230 orm encephalopathy (BSE)/variant Creutzfeldt-Jakob disease (vCJD), Nipah virus, several viral hemorrh

231 tissues of patients with variant Creutzfeldt-Jakob disease (vCJD), sheep with natural scrapie or rode

232 ons, the causal agent of variant Creutzfeldt-Jakob disease (vCJD).

233 profile associated with variant Creutzfeldt-Jakob disease (vCJD).

234 cally silent carriers of variant Creutzfeldt-Jakob disease (vCJD).

235 vidual can propagate the variant Creutzfeldt-Jakob disease agent and that the infectious agent can be

236 ated transmission of the variant Creutzfeldt-Jakob disease agent.

237 umulates in the brain in variant Creutzfeldt-Jakob disease also contains a minority type 1 component.

238 -mortem samples, of both variant Creutzfeldt-Jakob disease and Alzheimer's disease patients, also sug

239 odegenerative conditions variant Creutzfeldt-Jakob disease and Alzheimer's disease.

240 o subsequently developed variant Creutzfeldt-Jakob disease and an asymptomatic red cell transfusion r

241 e urine of patients with variant Creutzfeldt-Jakob disease and had the typical electrophoretic profil

242 ained from patients with variant Creutzfeldt-Jakob disease and in none of the 224 urine samples obtai

243 on of 10% (wt/vol) human variant Creutzfeldt-Jakob disease brain homogenate, with >3,800-fold binding

244 nsfusion-transmission of variant Creutzfeldt-Jakob disease by red cell preparations.

245 iew, the transmission of variant Creutzfeldt-Jakob disease by transfusion has been confirmed.

246 against transmission of variant Creutzfeldt-Jakob disease by transfusion of domestic blood or red bl

247 Recent evidence that variant Creutzfeldt-Jakob disease can be transmitted by transfusion of red c

248 were followed-up in six variant Creutzfeldt-Jakob disease cases with 9.4 T high-resolution magnetiza

249 from a UK cohort of 171 variant Creutzfeldt-Jakob disease cases.

250 ained from patients with variant Creutzfeldt-Jakob disease contained minute quantities of PrP(Sc).

251 culation analysis of the variant Creutzfeldt-Jakob disease epidemic in the United Kingdom is used to

252 The recent emergence of variant Creutzfeldt-Jakob disease has led to major public health concerns, a

253 The outbreak of new variant Creutzfeldt-Jakob disease has raised the specter of a potentially la

254 Three cases of variant Creutzfeldt-Jakob disease have been identified following red cell tr

255 te and probable cases of variant Creutzfeldt-Jakob disease have been methionine homozygotes (MM).

256 scrapie in sheep and of variant Creutzfeldt-Jakob disease in humans.

257 dividuals diagnosed with variant Creutzfeldt-Jakob disease in the USA and Canada.

258 t numbers of subclinical variant Creutzfeldt-Jakob disease individuals in at least the United Kingdom

259 idence of any death from variant Creutzfeldt-Jakob disease or from conditions that could be confused

260 ents for transmission of variant Creutzfeldt-Jakob disease predicted that leukocyte reduction would b

261 Evidence suggests that variant Creutzfeldt-Jakob disease prions circulate in body fluids from peopl

262 found in all 21 cases of variant Creutzfeldt-Jakob disease tested, irrespective of brain region exami

263 results show PrP(Sc) in variant Creutzfeldt-Jakob disease to be remarkably stereotyped.

264 was also present in the variant Creutzfeldt-Jakob disease tonsil.

265 Transmission of variant Creutzfeldt-Jakob disease was observed from the MV blood recipient s

266 ypes was maintained when variant Creutzfeldt-Jakob disease was transmitted to wild-type mice and was

267 We report a case of variant Creutzfeldt-Jakob disease(vCJD) in a 74-year old man in whom diagnos

268 d animals, one of which (variant Creutzfeldt-Jakob disease) is known to be a zoonotic form of the cat

269 ncephalopathies, such as variant Creutzfeldt-Jakob disease, are believed to result from infectious fo

270 is a defining feature of variant Creutzfeldt-Jakob disease, but that the biochemical isoform of PrP(S

271 an effort to prevent new variant Creutzfeldt-Jakob disease, certain "specified offals," including neu

272 ient, who did not die of variant Creutzfeldt-Jakob disease, has been identified with prion protein de

273 transmission studies in variant Creutzfeldt-Jakob disease, including those on the spleen and brain o

274 red human prion disease, variant Creutzfeldt-Jakob disease, is thought to result from oral exposure t

275 In variant Creutzfeldt-Jakob disease, prion replication is thought to occur fir

276 n humans associated with variant Creutzfeldt-Jakob disease, pulls the N terminus into the sheet.

277 e urine of patients with variant Creutzfeldt-Jakob disease, we used the protein misfolding cyclic amp

278 f mid-2016, 231 cases of variant Creutzfeldt-Jakob disease-the human form of a prion disease of cattl

279 to-human transmission of variant Creutzfeldt-Jakob disease.

280 sporadic, iatrogenic and variant Creutzfeldt-Jakob disease.

281 ote to both sporadic and variant Creutzfeldt-Jakob disease.

282 ired, as is the case for variant Creutzfeldt-Jakob disease.

283 series of nine cases of variant Creutzfeldt-Jakob disease.

284 respiratory syndrome, or variant Creutzfeldt-Jakob disease.

285 (BSE) prions causes new variant Creutzfeldt-Jakob disease.

286 affected by sporadic and variant Creutzfeldt-Jakob disease.

287 rus, enterovirus 70, and variant Creutzfeldt-Jakob disease.

288 humans were diagnosed as variant Creutzfeldt-Jakob disease.

289 ations are applicable to variant Creutzfeldt-Jakob in humans then a method for rendering human red ce

290 probable transmission of variant Creutzfeldt-Jakob infectivity by transfusion of red cell preparation

291 anding of the risks of (variant) Creutzfeldt-Jakob disease transmission via dental practice, and whet

292 successfully propagated various Creutzfeldt-Jakob disease (CJD) isolates (sporadic, variant, and iat

293 sitive in 30 of 31 patients with Creutzfeldt-Jakob disease (15 of 15 with definite sporadic Creutzfel

294 erks develop in individuals with Creutzfeldt-Jakob disease (CJD), an incurable brain disorder caused

295 en exposed to medium spiked with Creutzfeldt-Jakob disease brain homogenate, resulting in a coarse gr

296 mone derived from a patient with Creutzfeldt-Jakob disease expressing prion protein valine 129.

297 NS) in five of six patients with Creutzfeldt-Jakob disease.

298 ive in 43 of 43 patients without Creutzfeldt-Jakob disease, indicating a sensitivity of 97% (95% conf

299 traussler syndrome and hereditary Creuzfeldt-Jakob disease, tau mutations cause autosomal dominant fr

300 was shown to have pathology-proven sporadic Jakob-Creutzfeldt disease.