ライフサイエンスコーパス: Joseph disease

1 causes the neurodegenerative disease Machado-Joseph disease.

2 biquitinating enzyme associated with Machado-Joseph disease.

3 torubral-pallidoluysian atrophy, and Machado-Joseph disease.

4 s a promising therapeutic target for Machado-Joseph disease.

5 ng is beneficial in animal models of Machado-Joseph disease.

6 utant ataxin-3, the genetic cause of Machado-Joseph Disease, also contains an expanded CAG repeat.

7 d longevity in a Drosophila model of Machado-Joseph disease and effectively reduced aggregated ATXN3

8 ially promising therapeutic drug for Machado-Joseph disease and possibly other neurological proteinop

9 polyglutamine disease known both as Machado-Joseph disease and spinocerebellar ataxia type 3.

10 ar ataxia type-3 (SCA3), also called Machado-Joseph disease, and is cleaved in mammalian cells, trans

11 ch correlated with preservation from Machado-Joseph disease-associated neuropathology, namely reducti

12 ebellar ataxia type 3, also known as Machado-Joseph disease, causes dendritic and synapse loss in cul

13 Patients with Machado-Joseph disease exhibit significant motor impairments suc

14 d neurotoxic protein (MJDtr78Q; MJD, Machado-Joseph disease) in the major timeless (tim)-expressing c

15 Machado-Joseph disease is a neurodegenerative disease without ef

16 Machado-Joseph disease is caused by an expansion of a trinucleot

17 g Jews of North African descent, and Machado-Joseph disease is particularly frequent in Yemenite Jews

18 eatment of symptomatic patients with Machado-Joseph disease may require cell replacement, which we in

19 ntation into the cerebellum of adult Machado-Joseph disease mice, cerebellar neural stem cells differ

20 ubral pallidoluysian atrophy (DRPLA) Machado-Joseph disease (MJD or SCA3) and SCA2.

21 These include Machado-Joseph disease (MJD) and Huntington's disease (HD), whic

22 Huntington's disease (HD) and Machado Joseph Disease (MJD) are severe neurological disorders t

23 Machado-Joseph disease (MJD) is a late-onset, progressive, neuro

24 Machado-Joseph disease (MJD) is a neurodegenerative disorder ass

25 Machado-Joseph disease (MJD) is a neurodegenerative disorder cha

26 Machado-Joseph disease (MJD) is an autosomal dominant neurodegen

27 Machado-Joseph disease (MJD) is an inherited neurodegenerative d

28 Machado-Joseph disease (MJD) is one of at least six neurodegener

29 The neurodegenerative disease Machado-Joseph disease (MJD), also known as spinocerebellar atax

30 ncy of SCA2 compared with SCA1, SCA3/Machado-Joseph disease (MJD), and dentatorubropallidoluysian atr

31 pinocerebellar ataxia type 1 (SCA1), Machado-Joseph disease (MJD), and Friedreich ataxia.

32 ataxia type 3 (SCA3), also known as Machado-Joseph disease (MJD), is an autosomal-dominant neurodege

33 in patients of Japanese descent with Machado-Joseph disease (MJD), it was reported that disease allel

34 , a deubiquitylase (DUB) involved in Machado-Joseph Disease (MJD), remains elusive.

35 Machado-Joseph disease (MJD; MIM 109150) is a late-onset neurode

36 lts in spinocerebellar ataxia type 3/Machado-Joseph disease, one of the nine polyglutamine neurodegen

37 Machado-Joseph disease or spinocerebellar ataxia 3 (SCA3) is a p

38 Spinocerebellar ataxia type 3 (SCA3)/Machado Joseph disease results from expansion of the polyglutami

39 Spinocerebellar ataxia type-3 or Machado-Joseph disease (SCA3/MJD) is a member of the CAG/polyglu

40 ebellar ataxia type 3, also known as Machado-Joseph disease (SCA3/MJD), is one of at least eight inhe

41 ein in spinocerebellar ataxia type 3/Machado-Joseph disease (SCA3/MJD), or an unrelated green fluores

42 ebellar ataxia type 3, also known as Machado-Joseph disease (SCA3/MJD), we show that the disease prot

43 Machado-Joseph disease (spinocerebellar ataxia type 3) (prevalen

44 t ataxias was high, particularly for Machado-Joseph disease (spinocerebellar ataxia type 3).

45 that exclusively silenced the mutant Machado-Joseph disease/spinocerebellar ataxia type 3 allele whil

46 ent and neuroprotective approach for Machado-Joseph disease therapy.

47 m cells into the cerebellum of adult Machado-Joseph disease transgenic mice and assessed the effect o