ライフサイエンスコーパス: K. pneumoniae

1 K. pneumoniae can evade serum killing and phagocytosis p

2 K. pneumoniae challenge resulted in significantly increa

3 K. pneumoniae has become a common pathogen of monomicrob

4 K. pneumoniae infection of mice lacking Nlrp3 results in

5 K. pneumoniae infection of STAT6 knockout mice resulted

6 K. pneumoniae is ubiquitous in the environment and can c

7 K. pneumoniae may establish these infections in vivo fol

8 K. pneumoniae must acquire iron to replicate, and it uti

9 K. pneumoniae were confirmed to belong to the same clone

10 Of the 15 K. pneumoniae strains detected in the study, four were d

11 teristics of four infections caused by KPC-3 K. pneumoniae strains.

12 A total of 3846 K. pneumoniae cultures were identified, with an overall

13 ta-lactamase-producing clinical isolates (39 K. pneumoniae and 30 K. oxytoca isolates).

14 d recovery from infection with each of the 5 K. pneumoniae strains, revealing a contribution of these

15 with abscesses caused by community-acquired K. pneumoniae in the kidneys and spleen without liver in

16 neutrophil recruitment in response to acute K. pneumoniae infection and thereby increases the lung K

17 In addition, K. pneumoniae-induced late NF-kappaB activation and phos

18 inetobacter spp., C. freundii, E. aerogenes, K. pneumoniae, P. aeruginosa, and S. marcescens) became

19 resistance to bacterial dissemination, after K. pneumoniae infection or cecal ligation and puncture s

20 ntratracheal rG-CSF to MCP-1(-/-) mice after K. pneumoniae infection rescued survival, bacterial clea

21 CRAMP exerted bactericidal activity against K. pneumoniae in vitro.

22 howed potent bacteriostatic activity against K. pneumoniae, which was dependent on lipocalin 2 (LCN2)

23 ch to identify protective antibodies against K. pneumoniae Several monoclonal antibodies were isolate

24 underlying KC-mediated host defense against K. pneumoniae have not been explored.

25 to the role of NLRC4 in host defense against K. pneumoniae infection.

26 ctive role of Mincle in host defense against K. pneumoniae pneumonia by coordinating bacterial cleara

27 nt cells contributes to host defense against K. pneumoniae.

28 wever, polymyxin B MICs are elevated against K. pneumoniae isolates with increasing frequency, leavin

29 CCL8 in lung antibacterial immunity against K. pneumoniae and suggest new mechanisms of orchestratin

30 hils and in regulating host immunity against K. pneumoniae infection.

31 nd SP-B(N) conferred more protection against K. pneumoniae infection than each protein individually.

32 nge conferred significant protection against K. pneumoniae infection.

33 bacteriovorus acting therapeutically against K. pneumoniae in serum, informing future research into t

34 All K. pneumoniae strains tested positive for K. pneumoniae

35 ent in spectra from retrospectively analyzed K. pneumoniae outbreak isolates, concordant with results

36 most common pathogens were GAS (n = 16) and K. pneumoniae (n = 15).

37 The CFU of recoverable P. aeruginosa and K. pneumoniae isolates were decreased, but the biofilm b

38 s or decreasing the CFU of P. aeruginosa and K. pneumoniae within a biofilm.

39 us collection of 196 isolates of E. coli and K. pneumoniae (PRIMERS II) were examined.

40 1-producing E. coli in blood and E. coli and K. pneumoniae in rectal specimens, both containing the s

41 tamase (ESBL)-producing Escherichia coli and K. pneumoniae isolates using MinION allowed successful i

42 ce variation between the FimH of E. coli and K. pneumoniae results in significant differences in func

43 d sisomicin suppressed growth of E. coli and K. pneumoniae, with N1MS exhibiting superior activity ag

44 tment to the airspace in response to LPS and K. pneumoniae by impairing both chemokine induction in t

45 cytokine expression induced by both LPS and K. pneumoniae.

46 rum amyloid A2 (SAA2) and that SAA2 had anti-K. pneumoniae bactericidal activity in vitro.

47 candidate target in the development of anti-K. pneumoniae drugs.

48 he resurgence of severe community-associated K. pneumoniae infections has led to increased recognitio

49 Analysis of the available K. pneumoniae genomes revealed that this pathogen's geno

50 KC in bone marrow-derived macrophages before K. pneumoniae challenge decreases bacteria-induced produ

51 Neutrophil depletion in mice before K. pneumoniae infection reveals no differences in the pr

52 omparisons have revealed differences between K. pneumoniae strains, but the impact of genomic variabi

53 eceptor Mincle in pneumonic sepsis caused by K. pneumoniae.

54 th care environment, patient colonization by K. pneumoniae precedes infection, and transmission via c

55 ibility to acute intrapulmonary infection by K. pneumoniae, regardless of strain.

56 ates from a collection of well-characterized K. pneumoniae and E. coli strains and salvage rectal swa

57 We chose K. pneumoniae for our in vivo model, since K. pneumoniae

58 ive) were compared with those of the classic K. pneumoniae (cKP) isolates.

59 rains are an emerging variant of "classical" K. pneumoniae (cKP) that cause organ and life-threatenin

60 A total of 46 clinical K. pneumoniae isolates with KPC genotypes, all modified

61 e 43816 strain and 4 newly isolated clinical K. pneumoniae strains.

62 The clinical K. pneumoniae strains, including one carbapenem-resistan

63 for bacteria including E. faecalis, E. coli, K. pneumoniae and S. aureus.

64 100 genome copies of A. baumannii, E. coli, K. pneumoniae, and P. aeruginosa.

65 ae to human clinical infections, we compared K. pneumoniae isolates from retail meat products and hum

66 d-type, magA-deficient, or magA-complemented K. pneumoniae into the posterior segments of mouse eyes.

67 vascular-magnitude fluid dynamic conditions, K. pneumoniae spontaneously develops into multicellular

68 These data confirm K. pneumoniae colonization is a significant risk factor

69 Of note, 25/26 cultures containing K. pneumoniae that were reported as not detected by the

70 In contrast, K. pneumoniae-infected Rag2(-/-)Il2rg(-/-) mice failed t

71 pal-, lppA-, and ompA-deficient K. pneumoniae strains were constructed using an unmarked

72 mans can become infected with many different K. pneumoniae strains that vary in genetic background, a

73 e specific than (18)F-FDG in differentiating K. pneumoniae lung infection from lung inflammation.

74 erum sensitivity and virulence of 3 distinct K. pneumoniae (hypermucoviscous K1, research K2, and car

75 During K. pneumoniae infection, we observed subtle differences

76 in neutrophil-mediated host immunity during K. pneumoniae pneumonia and illustrate that G-CSF could

77 rophil influx into the alveolar space during K. pneumoniae infection was delayed early but increased

78 ndent mechanism critical for survival during K. pneumoniae bacteremia.

79 NDM-1-producing Enterobacteriaceae (K. pneumoniae and Escherichia coli) were clinically and

80 zation by vancomycin-resistant Enterococcus, K. pneumoniae, and E. coli.

81 henotype in the pathogenesis of experimental K. pneumoniae endophthalmitis.

82 so showed reduced bacterial burden following K. pneumoniae challenge.

83 MCP-1 treatment in MCP-1(-/-) mice following K. pneumoniae infection rescued impairment in survival,

84 is a critical mediator of survival following K. pneumoniae infection and sepsis and suggest that IL-6

85 erstand potential contributions of foodborne K. pneumoniae to human clinical infections, we compared

86 Norgen) and 80 CFU/ml urine, on average, for K. pneumoniae (Norgen).

87 NLRC4 is essential for K. pneumoniae-induced production of IL-1beta, IL-17A, an

88 we present a detailed genomic framework for K. pneumoniae based on whole-genome sequencing of more t

89 Further, for K. pneumoniae (KpI), the entity most frequently associat

90 ll K. pneumoniae strains tested positive for K. pneumoniae carbapenemase (KPC) genes by real-time PCR

91 ed in 88 patients with cultures positive for K. pneumoniae hospitalized in the Beijing You'an Hospita

92 Periodic patient screening for K. pneumoniae colonization has the potential to curb the

93 ng potential carbon and nitrogen sources for K. pneumoniae and of 99% in predicting nonessential gene

94 sults support MrkA as a promising target for K. pneumoniae antibody therapeutics and vaccines.

95 The conjugation frequency of OXA-48 from K. pneumoniae and E. coli in the gut of low-complexity-m

96 b OXA-48-containing IncL/M-type plasmid from K. pneumoniae to E. coli belonging to the novel ST666 in

97 PqqE from K. pneumoniae was cloned into Escherichia coli and expre

98 ) were Klebsiella pneumoniae and 74 harbored K. pneumoniae carbapenemase (56.1%), 54 metallo-beta-lac

99 OXA-48-harboring K. pneumoniae isolates belonging to ST14 were isolated d

100 Five of 7 eyes had <100 CFU HMV- K. pneumoniae at 27 hours PI.

101 viscous (HMV+) or nonhypermucoviscous (HMV-) K. pneumoniae.

102 88 blocking peptide exhibited attenuation in K. pneumoniae-induced neutrophil influx and enhanced bac

103 gulated promoters have been characterized in K. pneumoniae, and nine NAC-regulated promoters have bee

104 ltered type 3 fimbrial surface expression in K. pneumoniae.

105 ddition, FimH-dependent biofilm formation in K. pneumoniae is inhibited by heptyl mannose, but not me

106 fimbria production and biofilm formation in K. pneumoniae.

107 2,) RNS production, and bacterial killing in K. pneumoniae-infected CXCL1(-/-) neutrophils.

108 e investigated the role of TRIF and MyD88 in K. pneumoniae pneumonia.

109 ons of the chromosome associated with NAC in K. pneumoniae.

110 The large size of the NAC regulon in K. pneumoniae indicates that NAC plays a larger role in

111 Furthermore, fluoroquinolone-resistance in K. pneumoniae clinical isolates is reversed by expressio

112 The majority of bla(KPC) genes were in K. pneumoniae isolates, which fell into 14 clonal groups

113 The epidemic curve of incident K. pneumoniae cases showed a bimodal distribution of cas

114 nction against invading pathogens, including K. pneumoniae.

115 bacteriophage (NTUH-K2044-K1-1) that infects K. pneumoniae NTUH-K2044 (capsular type K1) was isolated

116 ial cell characteristics in an international K. pneumoniae isolate collection (n = 48), with a range

117 NF-kappaB and MAPKs following intratracheal K. pneumoniae infection.

118 educed survival in response to intratracheal K. pneumoniae administration.

119 that in the eye, the K1 capsule of invasive K. pneumoniae significantly contributes to the ability o

120 ead to the emergence of untreatable invasive K. pneumoniae infections; our data provide the whole-gen

121 The isolated K. pneumoniae strains (n = 10) were of capsular polysacc

122 the virulence gene profiles of the isolated K. pneumoniae strains.

123 ass and reduced the CFU of E. coli isolates, K. pneumoniae isolates were observed to have a reduction

124 e used for the diagnosis and treatment of K1 K. pneumoniae infections.

125 s administered orogastrically in serotype K1 K. pneumoniae-colonized mice and the outcome was compare

126 Wild-type K1 K. pneumoniae caused significant ocular disease.

127 In the kidneys, K. pneumoniae outcompeted E. coli in healthy mice but in

128 alveolar macrophages with LPS or heat-killed K. pneumoniae recapitulated the increase in IL-10 produc

129 most common resistance mechanisms were KPC (K. pneumoniae carbapenemases) beta-lactamases encoded by

130 pneumoniae into three distinct species, KpI (K. pneumoniae), KpII (K. quasipneumoniae), and KpIII (K.

131 lly, we demonstrated that the decreased lung K. pneumoniae burden associated with allergic airway inf

132 We showed that the decreased lung K. pneumoniae burden was independent of IL-4, IL-5, and

133 nflammation significantly decreased the lung K. pneumoniae burden and postinfection mortality.

134 iae infection and thereby increases the lung K. pneumoniae burden.

135 E. coli lipid A, whereas only LpxL2 mediated K. pneumoniae lipid A acylation.

136 In MyD88(-/-) mice, K. pneumoniae-induced early NF-kappaB and MAPK activatio

137 ta(2)-microglobulin expression during murine K. pneumoniae bacteremia.

138 m-susceptible from carbapenem-nonsusceptible K. pneumoniae isolates without the need for MHT, while t

139 ains were identified, responsible for 12% of K. pneumoniae infections in ICU.

140 Nearly 25% of K. pneumoniae clinical isolates in a US network of LTACH

141 In sum, 49% of K. pneumoniae infections were caused by the patients' ow

142 r for infection in ICU, and indicate 50% of K. pneumoniae infections result from patients' own micro

143 Overall, 33.0% (29/88) of K. pneumoniae isolates were hvKP.

144 e screened for rectal and throat carriage of K. pneumoniae shortly after admission.

145 In contrast to cases of K. pneumoniae bacteremia with primary liver abscesses in

146 Three categories of K. pneumoniae isolates were identified: enterobactin pos

147 Optimal clearance of K. pneumoniae from the host lung requires TNF and IL-17A

148 While pulmonary clearance of K. pneumoniae is preserved in neutrophil-depleted mice,

149 ophils and CCR2(+) monocytes to clearance of K. pneumoniae pulmonary infection.

150 ter microbiota depletion, early clearance of K. pneumoniae was impaired, and this could be rescued by

151 sion causes neutrophil-mediated clearance of K. pneumoniae, the mechanisms underlying KC-mediated hos

152 in an epidemic multidrug-resistant clone of K. pneumoniae (ST258).

153 uggest that MrkD1P allows for competition of K. pneumoniae with P. aeruginosa in a mixed-species biof

154 nstrate the site-threatening consequences of K. pneumoniae endophthalmitis and the importance of the

155 ified self ligands, is a host determinant of K. pneumoniae pathogenicity.

156 vides new insights into host determinants of K. pneumoniae pathogenicity and raises the possibility t

157 gate the evolution and spatial dispersion of K. pneumoniae in support of hospital infection control.

158 ounts, as well as increased dissemination of K. pneumoniae to blood and liver, compared with control-

159 Although the adhesin domain of K. pneumoniae TOP52 FimH (FimH(52)) is highly homologous

160 dy was to determine whether the incidence of K. pneumoniae bloodstream infection (BSI) was higher dur

161 This molecule is a competitive inhibitor of K. pneumoniae OHCU decarboxylase with a K(i) of 30 +/- 2

162 potential, and host-pathogen interactions of K. pneumoniae.

163 The IR of K. pneumoniae BSI during the 4 warmest months of the yea

164 essures may lead to an increase in the IR of K. pneumoniae BSI during the warmest months of the year.

165 2.23/10,000 patient-days, whereas the IR of K. pneumoniae BSI for the other 8 months was 1.55/10,000

166 ed this assay to screen clinical isolates of K. pneumoniae and Klebsiella oxytoca for the presence of

167 stant gram-negative bacteria, 12 isolates of K. pneumoniae that exhibited nonsusceptibility to extend

168 factor among clinical bacteremia isolates of K. pneumoniae.

169 observed reduced phagocytosis and killing of K. pneumoniae in AMs from l/l mice that was associated w

170 blish the first report, to our knowledge, of K. pneumoniae containing bla(KPC-3) in an LTCF caring fo

171 ocytes are rapidly recruited to the lungs of K. pneumoniae-infected mice and produce TNF, which marke

172 sion of MGL1 was upregulated in the lungs of K. pneumoniae-infected mice, and the deficiency of this

173 ed an increased influx in pneumonic lungs of K. pneumoniae-infected mice.

174 selective alternatives for the management of K. pneumoniae pneumonia.

175 this study, an experimental murine model of K. pneumoniae endophthalmitis was established, and the r

176 ld-type and O-antigen or capsular mutants of K. pneumoniae were grown as broth culture in a Taylor-Co

177 airway inflammation decreased the number of K. pneumoniae-induced airway neutrophils and lung IL-17A

178 ve diminished survival and higher numbers of K. pneumoniae following i.p. infection.

179 icillin/ampicillin may lead to overgrowth of K. pneumoniae in the intestine and predispose to KPLA.

180 onal differences seen in the pathogenesis of K. pneumoniae UTI compared to E. coli UTI.

181 y and constitute an increasing proportion of K. pneumoniae strains, indicating an increasing propensi

182 h linearly predictive of increasing rates of K. pneumoniae BSI.

183 like receptor (TLR)-dependent recognition of K. pneumoniae.

184 To assess the role of K. pneumoniae capsule in endophthalmitis, the authors in

185 rred protection against several serotypes of K. pneumoniae, including the recently described multidru

186 ide genome-wide support for the splitting of K. pneumoniae into three distinct species, KpI (K. pneum

187 have used the rodent-adapted 43816 strain of K. pneumoniae and demonstrated that neutrophils are esse

188 model for KPPR1, a highly virulent strain of K. pneumoniae.

189 e is known about the population structure of K. pneumoniae, so it is difficult to recognize or unders

190 In vivo, we found that treatment of K. pneumoniae-infected mice with SP-A and SP-B(N) confer

191 gulatory gene fimK promotes the virulence of K. pneumoniae strain TOP52 in murine pneumonia.

192 P-2 and activation of NF-kappaB and MAPKs on K. pneumoniae infection.

193 ene in genomic DNA extracted from E. coli or K. pneumoniae clinical isolates within a few minutes.

194 ice but in diabetic mice E. coli outcompeted K. pneumoniae and caused severe pyelonephritis.

195 hat E. coli had a significant advantage over K. pneumoniae in the bladders of healthy mice and less o

196 p-PCR indicated that all bla(KPC-3)-positive K. pneumoniae strains were genetically related (>/=98% s

197 ty of method 1 for detection of KPC-positive K. pneumoniae and E. coli in 149 rectal swab specimens w

198 In addition, we evaluated 13 KPC-positive K. pneumoniae isolates by using each of these methods an

199 (ESBL/Omp strains), and 42 blaKPC-possessing K. pneumoniae (KPC-Kp) isolates were evaluated.

200 Ampicillin administration predisposed K. pneumoniae-colonized mice to increased bacterial burd

201 t Klebsiella pneumoniae strains that produce K. pneumoniae carbapenemase (KPC) have spread globally i

202 bsiella pneumoniae (Kp) strains that produce K. pneumoniae carbapenemases (KPCs) has become a signifi

203 Five NDM-1-producing K. pneumoniae colonizing and/or clinically infecting pat

204 We report a NDM-1-producing K. pneumoniae outbreak in Ontario, Canada.

205 nts were identified carrying NDM-1-producing K. pneumoniae, all of them epidemiologically linked with

206 interpretations for carbapenemase-producing K. pneumoniae differ by methodology.

207 lebsiella pneumoniae carbapenemase-producing K. pneumoniae followed a similar path some 20 years late

208 lebsiella pneumoniae carbapenemase-producing K. pneumoniae infectious episodes in 22 polytrauma inten

209 by highly resistant carbapenemase-producing K. pneumoniae.

210 clinical strains of carbapenemase-producing K. pneumoniae.

211 lebsiella pneumoniae carbapenemase-producing K. pneumoniae; and present strategies used to halt the s

212 69/638 isolates) and 67.7% of ESBL-producing K. pneumoniae isolates (155/229 isolates).

213 lla pneumoniae carbapenemase (KPC)-producing K. pneumoniae has become endemic in many US hospitals.

214 lla pneumoniae carbapenemase (KPC)-producing K. pneumoniae were studied.

215 ce then, regional outbreaks of KPC-producing K. pneumoniae (KPC-Kp) have occurred in the USA, and hav

216 with imipenem for detection of KPC-producing K. pneumoniae and E. coli in surveillance specimens.

217 e, the international spread of KPC-producing K. pneumoniae is primarily associated with a single mult

218 factor that is prevalent among KPC-producing K. pneumoniae isolates and promotes respiratory tract in

219 nt progresses in understanding KPC-producing K. pneumoniae that are contributing to our knowledge of

220 for susceptibility testing of KPC-producing K. pneumoniae, as Vitek 2 did not provide reliable resul

221 outbreak of colistin-resistant KPC-producing K. pneumoniae.

222 signaling in host defense against pulmonary K. pneumoniae infection has not been elucidated.

223 F and MyD88 signaling triggered by pulmonary K. pneumoniae infection in the lungs and demonstrate the

224 ost defense functions of KC during pulmonary K. pneumoniae infection using KC(-/-) mice.

225 (-/-) mice are more susceptible to pulmonary K. pneumoniae infection and show higher bacterial burden

226 endered germfree mice resistant to pulmonary K. pneumoniae infection, abrogated IL-10 production, and

227 DNase I footprinting studies using purified K. pneumoniae ArgP protein indicated that ArgP bound the

228 -generation cephalosporin-resistant (Ceph-R) K. pneumoniae, and susceptible K. pneumoniae isolates ca

229 bacteria were unable to significantly reduce K. pneumoniae burden in the blood or prevent disseminati

230 transmitting virulent, antibiotic-resistant K. pneumoniae from food animals to humans.

231 describe an outbreak of carbapenem-resistant K. pneumoniae containing the blaOXA-232 gene transmitted

232 atients with blaOXA-232 carbapenem-resistant K. pneumoniae infections were identified at a tertiary c

233 Here, we describe three carbapenem-resistant K. pneumoniae isolates recovered from pediatric patients

234 atients with blaOxa-232 carbapenem-resistant K. pneumoniae isolates, including 9 with infections, 7 a

235 e to infection with the carbapenem-resistant K. pneumoniae ST258 strain.

236 bruary 2013, twenty-one multi-drug resistant K. pneumoniae strains, were collected from patients hosp

237 erapeutic strategy even for highly resistant K. pneumoniae infections, and underscore the effect humo

238 eat infections caused by multidrug resistant K. pneumoniae.

239 most prevalent cause of multidrug-resistant K. pneumoniae infections in the United States and other

240 evolutionary changes in multidrug-resistant K. pneumoniae, demonstrating the highly recombinant natu

241 We show K. pneumoniae has a large accessory genome approaching 3

242 of respiratory and fecal specimens, showing K. pneumoniae species and clonal group identification an

243 e K. pneumoniae for our in vivo model, since K. pneumoniae increases IL-17A expression and gammadelta

244 Meat-source K. pneumoniae isolates were more likely than clinical is

245 gion has contributed to the success of ST258 K. pneumoniae.

246 e hypothesis that carbapenem-resistant ST258 K. pneumoniae is a single genetic clone that has dissemi

247 genome of these isolates revealed that ST258 K. pneumoniae organisms are two distinct genetic clades.

248 y providing an alternative tool for studying K. pneumoniae pathogenesis and control within the lung.

249 tant (Ceph-R) K. pneumoniae, and susceptible K. pneumoniae isolates causing bloodstream infections at

250 Interestingly, a carbapenem-susceptible K. pneumoniae ST278 (KpN06) was obtained 1 month later f

251 We found that K. pneumoniae carries an extra gene of unknown function

252 Our findings indicate that K. pneumoniae Pal and LppA proteins are important in the

253 rt alerts clinicians to the possibility that K. pneumoniae bacteremia combined with multiple abscesse

254 Our results revealed that K. pneumoniae capsule polysaccharide (CPS) was necessary

255 Recently our group has shown that K. pneumoniae dampens the activation of inflammatory res

256 It has been shown that K. pneumoniae infections are characterized by reduced ea

257 The time-scaled phylogeny suggested that K. pneumoniae strains isolated during the study period m

258 The K. pneumoniae strain was a hypermucoid K2 serotype carry

259 model of UTI demonstrated that although the K. pneumoniae strain TOP52 required FimH(52) for invasio

260 n minimal medium has been proposed to be the K. pneumoniae ArgP protein.

261 Klebsiella pneumoniae isolates harboring the K. pneumoniae carbapenemase gene (bla(KPC)) are creating

262 A knockout mutation of the K. pneumoniae argP gene was generated and used to assess

263 Herein we show that coexpression of the K. pneumoniae atsB gene with a plasmid that encodes gene

264 tting revealed "low-level" production of the K. pneumoniae carbapenemase, and rep-PCR indicated that

265 tance plasmids, particularly variants of the K. pneumoniae carbapenemase.

266 The pathogenesis of the K. pneumoniae cystitis isolate TOP52 was compared to tha

267 Mutants of the K. pneumoniae strain IA565 lacking the plasmid-borne mrk

268 Phylogenetic analysis showed that the K. pneumoniae ST278 from patient 2 was likely a descenda

269 ctors of 30-day mortality rates, whereas the K. pneumoniae susceptibility phenotype was not.

270 Thus, K. pneumoniae appears programmed for minimal expression

271 ver, whether CCR2(+) monocytes contribute to K. pneumoniae clearance from the lung.

272 naling in hematopoietic cells contributes to K. pneumoniae-induced lung inflammation.

273 e of multidrug resistance, especially due to K. pneumoniae carbapenemases (KPCs).

274 ations in CD36 may predispose individuals to K. pneumoniae syndromes.

275 ate that CD36 enhances LPS responsiveness to K. pneumoniae to increase downstream cytokine production

276 a281 knockout) mice were more susceptible to K. pneumoniae bacteremia.

277 ignificantly increased susceptibility toward K. pneumoniae pneumonia.

278 postinfection, eyes infected with wild-type K. pneumoniae retained significantly less retinal A-wave

279 ted with the magA mutant than with wild-type K. pneumoniae.

280 the weak inflammatory response of untreated K. pneumoniae-infected mice.

281 Finally, while the widely used K. pneumoniae model strain 43816 produces rapid dissemin

282 To determine whether K. pneumoniae must produce Lcn2-resistant siderophores t

283 type 1 pili, which may explain, in part, why K. pneumoniae is a less prevalent etiologic agent of UTI

284 ith E. coli, 2/3 with K. oxytoca, 16/17 with K. pneumoniae, and 0/1 with Proteus spp.

285 and protection from pulmonary challenge with K. pneumoniae.

286 th wild-type neutrophils when incubated with K. pneumoniae.

287 However, MyD88(-/-) mice infected with K. pneumoniae showed a much more remarkable phenotype, i

288 TRIF(-/-) mice infected with K. pneumoniae showed impaired survival and reduced bacte

289 ild type mice were created and infected with K. pneumoniae via the airways.

290 g and improved survival after infection with K. pneumoniae compared with wild-type controls, an effec

291 d the lungs of l/l mice after infection with K. pneumoniae in vivo.

292 ncreases in susceptibility to infection with K. pneumoniae or E. coli.

293 l depletion markedly worsened infection with K. pneumoniae strain 43816 and three clinical isolates b

294 /-) mice undergoing pulmonary infection with K. pneumoniae was compared.

295 ificantly more susceptible to infection with K. pneumoniae, confirming the likely in vivo relevance o

296 type mice after intratracheal infection with K. pneumoniae.

297 challenge prior to acute lung infection with K. pneumoniae.

298 une defense against pulmonary infection with K. pneumoniae.

299 hat, during pulmonary infection of mice with K. pneumoniae, conventional NK cells are required for op

300 els of IL-22 in the lungs postinfection with K. pneumoniae.