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1 KLH added to DC immunizations markedly enhances tumor-sp
2 KLH conjugate 2 has been subsequently submitted to precl
3 KLH had a different safety profile and was inferior to M
4 KLH tended to be more effective than MM in preventing pr
5 antibodies generated in response to the KH-1-KLH construct recognized not only KH-1 antigen but also
12 jugated to keyhole limpet hemocyanin (NP(5)- KLH) or infected with HSV-1, and the Ab response was eva
13 ein to restore the humoral response to NP(5)-KLH in C4-deficient animals when administered along with
16 hemocyanin (KLH) mixed with HKL generated a KLH-specific primary response characterized by productio
18 ose injections of CORT on days 5 and 7 after KLH had anti-KLH IgG levels equal to those of sham-opera
21 y proliferated in response to the protein Ag KLH presented by host MHC following in vivo immunization
24 diabetic rats immunized with adjuvant alone, KLH-immunized diabetic rats had decreased levels of glyc
26 te and multivariate Cox regression analysis, KLH was less effective than MM regarding RFS (all P < .0
27 intradermal injections of HPV E7 antigen and KLH were detected for all patients after vaccination.
29 MoDC contained significantly more HLA-DR and KLH than those purified from control MoDC, and KLH was c
31 H than those purified from control MoDC, and KLH was concentrated specifically in exosomes that were
33 sterolemia responded to a one-time OxLDL and KLH challenge with greater OxLDL-specific IgM responses,
34 nus toxoid, pneumococcal polysaccharide, and KLH vaccines as well as a Candida albicans skin test wer
35 rmine if the foreign helper proteins (TT and KLH) were essential for CD8(+) T-cell responses to the v
37 vaccine (47% of patients had detectable anti-KLH IgG, compared with 93% of patients treated with MTX
38 uced T-cell proliferation and serum for anti-KLH antibody was obtained at baseline and after feeding,
39 s of CORT on days 5 and 7 after KLH had anti-KLH IgG levels equal to those of sham-operated controls.
40 nization in the control group; however, anti-KLH antibody was seen after oral administration in both
41 ocyanin (KLH) resulted in a decrease in anti-KLH IgG accompanied by increases of anti-KLH IgA and IgE
42 limpet hemocyanin (KLH) Ab, increasing anti-KLH IgG, IgG2a, and IgE, whereas B7.2-Fc did not affect
44 ts with no CORT replacement had reduced anti-KLH IgM and IgG responses compared with sham-operated co
46 studies show that patients make strong anti-KLH responses despite recent high-dose therapy and that
51 ed peptides from rat serum reacted with anti-KLH antibodies at a faster rate than normal IgG and sele
54 ma, we demonstrate that DCs pulsed with both KLH and tumor lysate mediate enhanced immune priming and
56 eukin 2 augments the enhancement afforded by KLH, as measured by cure rates and overall survival, in
57 ce immunized with P315-KLH were inhibited by KLH treated with glutaraldehyde (KLH-g), but not by P315
58 infer that the presence of IL-4 secreted by KLH-specific memory Th2 cells in the lymphoid system mic
61 labeled hemocyanin from Megathura crenulata (KLH) were prepared as effective immunoconjugates contain
66 robust in C57BL/6J NOS2(-/-) mice following KLH/CFA immunization, including the magnitude of the del
71 e adduction reactions were inhibited by free KLH and by reduction of glycated peptides with borohydri
74 unized mice were still capable of generating KLH-specific gamma interferon (IFN-gamma) as well as cor
79 it was concluded that both GM2-MPLA and GM2-KLH are promising candidates as therapeutic cancer vacci
82 ncer stage II) were randomly assigned to GM2-KLH/QS-21 vaccination (n = 657) or observation (n = 657)
84 assess the surmountability potential of GNC-KLH-induced antibody titers by cocaine self-administrati
85 ed with controls, animals immunized with GNC-KLH did not reinstate cocaine self-administration behavi
92 ably, cancer patients immunized with globo H-KLH produce anti-globo H antibody levels often exceeding
94 ocyanin; KLH) and recall (Bet v 1) Ags (H4B4*KLH and H4B4*Bet v 1) induced significantly less CD4 cel
96 acellular vesicles from supernatants of H4B4*KLH-pulsed MoDC contained significantly more HLA-DR and
98 ein conjugated to keyhole limpet hemocyanin (KLH) (TCR Id:KLH) and injected with a chemical adjuvant
99 roduction of anti-keyhole limpet hemocyanin (KLH) Ab, increasing anti-KLH IgG, IgG2a, and IgE, wherea
101 Id) conjugated to keyhole limpet hemocyanin (KLH) and administered with granulocyte-monocyte colony-s
102 alently linked to keyhole limpet hemocyanin (KLH) and monophosphoryl lipid A (MPLA) to form novel the
103 foreign proteins, keyhole limpet hemocyanin (KLH) and tetanus toxoid (TT), as well as an HLA A2.1-res
104 conjugates, Tn(c)-keyhole limpet hemocyanin (KLH) and Tn(c)-palmitic acid (PAM) with the saponin immu
105 23, conjugated to keyhole limpet hemocyanin (KLH) as a carrier and given with Bacillus Calmette-Gueri
107 Subjects were fed keyhole limpet hemocyanin (KLH) before subcutaneous immunization and booster immuni
108 thiolated MEP to keyhole limpet hemocyanin (KLH) by using succinimidyl-4-(N-maleimidomethyl)cyclohex
109 the glycoprotein keyhole limpet hemocyanin (KLH) can cross-link with reactive carbonyl residues on p
110 ycopeptide to the keyhole limpet hemocyanin (KLH) carrier protein completed the preparation of the va
111 aleimide-modified keyhole limpet hemocyanin (KLH) carrier protein through backbone Cys residues.
112 SF, or linkage to keyhole limpet hemocyanin (KLH) carrier protein were increasingly potent in their a
113 this problem, the keyhole limpet hemocyanin (KLH) conjugates of a series of GM3 derivatives were synt
114 human betaS, and keyhole limpet hemocyanin (KLH) control proteins induced no symptoms or pathology.
115 re immunized with keyhole limpet hemocyanin (KLH) first orally and then parenterally or only parenter
118 OH) conjugated to keyhole limpet hemocyanin (KLH) has shown early proof-of-efficacy in rodents as a c
119 ine immunogen GNC-keyhole limpet hemocyanin (KLH) in preventing cocaine self-administration reinstate
121 nized with the Ag keyhole limpet hemocyanin (KLH) mixed with HKL generated a KLH-specific primary res
122 munoconjugate GND-keyhole limpet hemocyanin (KLH) or with the anti-cocaine mAb GNC92H2 were assessed
123 ically coupled to keyhole limpet hemocyanin (KLH) plus granulocyte macrophage colony-stimulating fact
124 munogenic protein keyhole limpet hemocyanin (KLH) protects mice from tumor challenge with the murine
125 leimide-activated keyhole limpet hemocyanin (KLH) provided a PI3P immunogen, which was successfully u
126 nsgenic mice with keyhole limpet hemocyanin (KLH) resulted in a decrease in anti-KLH IgG accompanied
127 ation including a keyhole limpet hemocyanin (KLH) study and a collagen-induced arthritis (CIA) diseas
128 ted efficacy in a Keyhole Limpet Hemocyanin (KLH) study in rats, where the blockade of PI3Kdelta acti
130 n carrier protein keyhole limpet hemocyanin (KLH) using glutaraldehyde has shown promising results in
133 hallenge with TNP-keyhole limpet hemocyanin (KLH), Ab production in these mice was hapten-, carrier-,
134 ovalbumin (OVA), keyhole limpet hemocyanin (KLH), and a bis-maleimide; KLH conjugates are also made
136 n helper protein, keyhole limpet hemocyanin (KLH), can augment the efficacy of tumor lysate-pulsed de
139 y DCs pulsed with keyhole limpet hemocyanin (KLH), HLA-A*0201-positive restricted influenza matrix pe
140 PC conjugated to keyhole limpet hemocyanin (KLH), T15 Id(+) Abs constitute >90% of the serum Ig in B
141 ion protocol (mAb-keyhole limpet hemocyanin (KLH)-Calmette-Guerin bacillus (BCG), an autologous anti-
142 HDK-1 T cells (a keyhole limpet hemocyanin (KLH)-specific CD4+ Th1 clone) in the presence of KLH, th
148 8 E7 antigens and keyhole limpet hemocyanin (KLH; an immunological tracer molecule) and delivered in
149 ization with Ars-keyhole limpet hemocyanin, (KLH) and at day 6, large clusters of Ars-specific B cell
150 gates of primary (keyhole limpet hemocyanin; KLH) and recall (Bet v 1) Ags (H4B4*KLH and H4B4*Bet v 1
151 against the hypusine-containing hexapeptide-KLH and hypusine-containing hexapeptide-bis-maleimide co
154 upport the evaluation of sulfhydryl-based Id-KLH vaccines in lymphoma clinical trials and possibly th
155 Importantly, standard glutaraldehyde Id-KLH conjugation procedures could result in "overconjugat
163 accination received booster injections of Id-KLH protein, and tumor regression was observed in 3 of t
166 e immunity superior to that obtained with Id-KLH plus a chemical adjuvant, and protection was not dep
168 The administration of Id-pulsed DC and Id/KLH vaccines were well tolerated with patients experienc
175 d to keyhole limpet hemocyanin (KLH) (TCR Id:KLH) and injected with a chemical adjuvant (QS-21) induc
178 demonstrated the ability of the tumor lysate/KLH-pulsed DC to generate specific T-cell responses and
180 onse to PI Ag, and immune sera from m1E41920-KLH-immunized mice was able to inhibit C. burnetii infec
184 0-kDa IL-6 complexes, while 2) sera from mAb-KLH+BCG patients contained 200-kDa IL-6 complexes inacti
186 impet hemocyanin (KLH), and a bis-maleimide; KLH conjugates are also made with the deoxyhypusine- and
187 c activity was lower only in the sera of MEP-KLH conjugate-immunized mice with preexisting antibodies
188 contrast to the native MEP polymer, the MEP-KLH conjugate vaccine induced high titers of MEP-specifi
193 Tn(c), when given with the carrier molecule KLH and QS21, stimulated the production of high-titer im
194 Sera from mice immunized with either native KLH or KLH-g cross-reacted with several other carbohydra
195 ne of beta2-adrenergic receptor (beta2AR)neg KLH-specific Th2 cells and resting trinitrophenyl (TNP)-
200 ophenyl acetyl-keyhole limpet hemocyanin (NP-KLH) and NP-OVA develops within ectopic lymphoid tissue
201 NP)-conjugated keyhole limpet hemocyanin (NP-KLH) or ovalbumin(323-337) peptide, using either U1 RNA
203 with wt, sheep red blood cell (SRBC)-, or NP-KLH-immunized SWAP-70(-/-) mice have strongly reduced nu
204 vivo for normal Th2 humoral responses to NP-KLH (4-hydroxy-3-nitrophenylacetyl/keyhole lymphocyte he
206 djuvant, alum, U1 RNA coadministered with NP-KLH enhanced production of NP-specific IgM and IgG (on d
210 In H4B4*KLH-pulsed MoDC, the duration of KLH residence in MHC class II loading compartments was s
215 oduction of Th2 cytokines and high levels of KLH-specific IgE and induced a Th1-type response with hi
216 -specific CD4+ Th1 clone) in the presence of KLH, they showed conspicuous cell death as measured by p
219 indicating that glutaraldehyde treatment of KLH reveals an epitope(s) that cross-reacts with GXM.
220 ardization issues associated with the use of KLH and BCG in the clinical setting have prompted us to
224 rom mice immunized with either native KLH or KLH-g cross-reacted with several other carbohydrate Ags,
225 MoDC pulsed with H4B4*KLH, but not the other KLH preparations, induced robust proliferation of CD4 ce
226 XM-binding Abs from mice immunized with P315-KLH were inhibited by KLH treated with glutaraldehyde (K
227 e immunological response in cancer patients, KLH is also an immunogenic carrier protein to elicit T-c
231 immunization and booster resulted in reduced KLH-specific T-cell proliferation compared with the grou
232 Analysis of KLH-specific antibody responses, KLH-specific cytokines, and local inflammation demonstra
235 Eleven of the 12 patients generated strong KLH-specific cellular proliferative immune responses sho
240 ollectively, these findings demonstrate that KLH addition to tumor antigen-pulsed DC immunizations ca
244 Also, clones P-MoPn and N-MoPn but not the KLH-1 line migrated to the mesenteric lymph node, sugges
245 tion removed a significant proportion of the KLH-specific cells (mean decrease in proliferative respo
246 elicited low levels of immune response, the KLH conjugates of N-propionyl, N-butanoyl, N-iso-butanoy
250 ir ability to induce Th2 responses after TNP-KLH challenge and that such immunization also leads to a
254 eta early (day 2), whereas LP T cells in TNP-KLH-immunized IL-2+/+ mice exhibit an approximately eigh
256 Even in the presence of overt infection, TNP-KLH-plus-rmIL-12-immunized mice were still capable of ge
257 ty of rmIL-12 to drive a Th1 response to TNP-KLH in the presence of an ongoing Th2-mediated disease.
258 and co-administration of anti-IL-12 with TNP-KLH completely prevented colitis and significantly reduc
259 shed, groups of mice were immunized with TNP-KLH in the presence or absence of exogenous rmIL-12.
260 Moreover, rmIL-12 administered with TNP-KLH late in infection did not alter the parasite-specifi
261 ugate the sTn double C-glycoside hapten 2 to KLH carrier protein for biological evaluation as a vacci
262 % of patients treated with MTX alone) and to KLH vaccine (47% of patients had detectable anti-KLH IgG
268 dult zebra finches against VIP conjugated to KLH and compared neuronal recruitment in their brains, w
271 hydrocodone-based haptens were conjugated to KLH to generate immunogens that would recognize both oxy
273 results indicate that conjugation of MEP to KLH significantly enhances its immunogenicity and the el
276 also controlled Tfh memory cell responses to KLH stimulation more efficiently than CD80/86 blockade.
277 bited T cell-dependent antibody responses to KLH without significant peripheral B cell depletion.
278 nted total IgG, IgG1, and IgG2a responses to KLH/CFA compared with that seen in Ag-fed wild-type mice
280 dition to describing the complexity of using KLH and glutaraldehyde in the development of vaccines to
281 f interferon-gamma (IFN-gamma) and IL-4 when KLH-pulsed B cells or spleen cells were used as antigen
283 atants from (i) CD4(+) T cells cultured with KLH-pulsed DC or (ii) DC cultured with recombinant GM-CS
284 In contrast, maternal immunization with KLH, a T cell-dependent nonmammalian antigen, did not in
285 ponses, respectively, than immunization with KLH-conjugated mAb MK2-23 and separate administration of
289 lymph nodes draining the skin immunized with KLH and their production of IFN-gamma, IL-4, and IL-10 i
290 T cells from GM-CSF -/- mice immunized with KLH showed impaired proliferative responses and produced
291 ns in volunteers parenterally immunized with KLH, regardless of whether a preceding mucosal priming h
293 was observed in all 9 subjects injected with KLH-pulsed DCs, and boosting of TT-specific T-cell immun
294 16 adjuvant intravesical instillations with KLH after preimmunization, and 270 patients were randoml
296 ed streptozotocin-induced diabetic rats with KLH to assess the capacity of the elicited antibodies to
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