ライフサイエンスコーパス: KO

1 itor, and abolished by TRPM2 knockout (TRPM2-KO).

2 nsory cortex of the mouse model of FXS (Fmr1 KO).

3 nsory cortex of the mouse model of FXS (Fmr1 KO).

4 M2 channel inhibitor, and prevented by TRPM2-KO.

5 ) diet was significantly impaired in betaTFG KO.

6 n crystal diameters in beta-cells of betaTFG KO.

7 ase isoforms [NO-GC1 knockout (KO) or NO-GC2 KO].

8 In VDR knockout mouse epithelial cells (KO), 1,25(OH)2D3 increased CYP24A1 and CYP27B1 protein e

9 oped massive albuminuria (controls: 35-fold; KO: 5400-fold versus baseline), hypoalbuminemia, reduced

10 These effects were independent of potential KO actions on network excitation.

11 ed gait alterations in Chn1KO/KO and Epha4KO/KO adult mice.

12 popolysaccharide (LPS) stimulation, and CTSD KO also reduced caspase-3 activation and apoptosis in ac

13 e investigated whether Tric-a gene knockout (KO) alters the single-channel function of skeletal RyR (

14 Mesenteric lymph node cultures from VDR KO and B-VDR KO mice secreted higher IgE ex vivo than wi

15 eviously reported gait alterations in Chn1KO/KO and Epha4KO/KO adult mice.

16 Wildtype, Ucp1-KO and Fgf21-KO mice were placed on control and low prot

17 od between induction of total PP or PP/Trp53 KO and melanoma development indicates that additional ge

18 STIM1-KO and ORAI1-KO cell lines were generated by CRISPR/Cas9

19 the LV-wall adhesions between age-grouped PV-KO and wild-type mice, suggesting a delay in microglial

20 the difference in IgE production between VDR KO and WT cultures.

21 pecific Cx43 knockout in mice (Gja1 (adipoq) KO) and by overexpression and knockdown of Cx43 in cultu

22 meostasis in obesity, we fed A2AAR-knockout (KO) and control mice an HFD for 16 wk to initiate HFD-in

23 induced experimental asthma in ST2 knockout (KO) and wild-type control mice.

24 1(phox) knockout [KO]), iNOS-deficient (iNOS KO), and C57BL/6 wild-type mice were orally infected wit

25 e-N-acetylneuraminic acid hydroxylase (CMAH) KO, and GGTA1/ CMAH /b1,4 N-acetylgalactosaminyl transfe

26 tate receptors (NMDAR) in the NAc core, TLR4.KO animals exhibit a deficit in low-frequency stimulatio

27 GSNOR KO animals receiving WT bone marrow had significantly re

28 om uninfected C57BL/6 WT and C57BL/6 IL-17RA KO animals serving as negative controls.

29 ) elicited hyperalgesia in WT but not in MOR KO animals, as well as in both MOR flox and MOR-Nav1.8 s

30 Some alpha9 and alpha9/10 KO animals, however, had normal or near-normal threshold

31 were lower in the white gastrocnemius of the KO animals.

32 increased reliance on fatty acids in resting KO animals.

33 We observed that Muc4(ko) animals are fertile and develop normally, and adult

34 re further validated using CLEC12A knockout (KO) animals wherein EAE disease induction was delayed an

35 In PDC "knockout" (KO) animals, the long-term regenerative potential of hep

36 The alternative splicing effects of FTO KO anti-correlate with METTL3 knockdown suggesting the i

37 offers several advantages over conventional KO approaches and allows for generation of clean CRISPR/

38 (F-actin) is drastically increased in Rictor KO B cells after BCR stimulation through dysregulating t

39 in polymerization with latrunculin in Rictor KO B cells rescues the defects of BCR signaling and B ce

40 a human ApoE knock-in (KI) or ApoE knockout (KO) background, here we show that P301S/E4 mice have sig

41 , we generated Nlrp3-knockin mice on various KO backgrounds including Il1b/Il18-, caspase-1-, caspase

42 sed the skewed lineage specification of Klf5 KO blastocysts.

43 i ANKA infection compared to those receiving KO bone barrow (P < 0.001).

44 STIM1-KO and ORAI1-KO cell lines were generated by CRISPR/Cas9 genome editi

45 WT cell proliferation, but did stimulate VDR KO cell proliferation.

46 atients were screened on GGTA1/CMAH/B4GalNT2 KO cells and a subset with elevated binding was evaluate

47 this study, we generated and analyzed mNEET KO cells and found that in these cells the mitochondrial

48 d from heterozygous Polbeta mouse tissue and KO cells had lower nucleotide incorporation activity.

49 (-) Triacylglycerol concentrations in the NR-KO cells increased immediately following the addition of

50 s partially restored IL-1 signaling in TRAF6 KO cells, but not in TRAF6/Pellino1/Pellino2 triple-KO c

51 s in PM lipid homeostasis observed in E-Syts KO cells, delayed diacylglycerol clearance from the PM a

52 Unassimilated NO3(-) accumulated in NR-KO cells, resulting in swelling and associated changes i

53 ls, but not in TRAF6 KO or Pellino1/2 double-KO cells.

54 tributing to the enhanced lipolysis in Cav-1 KO cells.

55 s, but not in TRAF6/Pellino1/Pellino2 triple-KO cells.

56 eparan sulfate proteoglycan (HSPG)-knockout (KO) cells by using a clustered regularly interspaced sho

57 Additionally, Phf6(KO) cells show significant down-regulation of genes invo

58 in TRAF6/Pellino1/Pellino2 triple-knockout (KO) cells, but not in TRAF6 KO or Pellino1/2 double-KO c

59 ted podocyte-specific (pod) GC-A conditional KO (cKO) mice.

60 ow gamma (30-60 Hz) activity was elevated in KO compared with OE mice in NREM and REM sleep.

61 58M) ), hESC line expressing no MECP2 (MECP2-KO), congenic pair of wild-type and mutant RTT patient-s

62 ematopoietic DREAM knockout (KO) mice, DREAM KO control and hematopoietic DREAM KO mice showed a sign

63 Tail bleeding time was prolonged in DREAM KO control mice, but not in WT or DREAM bone marrow chim

64 question, heterozygous ERalpha knockout (WT/KO) dams were fed a control breeder chow diet (25% fat)

65 Nevertheless, the TbHrg KO developed normally in the tsetse flies at rates compa

66 Interestingly, betaTFG KO displayed marked glucose intolerance with reduced ins

67 I2 (PGI2, also called prostacyclin) in Cav-1 KO EC, and this PGI2 increase appeared to stimulate cAMP

68 ed specifically in nasal processes of Mllt10-KO embryos.

69 antly decreased in nasal processes of Mllt10-KO embryos.

70 Mice lacking densin (densin KO) exhibit defects in synaptic plasticity, spatial memo

71 d homozygous Mllt10 knockout mutants (Mllt10-KO) exhibit midline facial cleft.

72 SAN cells isolated from the NCX KO exhibited higher SK current than wildtype (WT) and ap

73 We report here the generation of KO-first (Myo10 (tm1a/tm1a) ), floxed (Myo10 (tm1c/tm1c)

74 present after noise exposure in the Foxo3KO/KO fourteen days post noise (DPN).

75 WT), alpha1, 3-galactosyltransferase (GGTA1) KO, GGTA1/ cytidine monophosphate-N-acetylneuraminic aci

76 iveness, we found that Pde11a knockout mice (KO) given 0.4% lithium chow for 3+ weeks exhibit greater

77 MOR KO mice was found in both sexes, in two KO global mutant lines, and for mechanical, heat and col

78 Of note, the CTSD KO greatly reduced CTSB and trypsinogen activation in ac

79 Human kidney cells with Polbeta knockout (KO) had higher endogenous mitochondrial DNA (mtDNA) dama

80 support the use of the newly described STAT2 KO hamster model for evaluation of promising antiviral t

81 ynthasome disassembly in WT, but not in CypD KO heart mitochondria.

82 rial and ventricular tissue from adult MEF2A KO hearts revealed a striking difference in chamber gene

83 ecrease in Nrf2-target mRNA were observed in KO hearts.

84 pon DNAJB6 re-introduction into these DNAJB6-KO HEK293T-alpha-syn cells, aggregation is reduced to th

85 n of cytokines and chemokines in WT and TLR4-KO HSCs.

86 Our findings confirm that Ctcf KO in postnatal neurons causes a neurobehavioral phenoty

87 nducible homozygous deficient mice (Erg (iEC-KO) ), in a SMAD3-dependent manner.

88 ADPH oxidase-deficient (gp91(phox) knockout [KO]), iNOS-deficient (iNOS KO), and C57BL/6 wild-type mi

89 Preceding RGC loss in the Ndufs4 KO is the loss of starburst amacrine cells, which may be

90 tation of Eukaryotic Orthologous Groups) and KO (KEGG Orthology) in addition to Pfam domains; (iii) i

91 rsely, genetic or shRNA-mediated conditional KO/knockdown of GSK3beta reduced inhibitory phosphorylat

92 recognized and ubiquitinated by pVHL in IPMK KO (knockout) cells.

93 Hcrt loss in Hcrt(ko/ko) mice causes impaired TDW maintenance in baseline

94 The low homeostatic impact of Hcrt(ko/ko) mouse spontaneous waking correlates with decrease

95 e second-generation human genome-wide CRISPR-KO libraries that included at least one of the improveme

96 Overall, oxphos activity in KO livers and hepatoblastoma was comparable with that of

97 (GBPs), are downregulated in STING knockout (KO) macrophages infected with Brucella or transfected wi

98 sors was not altered significantly in Ptchd1 KO male mice.

99 ganese homeostasis, we used Zip14 knock-out (KO) male and female mice to conduct comparative metaboli

100 Ptchd1 knock-out (KO) male mice exhibit cognitive alterations, including d

101 FD (45% fat) 4 weeks prior to mating with WT/KO males or heterozygous males with an ERalpha DNA-bindi

102 However, exome sequencing of PP;Trp53 KO melanomas failed to reveal any additional recurrent d

103 1a/tm1a) ), floxed (Myo10 (tm1c/tm1c) ), and KO mice (Myo10 (tm1d/tm1d) ).

104 Il28ra(-/-) and Stat1IEC-KO mice also developed more severe colitis in response t

105 Nat1 KO mice also displayed reduced whole-body energy expendi

106 ocytes to 1% of the control level, Podo-GC-A KO mice and control littermates did not differ in BP, GF

107 affecting LMA; these effects were absent in KO mice and potentiated in OE mice.

108 We generated HSC-specific NOX4 KO mice and these were pair-fed on alcohol diet.

109 Brucella DNA colocalizes with AIM2, and AIM2 KO mice are less resistant to B. abortus infection.

110 We find that RyR1 from Tric-a KO mice are more sensitive to inhibition by divalent cat

111 n the observed osteopenic phenotype of TIEG1 KO mice as well as the known links between TIEG1 express

112 The direction of circuit alterations in Fmr1 KO mice changes across development.

113 e in achieved systolic BP, AngII-treated APA-KO mice developed a significant rise in albuminuria not

114 Finally, DHHC7 KO mice developed hyperglycemia and glucose intolerance,

115 However, only Podo-GC-A KO mice developed massive albuminuria (controls: 35-fold

116 By contrast, Chn1KO/KO mice did not have DRS, and embryos displayed abducens

117 Upon return to normoxia, Ndufs4 KO mice die within days.

118 Both WT and KO mice discriminated between reward and no-reward lever

119 ynaptic connectivity of interneurons in Fmr1 KO mice during a critical period of cortical development

120 Impaired hepatic zinc uptake in Zip14 KO mice during ER stress coincides with greater expressi

121 cells and re-established mortality of IL-15 KO mice during septic shock.

122 During retinal angiogenesis, KO mice exhibit a 50% decrease in endothelial filopodia

123 L2hgdh KO mice exhibit white matter abnormalities, extensive gl

124 betaENaC MG KO mice exhibited a striking age-dependent, female-predo

125 Furthermore, calpain-1 KO mice exhibited impairment in fear memory extinction t

126 urvival curves and organ pathology in Ndufs4 KO mice exposed to hypoxia or hyperoxia.

127 etween reward and no-reward levers; however, KO mice failed to discriminate based on relative quantit

128 taneous and visceral adipose tissue of TRPC1 KO mice fed a HF diet and exercised.

129 During fasting, the KO mice had a defect in fatty acid oxidation.

130 M. tuberculosis-infected IL-21R KO mice had enhanced bacterial burden and reduced infilt

131 the lungs of M. tuberculosis-infected IL-21R KO mice had increased expression of T cell inhibitory re

132 Tumors in CLEC14A-KO mice had increased numbers of nonfunctional blood ves

133 Male WD-fed FXR KO mice had the most severe steatohepatitis.

134 Our data revealed that male WD-fed FXR KO mice had the most severe steatosis and highest hepati

135 We generated KO mice harboring a transgene, TgAC1, consisting of Clrn

136 nd no differences between wild-type and Fmr1 KO mice in overall whisker-evoked activity, though 45% f

137 IL-17C+KO mice initially exhibited decreased skin inflammation;

138 ensity of MR images from brains of the Zip14 KO mice is indicative of major manganese accumulation.

139 didymal white adipose tissue (eWAT) of PDE3B KO mice on a SvJ129 background, cAMP/protein kinase A (P

140 APP-KO mice presented a higher number of circulating platele

141 Moreover, Malat1 KO mice presented larger brain infarct size, worsened ne

142 IL-17 receptor C and Pten double KO mice recapitulated the weak EMT characteristics obser

143 Gja1 (adipoq) KO mice reduced mitochondrial density and increased the

144 vity, though 45% fewer neurons in young Fmr1 KO mice responded in a time-locked manner.

145 otypic characterization of unimmunized ALCAM KO mice revealed a reduced expression of BBB junctional

146 Telemetric analysis from conscious Cx36 KO mice revealed higher variance in heart rate and blood

147 Only infected gp91(phox) KO mice revealed significant loss of alveolar bone volum

148 ic lymph node cultures from VDR KO and B-VDR KO mice secreted higher IgE ex vivo than wild-type (WT)

149 physiology, because both C57BL/6J and Pde11a KO mice show increased expression of the pro-inflammator

150 We show that muscle cells of syndapin III KO mice show severe reductions of caveolae reminiscent o

151 ce, DREAM KO control and hematopoietic DREAM KO mice showed a significant delay in time to occlusion.

152 Compared with controls, Ati-CB1-KO mice showed decreased body weight, reduced total adip

153 SIRT6-KO mice showed degenerated skeletal muscle phenotype wit

154 IL-15 KO mice showed improved survival, attenuated hypothermia

155 After SCI, astrocyte-specific trkB.T1 KO mice showed reduced hyperpathic responses and improve

156 Shisa7 KO mice showed reduced initiation and maintenance of lon

157 NIS KO mice showed undetectable serum T4 and very low serum

158 metabolomic signature associated with MAT1A-KO mice that also was present in 49% of the patients; ba

159 All Myo10 KO mice that survive birth exhibit a white belly spot, a

160 The absence of OIH in MOR KO mice was found in both sexes, in two KO global mutant

161 MAT1A-KO mice were also given SAMe (30 mg/kg/day for 8 weeks);

162 ortical morphology and layering in adult Hdc KO mice were also preserved.

163 patic stellate cells (HSCs) from WT and TLR4-KO mice were assessed in vitro.

164 Livers of MAT1A-KO mice were characterized by high levels of triglycerid

165 GBP(chr3) but not GBP2 KO mice were more susceptible to bacterial infection, an

166 Wildtype, Ucp1-KO and Fgf21-KO mice were placed on control and low protein (LP) diet

167 mory and LTP is dependent upon APP since APP-KO mice were resistant to oAbeta- and oTau-induced defec

168 used, and high salt-fed (ALDO) systemic GC-A KO mice with enhanced phosphorylation of p38 mitogen-act

169 metabolomes of patients with NAFLD and MAT1A-KO mice with steatohepatitis, we identified 2 major subt

170 sults reveal that hungry mice lacking GPR88 (KO mice) were slow to acquire food-reinforced lever pres

171 stently, mGluR-LTD was impaired in calpain-1 KO mice, and the impairment could be rescued by phosphat

172 In contrast to wild-type (WT) and WAVE1 D2-KO mice, cocaine-induced sensitized locomotor behavior w

173 differences in metabolites in the livers of KO mice, compared to WT and Het mice.

174 In NIS KO mice, in the thyroid, stomach, and salivary gland, NI

175 adhesion were altered in the brain of Crmp4-KO mice, mostly in a gender-dependent manner.

176 Moreover, using liver-specific TRbeta1-KO mice, we demonstrate that hypothyroidism-associated c

177 , which cannot interact with the TR, in Pax8-KO mice, which make no thyroid hormone.

178 d injury in previously untreated WT and TLR4-KO mice.

179 lar but less marked changes were seen in PrP KO mice.

180 ker stimulation in both young and adult Fmr1 KO mice.

181 inhibitory neurotransmission evident in Fmr1-KO mice.

182 nt murine CIRP, but not in the lungs of TLR4 KO mice.

183 pressant-like behavioral phenotype of TRIP8b KO mice.

184 re skeletal abnormalities than those of Cx43-KO mice.

185 n quadriceps of control mice but not in ATF3-KO mice.

186 cholinergic interneurons were normal in Hdc KO mice.

187 ides and phospholipids, in WT, but not TRPC5 KO mice.

188 hanced the survival of tumor-bearing CLEC14A-KO mice.

189 nd endothelial integrity in 6 week-old Cd2ap-KO mice.

190 ulated autophagy in the BAT of Gja1 (adipoq) KO mice.

191 d lymphocytes in CD-fed, but not WD-fed, FXR KO mice.

192 ox and MOR-Nav1.8 sensory neuron conditional KO mice.

193 inputs on to these neurons in neonatal Fmr1 KO mice.

194 orptive state were comparable for the WT and KO mice.

195 and mucus production in allergen-treated ST2 KO mice.

196 otor behavior was not maintained in WAVE1 D1-KO mice.

197 on IL-10 secreting B cells was lower in VDR KO mice.

198 adiponectin level compared with that in ApoE-KO mice.

199 n of cytokines and chemokines in WT and TLR4-KO mice.

200 t of invasive prostate cancer in Pten single KO mice.

201 c WT mice and significantly blunted in TRPC5 KO mice.

202 nucleus, are reduced in neurons from densin KO mice.

203 and ameliorates cognitive defects in IL-1R8 KO mice.

204 WT mice, with a reduction observed in TRPC5 KO mice.

205 uld reduce hepatic lymphocytes in WD-fed FXR KO mice.

206 decreased humoral immune response in Rictor KO mice.

207 rse agonist, GR113808 in the PFC of CK2alpha KO mice.

208 mpaired motor function observed in the Zip14 KO mice.

209 Both Tie2-CreNox2 knockout (KO) mice (in which Nox2 was deficient in both endothelia

210 Clrn1 knockout (KO) mice develop hair cell defects by postnatal day 2 (P

211 present study, we found that ALCAM knockout (KO) mice developed a more severe myelin oligodendrocyte

212 urons in the barrel cortex of BC1 knock out (KO) mice display larger excitatory postsynaptic currents

213 Panx3-knockout (KO) mice have more severe skeletal abnormalities than th

214 Knockout (KO) mice have shown that RB plays roles in cell migratio

215 GSNOR knockout (KO) mice infected with Plasmodium berghei ANKA had signi

216 one-specific conditional PKD1-knockout (PKD1-KO) mice models.

217 analysis of tubules isolated from knockout (KO) mice suggested that ClC-K2 is the main basolateral c

218 s study used B cell-specfic Rictor knockout (KO) mice to investigate how Rictor regulates BCR signali

219 PAK4 knock-out (KO) mice were born at Mendelian ratios in both genders.

220 Apolipoprotein E knockout (ApoE-KO) mice were infused with angiotensin II (AngII) for 28

221 from somatosensory cortex of Fmr1 knock-out (KO) mice, a model of Fragile-X Syndrome, to test the E/I

222 In the apolipoprotein E-knockout (ApoE-KO) mice, adiponectin and T-cadherin colocalized on endo

223 control and nonhematopoietic DREAM knockout (KO) mice, DREAM KO control and hematopoietic DREAM KO mi

224 fat diet-induced ER stress using Zip14(-/-) (KO) mice, which exhibit impaired hepatic zinc uptake.

225 onine adenosyltransferase 1a knockout (MAT1A-KO) mice, which have chronically low levels of hepatic S

226 d in the inflamed colons of AKAP12 knockout (KO) mice.

227 ytotoxic T cells (CD8+) in the p65 knockout (KO) mice.

228 ed podocyte-specific Shp2 knockout (pod-Shp2 KO) mice.

229 berculosis infection, using IL-21R knockout (KO) mice.

230 n of NMDARs, we also analyzed PrP knock-out (KO) mice.

231 acy of LY2828360 was absent in CB2 knockout (KO) mice.

232 eloid cell-specific Nrp1-knockout (Nrp1(myel-KO)) mice and applied 2 stringent animal models of sepsi

233 Sspn knockout (Sspn(KO)) mice do not have heart defects, but Nkx2-5(+/-)/Ssp

234 ood-lymphatic mixing and lethality of CLEC-2 KO models, but not their hemostatic/thrombotic defect.

235 Sequential glycan KO modifications significantly reduce antibody binding o

236 We used DAT-KO mouse as model for DTDS to explore the potential util

237 xpression remained unaltered in adult WT and KO mouse brain, SC, and kidneys.

238 Thus, in the Ndufs4 KO mouse model of mitochondrial optic neuropathy, papave

239 vention studies using DBA2/J and Nos3 (eNos) KO mouse models of diabetes, TEPP-46 treatment reversed

240 expression was about the same in both WT and KO mouse visceral yolk sac, brain, and spinal column.

241 DAT-Knockout (DAT-KO) mouse is currently the best animal model for this sy

242 dence for this problem in the Fmr1-knockout (KO) mouse model of Fragile X syndrome and describe poten

243 A conditional betaENaC MG knockout (KO) mouse model was generated to elucidate the pathogene

244 cific Na(+) /Ca(2+) exchange (NCX) knockout (KO) mouse, a model of cellular Ca(2+) overload.

245 r outflow tract, but in the Nkx2-5(+/-)/Sspn(KO) mutant they commonly deviate into the septum even in

246 not have heart defects, but Nkx2-5(+/-)/Sspn(KO) mutants have a higher incidence of muscular VSD than

247 tological analysis of lung lesions from Muc4(ko)/NDL mice revealed a reduced association of dissemina

248 Moreover, isolated cells derived from Muc4(ko)/NDL tumors interact with fewer blood cells when inje

249 eficit in HSP is bidirectional because Mecp2 KO neurons also failed to scale down mEPSC amplitudes an

250 PA-type of glutamate receptors in HSP, Mecp2 KO neurons have lower levels of early endosome antigen 1

251 egradation and why this is defective in Fmr1 KO neurons is unknown.

252 ation of a molecular deficit in HSP in Mecp2 KO neurons provides potentially novel targets of interve

253 In addition, expression of EEA1 in Mecp2 KO neurons reduced mEPSC amplitudes to wild-type levels,

254 xin (TeNT), also in TI-VAMP/VAMP7 knock-out (KO) neurons).

255 omotor activity (LMA) were recorded in Taar1 KO, OE, and WT mice.

256 Conditional KO of Prlr from neuronal subpopulations expressing the n

257 strate that a CRISPR/Cas9-mediated knockout (KO) of a DnaJ protein, DNAJB6, in HEK293T cells expressi

258 f AKT rescued GCB-DLBCL lines from knockout (KO) of the BCR or 2 mediators of tonic BCR signaling, SY

259 Specifically, Cav1.2(KO) OPCs mature slower and produce less myelin than cont

260 ion was combined with either AMPK beta1beta2 KO or alpha2KD, contraction-stimulated glucose transport

261 triple-knockout (KO) cells, but not in TRAF6 KO or Pellino1/2 double-KO cells.

262 guanylate cyclase isoforms [NO-GC1 knockout (KO) or NO-GC2 KO].

263 ot seen in PKR-like ER kinase knockout (PERK-KO) or phosphodeficient eukaryotic translation initiatio

264 on knocked in (WT/KI) to produce WT, ERalpha KO, or ERalpha KIKO females lacking ERE-dependent ERalph

265 ed aberrant Tuj1(+) neuronal migration in RB-KO organoids and upregulation of the gene encoding VLDLR

266 Corroborating the results in RB-KO organoids in vitro, we observed ectopically localized

267 al transplant patients to 3 glycan knockout (KO) pig cells and class I swine leukocyte antigens (SLA)

268 -acetylgalactosaminyl transferase (B4GalNT2) KO pigs were screened for human antibody binding using f

269 CD163 knockout (KO) pigs are resistant to infection with genotype 2 (typ

270 te the marked reduction of GC-A mRNA in GC-A KO podocytes to 1% of the control level, Podo-GC-A KO mi

271 is sufficient to cause the apneas in Necdin-KO pups, and that fluoxetine may offer therapeutic benef

272 In Necdin-KO pups, the genetic deletion of Slc6a4 or treatment wit

273 The Cyp3a1/2 double KO rat model was successfully generated and characterize

274 Using CRISPR/Cas9, we generated HID-1 KO rat neuroendocrine cells, and we show that the absenc

275 on was completely absent in the liver of the KO rat.

276 However, experiments with Kv1.3 KO rats and Kv1.3 siRNA knockdown or channel-specific in

277 The Cyp3a1/2 double KO rats were viable and fertile, and had no obvious phys

278 as no change in mitochondrial content in the KO rats, maximal ADP-stimulated respiration was higher i

279 n at various intensities was impaired in the KO rats.

280 CYP3A1/2 was functionally inactive in double KO rats.

281 ethanol-trained wild-type (WT), but not Tlr4 KO rats.

282 mune responses are normal in Kv1.3 knockout (KO) rats, suggesting that KCa3.1 can compensate for the

283 KO reduced both beta and gamma local field potential osc

284 III is crucial for caveolar invagination and KO rendered the cells sensitive to membrane tensions.

285 Frataxin KO results in fatal cardiomyopathy, whereas skeletal mus

286 xpression of AtGET3a in a receptor knockout (KO) results in severe growth defects, suggesting presenc

287 er genes, leading to premature senescence of KO siliques, whereas RCS and senescence marker levels in

288 of CLEC-2 in vivo have focused on knockout (KO) studies in which both the receptor and its signaling

289 We generated beta-cell-specific Syn-1A-KO (Syn-1A-betaKO) mice to mimic beta-cell Syn-1A defici

290 We also present reasons why KO(t)Bu is an active catalyst whereas sodium tert-butoxi

291 The unique role of KO(t)Bu is traced, in part, to the stabilization of cruc

292 r a neutral heterolytic route involving the [KO(t)Bu]4 tetramer.

293 ed ectopically localized Tuj1(+) cells in RB-KO teratomas grown in vivo Taken together, these results

294 n rates of MG cells derived from betaENaC MG KO than control mice, suggesting that betaENaC plays a r

295 revealed smaller beta-cell masses in betaTFG KO than in controls, likely attributable to diminished b

296 reduced only at 1 h, whereas in the complete KO, this effect also included the late disease phase (8

297 flex increased and the duration decreased in KO versus WT rats.

298 Using the mouse model of FXS (Fmr1 KO), we demonstrate that functional maturation of audito

299 eta-cell specific TFG knockout mice (betaTFG KO) were generated.

300 ine embryos lacking EPH receptor A4 (Epha4KO/KO), which is upstream of alpha2-chimaerin in corticospi