ライフサイエンスコーパス: Kirsten

1 Kirsten-Ras (K-Ras) knockout fibroblasts express undetec

2 s in codons 248 and 273 of TP53 and codon 12 Kirsten-ras (KRAS) are commonly found in human carcinoma

3 fic TM isoforms in transformed cells using a Kirsten virus-transformed cell line (ATCC NRK1569) as a

4 red with those expressing G35 to A activated Kirsten ras.

5 epidermal growth factor receptor (EGFR) and Kirsten ras (KRAS) confer sensitivity and resistance, re

6 over-expression of both wild-type Harvey and Kirsten Ras proteins as contributors to rat mammary carc

7 Oncogenic mutations in B-Raf and Kirsten-Ras (K-Ras) are mutually exclusive during human

8 s not present in human neutrophils, but both Kirsten-ras (K-ras) and Neuronal-ras are.

9 Elevated expression of either c-Kirsten A-Ras or c-Kirsten B-Ras did not reverse the apo

10 ed expression of either c-Kirsten A-Ras or c-Kirsten B-Ras did not reverse the apoptotic sensitivity

11 We additionally compared Kirsten rat sarcoma viral oncogene homolog (KRAS) mutati

12 Exclusive activation of either the Harvey-, Kirsten-, or N-ras gene is often found in human and rode

13 1 (lung adenoma susceptibility 1) and Kras2 (Kirsten rat sarcoma oncogene 2) genes as primary candida

14 n 0.5 Mb in which at least two genes, Kras2 (Kirsten rat sarcoma oncogene 2) and Casc1 (cancer suscep

15 nesylation and carboxymethylation of KRAS4b (Kirsten rat sarcoma isoform 4b) are essential for its in

16 dermal growth factor receptor (EGFR), mutant Kirsten rat sarcoma viral oncogene homolog (Kras), or ov

17 Notably, Kirsten rat sarcoma (KRAS)-driven tumors have been repor

18 Expression of Kirsten rat sarcoma viral oncogene [Kras(G12V)] and disr

19 ene derivatives bind to transient pockets on Kirsten-Ras (K-Ras) and inhibit GDP-GTP exchange.

20 lung cancer based on activation of oncogenic Kirsten rat sarcoma viral oncogene homolog (Kras) and lo

21 Aberrant expression of the oncogenic Kirsten-Ras (Ki-Ras) and interferon-stimulated gene 15 (

22 e activated or wild-type forms of Harvey- or Kirsten-ras.

23 K-Ras (Kirsten-rat sarcoma viral oncogene homolog) is a promine

24 Of the three different isoforms of Ras (Kirsten, Harvey, and Neural), we previously demonstrated

25 noma (PDAC) involves activation of c-Ki-ras2 Kirsten rat sarcoma oncogene homolog (KRAS) signaling, b

26 The vi-Ki-ras2 Kirsten rat sarcoma viral oncogene (KRAS) represents one

27 Directly targeting oncogenic V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (K-Ras) with

28 se (ALK), EGF receptor (EGFR), and V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) are ma

29 imaging to provide a signature for V-KI-RAS2 Kirsten rat sarcoma viral oncogene homolog (KRAS) gene m

30 Additional activation of v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) networ

31 viral oncogene homolog B1 (BRAF), v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS), or ep

32 kers were associated with non-pCR; v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog mutation (P =

33 h both tumor protein p53 (p53) and v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog mutations had

34 her, in patients with both p53 and v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog mutations or

35 ey ras expression was 1.5-2-fold higher than Kirsten ras or N-ras at each adult stage of development,

36 Activating mutations in the Kirsten rat sarcoma viral oncogene homolog (KRAS) underl

37 Mutations in the Kirsten-ras (K-ras) oncogene occur early and frequently

38 th colorectal liver metastases (CRLM) is the Kirsten rat sarcoma viral oncogene homolog (KRAS); howev

39 carrying either three or seven copies of the Kirsten ras gene under the same promoter (HrKr) were pro

40 er a (Clec9a) locus causes expression of the Kirsten rat sarcoma viral oncogene homolog (Kras)(G12D)

41 Neural), we previously demonstrated that the Kirsten isoform is key in the control of renal fibroblas

42 To examine whether the Kirsten rat sarcoma viral oncogene homolog (KRAS)-varian

43 survival disadvantage, especially within the Kirsten rat sarcoma viral oncogene homolog (KRAS) mutant

44 orexin receptor 1 (HcrtR1/OX(1)R) but not to Kirsten murine sarcoma virus transformed rat kidney epit

45 sing wild-type Harvey ras, but not wild-type Kirsten ras.

46 nitumumab on cell lines expressing wild-type Kirsten-Ras (K-Ras) and oncogenic K-Ras mutations.

47 ostate epithelial cells transformed by viral Kirsten-ras (267B1/Ki-ras cells) compared with those in

48 erall survival was found among patients with Kirsten rat sarcoma viral oncogene homolog (KRAS)-mutate