ライフサイエンスコーパス: L

1 mycin MIC was 0.28 mg/L (range, <0.016-24 mg/L).

2 -3-xyloside-galactoside (C3XG, 49.56-70.12mg/L).

3 drophobic peptides (IC50 between 12 and 21mg/l).

4 RT-qPCR reduction between 300 and 360 mg-min/L.

5 ent in those with 25(OH)D status below 20 ng/l.

6 he biosensor with putrescine oxidase was 1mg/L.

7 -1.93) for participants with serum CRP >3 mg/L.

8 nmol/L, and insufficiency as PLP 20-30 nmol/L.

9 by these flavors, it never exceeded 20microg/L.

10 he upper detectable concentration of 300 mug/L.

11 eting the ITS region of Carthamus tinctorius L.

12 95% probability could be estimated at 2.0 kU/l.

13 at concentrations ranging from 25 to 172 mug/L.

14 ctrochemical system, with up to 880 mg of Nd L(-1) achieved within 4 days (at 40 A m(-2)).

15 1)) or branched enoic acids (1.12 +/- 0.06 g L(-1)) in the presence of a dehydratase at 44% and 87% y

16 iral 2-methyl-3-hydroxy acids (1.1 +/- 0.2 g L(-1)) or branched enoic acids (1.12 +/- 0.06 g L(-1)) i

17 those in urine and wastewater (0.004-1.5 mug L(-1)) were at the level usually found in real-world app

18 hs-cTnI<2 ng/L), single cutoff (hs-cTnI<5 ng/L), 1-hour algorithm (hs-cTnI<5 ng/L and 1-hour change<2

19 eet-wide mean of 5.6 L/100 km in 2014 to 3.0 L/100 km by 2030.

20 n improvements from a fleet-wide mean of 5.6 L/100 km in 2014 to 3.0 L/100 km by 2030.

21 x 106/l +/- 18.94 control versus 1,092 x 106/l +/- 165 trauma, p < 0.0005) and CD14+HLA-DRlow/- monoc

22 CD16BRIGHT CD62LDIM neutrophils (82.07 x 106/l +/- 18.94 control versus 1,092 x 106/l +/- 165 trauma,

23 AgBF4 formed the metal-free radical dication L(.2+) .

24 boxylbetaine) (pCB) and four surface-binding l-3,4-dihydroxyphenylalanine (DOPA) groups, pCB-(DOPA)4,

25 and CD14+HLA-DRlow/- monocytes (34.96 x 106/l +/- 4.48 control versus 95.72 x 106/l +/- 8.0 trauma,

26 rcuits of a population of cells in V1 layer (L)4B that project to area V2.

27 x 106/l +/- 4.48 control versus 95.72 x 106/l +/- 8.0 trauma, p < 0.05) and reduced leukocyte cytoki

28 the protection of cells from the toxicity of l-Abeta42 at concentrations up to 50 mum.

29 microtubules are the cellular targets of the L-acetate fraction.

30 on in murine macrophages, compared it to the LD adipose differentiation-related protein (Adrp)/perili

31 count of lower than 30 x 10(9) platelets per L, aged at least 18 years, with refractoriness, ineligib

32 rodrug metabolite formation, yet exacerbated L-ala,SP + amiodarone effects, implicating the prodrugs

33 Cathepsin A (CatA) inhibitors attenuated L-ala,SP prodrug metabolite formation, yet exacerbated L

34 Co-applied with amiodarone, L-ala,SP prodrugs increased beating rate and decreased b

35 beta-methylamino-L-alanine (BMAA) has been linked to several interrelated

36 the rabies virus genome, we demonstrate that L alone initiates synthesis on naked RNA and that P serv

37 lls (293T/S-alphaPEG, short-type cells; 293T/L-alphaPEG, long-type cells; 293T/SL-alphaPEG, hybrid-ty

38 d/l-Amino acid mixtures play a key role in human physiolog

39 ionization mode, the application of 10 mmol/L ammonium formate led to the best findings, while the u

40 cTnI<5 ng/L), 1-hour algorithm (hs-cTnI<5 ng/L and 1-hour change<2 ng/L), and the 0/1-hour algorithm

41 ticipants with serum CRP levels of 1 to 3 mg/L and 1.12 (95% CI, 0.65-1.93) for participants with ser

42 Its detection thresholds were 10microg/L and 11microg/L in must and wine model solution, respec

43 ns for pseudouridine were 2.89/5.67 micromol/L and 39.7/33.9 micromol/mmol creatinine.

44 entrations of 17beta-estradiol (E2beta; 2 ng/L and 50 ng/L) during four distinct stages of developmen

45 Tregs expanded using soluble OX40 L and JAG1 were of suppressive phenotype and delayed the

46 n rule was platelet count >110 x 10(9) cells/L and LSM <25 kPa.

47 l cells that receive nonselective input from L and M cones.

48 r has a limit of detection (LOD) of 0.11 mug/L and the upper detectable concentration of 300 mug/L.

49 crog/L; interquartile range, 6.5-14.9 microg/L) and controls (median, 12.2 microg/L; interquartile ra

50 atelets per L vs >/=10 x 10(9) platelets per L) and disease (MDS vs AML).

51 ncreased in patients with MCI (mean, 42.8 ng/L) and patients with AD dementia (mean, 51.0 ng/L) compa

52 ns using Linkage Disequilibrium method (LAMP-LD) and evaluated the association with common carotid ar

53 rithm (hs-cTnI<5 ng/L and 1-hour change<2 ng/L), and the 0/1-hour algorithm recommended in the Europe

54 n B-6 deficiency was defined as PLP <20 nmol/L, and insufficiency as PLP 20-30 nmol/L.

55 ometric mean SF concentrations were 6-21 mug/L, and prevalences of ID and IDA were 28-85% and 21-35%,

56 Baby-led approaches to complementary feeding, which promote s

57 investigated 81 saffron samples produced in L'Aquila, Citta della Pieve, Cascia, and Sardinia (Italy

58 On the contrary, hydrolysis with an alpha-l-arabinofuranosidase, removing single terminally-linked

59 nerated acidic H2 O2 can oxidize l-Arginine (l-Arg) into NO for enhanced gas therapy.

60 more, the generated acidic H2 O2 can oxidize l-Arginine (l-Arg) into NO for enhanced gas therapy.

61 ucoside-ferrulic acid (C3XGGF, 60.85-74.22mg/L) as the most abundant anthocyanin compound, followed b

62 decrease) compared with the anterior sclera (LD-AS decrease) reference plane (hazard ratio, 3.23; P <

63 ABSTRACT: Because the lipid droplet (LD)-associated perilipin (PLIN) proteins promote intramu

64 in fruits, leaves, stems and roots of three L. barbarum varieties ('No.

65 sistently low (lactate dehydrogenase < 100 U/L, below analyzer range; aspartate aminotransferase 0 ho

66 essary and sufficient for starvation-induced LD biogenesis.

67 d more frequently with the Bruch's membrane (LD-BM decrease) compared with the anterior sclera (LD-AS

68 ononuclear cells from patients infected with L. braziliensis and reduced IL-1beta levels after cure.

69 study, the role of AnxA1 was investigated in L. braziliensis-infected BALB/c mice.

70 Screening led by either specialists or ICU teams was equally prefe

71 on, identifying an important role for CaV1.3 L-CDF in regulating neuronal excitability.

72 rogation of paired H chain V region (VH) and L chain V region (VL) sequences of individual and Ag-spe

73 n RV144 V2 Ab but paired with a mouse lambda L chain.

74 sulted in human VH pairing with mouse lambda L chains instead of allowing otherwise subdominant V2-gl

75 ethnographic study of nurses' roles in nurse-led chemotherapy clinics, including semi-structured inte

76 We evaluated the associations among ESI and LS, circumferential strain, and e' velocity using multiv

77 and patients with AD dementia (mean, 51.0 ng/L) compared with controls (mean, 34.7 ng/L) (P < .001) a

78 reas mutation of Arg36 (R36W) or Arg35 (R35H/L) completely abolished DNA binding, mutation of Arg60 (

79 with CuI formed the unique, neutral Cu2 I2 (L(.) ) complex of a ligand-centered radical, whereas rea

80 antification of both the concentration and d/l composition of amino acids is very promising for the s

81 beta-hGly residue instead of a (S)-beta-Caa(l) constituent.

82 Twenty-eight (96.6%) of 29 available LS CRCs demonstrated abnormal MSI/MMR results.

83 , we explore the effect of low dose N-acetyl-L-cysteine therapy, delivered using a targeted, systemic

84 tensity was higher in in-line than in angled LS DESI MS.

85 ng this high quality AlN template: a deep UV-LED device fabricated and showed a strong single sharp e

86 llowing for further re-growth of the deep UV-LED device.

87 replete, and excess iron stores (SF >100 mug/L) did not appear to be a concern.

88 ents known as dyskinesia upon treatment with L-DOPA.

89 f 17beta-estradiol (E2beta; 2 ng/L and 50 ng/L) during four distinct stages of development: gonad dev

90 ents with initial normal lactate (< 2.2 mmol/L), elevated lactate (>/= 2.2 to < 4 mmol/L), or severe

91 running a program for 17h that turned on an LED every 60s.

92 diated by the iron dipyrrinato complex ((Ad) L)FeCl(OEt2 ) provided a model for diastereoinduction an

93 concentrations are as follows: 120-360 mumol/L for individuals aged 0-12 years and for maternal PKU,

94 ears and for maternal PKU, and 120-600 mumol/L for non-pregnant individuals older than 12 years.

95 es comprehensive risk estimation of all five LS genes and supports LS genetic testing for individuals

96 arbored several exclusive, lineage-specific (LS) genes within LS regions (LSRs).

97 estimation of all five LS genes and supports LS genetic testing for individuals with scores >/= 2.5%.

98 atients harboring a WBC count >/=200 x 10(9)/L, gHiR classifier, and MRD >/=10(-4) demonstrated a 5-y

99 patients (30%) with a WBC count <200 x 10(9)/L, gLoR classifier, and MRD <10(-4) had a very low risk

100 with cholesterol, in the presence of EFV or l-Glu, suggest that water displacement from the heme iro

101 ta and observe that three methods, HUBALIGN, L-GRAAL and NATALIE, regularly produce the most topologi

102 hensive annotated transcriptome assembly for L. granatensis.

103 ompound exhibits a spin transition between a LS ground state and an ordered HS-LS phase with symmetry

104 ficiency (EQE) of about 0.03%, for a deep UV-LED grown on Si substrate.

105 from seeds of common beech (Fagus sylvatica L.) has been presented.

106 epifluorescence microscopy under high power LED illumination, followed by serial image section decon

107 n (MIC) was 4 mg/L in 78 (69.6%) and </=2 mg/L in 34 (30.4%) isolates.

108 imum inhibitory concentration (MIC) was 4 mg/L in 78 (69.6%) and </=2 mg/L in 34 (30.4%) isolates.

109 tion thresholds were 10microg/L and 11microg/L in must and wine model solution, respectively.

110 d neutrophilia (HR, 1.06 per 109 neutrophils/L increase; 95% CI, 1.03-1.10).

111 Thus the increase of miRNP stability in Ld-infected cells curtails production of proinflammatory

112 a diagnosis of dementia (median, 11.5 microg/L; interquartile range, 6.5-14.9 microg/L) and controls

113 microg/L) and controls (median, 12.2 microg/L; interquartile range, 7.3-16.0 microg/L; P < .001).

114 complexity of bread wheat (Triticum aestivum L.) is a cornerstone in the quest to unravel the process

115 Leafy spurge (Euphorbia esula L.) is an herbaceous perennial weed that maintains its p

116 he domesticated sunflower, Helianthus annuus L., is a global oil crop that has promise for climate ch

117 The average sensitivity of LS-IVCM for detecting fungal filaments was 71.4% +/- 0%

118 Y., Kazimirova, M., Roller, L., Jobichen, C., Swaminathan, K., Mizuguchi, J., Iwanag

119 -1203), are constructed from Ca(2+) ions and l-lactate [CH3CH(OH)COO(-)], where Ca(2+) ions are bridg

120 graphic analysis of allosterically inhibited L-lactate dehydrogenase.

121 chiral metal-organic frameworks (MOFs), Ca14(l-lactate)20(acetate)8(C2H5OH)(H2O) (MOF-1201) and Ca6(l

122 20(acetate)8(C2H5OH)(H2O) (MOF-1201) and Ca6(l-lactate)3(acetate)9(H2O) (MOF-1203), are constructed f

123 The enzyme interconverts d- and l-lactic acid, which is important for the assembly of ce

124 ng ultrahigh molecular weight amorphous poly-l-lactic acid-based BRS (APTITUDE, Amaranth Medical [AMA

125 rizations of selected diluents with a poly(d,l-lactide) (PLA), polydimethylsiloxane (PDMS), or polyst

126 gens via the gut through Lactococcus lactis (L. lactis) has been demonstrated to be a promising appro

127 n of an elastomer-mounted extreme high-power LED lamp and a swimming soft robot.

128 sponse surface experiments showed that a 10g/l liquid to solid ratio, 58% acetone, and 12h extraction

129 pure water permeability (PWP) of 82.5-117.6 L m(-2) h(-1) bar(-1).

130 The biochemical characterization of the L. major phosphatase revealed that the enzyme is redox s

131 te that the 65 kDa protein encoded by CPSF30-L mediates nitrate signaling in part by regulating NRT1.

132 n microbial community affects performance in L. melissa.

133 Here we report a versatile S-adenosyl-l-methionine (SAM)-dependent enzyme, LepI, that can cata

134 found in human cones, i.e. long-wavelength (L)-, middle-wavelength (M)-, and short-wavelength sensit

135 Using a mouse model of foodborne L. monocytogenes infection, a reduced number of the muta

136 demonstrated that a low concentration (10 mg/L) Na humate solution in synthetic water significantly i

137 e centered in a region with a high degree of LD near the AHSG locus.

138 disability abolished the spacing effect and led neurons to decode distinct stimulation patterns as m

139 eased minor amounts of cis- and up to 35 mug/L of trans-4-MCHM into water, indicating 4-MCHM was pres

140 Instead, decreased peak ICa-L offsets increased SR load such that Ca(2+) release fro

141 The L(OH) complex maintains its SOD activity in the presence

142 Inner membrane-anchored long OPA1 (L-OPA1) undergoes proteolytic cleavage resulting in shor

143 r amounts of alpha4 or beta2 subunits in the LS or HS nAChR populations, respectively.

144 ns requiring immediate intervention and that led (or could have led) to major disability or death.

145 ol/L), elevated lactate (>/= 2.2 to < 4 mmol/L), or severe hyperlactatemia (>/= 4 mmol/L), the freque

146 EGs) were found in LD vs MD, LE vs ME, LE vs LD, or ME vs MD comparisons.

147 ng/L) compared with controls (mean, 34.7 ng/L) (P < .001) and had high diagnostic accuracy for patie

148 15.6 +/- 9.3 U/L vs 7 hours, 24.8 +/- 14.6 U/L, P = 0.298).

149 crog/L; interquartile range, 7.3-16.0 microg/L; P < .001).

150 uced in delayed-start patients (from -2.26 g/L per year to -1.26 g/L per year), but no significant di

151 rt patients during this time period (-1.51 g/L per year to -1.63 g/L per year), thus in early-start p

152 patients (from -2.26 g/L per year to -1.26 g/L per year), but no significant difference was seen in t

153 s time period (-1.51 g/L per year to -1.63 g/L per year), thus in early-start patients the efficacy w

154 centration range of 6.3x10(-7)-1.0x10(-3)mol/L perchlorate.

155 nsits into a magnetically distinguishable HS-LS phase with monoclinic P21 symmetry before returning i

156 between a LS ground state and an ordered HS-LS phase with symmetry breaking from monoclinic P21/n in

157 linic P21 symmetry before returning into the LS phase.

158 utant mouse (Dclre1c(leaky)) that develops a LS phenotype.

159 replacing tyrosine 48 with p-carboxy-methyl-l-phenylalanine (pCMF).

160 the nonoxidative elimination of ammonia from l-phenylalanine to give trans-cinnamate.

161 pecific incorporation of a clickable p-azido-L-phenylalanine to Uox and strain-promoted azide-alkyne

162 oreactive, non-natural amino acid, p-benzoyl-l-phenylalanine, into various positions of the structura

163 the gene encoding LegC4 resulted in enhanced L. pneumophila in the lungs of infected mice but not wit

164 roximity labeling to study the regulation of LD proteomes.

165 on dand5 expression pattern and left-right (L-R) axis establishment.

166 Mean azithromycin MIC was 0.28 mg/L (range, <0.016-24 mg/L).

167 xclusive, lineage-specific (LS) genes within LS regions (LSRs).

168 C3 and PC3-TXR cells was 55.6 and 2,580 nmol/L, respectively, but decreased to 49.8 and 93.2 nmol/L w

169 ion (-21 +/- 212 compared with 24 +/- 184 mU/L, respectively; P = 0.9).

170 3% vs. 67.9%, p = 0.8897) between CT-RFA and L-RFA.

171 gars and sugar derivatives tested, including l-ribulose.

172 L. rubellus appears to provide an exemplary system for e

173 (LD)-weighted genic annotation scores, total LD scores and heterozygosity.

174 andomized controlled studies comparing nurse-led self-management interventions to usual care Seven el

175 accumulation of Tyr359-phosphorylated hnRNP L sequesters miR-574-3p, overcoming its decoy activity a

176 However, dorsal hippocampus inputs to LS showed enhanced neuronal activation (as measured by F

177 egies: limit of detection (LOD, hs-cTnI<2 ng/L), single cutoff (hs-cTnI<5 ng/L), 1-hour algorithm (hs

178 on were synthesized from a readily available l-sorbose-derived ketonitrone.

179 ata provide an important resource for future LD studies and demonstrate the utility of proximity labe

180 ree species of snappers (Lutjanus purpureus, L. synagris, and Ocyurus chrysurus).

181 l-Th enhances the umami taste but its use is limited due

182 ol/L), or severe hyperlactatemia (>/= 4 mmol/L), the frequency of citrate accumulation was 0.77%, 2.7

183 In rodents, URMC-099 activation of autophagy led to 50-fold increases in the plasma drug concentratio

184 ng storage by the use of the coatings, which led to a 2-fold increase in plum storability.

185 Loss of circular fibres led to a bifurcated anterior-posterior axis with fused h

186 stal packing would improve solubility, which led to a change from N-methylpyridone to a tetrahydropyr

187 Overall, (68)Ga-PSMA PET/CT scanning led to a change in planned management in 51% of patients

188 All images led to a clear final diagnosis.

189 gamma-Irradiation led to a decrease in the concentration of gamma- and del

190 Oral leniolisib led to a dose-dependent reduction in PI3K/AKT pathway ac

191 ely singly scattered light-to reveal GCs has led to a focus on multiply-scattered, fluorescence, two-

192 After 3 years, surgery led to a gain of 0.199 QALYs compared with no surgery at

193 who required surgery, mepolizumab treatment led to a greater reduction in the need for surgery and a

194 increased basal colonic inflammation, which led to a less-diverse microbiome and loss of protective

195 CD11d deficiency led to a marked reduction in lipid deposition in aortas

196 ed with either 1 or 10 ng venlafaxine, which led to a rapid reduction (90%) of this drug in the embry

197 ay occur in one-third of patients, which has led to a search for alternative techniques such as multi

198 ally, vigilin downregulation in target cells led to a significant increase in NK cell activation agai

199 17beta-estradiol led to a significant upregulation in pentose phosphate f

200 oss of Sin3a in mouse early foregut endoderm led to a specific and profound defect in lung developmen

201 We found that the CARD8-FS variant led to a truncated CARD8 protein lacking the FIIND and C

202 The NIMH supported efforts have led to a vast increase in the amount of genetic and geno

203 This promoted myelin clearance but led to abnormalities in nonmyelinating and myelinating S

204 This work has led to advancements in a number of crucial sensing domai

205 Surprisingly, dnGluN1 expression led to an enhancement in the motivation to self-administ

206 Conversely, JMJD2B silencing led to an enhancement of the DNA-damage driven induction

207 age ZIKV infection of pregnant women's blood led to an exacerbated M2-skewed immunosuppression of non

208 ol structural unit in the pyranoanthocyanins led to an increase in their interaction with aPRPs.

209 However, roasting led to an increase in water absorption capacity (0.89-3.

210 mbining PvACR3 expression with HAC1 mutation led to As hyperaccumulation in the shoots, whereas combi

211 Protein design advancements have led to biotechnological strategies based on more stable

212 While ATP depletion led to cell death, over-acetylated tubulin led to inhibi

213 Structural optimization led to compound 28, which was 4-fold more potent than it

214 Pdx1 deficiency led to decreased Atf5 transcript, and primary islet ChIP

215 ling techniques showed that the pretreatment led to depectination of the outer layers thereby exposin

216 tical studies of electrosensory systems have led to detailed accounts of how negative images are form

217 diphenyl sulfide radical cation that in turn led to diphenyl sulfoxide.

218 ction of PU.1 with target gene promoters and led to downregulation of canonical PU.1 transcriptional

219 More intense processing conditions led to enzyme inactivation.

220 c mice with high titers of IgG1 anti-3F7.A10 led to glomerular deposits of IgG1/IgG2a complexes.

221 n shuttles, and the consequent ion migration led to high anode salinities and conductivity that favor

222 Msh3 overexpression led to high expansion activity and elevated levels of Mu

223 he transient activation of viral replication led to HIV-1 reservoir reduction after viremia resuppres

224 ss expression of CXCR4, which, when blocked, led to HSC mobilization and prolonged islet allograft su

225 methylpropanamide moieties at the 2-position led to identification of compound 25 as a potent and sel

226 ogenesis of different amyloid types and have led to identification of numerous new amyloid types, inc

227 ers of RCC cells to TRAIL-mediated apoptosis led to identification of the 17beta-hydroxywithanolide (

228 macrophages exposed to HIV-related proteins led to increased caspase 3 activation and reduced Bcl-2

229 Further, inhibition of MARKs led to increased pathological alpha-synuclein burden.

230 Active compared to sham tDCS led to increased performance in the orienting (mean diff

231 n led to cell death, over-acetylated tubulin led to inhibition of motility and mitosis.

232 These substitutions led to inhibitors with increased PACE4 selectivity and p

233 This stereochemical probe led to inversion of configuration in a kinetic resolutio

234 hifted dispersive waves were generated which led to large broadening from 1.5 um-25 um.

235 fluctuations, the energy-normalized signals led to larger values of MR and higher intelligibility th

236 ls prevented recovery from MRV infection and led to lethality in infected animals, whereas B cell-def

237 In this randomized trial, off-pump CABG led to lower rates of 5-year survival and event-free sur

238 d with other non-CBF aberrant karyotypes and led to lower remission rates (complete remission + compl

239 reasing presynaptic activity, which actually led to LTP in PE animals, whereas LTD was still observed

240 Improvements in care and treatment have led to more young adults with life-limiting conditions l

241 Perkinsea infections (SPI) were systemic and led to multiorganic failure and death.

242 ional depletion of Foxp1 in bone marrow MSCs led to premature aging characteristics, including increa

243 igation speed at endoluminal CT colonography led to progressive restriction of visual search patterns

244 Infection with low-dose A/X31 H3N2 led to prolonged deterioration of lung function, aggrava

245 lar to in many women with PCOS, DHT exposure led to reduced adiponectin levels, larger adipocyte size

246 osome, spurious poly(A) additions to mt-tRNA led to reduced levels of aminoacylated pool of certain m

247 ion in the quality of evoked potentials that led to reduced performance on the BCI task.

248 ent human papillomavirus (4vHPV) vaccine has led to reductions in the prevalence of human papillomavi

249 Gram-negative hospital pathogens, which has led to renewed efforts in antibiotic drug discovery.

250 sets, promoted excessive proliferation, and led to retinoblastoma with anaplastic changes.

251 g maintained hMSC stemness, engraftment, and led to robust motosensory improvement, neuropathic pain

252 f Fam20C in cells expressing type I collagen led to skeletal defects and hypophosphatemia.

253 he structural and mineralization abnormality led to slight reduction in apparent modulus, which could

254 ace UV radiation indicate that the eruptions led to stratospheric ozone depletion.

255 logical-level studies suggest that MMLs have led to substitution of cannabis for opioids, and also po

256 Prolonging the reaction period to 48-70 h led to successive gamma-C(sp(3))-H arylation/intramolecu

257 Apixaban 5 mg twice daily led to supratherapeutic levels in patients on hemodialys

258 Short-term IL-33 treatment in mice led to sustained expansion of IL-33 receptor-positive ki

259 he application of 10 mmol/L ammonium formate led to the best findings, while the use of 0.02% acetic

260 ation of occurrences in these eight contexts led to the characterization of three different Mg(2+) bi

261 rofiling and next-generation sequencing have led to the classification of HCCs based on molecular fea

262 ermeability and proliferation increase; this led to the concept that glia are required for maintenanc

263 Accordingly, these reactions led to the construction of new classes of pyrrolidone-ri

264 of nanoparticles (NPs) to drug delivery has led to the development of novel nanotherapeutics for the

265 ong older patients with palliative needs has led to the development of several service-level interven

266 This work led to the discovery of a highly selective PI3Kbeta/delt

267 Excavations at the site in 2014-2015 led to the discovery of cultural remains generally assoc

268 n of the center (S)-proline-based lead 7 has led to the discovery of noncovalent reversible and selec

269 cells in a TAS3 ta-siRNA-insensitive mutant led to the formation of supernumerary megaspore mother c

270 nd characterize HIV-specific antibodies have led to the identification of a new generation of potent

271 ased transcription factor binding prediction led to the identification of Hnf4a as the potential tran

272 esign an "educated guess" drug screen, which led to the identification of new, deleterious synthetic

273 rug design, and parallel medicinal chemistry led to the identification of pyridine 12.

274 dentification and drug-screening testing and led to the identification of the ERK inhibitor SCH772984

275 sing concentration of the dyes in a solution led to the increase in absorption band intensity in diff

276 JB12 knockdown by siRNA led to the induction of caspase processing but not the u

277 selective advantage over Neanderthals, which led to the their extinction.

278 Recent evolutions in rectal cancer surgery led to transanal dissection of the rectum resulting in a

279 stry program starting from amicarbalide that led to two compounds with optimized pharmacological and

280 ate intervention and that led (or could have led) to major disability or death.

281 In this reaction, levansucrase (LS) transfers regioselectively a fructosyl residue to ei

282 thermal drying (TD), or lime stabilization (LS) treatment processes.

283 nce quenching measurements revealed that the l-tryptophan interacted with anthocyanins mainly through

284 LCS are triggered by both L-type Ca(2+) channel activity during the action potenti

285 in E-T coupling, activation of voltage-gated L-type Ca(2+) channels (LTCCs) in the plasma membrane ca

286 neurons that in turn pathologically recruits l-type Ca(2+) channels to facilitate coincidence detecti

287 fied by the Ca(2+)-dependent inactivation of L-type Ca(2+) channels, whose alteration contributes to

288 requency of Ca(2+) influx through T-type and L-type Ca(2+) channels.

289 tients using dynamic O-(2-(18)F-fluoroethyl)-l-tyrosine ((18)F-FET) PET.

290 This observation led us to explore the possibility that resident macropha

291 These observations led us to propose a metabolic model for autotrophic grow

292 This observation led us to speculate as to whether our data may form the

293 The role of hydrogen bonding led us to the rotation of NH4(+) within its solvent cage

294 ne platelet count (<10 x 10(9) platelets per L vs >/=10 x 10(9) platelets per L) and disease (MDS vs

295 tate aminotransferase 0 hour, 15.6 +/- 9.3 U/L vs 7 hours, 24.8 +/- 14.6 U/L, P = 0.298).

296 ntially expressed genes (DEGs) were found in LD vs MD, LE vs ME, LE vs LD, or ME vs MD comparisons.

297 nformation including linkage disequilibrium (LD)-weighted genic annotation scores, total LD scores an

298 ctively, but decreased to 49.8 and 93.2 nmol/L when treated in combination with rubone, demonstrating

299 ctivated outward rectifying K(+) current, IK,L , whose biophysical properties and molecular identity

300 In contrast, the reaction of L(-) with CuI formed the unique, neutral Cu2 I2 (L(.) )

301 ar and genetic evidence suggests that CPSF30-L works upstream of NRT1.1 and independently of NLP7 in