ライフサイエンスコーパス: L-alanine

1 e of them, too (e.g. 1-deoxysphinganine from L-alanine).

2 an operon and are required for catabolism of l-alanine.

3 athing motions in all systems except l-valyl-l-alanine.

4 rginine and pyruvate into 2-ketoarginine and L-alanine.

5 an alanine racemase inhibitor, and required L-alanine.

6 enosine, D-glucose, tryptophan, glycine, and L-alanine.

7 B are different, even though both respond to L-alanine.

8 e of L-[1-(13)C]alanine or unlabeled ((12)C) L-alanine.

9 vage of l-kynurenine to anthranilic acid and l-alanine.

10 ngest transport activities were specific for l-alanine.

11 with the wild-type enzyme in the presence of L-alanine.

12 expression of the operon in the presence of L-alanine.

13 ne the change in cell length induced by 5 mM L-alanine.

14 d inactivation by L-serine or by beta-chloro-L-alanine.

15 elective fluorination from readily available L-alanine.

16 L-ornithine, L-2,4-diaminobutyric acid, and L-alanine.

17 D-aspartate, but not that of D-glutamate or L-alanine.

18 strate L-serine to the alternative substrate L-alanine.

19 vibrational modes, with the exception being l-alanine.

20 erL were sufficient for germination in 50 mM L-alanine.

21 Finally, [2,3-(13)C(2),(15)N]-L-alanine (12) was prepared via alkylation of the lacton

22 ubjects (n = 29) using (18)F-dihydroxyphenyl-L-alanine ((18)F-DOPA) positron emission tomography.

23 ontrols) and underwent fluorodihydroxyphenyl-l-alanine ([18F]-DOPA) positron emission tomography to e

24 A small amount of 3,4-dihydroxyphenyl-l-alanine (2 mol %) can be detected by amino acid analys

25 a calix[4]resorcarene prepared from N-methyl-L-alanine (2) as a chiral NMR discriminating agent is co

26 -4-methylpentanoyl)-L-3-(tert-bu tyl)-alanyl-l -alanine, 2-aminoethyl amide), which has previously be

27 onspinning line width of a decoupled [3-13C]-L-alanine (99%) peak achieved is 1.3 Hz.

28 that catalyses the hydrolysis of beta-cyano-L-alanine, a nitrile common in the plant environment and

29 o effect on organic nutrient (the amino acid l-alanine) absorption.

30 isotropic Raman spectra of L-alanyl-D-alanyl-L-alanine, acetyl-L-alanyl-L-alanine, L-vanyl-L-vanyl-L-

31 of CaDPA release beginning immediately after L-alanine addition leading to approximately 65% CaDPA re

32 (i) Following L-alanine addition, wild-type and gerD spores and spores

33 yme, catalyzes the ATP-dependent ligation of L-alanine (Ala) and UDP-N-acetylmuramic acid (UNAM) to f

34 ved from alpha-aminoisobutyric acid (Aib) or l-alanine (Ala).

35 BOC-L-alanine alkyl esters and BOC-beta-alanine alkyl esters

36 followed by the pneumococcal N-acetylmuramyl-L-alanine amidase (amidase), the glycan strands of the p

37 PGRP-L is a Zn2+-dependent N-acetylmuramoyl-l-alanine amidase (EC 3.5.1.28), an enzyme that hydrolyz

38 CwlD in Escherichia coli results in muramoyl L-Alanine amidase activity but no muramic delta-lactam f

39 pPGRP-L1 and pPGRP-L2 have N-acetylmuramoyl-L-alanine amidase activity.

40 of AtlA is performed by the N-acetylmuramyl-l-alanine amidase AmiA, which cleaves the bond between t

41 which functions as both an N-acetylmuramoyl-L-alanine amidase and D-alanyl-glycine endopeptidase.

42 clusion, human PGRP-L is an N-acetylmuramoyl-l-alanine amidase and this function is conserved in prok

43 SLP shows weak homology to N-acetyl muramoyl-L-alanine amidase from Bacillus subtilis, and both the n

44 1,6-anhydro-N-acetylmuramic acid (anhMurNAc)-l-alanine amidase in Escherichia coli.

45 gonorrhoeae encodes a single N-acetylmuramyl-l-alanine amidase involved in cell separation (AmiC), as

46 al studies indicated that an N-acetylmuramyl-l-alanine amidase is responsible for cell wall breakdown

47 quences (R1ab-R2ab) of the N-acetyl-muramoyl-L-alanine amidase of Atl are essential for binding of hT

48 e is the first found for an N-acetylmuramoyl-l-alanine amidase PGRP that cleaves peptidoglycan at the

49 demonstrate that PlyL is an N-acetylmuramoyl-L-alanine amidase that cleaves the cell wall of several

50 n protein 2 (PGLYRP2) is an N-acetylmuramoyl-L-alanine amidase that hydrolyzes bacterial peptidoglyca

51 n protein 2 (PGLYRP2) is an N-acetylmuramoyl-L-alanine amidase that hydrolyzes bacterial peptidoglyca

52 la](beta1-4)-GlcNAc, whereas N-acetylmuramyl-L-alanine amidase treatment of the cell wall solubilized

53 s by pneumococcal autolysin (N-acetylmuramyl-L-alanine amidase) but were cleaved by the muramidases C

54 The lytA-encoded autolysin (N-acetylmuramoyl-L-alanine amidase) of Streptococcus pneumoniae is believ

55 pneumococcal autolysin (N-acetylmuramic acid-L-alanine amidase).

56 amidase_3 domain-containing N-acetylmuramyl-L-alanine amidase, a peptidoglycan remodelling enzyme im

57 ns (triacylglycerol lipase, N-acetylmuramoyl-L-alanine amidase, flagellin, outer membrane protein A,

58 ization of the mycobacterial N-acetylmuramyl-L-alanine amidase, Rv3717.

59 sed cell lysis by activating N-acetylmuramyl-L-alanine amidase, the pneumococcal autolysin.

60 we showed that Lc-Lys is an N-acetylmuramoyl-L-alanine amidase, whereas Lc-Lys-2 is a gamma-D-glutamy

61 t with a role for AmiC as an N-acetylmuramyl-l-alanine amidase.

62 amic acid residue by a cwlD-encoded muramoyl-L-Alanine amidase.

63 with N-acetylmuramidase and N-acetylmuramyl-L-alanine amidase.

64 enzyme is a zinc-dependent N-acetylmuramoyl-l-alanine amidase.

65 Three periplasmic N-acetylmuramoyl-l-alanine amidases are critical for hydrolysis of septal

66 The N-acetylmuramoyl-l-alanine amidases of Escherichia coli (AmiA, B and C) a

67 e three Tat substrates, the N-acetylmuramoyl-l-alanine amidases, AmiA and AmiC, and the cell division

68 proteins and found that two N-acetylmuramoyl-l-alanine amidases, encoded by amiA and amiC, elevated b

69 predicted product resembles N-acetylmuramoyl-L-alanine amidases.

70 of mutants defective for the N-acetylmuramyl-l-alanine amidases: AmiA, AmiB, and AmiC.

71 g an amino acid monomer as the precursor, an L-alanine amino acid derivatized with a protecting group

72 th peak serum levels of approximately 250 IU/L alanine aminotransferase and 420 IU/L aspartate aminot

73 otransferase (32.4 +/- 17.4 vs 21.5 +/- 6.9U/L), alanine aminotransferase (39.9 +/- 28.6U/L vs 23.8 +

74 time (pt) >100 sec, F7<1%, NH3 150 micromol/L, alanine aminotransferase 4079 U/L, total bilirubin le

75 re solved in the presence and absence of the l-alanine analogue, (R)-1-aminoethylphosphonic acid.

76 oethylphosphonic acid (L-Ala-P), a synthetic L-alanine analogue, has antibacterial activity and is a

77 entrations were between 500 muM and 2 mM for l-alanine and </=10 mM for l-valine, rates of gerP spore

78 ation increased up to between 200 mM and 1 M l-alanine and 100 mM l-valine, and at 1 M l-alanine, the

79 rom the decarboxylative condensation between l-alanine and acyl-S-ACP were detected by GC-MS.

80 nants (His, Pro, Trp, and Tyr combining with L-alanine and Ala, Cys, His, Met, Phe, Pro, Ser, Trp, Ty

81 cid and L-cysteine and to a lesser extent by L-alanine and aminoisobutyric acid, but was not inhibite

82 hydrolytic cleavage of l-kynurenine to give l-alanine and anthranilic acid.

83 ta-decarboxylation of l-aspartate to produce l-alanine and CO(2).

84 borinates 11 and 12 followed by heating with l-alanine and crystallization afforded (R,R,S)-13 (27%).

85 A series of analogues (including the L-alanine and D-amino acid scanned peptides) was synthes

86 ternal aldimine formation with either AIB or L-alanine and DGD-PLP is a rapid equilibrium process, as

87 nation kinetics at varying concentrations of l-alanine and different temperatures were studied by mon

88 e cluster in the presence of l-alanine or of l-alanine and ethylamine in place of l-lysine.

89 de novo pathway of SL synthesis, beta-chloro-L-alanine and fumonisin B1.

90 germination via GerA, spore germination via L-alanine and GerB or GerB* was not inhibited by D-alani

91 ase) of M. leprae showed K(m) and V(max) for L-alanine and glycine similar to those of Mycobacterium

92 ying reduced proline uptake, could transport l-alanine and glycine, a phenotype suppressed by the S13

93 functional allele that could also transport l-alanine and glycine, displaying a specificity profile

94 cyl-l(but not d)-amino acids, such as glycyl-l-alanine and glycyl-l-phenylalanine, are also good acce

95 uct formation give ratios of 105 and 14 with L-alanine and isopropylamine as substrates, respectively

96 cies in the transamination half-reactions of L-alanine and L-aminobutyrate show long-wavelength absor

97 The ability of fetal arterial boluses of L-alanine and L-leucine to stimulate release of amino ac

98 robe the ionization state of the amino-acids l-alanine and l-proline at the air/water surface and in

99 Desert sample is found to contain homochiral L-alanine and L-serine indicating the presence of extant

100 enantioselective recognition response toward L-Alanine and limit of detection (LOD) value is determin

101 olysis of L-alanine-p-nitroanilide producing L-alanine and p-nitroaniline as products; the formation

102 for formation of quinonoid intermediates of L-alanine and S-ethyl-L-cysteine is affected only twofol

103 The enzyme converts L-cysteine to L-alanine and sulfane sulfur (S(0)) in the form of a cys

104 catalyzes the fragmentation of l-cysteine to l-alanine and sulfane sulfur in the form of a cysteine p

105 decomposing cysteine or selenocysteine into L-alanine and sulfur or selenium, respectively.

106 inants that are released during germination, l-alanine and the 1:1 chelate of Ca(2)(+) and dipicolini

107 (Ald) catalyzes the oxidative deamination of L-alanine and the reductive amination of pyruvate.

108 concentrations (50, 75, 100, and 150 mM) of l-alanine and three different temperatures (30, 37, and

109 turating and subsaturating concentrations of l-alanine and with CaDPA.

110 alanine racemase with its natural substrate (L-alanine) and cofactor (pyridoxal 5'-phosphate).

111 gle Bacillus cereus spores in both nutrient (l-alanine) and non-nutrient (Ca-dipicolinic acid (DPA))

112 N delivered as nitrate, amino acid monomer (l-alanine) and short peptide (l-tetraalanine), and the r

113 ent inhibitor of wild-type Trpase, oxindolyl-L-alanine, and does not exhibit the pK(a) of 6.0 seen in

114 mino-1-cyclobutanecarboxylic acid (ACBC) and L-alanine, and full agonists glycine and D-serine.

115 L-alanyl-L-alanine, L-alanyl-glycine, glycyl-L-alanine, and glycyl-glycine, in which we attempt to is

116 cids, and GerA interacts only with L-valine, L-alanine, and its analogs.

117 of amino acids including glycine, L-serine, L-alanine, and L-cysteine, as well as their D-enantiomer

118 l-arginine, l-glycine, l-proline, l-serine, l-alanine, and l-glutamic acid.

119 id copolymer of L-tyrosine, L-glutamic acid, L-alanine, and L-lysine that is effective both in suppre

120 , glycine, L-lysine, L-arginine, L-cysteine, L-alanine, and L-proline--in aqueous solution adsorbed a

121 helical and beta-sheet conformations of poly-L-alanine, and polyglycine, are presented.

122 inA is induced in the presence of beta-cyano-L-alanine, and the beta-cyano-L-alanine precursors cyani

123 ytic base for the conversion of D-alanine to L-alanine, and the present results show that, at least s

124 and the carboxyl moieties of the inhibitor d,l-alanine, and the substrate ACC by analogy, coordinate

125 nprotonated for binding glycine or oxindolyl-L-alanine, and, by inference, L-serine.

126 spores more readily germinate in response to l-alanine as a co-germinant.

127 llows P. fluorescens SBW25 to use beta-cyano-L-alanine as a nitrogen source and to tolerate toxic con

128 ynurenine to yield 3-hydroxyanthranilate and L-alanine as part of the tryptophan catabolic pathway le

129 is an aminoacyl ligase that adds l-serine or l-alanine as the first amino acid of a dipeptide branch

130 ed for growth on a minimal medium containing L-alanine as the major source of carbon.

131 d mutants grew poorly in minimal medium with L-alanine as the sole nitrogen source, reaching a satura

132 cine, N-acetyl-L-phenylalanine, and N-acetyl-L-alanine at 298.35K by porcine kidney acylase I (EC 3.5

133 gainst S. aureus, inoculated in a 1.0% d- or l-alanine-augmented trypticase soy broth medium.

134 res in melanoidins formed from d-glucose and l-alanine between 130 and 200 degrees C.

135 hypothesis that exposure to beta-methylamino-L-alanine (BMAA) could play a role in various neurodegen

136 beta-methylamino-L-alanine (BMAA) has been linked to several interrelated

137 beta-N-methylamino-l-alanine (BMAA) has been suspected of being involved in

138 toxic nonprotein amino acid beta-methylamino-l-alanine (BMAA) in the Guam ecosystem.

139 beta-methylamino-l-alanine (BMAA) is a naturally occurring nonprotein ami

140 of the genus Nostoc produce beta-methylamino-l-alanine (BMAA), a neurotoxic nonprotein amino acid.

141 beta-N-Methylamino-L-alanine (BMAA), a probable cause of the amyotrophic la

142 to AmpD, which is specific for the anhMurNAc-l-alanine bond, AmiD also cleaved the bond between MurNA

143 Inosine and L-alanine both play major roles as cogerminants with sev

144 s the tryptophan (Trp) analog 3-benzothienyl-l-alanine (Bta) with an imino-to-sulfur substitution in

145 c operon (dad) in the absence of the inducer L-alanine but also to a decreased expression of the oper

146 t encodes the spore's germinant receptor for L-alanine but not by overexpression of gerA operon homol

147 havior in the binding of l-phenylalanine and l-alanine but not in that of bicarbonate or l-arginine.

148 growth in high concentrations of beta-cyano-L-alanine, but also resulted in increased root elongatio

149 ) receptor responded to beta-alanine but not L-alanine by elevating intracellular [Ca(2+)], stimulati

150 molar mass distribution of end-charged poly-l-alanine by free solution CE, molar mass distribution o

151 eria, other than the reported replacement of l-alanine by glycine in the peptide side chains.

152 hesis of SLs by fumonisin B1 and beta-chloro-L-alanine completely abrogated the AT2 receptor-mediated

153 l-Alanine compounds are recognized as potent and selecti

154 ere increased markedly, in particular at low L-alanine concentrations, by overexpression of the trici

155 The dad operon is inducible by l-alanine, d-alanine, and l-valine, and induction is dep

156 om lipid I are predominantly N-acetylmuramyl-L-alanine-D-glutamate-meso-diaminopimelic acid-D-alanyl-

157 Bacterial UDP-N-acetylmuramyl-L-alanine:D-glutamate ligase (MurD), a cytoplasmic pepti

158 n mycobacterial superoxide dismutase (SodA), L-alanine dehydrogenase (AlaDH), and L-glutamine synthet

159 NAD(H)-dependent L-alanine dehydrogenase (EC 1.4.1.1) (Ald) catalyzes the

160 nt-starved tuberculosis models and codes for l-alanine dehydrogenase (MtbAld; Rv2780).

161 function mutations in ald (Rv2780), encoding L-alanine dehydrogenase, were associated with unexplaine

162 rmined by a coupled reaction with NAD(+) and L-alanine dehydrogenase.

163 ation in the absence of exogenous beta-cyano-L-alanine, demonstrating that beta-cyano-L-alanine nitri

164 All the phosphoramidates prepared were L-alanine derivatives with variations in the aryl moiety

165 We found that the L-alanine derived ProTides show anti-HIV activity at non

166 A 2-day exposure to N-CBZ-L-phenylalanyl-L-alanine-diazomethylketone (ZPAD), a selective inhibito

167 he recent report of 5, 5'-di(dihydroxyphenyl-L-alanine) (diDOPA) cross-links in byssus has raised que

168 competitive inhibitors glycine and oxindolyl-L-alanine display single pK(i) values of 7.3.

169 o the reaction of L-kynurenine, beta-benzoyl-L-alanine does not exhibit a significant solvent isotope

170 nversion of tyrosine to 3, 4-dihydroxyphenyl-L-alanine (DOPA) and serine to O-phosphoserine accounts

171 ch proteins that contain 3,4-dihydroxyphenyl-L-alanine (dopa) and undergo extensive stabilization by

172 hly specific ensemble of 3,4-dihydroxyphenyl-l-alanine (DOPA) containing proteins.

173 ydroxylation of peptidyl-3,4-dihydroxyphenyl-l-alanine (Dopa) was observed during tyrosinase incubati

174 y only four amino acids: 3,4-dihydroxyphenyl-L-alanine (dopa), lysine, proline, and valine at approxi

175 The 3,4-dihydroxyphenyl-l-alanine (Dopa)-containing proteins of mussel byssus pl

176 nce and Y is modified to 3,4-dihydroxyphenyl-l-alanine (Dopa).

177 ts basic pI and abundant 3,4-dihydroxyphenyl-L-alanine (Dopa; 30 mol %), but is distinct in two respe

178 Of these two volume-sensitive conductances, L-alanine elicited a specific increase in GVD, whereas G

179 In contrast, a 10% L-alanine-enriched diet increased dSL levels and led to

180 Acetyl-L-alanyl-L-alanine exhibits a structure which is very similar to

181 and these enzymes are thought to convert the l-alanine germinant into d-alanine, a spore germination

182 ESLI again reached its maximum value; (4) in L-alanine germination of spores lacking both CLEs and un

183 remaining CaDPA was released rapidly; (2) in L-alanine germination of wild-type spores and spores lac

184 imilar but not identical ESLI pattern during L-alanine germination to that seen with cwlJ sleB spores

185 In contrast to l-alanine germination via GerA, spore germination via L-

186 istent with different pathways for CaDPA and L-alanine germination, (b) at T(release), the ESLI again

187 uorescens kynureninase with L-kynurenine and L-alanine has been examined using rapid-scanning stopped

188 on L-arginine, suggesting the involvement of L-alanine in arginine catabolism.

189 miD also cleaved the bond between MurNAc and l-alanine in both muropeptides and murein sacculi.

190 e efficiency of the LIS device for detecting L-Alanine in human serum.

191 s measured with SAM bound to the cluster and l-alanine in place of l-lysine, with S-adenosyl-l-homocy

192 By incorporating L-alanine in place of L-serine, the mutant HSAN1-associa

193 kinetic studies with sarcosine and N-methyl-L-alanine in the absence or presence of a dead-end inhib

194 erent reactions with L-serine or beta-chloro-L-alanine in the presence or absence of indole.

195 observed for molecules with an odd number of l-alanines in the side chains.

196 Supplementation with l-serine or removal of l-alanine independently restored normal growth patterns

197 The L-alanine-induced activation of GVD was significantly re

198 thesized that Alr2 could affect C. difficile l-alanine-induced spore germination in a defined medium.

199 the enzyme serine palmitoyltransferase uses l-alanine instead of l-serine as its amino acid substrat

200 The ability of this mutant to convert L-alanine into D-alanine increased about 10-fold compare

201 action of the potassium form of DGD-PLP with L-alanine is 24 s(-1).

202 N-Methyl-L-alanine is a good alternate substrate, exhibiting a k(

203 Beta-benzoyl-L-alanine is a good substrate of kynureninase from Pseud

204 We recently reported that l-alanine is a preferred carbon source for P. aeruginosa

205 Of these, l-alanine is an effective co-germinant and is also a ger

206 The primary [2-(2)H]-L-alanine KIE on the transamination half-reaction is uni

207 l range of 66-90 cm(-1), or 2.0-2.7 THz, for L-alanine (L-Ala) and four L-Ala compounds in which hydr

208 te to form phosphonoacetaldehyde (P-Ald) and L-alanine (L-Ala).

209 3,4-Dihydroxyphenyl-L-alanine (L-DOPA)-induced dyskinesia (LID) is a debilit

210 on in the development of 3,4-dihydroxyphenyl-L-alanine (L-DOPA)-induced dyskinesia.

211 four zwitterionic model dipeptides, L-alanyl-L-alanine, L-alanyl-glycine, glycyl-L-alanine, and glycy

212 B, enabling it to recognize more efficiently l-alanine, l-azetidine-2-carboxylic acid, and glycine wi

213 s a random synthetic amino acid copolymer of L-alanine, L-glutamic acid, L-lysine, and L-tyrosine, ef

214 The transported substrates L-alanine, L-glutamine, and alpha-(methylamino)isobutyra

215 transport of neutral amino acids, including l-alanine, l-glutamine, and l-histidine, across the plas

216 ed analysis of MGL interaction with glycine, l-alanine, l-norvaline, and l-cycloserine was performed

217 hPAT1 interacted with glycine, L-alanine, L-proline, alpha-aminoisobutyrate (AIB) and g

218 L-alanyl-D-alanyl-L-alanine, acetyl-L-alanyl-L-alanine, L-vanyl-L-vanyl-L-valine, L-seryl-L-seryl-L-s

219 e N-(4-morpholine)carbonyl-beta-(1-naphthyl)-L-alanine-L-leucine boronic acid (MLN-273), an analogue

220 UDP-N-acetylmuramic acid:L-alanine ligase (MurC) catalyzes the addition of the fi

221 The bacterial UDP-N-acetylmuramyl-L-alanine ligase (MurC) from Escherichia coli, an essent

222 scherichia coli, MurC (UDP-N-acetyl-muramate:L-alanine ligase) of M. leprae showed K(m) and V(max) fo

223 that a single neurotoxin, beta-N-methylamino-L-alanine, may be produced by all known groups of cyanob

224 tevia glycine ethyl ester (ST-GL) and stevia l-alanine methyl ester (ST-GL), were synthesised and cha

225 However, l-glutamine and l-alanine model reactions showed the same browning index

226 of the substituted deuterium atom(s) in the L-alanine molecule, and the atoms contributing to the ab

227 xidize other secondary amino acids (N-methyl-L-alanine, N-ethylglycine, and L-proline), but N,N-dimet

228 The Km values for L-alanine, NAD+, pyruvate, NADH, and NH4+ were estimated

229 ano-L-alanine, demonstrating that beta-cyano-L-alanine nitrilase activity can have a significant effe

230 n the peptidoglycan of Mycobacterium leprae, L-alanine of the side chain is replaced by glycine.

231 ial for normal spore germination with either L-alanine or a mixture of L-asparagine, D-glucose, D-fru

232 Apstatin analogues lacking the L-alanine or having hydroxyproline in place of the proli

233 germination in C-cpe isolates only; and (ii) L-alanine or L-valine induced significant germination of

234 germination of Bacillus subtilis spores with L-alanine or L-valine, and these germinations were stimu

235 th l-asparagine, fructose, and K+ and either L-alanine or L-valine.

236 SAH bound to the cluster in the presence of l-alanine or of l-alanine and ethylamine in place of l-l

237 Because mutant SPT preferentially uses l-alanine over its canonical substrate l-serine, we also

238 osphinyl]-D-lactic acid as the inhibitor and L-alanine-p-nitroanilide as the substrate yielded a K(i)

239 aining VanX exhibit saturation kinetics when L-alanine-p-nitroanilide is used as the substrate with K

240 (II), or Ni(II), catalyzes the hydrolysis of L-alanine-p-nitroanilide producing L-alanine and p-nitro

241 The reaction of L-alanine-p-nitroanilide with VanX was studied in an eff

242 troanilide (BRpNA) over N-t-butyloxycarbonyl-L-alanine-p-nitrophenylester (BocApNP) was 2.1 as measur

243 is achieved with (18)F-fluorodihydroxyphenyl-l-alanine PET, somatostatin receptor SPECT, CT, or MR im

244 her oxygen linking its aromatic rings and an l-alanine polar side chain.

245 L-Alanine polypeptide thin films were synthesized via at

246 an alanyl residue of the UDP-N-acetylmuramyl-L-alanine precursor, generating the dipeptide.

247 of beta-cyano-L-alanine, and the beta-cyano-L-alanine precursors cyanide and cysteine.

248 erminate more efficiently in the presence of l-alanine, presumably because of their inability to conv

249 The l-alanine prodrug 8 (also known as brivanib alaninate/BM

250 The l-alanine prodrug of 12, BMS-582664 (21), is currently u

251 odrug phosphoramidate diastereochemistry (D-/L-alanine, R-/S-phosphoryl) in vitro and in vivo.

252 ion also yielded CBL(P113S), which catalyzes l-alanine racemization with a poor Km (58 mm) but a high

253 111, which acts as the catalytic acid during l-alanine racemization.

254 Furthermore, titration with L-alanine resulted in the appearance of an enzyme-substr

255 nation sphere amino acid, with D-leucine and L-alanine resulting in exclusively 3- and 4-coordinate s

256 That d-alanyl-l-alanine shows little activity as an acceptor suggested

257 es in production of muramic delta-lactam and L-alanine side chains and a slight increase in cross-lin

258 als of N-H, C-N, and C-H oscillations in the l-alanine spectrum are prone to inhomogeneous broadening

259 to beta-alanine from malonate semialdehyde, l-alanine, spermine, dihydrouracil, and acryloyl-coenzym

260 ding and the histamine-releasing activity of l-alanine substitutions for the five lysine residues and

261 f L-selenocysteine to elemental selenium and L-alanine suggested the possibility that this enzyme mig

262 educed olfactory response to all three cues (l-alanine, taurocholic acid, food cue) tested, suggestin

263 ants to grow in concentrations of beta-cyano-L-alanine that would otherwise prove lethal.

264 Substrate inhibition by UDP-N-acetylmuramyl-L-alanine, the acceptor substrate, was observed at conce

265 beta-Benzoyl-l-alanine, the analogue of l-kynurenine lacking the arom

266 M l-alanine and 100 mM l-valine, and at 1 M l-alanine, the rates of germination of wild-type and ger

267 de frequency shifts in deuterium-substituted L-alanine, three of which have previously only been calc

268 e transamination products 2-ketoarginine and L-alanine, thus demonstrating the proposed biochemical r

269 lators of ATP-PRT and identify 3-(2-thienyl)-L-alanine (TIH) as an allosteric activator of this enzym

270 ause of their inability to convert exogenous l-alanine to d-alanine, but they respond normally to oth

271 catalytic base involved in the conversion of L-alanine to D-alanine.

272 he reversible, NAD+-dependent deamination of L-alanine to pyruvate and NH4+.

273 group of muramic acid and the amino group of l-alanine to release a peptide moiety.

274 On addition of L-alanine to the bath there was an initial increase in c

275 Addition of 5 mM L-alanine to the bathing solution increased the whole ce

276 se capable of converting the spore germinant l-alanine to the germination inhibitor d-alanine.

277 noacyl-tRNA ligase that attaches L-serine or L-alanine to the stem peptide lysine of Lipid II in cell

278 onation to the ketimine intermediate for the L-alanine transamination half-reaction.

279 in the dead-time of the stopped-flow in the L-alanine transamination half-reaction.

280 to form alpha-ketobutyrate and ammonia) and L-alanine (transamination to form pyruvate), which have

281 CM treatment did not decrease L-alanine transport in WIF-B cells.

282 omplex with its product UDP-N-acetylmuramoyl-L-alanine (UMA), the nonhydrolyzable ATP analogue AMPPNP

283 amic acid (UNAM) to form UDP-N-acetylmuramyl-L-alanine (UNAM-Ala).

284 derivatives, depending on both the number of l-alanine units in the oligopeptide segments and length

285 ng study we found that (18)F-dihydroxyphenyl-L-alanine uptake was elevated in both the substantia nig

286 Furthermore, nigral (18)F-dihydroxyphenyl-L-alanine uptake was positively related with the severit

287 as nigral and striatal (18)F-dihydroxyphenyl-L-alanine uptake were positively related in control subj

288 (1-hydroperoxy-4-oxocyclohexa-2,5-dien-1-yl)-L-alanine was formed.

289 The amino acid L-alanine was the only independent germinant in B. anthr

290 -2-methyl-1,1'-biphenyl-4-yl)carbonyl]amino}-L-alanine (WAY-211686) (IC(50) = 190 +/- 10 nM).

291 anthracis spores germinated with inosine and L-alanine, we previously determined kinetic parameters f

292 show that S-2-aminobutyrate and beta-chloro-L-alanine were alternate substrates.

293 germination of Bacillus subtilis spores with L-alanine were increased markedly, in particular at low

294 ate kinetics of the reaction of beta-benzoyl-L-alanine were investigated by rapid scanning stopped-fl

295 S253G and W351F could transport l-alanine, whereas T414S, despite displaying reduced pro

296 helical and beta-sheet conformations of poly-L-alanine, which is in agreement with the reported quant

297 In plants cyanide is converted to beta-cyano-L-alanine, which is subsequently detoxified to aspartic

298 urenine to produce 3-hydroxyanthranilate and l-alanine, while l-kynurenine is the substrate of many p

299 The reaction of L-alanine with kynureninase exhibits the rapid formation

300 rmining step in the reaction of beta-benzoyl-L-alanine with kynureninase is C(beta)-C(gamma) bond cle

301 glucose model reactions with l-glutamine and l-alanine yielded similar colored solutions.