ライフサイエンスコーパス: L-cone

1 pigment activation effectively light adapted L cones in darkness, causing them to have a smaller and

2 Observers adjusted the speed of an L cone contrast pattern to match that of a variety of co

3 on resulted from the terminal division of an L-cone precursor, suggesting that such divisions contrib

4 ereby opening cation channels, whereas M and L cone stimuli suppress glutamate release onto ionotropi

5 ake a poorly understood choice between M and L cone subtype fates.

6 le, natural variation in the ratios of M and L cone subtypes was associated with a noncoding polymorp

7 development to generate the pattern of M and L cones across the human retina.

8 elected stimulation wavelengths for S, M and L cones as well as rod photoreceptors.

9 ping central retina contained a mix of M and L cones compared to the late-developing peripheral regio

10 first images of the arrangement of S, M and L cones in the living human eye.

11 To determine mechanisms specifying M and L cones, we developed an approach to visualize expressio

12 o basal synapses from approximately 20 M and L cones.

13 ey receive input indiscriminately from M and L cones.

14 red the light responses of primate S, M, and L cones.

15 d that the luminance channel has fast M- and L-cone input signals (+fM and +fL), and slow, spectrally

16 e (L-) cone modulation sensitivities, M- and L-cone phase delays, and flicker spectral sensitivities

17 e (L-) cone modulation sensitivities, M- and L-cone phase delays, and spectral sensitivities as a fun

18 ent differences in adaptation between M- and L-cone signaling pathways.

19 increase the difference of anomalous M- and L-cone signals.

20 suggesting that M cones are generated before L cones.

21 drives fluorescent protein expression before L-cone precursors themselves are produced permitted trac

22 cording revealed that both single and double L cones contained low levels of short wavelength-sensiti

23 ring motion contrast thresholds for drifting L cone and M cone gratings summed in different spatial p

24 s a larger contribution to the ERG than each L cone.

25 Every L cone in a local region resulted from the terminal divi

26 of L- and M-cones; in S- cells, signals from L-cones were usually opposed to those of S- and M-cones.

27 opsin percentages in darkness, being ~30% in L cones, ~3% in M cones, and negligible in S cones.

28 terase phototransduction step, especially in L cones, apo-opsin noise may not be easily distinguishab

29 Our results suggest that subtle changes in L-cone opsin wavelength absorption may have been adaptiv

30 excited equally by a stimulus that increased L-cone activity (appearing bright red) and by a stimulus

31 short (S cones), medium (M cones), or long (L cones) wavelengths.

32 receptor types, maximally sensitive to long (L-cone), middle (M-cone), and short (S-cone) wavelengths

33 e (short/S), green (medium/M), and red (long/L) cones.

34 st in rods, followed about 1 week later by M&L cone opsin.

35 Triple labeling using TUNEL, anti-M/L cone opsin and anti-rod opsin showed that hyperoxia ha

36 hich takes place in S cones a month before M/L cones.

37 lowed the repeatable segregation of S from M/L cones, likely from differences in functional or metabo

38 The S cones in the other species and the M/L cones in all species had a conventional topography wit

39 ysin, medium-to-long wavelength-sensitive (M/L) cone opsin, rod opsin, excitatory amino acid transpor

40 otein (GFAP), rhodopsin, S-cone opsin, and M/L-cone opsin were performed, as were axon counts of the

41 e used transretinal recordings to evaluate M/L-cone pigment regeneration in isolated retinas and eyec

42 amplitude and slowed the kinetics of mouse M/L-cone photoresponses, cone adaptation in bright, steady

43 or the initial rapid regeneration of mouse M/L-cone pigment during dark adaptation, whereas the slowe

44 Remarkably, the mouse retina promoted M/L-cone dark adaptation eightfold faster than the RPE.

45 mate retinae stained to distinguish S from M/L-cones.

46 is not critical for the function of mouse M/L-cones in bright light.

47 region, which contained a high proportion of L cones.

48 st sensitivity was approximately the same on L-cone (1.84 +/- 0.08 log contrast sensitivity) and M-co

49 ects have large patches in which either M or L cones are missing.

50 At 4 and 7.5 Hz, an increase in the relative L-cone illuminance steepened the slope of the rod-only T

51 dark current noise of individual salamander L cones.

52 The responses of individual salamander L-cones to light steps of moderate intensity (bleaching

53 sensitive (S) and long wavelength-sensitive (L) cone opsins.

54 expressed a human long-wavelength-sensitive (L) cone photopigment in the form of an X-linked polymorp

55 t of the noise in long wavelength-sensitive (L) cones arose from spontaneous activation of the photop

56 sensitive (M) and long wavelength-sensitive (L) cones.

57 middle- (M-) and long-wavelength-sensitive (L-) cone modulation sensitivities, M- and L-cone phase d

58 middle- (M-) and long-wavelength-sensitive (L-) cone modulation sensitivities, M- and L-cone phase d

59 In contrast, fast and slow L-cone input signals of opposite polarity (-sL and +fL)

60 In contrast, fast and slow L-cone signals of the same polarity (+sL and +fL) sum at

61 fficient to promote M cone fate and suppress L cone fate in retinal organoids.

62 using adaptation to 650-nm light to suppress L-cone activity, and substitution between 450 nm and 535

63 The L-cone system contributes to the desensitization of the

64 ficantly reduced contrast sensitivity on the L-cone test but normal performance on M- and S-cone test

65 t such divisions contribute significantly to L-cone production.