ライフサイエンスコーパス: L-glutamate

1 and valid variation in human umami taste of l-glutamate.

2 ncompetitive vs NADPH, and noncompetitive vs L-glutamate.

3 in the active R-state complexed with CoA and l-glutamate.

4 ansporter, EAAC1, whose level was doubled by L-glutamate.

5 is noncompetitive vs NADPH, alpha-AASA, and L-glutamate.

6 reacted with [5'-(3)H]adenosylcobalamin and L-glutamate.

7 glutarate to the excitatory neurotransmitter L-glutamate.

8 pathways for the degradation of N-formimino-L-glutamate.

9 botropic glutamate receptors with 100 microM L-glutamate.

10 of N-formimino-L-glutamate to formamide and L-glutamate.

11 lysis of N-formyl-L-glutamate to formate and L-glutamate.

12 d HutI to convert L-histidine to N-formimino-L-glutamate.

13 te (L-SOP), which antagonizes the effects of L-glutamate.

14 nd the natural substrate N-acetyl-l-aspartyl-l-glutamate.

15 te, and the neuropeptide N-acetyl-l-aspartyl-l-glutamate.

16 conversion of L-glutamate to alpha-N-acetyl-L-glutamate.

17 oxamine 5'-phosphate (PMP) in the presene of L-glutamate.

18 reacted with [5'-(3)H]-adenosylcobalamin and L-glutamate.

19 , but potentiates the receptor's response to l-glutamate.

20 capped with a single, terminal alpha-linked L-glutamate.

21 T352A not only transports aspartate but also l-glutamate.

22 , and standard peptide coupling with diethyl L-glutamate.

23 ousal similar to the excitatory transmitter, L-glutamate.

24 e commissural sub-nucleus, and replicated by L-glutamate.

25 , and standard peptide coupling with diethyl L-glutamate.

26 VZ cells than the neurotransmitters GABA and L-glutamate.

27 GltPh, with preference for l-aspartate over l-glutamate.

28 eases the potency for the endogenous agonist l-glutamate.

29 asis of sequence similarity, but do not bind l-glutamate.

30 ivation time course following the removal of L-glutamate.

31 inctively by the endogenous neurotransmitter L-glutamate.

32 inus or by microiontophoretic application of l-glutamate.

33 1 > Cl-, 0.34 > N-methyl-D-glucamine, 0.27 > L-glutamate, 0.15 approximately D-aspartate, 0.16.

34 6 kainate receptors observed following brief L-glutamate (10 mM Glu, 1 ms) applications differed by t

35 ular responses to microinjections (10 nl) of L-glutamate (10 mM) into the dorsal medulla were studied

36 observed for (18)F-labeled (2S,4R)-4-fluoro-l-glutamate (4F-GLU), suggesting that both are useful im

37 f RVLM, were replicated by microinjection of L-glutamate (5 nmol, 20 nl).

38 nophosphate enhanced taste cell responses to L-glutamate, a characteristic feature of umami taste.

39 ects of arecoline, a cholinergic agonist, or L-glutamate, a glutamatergic agonist, on retention.

40 dy-state currents than responses elicited by L-glutamate, a prominent feature of GLAST, and examinati

41 extracellular L-glutamate via the GltT-GltM L-glutamate ABC transporter, but the underlying mechanis

42 s designed to determine whether iron-induced L-glutamate accumulation in the CCM regulates L-cystine

43 L-SOP inhibition relative to the potency of L-glutamate activation in mGluR1 mutants and others that

44 mutations (E114G and V235A) had no effect on l-glutamate activation or ivermectin binding: one (T300S

45 We conclude that L-glutamate acts via amino acid and glucose via sweet ta

46 l-glutamate, alpha-amino-3-hydroxy-5-methyl-isoxozole pr

47 Application of L-glutamate also increased GABA release.

48 regardless of the presence of added Na(+) or l-glutamate, although their expression at alkaline pH wa

49 bution of the two glutamate transporters and L-glutamate-ammonia ligase strongly links glia to the pa

50 Similarly, expression of L-glutamate-ammonia ligase, the enzyme that converts glu

51 L-Glutamate, AMPA or NMDA enhanced the activity of 71, 7

52 thod with a 4-10 ms time resolution to apply L-glutamate and (2) a laser-pulse photolysis technique t

53 factor-independent stereoinversion of D- and L-glutamate and are important for viability in several g

54 rythrocytes have a low basal permeability to L-glutamate and are not known to have a functional gluta

55 Release of L-glutamate and D-aspartate through P2X7 channels was co

56 h arsenite was shown to induce the uptake of L-glutamate and D-aspartate, but not that of D-glutamate

57 talyze the reversible stereoisomerization of L-glutamate and D-glutamate with similar, but not identi

58 ase small molecules, such as the amino acids l-glutamate and d-serine as "gliotransmitters," which di

59 Furthermore, they show uptake of l-glutamate and d-serine that is driven by a proton elec

60 receptor) synaptobrevin 2, and contain both l-glutamate and d-serine.

61 Copolypeptides of L-glutamate and glucosylated L-/DL-allyl- or DL-propargy

62 aste by recording responses, specifically to l-glutamate and inosine 5'-monophosphate (IMP) mixtures

63 alpha-Kg) serves as the dead-end analogue of L-glutamate and is competitive vs L-glutamate and uncomp

64 L-glutamate and L-CCG-IV induce significantly slower dea

65 ynthesis of L-gamma-glutamyl-L-cysteine from L-glutamate and L-cysteine and the ATP-dependent synthes

66 rom mGluR4 and other group III mGluR in that L-glutamate and L-SOP activate it with low potency and e

67 or mGluR2, suggesting that co-recognition of L-glutamate and L-SOP arose early in evolution, and was

68 affinity and efficacy for activation by both L-glutamate and L-SOP.

69 catalyzes the reversible interconversion of L-glutamate and L-threo-3-methylaspartate via a radical-

70 ions expand substrate specificity to include l-glutamate and lead to an increase in specificity for l

71 ATs) buffer and remove synaptically released L-glutamate and maintain its concentrations below neurot

72 In the presence of l-glutamate and NAD(+), both proteins were required for

73 ential ring-opening polymerization of benzyl-L-glutamate and propargylglycine (PG) N-carboxyanhydride

74 e at the same sites, and both the effects of L-glutamate and PrRP were abolished following local admi

75 The mGluR agonists L-glutamate and quisqualate increased the open state pro

76 rolysis and subsequent coupling with diethyl l-glutamate and saponification afforded target compounds

77 the benzoic acid derivative 19 with diethyl L-glutamate and saponification.

78 tor mediated modulation of NMDA receptors by L-glutamate and serotonin (5-HT).

79 EC(50)s for L-glutamate and sodium are significantly lower after mod

80 induced loss of the endogenous intracellular L-glutamate and taurine.

81 me-based biosensors for the neurotransmitter L-glutamate and the energy metabolite L-lactate have bee

82 uctures with the endogenous neurotransmitter L-glutamate and the open-channel blocker picrotoxin.

83 l-Glutamate and total free amino acid content did not di

84 nalogue of L-glutamate and is competitive vs L-glutamate and uncompetitive vs L-AASA and NADPH.

85 (GDH) catalyzes the oxidative deamination of L-glutamate and, in animals, is extensively regulated by

86 een proposed to underlie umami, the taste of L-glutamate, and certain other amino acids and nucleotid

87 ctivity for L-aspartate over D-aspartate and L-glutamate, and lost their selectivity for Na(+) over L

88 s capable of storing and releasing d-serine, l-glutamate, and most likely other neuromodulators in an

89 inhibition studies using analogues of AASA, L-glutamate, and saccharopine.

90 he alpha-bromoketones, coupling with diethyl-L-glutamate, and saponification afforded 2-5.

91 rsors were deprotected, coupled with diethyl-L-glutamate, and saponified.

92 ing domain (LBD) that binds agonists such as L-glutamate, and the distal N-terminal domain (NTD), who

93 R1/T1R3 responds to the umami taste stimulus l-glutamate, and this response is enhanced by 5'-ribonuc

94 ht to affect mGluRs, behavioral detection of l-glutamate appears to require the contribution of the T

95 larger increase of the apparent affinity for l-glutamate, around 130-fold higher than that of wild ty

96 wn to mediate uptake of both L-aspartate and L-glutamate as well as having sensitivity to L-aspartate

97 The samples were assayed offline for L-glutamate at a rate of 15 samples/min by pumping them

98 lly, 4 and 5 potentiated responses of 10 muM L-glutamate at homomeric rat GluA2(Q)i receptors with EC

99 mimicked that produced by administration of L-glutamate at the same sites, and both the effects of L

100 hors found that the iron-induced increase in L-glutamate availability increased L-cystine uptake, wit

101 mino-terminal domain (ATD) distinct from the L-glutamate-binding domain.

102 lack of antagonist-bound structures for the L-glutamate-binding GluN2 subunits.

103 ed the Venus flytrap domain of T1R1 in which l-glutamate binds close to the hinge region and 5' ribon

104 ving the Venus flytrap domain of T1R1, where L-glutamate binds close to the hinge region, and 5' ribo

105 L-Glutamate binds in an extended conformation, similar t

106 Added l-glutamate (but not Na(+)) favored Ca(2+)-independent g

107 ble mutant retained the ability to transport l-glutamate, but its kinetic parameters were very simila

108 palm oil supplemented diets decreased brain L-glutamate by 15-20% and GABA by about 34% supporting t

109 associated with a substitution of the P(2)' l-glutamate by a l-glutamine corroborates the importance

110 rst, newly synthesized [(3)H]GABA from [(3)H]l-glutamate by membrane-associated GAD is taken up prefe

111 ostsynaptic-mGluR8a modulates the release of L-glutamate by photoreceptors and the responses of retin

112 that catalyze the oxidation of L-proline to L-glutamate by the sequential activities of proline dehy

113 The umami taste of L-glutamate can be drastically enhanced by 5' ribonucleo

114 The umami taste of l-glutamate can be drastically enhanced by 5' ribonucleo

115 he degradation of N-formimino-L-glutamate to L-glutamate can occur by three different pathways.

116 entities as well as those of the enzyme-NADP-l-glutamate complex.

117 idge between the heterocycle and the benzoyl-L-glutamate (compounds 2-5, respectively) were synthesiz

118 sium in physiological buffered saline evoked l-glutamate concentration transients that had an average

119 r 1 (EAAC1) is a high-affinity Na+-dependent L-glutamate/D,L-aspartate cell-membrane transport protei

120 s of evidence are presented to indicate that l-glutamate decarboxylase (GAD) can become membrane-asso

121 gamma-aminobutyric acid-synthesizing enzyme, l-glutamate decarboxylase (MGAD), is regulated by the ve

122 ) intermediate complexes of the bovine liver l-glutamate dehydrogenase-catalyzed reaction.

123 ion of the commercially available Amplex Red L-glutamate detection kit (Life Technologies).

124 -opening polymerization of poly(gamma-benzyl-L-glutamate) (DIBO-PBLG).

125 Haemonchus contortus were more sensitive to l-glutamate (EC(50) = 27.6 +/- 2.7 microM) than those fo

126 Among these, mGluR1 responds to L-glutamate effectively, whereas it binds weakly to anot

127 nds affect oxygen-glucose deprivation-evoked L-glutamate efflux from adult rat cerebrocortical prisms

128 modulatory effect of glutamate receptors on L-glutamate efflux.

129 responses to SSS stimulation (P < 0.001) and L-glutamate ejection (P < 0.001).

130 cular studies, physiologic studies show that l-glutamate elicits increases in intracellular Ca(2+) in

131 l-Glutamate elicits the umami taste sensation, now recog

132 8-37 also showed a significant inhibition of l-glutamate-evoked cell firing and firing evoked by stim

133 tagonist, GR127935 (P = 0.6), did not affect L-glutamate-evoked neuronal firing.

134 se drugs through their modulatory actions on L-glutamate-evoked third order neuronal firing.

135 tained import of L-cystine via the L-cystine/L-glutamate exchanger, system x(c)(-), is rate-limiting

136 d quinones enter the tunnel system and where L-glutamate exits.

137 or 9.0, especially with added Na(+) (but not l-glutamate), facilitated full-scale growth.

138 The concentration-response range for L-glutamate fell approximately within the physiologicall

139 utual vesicular synergy between d-serine and l-glutamate filling in glia vesicles.

140 rved Lcr(+) cells of Y. pestis supplied with l-glutamate first excreted and then destroyed l-aspartat

141 nt coupling of each regioisomer with diethyl-l-glutamate followed by saponification afforded 4 and 5.

142 ion was deprotected and coupled with diethyl l-glutamate followed by saponification.

143 ion was deprotected and coupled with diethyl L-glutamate followed by saponification.

144 on were deprotected and coupled with diethyl-l-glutamate followed by saponification.

145 ich were hydrolyzed and coupled with diethyl-L-glutamate, followed by saponification, to give the tar

146 tamyl-gamma-D-glutamate and L-glutamyl-gamma-L-glutamate, following which peracid-mediated epoxidatio

147 the exogenous acquisition of L-glutamine or L-glutamate for function.

148 only one pathway, involving oxaloacetate and l-glutamate, for de novo synthesis of homocysteine.

149 reductase (SR) [saccharopine dehydrogenase (l-glutamate forming), EC 1.5.1.10] catalyzes the condens

150 nvestigated with rapid photolytic release of L-glutamate from nitroindolinyl (NI)-caged glutamate wit

151 However, the L-glutamate gamma-carboxyl group interacts exclusively w

152 e to glutamate via the intermediates P5C and l-glutamate-gamma-semialdehyde (GSA).

153 In the P5CDH active site, l-glutamate-gamma-semialdehyde (the hydrolyzed form of D

154 g separate proline dehydrogenase (PRODH) and l-glutamate-gamma-semialdehyde dehydrogenase active site

155 DUF in addition to proline dehydrogenase and l-glutamate-gamma-semialdehyde dehydrogenase catalytic m

156 e showed the canonical arrangement of PRODH, l-glutamate-gamma-semialdehyde dehydrogenase, and C-term

157 unocytochemistry and by stimulation; 3-4 muM L-glutamate (Glu) and 3 muM carbachol (CCh) evoked rapid

158 tion factor, while the presence of exogenous l-glutamate (Glu) at the primary root tip slows primary

159 acute microinjection of the neurotransmitter l-glutamate (Glu) or its receptor agonist NMDA into the

160 mission and prevent neurotoxic accumulation, l-glutamate (Glu), the major excitatory neurotransmitter

161 d nonpathogenic mycobacteria and on the poly-L-glutamate/glutamine cell wall structure.

162 order of potency of agonists was ibotenate > L-glutamate > kainate = quisqualate.

163 mami" taste quality commonly associated with l-glutamate have been controversial.

164 arization and subsequent synaptic release of l-glutamate have been implicated in ischemic retinal dam

165 Increased levels of extracellular l-glutamate have been suggested to play a role in retina

166 N-Formimino-l-glutamate iminohydrolase (HutF) from Pseudomonas aerug

167 e distance between the bicyclic scaffold and l-glutamate in 3b would preserve transport selectivity a

168 nd, as predicted, blocked the umami taste of l-glutamate in human taste tests.

169 pathways for the degradation of N-formimino-L-glutamate in P. aeruginosa is unknown.

170 SA) which adds in rapid equilibrium prior to l-glutamate in the forward reaction direction.

171 n of imidazolone-5-propanoate to N-formimino-L-glutamate in the histidine degradation pathway.

172 osa catalyzes the deimination of N-formimino-l-glutamate in the histidine degradation pathway.

173 eptor agonist, and by the endogenous agonist l-glutamate in the presence of AMPA, NMDA, mGluR, and GA

174 n serve as a low-affinity taste receptor for l-glutamate in the presence of IMP.

175 As shown here, l-aspartate substituted for l-glutamate in this context but only Na(+) exacerbated t

176 that catalyze the oxidation of l-proline to l-glutamate in two successive reactions.

177 on range of 0-200 microM for calibrations of L-glutamate in vitro.

178 ACC microinjection of 2 mmol/L glutamate increased the VMR to CRD (10 mm Hg) in visce

179 viscerally hypersensitive rats, and 20 mmol/L glutamate induced a more potent VMR in viscerally hype

180 eased EAAT2 expression protects neurons from L-glutamate induced cytotoxicity and cell death in vitro

181 h various ligands reveal that the binding of L-glutamate induces a unique conformation at the backsid

182 The majority of the arsenite-induced L-glutamate influx was via a high-affinity, Na(+)-depend

183 T) system selectively mediates the uptake of L-glutamate into synaptic vesicles.

184 unctional studies involved microinjection of L-glutamate into the caudal dorsal motor nucleus of the

185 vs NADP and noncompetitive vs saccharopine, L-glutamate is noncompetitive vs both NADP and saccharop

186 L-Glutamate is the major excitatory neurotransmitter in

187 h lower than that for the natural substrate, L-glutamate (k(cat) = 5.6 s(-)(1)).

188 e of the catalytical amino acids of N-acetyl-L-glutamate kinase (Lys9, Lys216, and Asp150 in FomA); 2

189 In cyanobacteria, PipX and N-acetyl-L-glutamate kinase are receptors of PII signaling, and t

190 By contrast, the PII-N-acetyl-L-glutamate kinase interaction, which is negatively affe

191 Structural comparison with N-acetyl-L-glutamate kinase shows several similarities in the sit

192 D-Aspartate (D-Asp) can substitute for L-glutamate (L-Glu) at excitatory Glu receptors, and occ

193 P46A1 indicated that CYP46A1 is activated by l-glutamate (l-Glu), l-aspartate, gamma-aminobutyric aci

194 as identified by microinjections (100 nl) of L-glutamate (L-Glu).

195 cs of both natural substrates, L-cystine and L-glutamate (L-Glu).

196 Monosodium L-glutamate (L-MSG), a natural component of many foods,

197 l-Glutamate, l-aspartate and d-serine are simultaneously

198 e promotion of glutamine synthetase (GS) and L-Glutamate/L-Aspartate Transporter (GLAST) functions.

199 xpression (glial L-glutamate transporter and L-glutamate/L-aspartate transporter) along the abscess m

200 on of OAT2 in the presence of N-alpha-acetyl-L-glutamate led to a structure in which Thr-181 was acet

201 ocus encodes a tetrahydromethanopterin:alpha-l-glutamate ligase that forms tetrahydrosarcinapterin, a

202 01 (cofF) locus encodes a gamma-F420-2:alpha-l-glutamate ligase, which caps the gamma-glutamyl tail o

203 ld) rats, activation of group I metabotropic L-glutamate (mGlu) receptors by the specific agonist (RS

204 eptor TAS1R1-TAS1R3 responds specifically to l-glutamate mixed with the ribonucleotide IMP.

205 orientation of the side chain p-aminobenzoyl-L-glutamate moiety with respect to the pyrimidine ring a

206 ich, like the Sf6 knob, contains three bound L-glutamate molecules.

207 7BL/6ByJ (B6) strain consume more monosodium l-glutamate (MSG) than do mice from the 129P3/J (129) st

208 Eight of these were benzoic acid L-glutamate mustards for evaluation as prodrugs and the

209 l-Glutamate-N,N-diacetate (L-GLDA) was recently introduc

210 se II (GCPII) hydrolyzes N-acetyl-L-aspartyl-L-glutamate (NAAG) to liberate N-acetylaspartate and glu

211 e abundant neuropeptide, N-acetyl-L-aspartyl-L-glutamate (NAAG), to produce N-acetylaspartate and glu

212 The dose of either arecoline or L-glutamate needed to improve retention was reduced at l

213 (Es-HutI) bound to the product [ N-formimino-L-glutamate (NIG)] and an inhibitor [3-(2,5-dioxoimidazo

214 Considering that the L-glutamate obtained via GltT-GltM is utilized as a nutr

215 e thienoyl antifolates in which the terminal l-glutamate of the parent structure (7) was replaced by

216 c release (t (1/2) < 0.7 ms) of 7--70 microM L-glutamate on PNs voltage clamped at -65 mV activated f

217 uncaging of 4-methoxy-7-nitroindolinyl-caged L-glutamate onto isolated dendritic spines shows that th

218 1 region of the early postnatal hippocampus, l-glutamate or AMPA (applied in the presence of antagoni

219 of the MnPN via microdialytic application of L-glutamate or bicuculline resulted in reduced discharge

220 lly after activation by 1-ms photorelease of L-glutamate or by bursts of parallel fibre (PF) stimulat

221 lineage cells secreting the neurotransmitter L-glutamate or expressing G-protein-gated inwardly recti

222 Binding of l-glutamate or l-BSO to the two Mn2+/gamma-GCS species p

223 The addition of L-glutamate or pyruvate reversibly decreased the frequen

224 Addition of L-glutamate or sucralose to a perfusate containing low g

225 Iontophoresis of L-glutamate or vasopressin into the vicinity of a vasomo

226 Transamination between L-glutamate (or L-phenylalanine) and the alpha-ketogluta

227 e and lead to an increase in specificity for l-glutamate over 2-aminoisobutyrate of approximately 8 o

228 act that it also acts as a substrate for the L-glutamate oxidase (GluOx) reporter enzyme.

229 e recording site was coated with Nafion with L-glutamate oxidase and bovine serum albumin (BSA) cross

230 -phenylenediamine) layer and cross-linked to l-glutamate oxidase with poly(ethylene glycol) diglycidy

231 ol inhibited both responses (SSS, P = 0.003; L-glutamate, P < 0.001).

232 co-ejection of isoproterenol (SSS, P = 0.02; L-glutamate, P = 0.006).

233 ced no significant inhibition (SSS, P = 0.7; L-glutamate, P = 0.2), indicating an inhibitory role for

234 ist ICI 118,551 had no effect (SSS, P = 0.9; L-glutamate, P = 0.4), nor did the beta2 agonist procate

235 the beta2 agonist procaterol (SSS, P = 0.6; L-glutamate, P = 0.9).

236 ion of the folate catabolite p -aminobenzoyl-L-glutamate (pABGlu) to produce the major urinary produc

237 N-acetyl-L-aspartyl-L-glutamate peptidase-like 2 (NAALADL2) is a member of t

238 onance imaging (MRI) method, which uses poly-L-glutamate (PLG) as an MRI probe to map cathepsin expre

239 rine-O-phosphate or the physiological ligand l-glutamate produced a decrease in influx of extracellul

240 In these neurons, application of l-glutamate produced voltage-dependent modulation of N-t

241 The second method involves the detection of L-glutamate, produced during the regeneration of the cof

242 In addition, L-glutamate production, L-cystine uptake, and GSH concen

243 ut bacteriostasis other than that Na(+) plus l-glutamate promotes prompt restriction of Y. pestis.

244 l l-glutamate signal is mediated via mucosal l-glutamate receptors with activation of afferent nerves

245 s evidenced by similar calcium responses and L-glutamate release in the two genotypes.

246 MDA receptors were activated by DomA-induced l-glutamate release.

247 response to DomA and a lack of DomA-induced L-glutamate release.

248 re caps the chain with a single alpha-linked l-glutamate residue.

249 formation: a gamma-glutamyl ligase adds 1-3 l-glutamate residues and the ATP-grasp-type ligase descr

250 catalyses the GTP-dependent addition of two L-glutamate residues to F(420)-0 to form F(420)-2.

251 enum, which suggests the presence of luminal l-glutamate sensing.

252 Initial velocity studies with L-glutamate showed that even at concentrations of 600 mM

253 Furthermore, a luminal l-glutamate signal is mediated via mucosal l-glutamate r

254 (IMP), a ribonucleotide that potentiates the l-glutamate signal through the T1R1 + T1R3 heterodimer,

255 Analysis of the pH dependence of L-glutamate stereoisomerization suggested that RacE1 and

256 ect to chemotherapeutic drug design, because L-glutamate stereoisomerization to D-glutamate is predic

257 We show that dietary L-glutamate stimulates ISC division and gut growth.

258 in place of the gamma-carboxylic acid in the l-glutamate subunit of the potent GAR Tfase inhibitor 1,

259 s NADPH and noncompetitive vs alpha-AASA and L-glutamate, suggesting that the dinucleotide adds to th

260 lished the novel finding that iron regulates L-glutamate synthesis and accumulation in the cell-condi

261 The p-aminobenzoyl-l-glutamate tail of THF remains weakly bound in a widene

262 ted an ~15-fold higher apparent affinity for l-glutamate than the wild type transporter, and the M362

263 L-glutamate, the major excitatory neurotransmitter in th

264 L-glutamate, the photoreceptor neurotransmitter, depolar

265 lutamate dehydrogenase (GDH), which converts l-glutamate, the product of the AST pathway, in alpha-ke

266 yzes the reversible oxidative deamination of l-glutamate to 2-oxoglutarate using NAD(P)(+) as coenzym

267 yzes the reversible oxidative deamination of L-glutamate to 2-oxoglutarate.

268 s and catalyses the oxidative deamination of l-glutamate to 2-oxoglutarate.

269 6, to phenylalanine increased the EC(50) for l-glutamate to 92.2 +/- 3.5 microM, and reduced the Hill

270 pH from 7.5 to 6.5 decreases the EC(50) for L-glutamate to activate the anion conductance, without a

271 inine biosynthesis, namely the conversion of L-glutamate to alpha-N-acetyl-L-glutamate.

272 n to catalyze the deimination of N-formimino-L-glutamate to ammonia and N-formyl-L-glutamate, while P

273 e (RacE) is a bacterial enzyme that converts l-glutamate to d-glutamate, an essential precursor for p

274 acemase (RacE) is responsible for converting l-glutamate to d-glutamate, which is an essential compon

275 wn to catalyze the hydrolysis of N-formimino-L-glutamate to formamide and L-glutamate.

276 Pa5091 catalyzed the hydrolysis of N-formyl-L-glutamate to formate and L-glutamate.

277 -aminoadipate-delta-semialdehyde (AASA) with l-glutamate to give an imine, which is reduced by NADPH

278 The degradation of N-formimino-L-glutamate to L-glutamate can occur by three different

279 AT2 were studied using rapid applications of L-glutamate to outside-out patches excised from transfec

280 ring in response to the rapid application of l-glutamate to outside-out patches from human embryonic

281 utations that should abrogate the binding of L-glutamate to the needle do not appear to affect virion

282 currents evoked by exogenous application of L-glutamate to the slice.

283 o catalyze the GTP-dependent addition of two l-glutamates to the l-lactyl phosphodiester of 7,8-didem

284 y, GltPh-M362T exhibited l-aspartate but not l-glutamate transport.

285 and glutamate transporter expression (glial L-glutamate transporter and L-glutamate/L-aspartate tran

286 Expression of L-glutamate transporters by U373 cells was examined by r

287 ronal transporter, contributes more to [(3)H]l-glutamate uptake in OLs than GLT1 or GLAST.

288 NA-injected Xenopus oocytes by measuring [3H]L-glutamate uptake or glutamate-evoked uptake currents.

289 ltM is utilized as a nutrient in host cells, l-glutamate uptake via GltT-GltM plays multiple roles in

290 The measurement of L-glutamate using glutamate oxidase was the test system;

291 was triggered by the influx of extracellular L-glutamate via the GltT-GltM L-glutamate ABC transporte

292 Remarkably, the increase for d-aspartate and l-glutamate was 250- and 400-fold, respectively.

293 Chemical stimulation of the insula using L-glutamate was associated with both excitatory and inhi

294 Using this method, L-glutamate was monitored in the striatum of anesthetize

295 he rate of desensitization elicited by 10 mM L-glutamate was similar in control (taufast = 5.5 +/- 0.

296 y 5% of taste cells selectively responded to L-glutamate when it was focally applied to the apical ch

297 ormimino-L-glutamate to ammonia and N-formyl-L-glutamate, while Pa5091 catalyzed the hydrolysis of N-

298 fied recombinant PEB1a binds L-aspartate and L-glutamate with sub microM K(d) values.

299 boxy-2-nitrobenzyl)glutamate (alphaCNB-caged L-glutamate) with a time constant of 30 micros.

300 n Muller cells and depolarize in response to L-glutamate without significant change in membrane resis