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1 F) from glucose, guanine, and p-aminobenzoyl-l-glutamic acid.
2 glycine, l-proline, l-serine, l-alanine, and l-glutamic acid.
3 with a commercially available derivative of L-glutamic acid.
4 inofuro[2, 3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid (1) with respect to dihydrofolate reduct
5 and kinetics of (S)-4-(3-[18F]fluoropropyl)-l-glutamic acid ((18)F FSPG) in healthy volunteers and t
6 acid derivative (S)-4-(3-(18)F-Fluoropropyl)-l-glutamic acid ((18)F-FSPG, alias BAY 94-9392), a new P
7 2-chloroethyl)(2-mesyloxyethyl)amino]benzoyl-l-glutamic acid, 1a, which has been in clinical trials.
8 rothieno[2,3-d]pyrimidin-5-yl)thio]benzoyl} -L-glutamic acid 2 and 13 nonclassical analogues 2a-2m we
9 (pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic acid (2) and N-[2-amino-4-ethyl-6-methyl[(pyr
11 -pyrrolo[2,3-d]pyrimidin-6-yl)th io]benzoyl}-L-glutamic acid 3 and N-{4-[(2-amino-4-oxo-5-methyl-4,7-
12 opyrido[3,4-g]pteridin-7-yl)me thyl]benzoyl]-L-glutamic acid 3 was detrimental to DHFR inhibitory act
13 ibited by the gamma-boronic acid analogue of L-glutamic acid, 3-amino-3-carboxypropaneboronic acid (g
14 in-5-yl)ethyl]benzoyl inverted question mark-L-glutamic acid (3a) was designed and synthesized as a p
15 rrolo[3,2- d]pyrimidin-5-yl)methyl]benzoyl}- l-glutamic acid 4 and 11 nonclassical analogues 5- 15 as
16 -pyrrolo[2,3-d]pyrimidin-6-yl) thio]benzoyl}-L-glutamic acid 4 were designed, synthesized, and evalua
17 (pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-l -glutamic acid (4), were designed and synthesized as p
18 ,3-d]pyrimidin-5-yl) thio]-2'-fluorobenzoyl]-l-glutamic acid (4) and N-[4-[(2-amino-6-methyl-3,4-dihy
19 ieno[2,3- d]pyrimidin-5-yl)sulfanyl]benzoyl}-L-glutamic acid (4) and nine nonclassical analogues 5-13
20 -pyrrolo[2,3-d]pyrimidin-5-yl)t hio]benzoyl]-L-glutamic acid (4) and thirteen nonclassical analogues
21 no acids, L-aspartic acid 4-methyl ester and L-glutamic acid 5-methyl ester, is a convenient and sens
22 inofuro[2, 3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid (5) and its C8-C9 conformationally restr
23 ,3-d]pyrimidin-5-yl) thio]-2'-chlorobenzoyl]-l-glutamic acid (5), as TS inhibitors and antitumor agen
24 ibitor N-(p-methoxybenzenethiocarbonyl)amino-L-glutamic acid 6d, chosen for preliminary investigation
25 bis(2-bromoethyl)amino]-3,5-difluorobenzoyl}-L-glutamic acid and its iodoethylamino analogue were eff
26 es and antifolates as exemplified by pteroyl-l-glutamic acid and methotrexate (MTX), respectively.
29 ock copolymers, poly(ethylene glycol)-b-poly(L-glutamic acid)-b-poly(L-phenylalanine), which effectiv
30 ry neurotransmitter GABA is synthesized from L-glutamic acid by the enzyme glutamic acid decarboxylas
33 rrolo[2,3-d]-pyrimidin-6-yl)propyl]benzoy l}-L-glutamic acid (compound 2) and N-{4-[4-2-amino-4-oxo-4
34 rrolo[2,3-d]-pyrimidin-6-yl)butyl]benzoyl} *-L-glutamic acid (compound 3), respectively) were inhibit
36 lays an important role in regulating soluble l-glutamic acid decarboxylase (GAD) and membrane-associa
38 in the inner plexiform layer (IPL) of single L-glutamic acid decarboxylase-immunoreactive (GAD-IR) an
39 ribed starting from a commercially available L-glutamic acid derivative, (4S)-5-(tert-butoxy)-4-[(ter
41 n appropriate N-substituted (4-aminobenzoyl)-L-glutamic acid dialkyl ester or N-(5-amino-2-thenoyl)-L
43 ntifolate 7 utilized 4-(chloromethyl)benzoyl-l-glutamic acid diethyl ester (17) instead of the benzyl
45 e L-glutamine analogs showed that all except L-glutamic acid dimethyl ester inhibited ANR activity in
46 roxamate, L-glutamic acid gamma-ethyl ester, L-glutamic acid dimethyl ester, L-asparagine, L-aspartic
48 ydrazide, L-glutamic acid gamma-hydroxamate, L-glutamic acid gamma-ethyl ester, L-glutamic acid dimet
49 utamine (L-glutamic acid gamma-methyl ester, L-glutamic acid gamma-hydrazide, L-glutamic acid gamma-h
50 as due to formation of the glutamine analogs L-glutamic acid gamma-hydroxamate and L-glutamic acid ga
51 thyl ester, L-glutamic acid gamma-hydrazide, L-glutamic acid gamma-hydroxamate, L-glutamic acid gamma
52 rved between the strong inhibitory effect of L-glutamic acid gamma-methyl ester on ANR activity and t
53 the effects of eight analogs of L-glutamine (L-glutamic acid gamma-methyl ester, L-glutamic acid gamm
55 y of this enzyme to employ hydroxylamine and L-glutamic acid gamma-monohydroxamate (LGH) as alternati
56 -4-[bis(2-chloroethyl)amino]phenyl]carbamoyl-l-glutamic acid gave a differential of >227 in MDA MB361
57 oxidase (GmOx) microelectrode for measuring l-glutamic acid (GluA) in oxygen-depleted conditions, wh
59 um or the amino acids L-alanine, L-arginine, L-glutamic acid, glycine, and DL-serine as sole nitrogen
60 ein we report self-assembly behavior of poly(l-glutamic acid)-grafted gold NPs in solution and descri
61 ally pure 2-pyrrolidinones (4) derived from (L)-glutamic acid has been investigated as a method for t
63 solution, we identified three equivalents of l-glutamic acid (l-Glu) bound to each subunit interface.
64 ns that also can serve as substrates, namely L-glutamic acid (L-Glu), D-aspartic acid (D-Asp), and su
65 ynthetic amino acid copolymer of L-tyrosine, L-glutamic acid, L-alanine, and L-lysine that is effecti
66 synthetic amino acid copolymer of L-alanine, L-glutamic acid, L-lysine, and L-tyrosine, effective bot
67 pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]ben zoyl]-L-glutamic acid (LY231514) and 1, whereas 4 was inactive
68 yrrolo[2,3-d]pyrimidin-5-yl)ethyl ]-benzoyl]-L-glutamic acid (LY231514) is a novel pyrrolo[2,3-d]pyri
69 rbon sources (L-Asparagine, L-Aspartic Acid, L- Glutamic Acid, m- Erythritol, D-Melezitose, D-Sorbito
71 ed glutamate, N-(o-nitromandelyl)oxycarbonyl-L-glutamic acid (Nmoc-Glu), that liberates free glutamat
72 end on both the grafting density of the poly(l-glutamic acid) on the NPs and the size of the NPs.
74 threonine, D-threonine, L-leucine, L-lysine, L-glutamic acid, or diglycine with L-serine as a major c
75 ificantly higher in tumors treated with poly(L-glutamic acid)-paclitaxel (10.76 +/- 1.38 %ID/g; P = 0
76 .38 %ID/g; P = 0.001) and with combined poly(L-glutamic acid)-paclitaxel and C225 (9.84 +/- 2.51 %ID/
77 onal antibody C225, or a combination of poly(L-glutamic acid)-paclitaxel and C225, followed by intrav
79 g MDA-MB-468 breast tumors treated with poly(L-glutamic acid)-paclitaxel and cetuximab (IMC-C225) ant
81 respectively, 4 d after treatment with poly(L-glutamic acid)-paclitaxel or combined poly(L-glutamic
82 A-PEG-ovalbumin was also observed after poly(L-glutamic acid)-paclitaxel treatment (55.6%), although
84 zolinyl)methyl]-N-prop- 2-ynylamino]benzoyl]-L-glutamic acid (PDDF, 1) and N-[5-[N-[(3,4-dihydro-2-me
86 ultilayers ~700nm thick fabricated from poly-l-glutamic acid (PGA) and poly-l-lysine (PLL) can be loa
87 conformation of poly-l-lysine (PLL) and poly-l-glutamic acid (PGA) in their non-alpha-helical states.
88 nd Ida were covalently linked to poly(alpha)-L-glutamic acid (PGA) via reducible disulfide and acid-s
90 significant effect, negatively charged poly-L-glutamic acid, PLG, stabilized both heterodimers and h
91 g sequences for the expression of poly(alpha,L-glutamic acid) (PLGA) as fusion proteins with dihydrof
92 iants in complex with L-aspartic acid versus L-glutamic acid provide insights into their differential
93 olin-6-ylmethyl)-N-methyl-amino]-2-theno yl)-l-glutamic acid (raltitrexed, Tomudex; ZD1694), or N(alp
94 arged segments of poly(l-lysine HBr) or poly(l-glutamic acid sodium salt), and helical, hydrophobic s
95 8545 (Lithium Carbonate LSVEC), NIST RM8573 (L-Glutamic Acid USGS40), NIST RM8542 (IAEA-CH6 Sucrose)
96 T RM8542 (IAEA-CH6 Sucrose) and NIST RM8574 (L-Glutamic Acid USGS41) differed from reference values b
97 tter-tasting caffeine, and the umami-tasting l-glutamic acid were the main contributors to the taste
98 nfluence of polyions, poly-L-lysine and poly-L-glutamic acid, were investigated to determine the effe
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