ライフサイエンスコーパス: L-glutamine

1 bon polyunsaturated fatty acids coupled with l-glutamine.

2 otein or GS activity and was auxotrophic for L-glutamine.

3 forms polar zippers similar to those of poly-L-glutamine.

4 ngest transport activities were specific for l-glutamine.

5 the C1A AS-B mutant is incubated with [14C]-L-glutamine.

6 n behavior with increasing concentrations of L-glutamine.

7 m underlying the base-generating response to L-glutamine.

8 of glutamine-binding protein and its ligand, l-glutamine.

9 the complex of glutamine-binding protein and l-glutamine.

10 mutants with diminished ability to hydrolyze l-glutamine.

11 perifused in leucine 0-10 mmol/l with 2 mmol/l glutamine 0-25 mmol/l, AA 0-10 mmol/l, or glucose 0-25

12 rval, were obtained after no treatment, oral L-glutamine (0.5 g/kg), or glutamine followed by NMDA (a

13 hicle (489 mL diet soda) or vehicle plus 2 g L-glutamine (28 mg/kg body wt) was ingested and the gain

14 (18)F-labeled (2S,4R)-4-fluoro-l-glutamine (4F-GLN) has demonstrated high uptake in tum

15 n-derived uremic solutes: alpha-phenylacetyl-l-glutamine, 5-hydroxyindole, indoxyl glucuronide, p-cre

16 Efficient diffusion of L-glutamine across the outer membrane suggests that the

17 L-Glutamine administration significantly increased ECF G

18 ses, GFAT transfers the amino group from the L-glutamine amide to D-fructose 6-phosphate, producing g

19 The studies with the L-glutamine analogs showed that all except L-glutamic ac

20 10 mmol/L glutamine (EAS 44) or with 10 mmol/L glutamine and 20 mmol/L Pi(EAS 45), or in Adsol.

21 ic mechanism, with K(m) values of 280 mM for L-glutamine and 150 microM for acetyl-coenzyme A and wit

22 We show that cellular uptake of L-glutamine and its subsequent rapid efflux in the prese

23 However, l-glutamine and l-alanine model reactions showed the sam

24 ating aqueous d-glucose model reactions with l-glutamine and l-alanine yielded similar colored soluti

25 of MOP tested, only N-1-(1-deoxy-D-lyxityl)-L-glutamine and N-1-(1-deoxy-D-mannityl)-L-asparagine se

26 pecific for imine conjugates of D-hexose and L-glutamine and was not inhibited by sugars or amino aci

27 The transported substrates L-alanine, L-glutamine, and alpha-(methylamino)isobutyrate inhibite

28 rescine, p-aminobenzoic acid, L-cysteine and L-glutamine, and horse serum.

29 of neutral amino acids, including l-alanine, l-glutamine, and l-histidine, across the plasma membrane

30 640 supplemented with 5% fetal bovine serum, L-glutamine, and nonessential amino acids.

31 These results rule out a role for L-glutamine as a direct precursor of bicarbonate and ins

32 nsporter failed to grow on medium containing l-glutamine as the sole nitrogen source.

33 L-Glutamine blocked the responses of L-citrulline but no

34 by SF188 cells is comparable to that of (3)H-L-glutamine but higher than that of (18)F-FDG.

35 at acts to hinder the correct positioning of l-glutamine but not l-asparagine.

36 The in vitro biosynthesis of N-linolenoyl-l-glutamine by membrane-associated enzyme(s) in M. sexta

37 the fatty acid amide elicitor, N-linolenoyl-l-glutamine, by microsomal fractions of several alimenta

38 ell lines with high basal cellular levels of L-glutamine bypass the need for L-glutamine uptake and a

39 L-Glutamine can reverse pilT downregulation of the ABC t

40 We identify regulation of the L-glutamine carrier proteins SLC1A5 and SLC38A2 (SLC1A5/

41 Increases in l-glutamine concentration in the pathophysiological rang

42 a substitution of the P(2)' l-glutamate by a l-glutamine corroborates the importance of a carboxylate

43 Other substrates of asparaginases include L-glutamine, D-asparagine, and succinic acid monoamide.

44 noviral properties relative to corresponding L-glutamine-derived molecules.

45 L-Arginine, L-glutamine, DL-histidine, malate, and DL-ornithine prom

46 els increased significantly 2.5 h after oral L-glutamine (e.g., from 1.76 +/- 0.04 micromol/g in vehi

47 sodium chloride, and mannitol, with 10 mmol/L glutamine (EAS 44) or with 10 mmol/L glutamine and 20

48 Our structure of poly-L-glutamine fibers may explain why, in all but one of th

49 and hitherto enigmatic x-ray diagram of poly-L-glutamine fits a cylindrical sheet of 31 A diameter ma

50 Thus, L-glutamine flux regulates mTOR, translation and autopha

51 li asparagine synthetase B (AS-B) with [14C]-L-glutamine gives a covalent adduct that can be isolated

52 1, GlnA3 and GlnA4 catalyse the synthesis of L-glutamine, GlnA2 catalyses the synthesis of D-glutamin

53 tudying the response to the substrate glycyl-L-glutamine (Gly-Gln) of the proton-coupled peptide tran

54 Glycyl-L-glutamine (Gly-Gln; beta-endorphin 30-31) is an endoge

55 In glutamine-starved cells, 10 mmol/L glutamine in the absence of serum stimulated [(3)H]thy

56 sue-independent biosynthesis of N-linolenoyl-l-glutamine in M. sexta.

57 presence of low millimolar concentrations of l-glutamine in the extracellular solution.

58 L-glutamine, the effective concentration of L-glutamine in the M. tuberculosis phagosome of THP-1 ce

59 In contrast, L-glutamine increased plasma bicarbonate concentration (

60 Furthermore, L-glutamine increased the speed of recovery of IAS tone

61 also lactonized N-l-(1,2-dideoxy-D-mannityl)-L-glutamine, indicating that a hydroxyl group at carbon

62 N-linolenoyl-l-glutamine is a structural analog of several other elic

63 ation in which the alpha amino group of mono-l-glutamine is covalently linked to the side chain of gl

64 When GlnT is transfected into CV-1 cells, L-glutamine is the preferred substrate.

65 t that this newly discovered enzyme be named l-glutamine kinase.

66 IM862 is a synthetic dipeptide (L-glutamine L-tryptophan) with in vitro and in vivo anti

67 The low pH may inhibit the SNAT2 l-Glutamine (L-Gln) transporter, which controls protein

68 , we studied the effects of eight analogs of L-glutamine (L-glutamic acid gamma-methyl ester, L-gluta

69 , L-phenylalanine, 6-diazo-5-oxo-norleucine, L-glutamine, L-cysteine and L-glutamate were poor inhibi

70 p of amino acids that includes l-asparagine, l-glutamine, l-threonine, l-arginine, l-glycine, l-proli

71 is selected following prolonged culturing in L-glutamine-limited chemostats in a manner analogous to

72 of plant volatiles, N-(17-hydroxylinolenoyl)-L-glutamine, named volicitin and isolated from beet army

73 te and requires the exogenous acquisition of L-glutamine or L-glutamate for function.

74 er that regulates the simultaneous efflux of L-glutamine out of cells and transport of L-leucine/EAA

75 nt in Relenza) via a flexible linker to poly-l-glutamine (PGN) enhances the anti-influenza virus acti

76 The l-glutamine-phosphate product was characterized using (3

77 c-resolution structural information for poly(l-glutamine) (polyQ) in aqueous solution experimentally,

78 such as volicitin [N-(17-hydroxylinolenoyl)-L-glutamine], present in caterpillar oral secretions.

79 insulin secretion in the presence of 2 mmol/l glutamine (Q2) in cultured mouse islets pretreated for

80 incorporate P1 lactam moieties in lieu of an L-glutamine residue are described.

81 ternative substrates in place of ammonia and L-glutamine, respectively, has been investigated.

82 The molecular basis for L-glutamine sensitivity is due to SLC7A5/SLC3A2, a bidir

83 transport of changes in pH and extracellular l-glutamine, such as occur in cerebral ischemia and hepa

84 (SodA), L-alanine dehydrogenase (AlaDH), and L-glutamine synthetase (GlnS) proteins.

85 in the presence of various concentrations of L-glutamine, the effective concentration of L-glutamine

86 This activity allowed the diffusion of L-glutamine, the monosaccharides arabinose and glucose,

87 The activity allows the diffusion of L-glutamine, the monosaccharides arabinose and glucose,

88 cat)/K(M)) of nitrogen transfer from LGH and L-glutamine to beta-aspartyl-AMP are almost identical fo

89 Due to a fast occurring cyclization of l-glutamine to pyroglutamic acid, the typical amino-carb

90 sugars by transferring the amino group from l-glutamine to the acceptor substrate, fructose 6-phosph

91 ar levels of L-glutamine bypass the need for L-glutamine uptake and are primed for mTOR activation.

92 ystem-N transport plays an important role in l-glutamine uptake into isolated rat choroid plexus but

93 L-glutamine uptake is regulated by SLC1A5 and loss of SL

94 Krebs-Ringer bicarbonate buffer with 2 mmol/l glutamine using 10 mmol/l 2-aminobicyclo[2,2,1]-heptan

95 rmation of L-asparagine from L-aspartate and L-glutamine, via a beta-aspartyl-AMP intermediate.

96 that catalyzed biosynthesis of N-linolenoyl-l-glutamine was localized within the integral membrane p

97 ,3,4 - tetrahydro-3-isoquinolinyl]-carbonyl]-L-glutamine, was evaluated in vivo along with (S*,R*)-N-

98 or L-arginine were examined before and after L-glutamine, which is a putative blocker of L-citrulline

99 culocytes in McCoy's 5A medium modified with L-glutamine with 25 mM Hepes buffer supplemented with 20

100 ect phosphorylation of the amide nitrogen of l-glutamine with ATP by the catalytic activity of Cj1418