ライフサイエンスコーパス: L-histidine

1 the natural dipeptide carnosine (beta-alanyl-L-histidine).

2 the penultimate step in the biosynthesis of L-histidine.

3 ity, a K(ii) value of 4 muM was obtained for l-histidine.

4 r in solution, in the presence or absence of l-histidine.

5 occupancy of the allosteric sites by TIH and L-histidine.

6 f apoptosis, by the singlet oxygen scavenger L-histidine.

7 throcytes incubated in the presence of 40 mM L-histidine.

8 L-Histidine (1 mM) at pH 8.5, at which histidine is unch

9 and Na+-dependent with a 14-fold increase in L-histidine- (1 mM) evoked current (I(His) = -14.7 +/- 1

10 and low conductivity species such as: d- and l-histidine; 1- and 3-methylhistidines; carnosine; imida

11 L-histidine (1000 mg/kg) and thioperamide (5 mg/kg) were

12 ionic micelle from a block copolymer of poly(L-histidine) (3.7kDa) and short branched polyethyleneimi

13 Anserine (beta-alanyl-N(Pi)-methyl-L-histidine), a methylated derivative of carnosine (beta

14 acids, including l-alanine, l-glutamine, and l-histidine, across the plasma membrane and are involved

15 L-histidine, an inhibitor of mitochondrial glutamine tra

16 We complexed (64)Cu to l-histidine and analyzed clearance from blood, uptake in

17 luble receptor of this permease, HisJ, binds L-histidine and L-arginine (tightly) and L-lysine and L-

18 free media) only a partial inhibitor whereas L-histidine and L-cysteine are fully effective.

19 rgoing sizable reductions, including loss of L-histidine and L-tryptophan biosynthesis.

20 Peptides rich in L-histidine and L-tryptophan residues are selectively re

21 no acid transporters including Na+-dependent L-histidine and Na+-independent L-arginine and L-phenyla

22 In this study we tested administration of L-histidine and thioperamide in surgical brain injury in

23 We conclude that combined treatment with l-histidine and thioperamide leads to increased BBB brea

24 in rodents have shown that administration of L-histidine and thioperamide reduces ischemic tissue los

25 33), and surgical brain injury with combined l-histidine and thioperamide treatment (SBI+H) (n=29).

26 -aminothiazole, 2amino-4,5-dimethylthiazole, L-histidine, and 7-nitroindazole resulted in high spin h

27 were conducted with amino acids (l-arginine, l-histidine, and glycine) that are representative of tho

28 Competition studies with free glycine, l-histidine, and nitrilotriacetic acid (NTA) indicate an

29 The cell permeability was unaffected by l-histidine, and the sensor response remained unchanged.

30 l ligand derived from the natural amino acid l-histidine, are replaced by CH3NH3(+).

31 to use the dipeptide carnosine (beta-alanyl-L-histidine) as a sole carbon or nitrogen source was iso

32 acid transporter, with unique selectivity to L-histidine at neutral pH (K(0.5)(L-His) = 0.34 +/- 0.07

33 endogenous dipeptide carnosine (beta-alanyl-L-histidine), at 0.1-10 mM, provokes sustained contractu

34 cid groups and an unusual threo-beta-hydroxy-l-histidine available for Fe(III) chelation.

35 ion (K(ii)), on the contrary, indicates that l-histidine better inhibits MtATP-phosphoribosytransfera

36 y nuclear magnetic resonance, indicates that l-histidine binds better as the neutral alpha-amino grou

37 se catalyzes the first and committed step in l-histidine biosynthesis in Mycobacterium tuberculosis a

38 f the enzyme closely resembles the inhibited L-histidine-bound closed conformation, revealing the unc

39 L-histidine, but not D-histidine, stimulated 65Zn uptake

40 olymer, methoxy poly(ethylene glycol)-b-poly(l-histidine-co-l-phenylalanine) (PEGbPHF).

41 , although the enzymes also methylated other l-histidine-containing di- and tripeptides.

42 Wild-type (WT) and l-histidine decarboxylase (Hdc(-/-)) mice were fed a con

43 lood FCER1A, carboxypeptidase A3 (CPA3), and L-histidine decarboxylase (HDC) gene expression; and ser

44 rocessing of the histamine-producing enzyme, L-histidine decarboxylase (HDC), leads to the formation

45 strin receptor and regulates the activity of L-histidine decarboxylase (HDC), the enzyme that produce

46 functional mutation in the HDC gene encoding L-histidine decarboxylase, the rate-limiting enzyme in h

47 are genetic form of Tourette syndrome due to L-histidine-decarboxylase mutation, with similar feature

48 Target compound 5, the N tau-(carboxymethyl)-L-histidine derivative of 4, was also prepared.

49 tidine uptake was inhibited significantly by L-histidine followed by 2-endoamino-bicycloheptane-2-car

50 ldol reaction catalyzed by readily available l-histidine followed by biotransformation of the aldol a

51 The presence of threo-beta-hydroxy-l-histidine gives rise to a unique mode of Fe(III) coord

52 ation at the C-5 position of fully protected L-histidine has been achieved via a palladium-catalyzed

53 the transport of another System-N substrate, l-histidine, has yet to be determined.

54 e a, were incorporated into the bis(3-methyl-l-histidine) heme binding sites in [Delta7-H3m](2).

55 -helix bundle that contains two bis(3-methyl-l-histidine) heme binding sites with known absolute ferr

56 tes, bacteria, and archaebacteria synthesise L-histidine (His) in a similar, multistep pathway that i

57 ino)isobutyric acid, implying that uptake of L-histidine in H2.35 cells is primarily mediated by syst

58 ate and methotrexate analogues 6 and 4, with L-histidine in place of L-glutamate, were designed and s

59 acid transporter (NBAT)-induced transport of L-histidine in Xenopus laevis oocytes.

60 rsor of the dipeptide carnosine (beta-alanyl-l-histidine) in muscle.

61 e-limiting for the overall reaction and that l-histidine inhibition is caused by trapping the enzyme

62 teady-state kinetic studies demonstrate that l-histidine inhibition is uncompetitive versus ATP and n

63 udies showing that, relative to D-histidine, L-histidine is able to more strongly bind to RNA.

64 hylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate s

65 at catalyzes the formation of histamine from L-histidine, is an essential regulator of histamine leve

66 ropyl methacrylate (HPMA-Cl) and followed by L-Histidine (L-His) modification.

67 MF), methyl salicylate, caffeine, l-leucine, l-histidine, loratadine, ibuprofen, acetaminophen, acety

68 e acetal monomers (3-dimethoxymethylbenzoyl)-L-histidine methyl ester 1 and (3-dimethoxymethylbenzoyl

69 1 and (3-dimethoxymethylbenzoyl)-tau-benzyl-L-histidine methyl ester 2 were prepared from a histidin

70 The probe contains a naphthalimide core, an l-histidine methyl ester linker, and an acetylated galac

71 id based recognition element, N-methacryloyl-L-histidine methylester (MAH), 2-Hydroxyethyl methacryla

72 of this unique feature, we have incorporated L-histidine (N,N-di-n-hexadecylamine) ethylamide (L(H))

73 d deoxyribozyme from this selection requires L-histidine or a closely related analog to catalyze RNA

74 sed by families of ligands such as imidazole/L-histidine or thiazole/2-aminothiazole confirms the con

75 Transport of L-histidine (pH 7.5) was electrogenic and Na+-dependent

76 The present study examined whether L-histidine similarly abolishes OS, the mPT, and brain e

77 By comparing Ir1 binding to BNT-II versus L-histidine, steric and quenching effects were noted in

78 These changes were completely abolished by L-histidine, supporting a key role of mitochondrial glut

79 to one of the aromatic nitrogen atoms of the l-histidine through a hydrolyzable N-glycosidic bond.

80 he action of HutH, HutU, and HutI to convert L-histidine to N-formimino-L-glutamate.

81 ments were performed for a similar molecule, l-histidine, to test for selectivity.

82 The induction of Na+-dependent L-histidine transport in NBAT-expressing oocytes provide

83 ike L-phenylalanine or L-arginine transport, L-histidine transport is Na+-dependent and stereoselecti

84 y, the possible effects on System-N mediated l-histidine transport of changes in pH and extracellular

85 L-Histidine transport, at pH 7.5, is stimulated by NBAT

86 It accounted for 30% of l-histidine uptake in the presence of physiological conc

87 tion in the pathophysiological range reduced l-histidine uptake via both System-L and -N.

88 The L-histidine uptake was inhibited significantly by L-hist

89 d to synthesize a series of protected 5-aryl-L-histidines using aryl iodides as coupling partners, in

90 e MProP-silicas exhibit high affinity toward L-histidine via metal-nitrogen axial ligation interactio

91 Consistently, the transport of the substrate l-histidine was increased with short, but not long, trea

92 tial production of NH2Cl from l-arginine and l-histidine was observed at Cl/P = 1.0 and 2.0 when post

93 At pH 7.5, L-histidine weakly inhibited the Na+-independent L-argin

94 m UV254-irradiated samples of l-arginine and l-histidine when Cl/P = 2.0 and 3.0, as well as from gly

95 AtmBAC1 recognized l-histidine whereas both yeast Ort1p and the mammalian o

96 ific for the side chain and binds protonated L-histidine with 10(2)-10(3)-fold stereoselectivity and

97 is residues, the reactions of Nalpha-benzoyl-L-histidine with autoxidizing linoleic acid and with the

98 he biosynthetic oxidation of L-histidinol to L-histidine with sequential reduction of two molecules o

99 zole side-chain orientation in U-[13C6,15N3]-L-histidine x HCl x H2O.