ライフサイエンスコーパス: L-methionine

1 and without (2.0 A) its cofactor S-adenosyl-L-methionine.

2 with a fresh molecule of cofactor S-adenosyl-L-methionine.

3 to l-homocysteine, yielding two molecules of l-methionine.

4 te and methane in the presence of S-adenosyl-L-methionine.

5 anine (S(6)mG) in the presence of S-adenosyl-l-methionine.

6 ne and the methyl donor substrate S-adenosyl-l-methionine.

7 onditions, Met oxidation can be prevented by L-methionine.

8 rated by a reductive cleavage of S-adenosyl- l-methionine.

9 n or for allosteric regulation by S-adenosyl-L-methionine.

10 onded to allosteric activation by S-adenosyl-L-methionine.

11 l and 54.5 microm for S-[methyl-14C]adenosyl-l-methionine.

12 6-mercaptopurine but not K m for S-adenosyl- l-methionine.

13 s a methyl group originating from S-adenosyl-l-methionine.

14 t disrupt binding of the cofactor S-adenosyl-L-methionine.

15 e measured value for S-3',4'-anhydroadenosyl-l-methionine.

16 polymerase for the methyl donor, S-adenosyl-l-methionine.

17 th purified methyltransferase and S-adenosyl-L-methionine.

18 ubstrates, hemimethylated DNA and S-adenosyl-l-methionine.

19 N and L49A bound the co-substrate S-adenosyl-L-methionine.

20 H3K36 using specifically labeled S-adenosyl-l-methionine.

21 TPsiC-loop of tRNA, from cofactor S-adenosyl-L-methionine.

22 catalyze the high affinity uptake of D- and L-methionine.

23 lting peptide with tritiated S-(5'-adenosyl)-l-methionine.

24 heme, pyridoxal-5'-phosphate, and S-adenosyl-l-methionine.

25 ar mechanism of CBS activation by S-adenosyl-l-methionine.

26 l-Methionine (1 mm), a specific TREK-1 inhibitor, dramat

27 l chains derived from the natural amino acid l-methionine (1) has been rationally prepared.

28 ollowed by PET using (18)F-FDG, (11)C-methyl-l-methionine ((11)C-MET), and 3'-deoxy-3'-(18)F-fluoroth

29 d more tightly in the presence of S-adenosyl-L-methionine (3), suggesting that the binding of the lat

30 .04-fold), (123)I-MIBG (3.25-fold), and (3)H-l-methionine (3.11-fold).

31 mpared normal mice with mice pretreated with l-methionine (5.2 mmol/kg s.c. twice a day for 7 days) t

32 , 4-azidobut-2-enyl derivative of S-adenosyl-L-methionine (Ab-SAM) was reported as a suitable BPPM co

33 ombin levels, and the latter was reversed by L-methionine administration.

34 ransferase (SAMT), which utilizes S-adenosyl-l-methionine (AdoMet or SAM) as the methyl donor.

35 al velocity data with peptide and S-adenosyl-L-methionine (AdoMet) and product inhibition studies wit

36 Recombinant TrmO employs S-adenosyl-L-methionine (AdoMet) as a methyl donor to methylate t(6

37 pA-RNA --> m(7)GpppAm-RNA), using S-adenosyl-l-methionine (AdoMet) as a methyl donor.

38 of these MTases use the cofactor S-adenosyl-l-Methionine (AdoMet) as a methyl source.

39 class of metalloenzymes that use S-adenosyl-l-methionine (AdoMet) as a source of a 5'-deoxyadenosyl

40 TrmD enzymes are known to use S-adenosyl-l-methionine (AdoMet) as substrate; we have shown that 3

41 ethyltransferase fold and employs S-adenosyl-l-methionine (AdoMet) as the cofactor in methyl transfer

42 S-Adenosyl-L-methionine (AdoMet) is one of Nature's most diverse me

43 The biological methyl donor S-adenosyl-l-methionine (AdoMet) is spontaneously degraded by inver

44 ilic attack of cytosine C5 on the S-adenosyl-L-methionine (AdoMet) methyl group is concerted with for

45 m Bacillus circulans (BtrN) is an S-adenosyl-l-methionine (AdoMet) radical enzyme.

46 Eighteen subclasses of S-adenosyl-l-methionine (AdoMet) radical proteins have been aligned

47 Asp-134 and methyl transfer from S-adenosyl-L-methionine (AdoMet) to GAA are concerted.

48 e, catalyzes methyl transfer from S-adenosyl-l-methionine (AdoMet) to glycine to form S-adenosyl-l-ho

49 BS is modulated by the binding of S-adenosyl-l-methionine (AdoMet) to its regulatory domain, which ac

50 e transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to the 5-position of cytosine resi

51 r one to three methyl groups from S-adenosyl-L-methionine (AdoMet) to the epsilon-amino group of the

52 e transfer of a methyl group from S-adenosyl-l-methionine (AdoMet) to the N1 position of G37 in the a

53 rom the activated methyl group of S-adenosyl-L-methionine (AdoMet), affording S-adenosyl-L-homocystei

54 ransferases use the methyl donor, S-adenosyl-L-methionine (AdoMet), as a cofactor.

55 te and the methyl donor cofactor, S-adenosyl-l-methionine (AdoMet), displayed AdoMet non-competitive

56 eavage of the sulfonium center of S-adenosyl-L-methionine (AdoMet), generating methionine and a trans

57 e of the CBS allosteric regulator S-adenosyl-l-methionine (AdoMet), only C15 and C431 of human CBS ar

58 xample, how both the methyl donor S-adenosyl-l-methionine (AdoMet), which is water-soluble, and the m

59 and found that it belongs to the S-adenosyl-L-methionine (AdoMet)-dependent alpha/beta-knot superfam

60 dification of protein residues by S-adenosyl-L-methionine (AdoMet)-dependent methyltransferases impac

61 S-adenosyl-L-methionine (AdoMet)-dependent O-methyltransferases (OM

62 lavodoxin and a methyl group from S-adenosyl-L-methionine (AdoMet).

63 eine, methyltetrahydrofolate, and S-adenosyl-l-methionine (AdoMet).

64 ulatory C-terminal domain binding S-adenosyl-l-methionine (AdoMet).

65 me-coupled luminescence assay for S-adenosyl-l-methionine (AdoMet/SAM)-based PMTs.

66 ay to quantitatively characterize S-adenosyl-L-methionine (AdoMet/SAM)-dependent methyltransferase ac

67 S-adenosyl-L-methionine- (AdoMet-) dependent methyltransferases are

68 s VSCs by suppressing mgl, the gene encoding L-methionine-alpha-deamino-gamma-mercaptomethane-lyase,

69 , they demonstrate that supplementation with L-methionine, an essential amino acid that assists in th

70 Sinefungin (SIN), a natural S-adenosyl-L-methionine analog produced by Streptomyces griseolus,

71 -methionine, which is reductively cleaved to L-methionine and 5'-deoxyadenosine.

72 ine is a competitive inhibitor of S-adenosyl-l-methionine and a mixed inhibitor of substrate peptide.

73 binding site for the methyl donor S-adenosyl-l-methionine and are inhibited by individual amino acid

74 Escherichia coli in complex with S-adenosyl-L-methionine and dethiobiotin has been determined to 3.4

75 rine lactones (AHL) signals using S-adenosyl-l-methionine and either cellular acyl carrier protein (A

76 we show that NMB0573 binds to l-leucine and l-methionine and have solved the structure of the protei

77 A redox-reconfigurable catalyst derived from L-methionine and incorporating catalytic urea groups has

78 (2-AP-6-SO3H) upon reaction with S-adenosyl-L-methionine and irradiation with UVA light, respectivel

79 does not interact strongly with N-palmitoyl-l-methionine and is found positioned at the enzyme-solve

80 ase (MGL) catalyzes the gamma-elimination of l-methionine and its derivatives as well as the beta-eli

81 abeled on-blot using [methyl-(3)H]S-adenosyl-L-methionine and recombinant PIMT.

82 Two structures with bound S-adenosyl-L-methionine and S-adenosyl-L-homocysteine confirm that

83 ltiple kinetic isotope effects.(36)S-labeled l-methionine and S-adenosyl-l-methionine were synthesize

84 e, and its non-reactive analogs Aza-adenosyl-L-methionine and Sinefungin, and characterized the bindi

85 a succinimide on incubation with S-adenosyl-l-methionine and the commercially available enzyme, prot

86 by mimicking each substrate, the S-adenosyl-l-methionine and the deoxycytidine, and linking them tog

87 ited by reagents that block TREK-1 channels, l-methionine and/or methioninol.

88 c-sestamibi (MIBI), (18)F- or (3)H-FDG, (3)H-l-methionine, and (3)H-thymidine.

89 r (18)F- or (3)H-FDG, 1.93 +/- 0.87 for (3)H-l-methionine, and 1.22 +/- 0.74 for (3)H-thymidine.

90 e catalytic tetrad, interact with S-adenosyl-l-methionine, and contribute to autoguanylation.

91 bunit methyltransferase, bound to S-adenosyl-L-methionine, and its non-reactive analogs Aza-adenosyl-

92 yruvate, one carbon from the methyl group of l-methionine, and one carbon directly from CO(2).

93 ution of MoaA incubated with GTP, S-adenosyl-L-methionine, and sodium dithionite in the absence of Mo

94 th (18)F- or (3)H-FDG, (123)I-MIBG, and (3)H-l-methionine, and the immunohistostaining findings, sugg

95 The SAM surrogate S-3',4'-anhydroadenosyl-L-methionine (anSAM) can replace SAM as a cofactor in th

96 ethyltransferase enzymes that use S-adenosyl-l-methionine as a cofactor.

97 n S-COMT in the presence of S-[(3)H]adenosyl-l-methionine as a methyl group donor.

98 ylating them in a reaction using S-adenosyl- l-methionine as the donor.

99 n and a third with bound cofactor S-adenosyl-L-methionine at 1.75 A each exhibit distinct relative po

100 ing from in situ demethylation of S-adenosyl-L-methionine, at 2.05 or 1.82 A resolution, respectively

101 stem that linked the viability of an E. coli L-methionine auxotroph to the activity of the improved e

102 ucts can be incorporated into proteins using L-methionine auxotrophs.

103 light on the structural basis of S-adenosyl-L-methionine binding and methyltransferase activity.

104 ylation domain interrupted by the S-adenosyl-l-methionine binding region of a methyltransferase enzym

105 sidue within a putative conserved S-adenosyl-l-methionine-binding domain of the L protein.

106 two methylase activities share an S-adenosyl-l-methionine-binding site and show that, in contrast to

107 ous studies of the K41A mutant enzyme showed L-methionine bound in an external Schiff base (ESB) link

108 as determined to a resolution of 2.33 A with l-methionine bound in the active site.

109 including the first structure of S-adenosyl-l-methionine bound to a KsgA/Dim1 enzyme in a catalytica

110 ystal structure determination of N-palmitoyl-l-methionine bound to the heme domain of P450BM-3, appea

111 ete with the enzyme cofactor SAM (S-adenosyl-L-methionine) but not the substrate nucleosome.

112 l-Homocysteine can be remethylated to form l-methionine by betaine or N(5)-methyltetrahydrofolate.

113 yl-carrier protein (acyl-ACP) and S-adenosyl-L-methionine by the AHL synthase enzyme.

114 Antioxidant seleno-l-methionine; chemical inhibitors of p38, ERK1/2, and mi

115 f this enzyme in complex with the S-adenosyl-l-methionine cofactor at 1.7 A resolution confirms that

116 ulfoxides (S) and (R), respectively, back to L-methionine consequently repairing oxidatively damaged

117 es the unique metabolite carboxy-S-adenosine-L-methionine (Cx-SAM) and catalyzes a carboxymethyl tran

118 escribe a new metabolite, carboxy-S-adenosyl-l-methionine (Cx-SAM), its biosynthetic pathway and its

119 (k(cat)/K(m) = 5.2 x 10(6) M(-1) s(-1)), and l-methionine-d-glutamate (k(cat)/K(m) = 3.4 x 10(5) M(-1

120 ylamino)azobenzene-4'-sulfonyl derivative of l-methionine (dabsyl Met), the product of the enzymatic

121 ate that the pyruvoyl cofactor of S-adenosyl-L-methionine decarboxylase (AMD1) is dynamically control

122 The role of Glu119 in S-adenosyl-L-methionine-dependent DNA methyltransferase M.HhaI-cata

123 RI, a bacterial sequence-specific S-adenosyl-L-methionine-dependent DNA methyltransferase, relies on

124 he methylthiolase MiaB, a radical S-adenosyl-L-methionine-dependent enzyme involved in the maturation

125 nsferases (MTs) that catalyze the S-adenosyl-L-methionine-dependent methylation of natural chemicals

126 r phosphocholine via a three-step S-adenosyl-L-methionine-dependent methylation of phosphoethanolamin

127 d PRMT7 catalyzes the S-adenosyl-[methyl-3H]-l-methionine-dependent methylation of the synthetic pept

128 RsmC is a class I S-adenosyl-L-methionine-dependent methyltransferase composed of two

129 ated that genetic deletion of the S-adenosyl-L-methionine-dependent methyltransferase from the PZN bi

130 The S-adenosyl-L-methionine-dependent methyltransferase KsgA introduces

131 We characterized Rv0560c as an S-adenosyl-L-methionine-dependent methyltransferase that N-methylat

132 additional gene, tam, encoding an S-adenosyl-l-methionine-dependent methyltransferase.

133 n of a C. roseus cDNA encoding an S-adenosyl-L-methionine-dependent N methyltransferase that catalyze

134 from time course experiments and S-adenosyl-l-methionine-dependent O-methyltransferase inhibition st

135 NovP is an S-adenosyl-l-methionine-dependent O-methyltransferase that catalyze

136 , unveiling that: (i) NcsB1 is an S-adenosyl-L-methionine-dependent O-methyltransferase; (ii) NcsB1 c

137 A conserved S-adenosyl-l-methionine-dependent RNA methyltransferase, HUA ENHANC

138 o enzyme studies identified a new S-adenosyl-l-methionine-dependent S-MT (TmtA) that is, surprisingly

139 ibe in P. falciparum a plant-like S-adenosyl-l-methionine-dependent three-step methylation reaction t

140 of the Pseudomonas denitrificans S-adenosyl-L-methionine-dependent uroporphyrinogen III methyltransf

141 The radical S-adenosyl-L-methionine enzyme DesII from Streptomyces venezuelae i

142 The radical S-adenosyl-L-methionine enzyme HydG lyses free tyrosine to produce

143 show that PhnJ is a novel radical S-adenosyl-L-methionine enzyme that catalyses C-P bond cleavage thr

144 yces venezuelae is a radical SAM (S-adenosyl-l-methionine) enzyme that catalyzes the deamination of T

145 Intriguingly, radical S-adenosyl-L-methionine enzymes are vital for the assembly of all t

146 HydG is a member of the radical S-adenosyl-L-methionine family of enzymes that transforms Fe and L-

147 id L-azidohomoalanine (AHA), a surrogate for l-methionine, followed by fluorescent labelling of AHA-c

148 bound with methylation cofactor, S-adenosyl-L-methionine from Pyrococcus furiosus, at 2.7 A.

149 In a frying study with potato cubes, 5.5mM l-methionine had significantly stronger antioxidant acti

150 The radical S-adenosyl-l-methionine HydG, the best characterized of these prote

151 Incorporation experiments with [(13)C-methyl]l-methionine implicated an alpha-dimethyl-beta-keto acid

152 l-Methionine is an essential amino acid and is required

153 g of microbial strains for the production of l-methionine is of major interest in industrial biotechn

154 cal data collectively reveal that S-adenosyl-L-methionine is selectively recognized through carbon-ox

155 eine, which is produced in the metabolism of l-methionine, is remethylated 2-4 times before it is des

156 ) were 0.9 and 1.0 microM and for S-adenosyl-L-methionine (K(m)(AdoMet)) were 1.8 and 0.6 microM, res

157 ine (SAH) or 5'-deoxyadenosine (5'-dAdo) and l-methionine (l-Met).

158 tAPs in the presence of the reaction product l-methionine (L-Met).

159 is dominated by l-leucine but also includes l-methionine, l-isoleucine, and l-valine.

160 esides l-Lys, recombinant ALD1 transaminates l-methionine, l-leucine, diaminopimelate, and several ot

161 altered after H(2)O(2)-mediated oxidation of L-methionine, L-tryptophan, and L-cysteine residues in i

162 n of S-adenosylmethionine (SAM) from ATP and l-methionine (Met) and hydrolysis of tripolyphosphate to

163 l-Methionine (Met) is an essential amino acid for humans

164 of mice exposed to protracted treatment with l-methionine (MET) is attributed to RELN and GAD(67) pro

165 receiving methyl supplementation via chronic l-methionine (MET) underwent either a sensitization regi

166 gated chemical compounds of selenium: seleno-l-methionine, methyl-seleno-l-cysteine, l-selenocystine,

167 The mouse treated with l-methionine models some of the molecular neuropathologi

168 However, only one S-adenosyl-L-methionine molecule and one substrate molecule, guanos

169 ition is due to noncompetitive inhibition by L-methionine, much like a negative feedback loop.

170 stent with a role for ADK and the S-adenosyl-L-methionine pathway in the control of root gravitropism

171 signed to target specifically the S-adenosyl-l-methionine pocket of catechol O-methyl transferase all

172 er dabsyl l-methionine S-sulfoxide or dabsyl l-methionine R-sulfoxide is used as a substrate.

173 rovide the substrates of LipA, an S-adenosyl-L-methionine radical enzyme that inserts two sulfur atom

174 ss substrate for DNA methylation (S-adenosyl-L-methionine) rescues the suppression of mEPSCs by DNMT

175 Such high concentrations of H(2)O(2) oxidize L-methionine residues in proteins and peptides to (R and

176 rous cellular processes involving S-adenosyl-l-methionine result in the formation of the toxic by-pro

177 hylation site, in the presence of S-adenosyl-L-methionine, reveals a V-like protein structure and sug

178 zed by S-adenosylmethionine synthetase (ATP: L-methionine S-adenosyltransferase (MAT)), which is a ta

179 S-Adenosylmethionine synthetase (ATP: L-methionine S-adenosyltransferase) catalyzes a two-step

180 f the enzymatic reactions when either dabsyl l-methionine S-sulfoxide or dabsyl l-methionine R-sulfox

181 L-methionine-S,R-sulphoximine (MSO), previously demonstr

182 f enzymes that reductively cleave S-adenosyl-l-methionine (SAM or AdoMet) to generate a 5'-deoxyadeno

183 catalyzed by multiple families of S-adenosyl-L-methionine (SAM or AdoMet)-dependent methyltransferase

184 S-adenosyl-L-methionine (SAM) acts as a signal and binds the methyl

185 ic PMTs are engineered to process S-adenosyl-L-methionine (SAM) analogs as cofactor surrogates and la

186 f vSET in vivo with an engineered S-adenosyl-l-methionine (SAM) analogue as methyl donor cofactor, we

187 sis of an azide-bearing N-mustard S-adenosyl-L-methionine (SAM) analogue, 8-azido-5'-(diaminobutyric

188 tic platform for the synthesis of S-adenosyl-L-methionine (SAM) analogues compatible with downstream

189 seq involves in vivo synthesis of S-adenosyl-L-methionine (SAM) analogues from cell-permeable methion

190 omain and some of them presenting S-adenosyl-l-methionine (SAM) and nuclear receptor box (NRB) motifs

191 NSD2 binds to S-adenosyl-l-methionine (SAM) and nucleosome substrates to catalyze

192 l methyltransferases that utilize S-adenosyl-L-methionine (SAM) as a cofactor.

193 pA-RNA-->m(7)GpppAm-RNA, by using S-adenosyl-l-methionine (SAM) as a methyl donor.

194 olecular modeling and competitive S-adenosyl-l-methionine (SAM) binding assay suggest that these comp

195 y on the resting oxidized and the S-adenosyl-l-methionine (SAM) bound forms of pyruvate formate-lyase

196 in the conversion of 5'-ClDA into S-adenosyl-l-methionine (SAM) but a reduced kcat value in the conve

197 iodiesel produces FAMEs by direct S-adenosyl-L-methionine (SAM) dependent methylation of free fatty a

198 chemical reaction catalysed by an S-adenosyl-L-methionine (SAM) dependent Methyltransferase (NirE).

199 S-adenosyl-l-methionine (SAM) dependent O-methyltransferases (OMTs)

200 ,3-aminomutase (LAM) is a radical S-adenosyl-L-methionine (SAM) enzyme and, like other members of thi

201 DesII, a radical S-adenosyl-l-methionine (SAM) enzyme from Streptomyces venezuelae,

202 ve mutations in MOCS1A, a radical S-adenosyl-l-methionine (SAM) enzyme involved in the conversion of

203 monstrate that a putative radical S-adenosyl-L-methionine (SAM) enzyme superfamily member encoded by

204 which is a member of the radical S-adenosyl-L-methionine (SAM) enzyme superfamily.

205 DesII is a radical S-adenosyl-l-methionine (SAM) enzyme that can act as a deaminase or

206 ptophan lyase (NosL) is a radical S-adenosyl-l-methionine (SAM) enzyme that catalyzes the formation o

207 ting enzyme (PFL-AE) is a radical S-adenosyl-l-methionine (SAM) enzyme that installs a catalytically

208 erin is predicted to be a radical S-adenosyl-l-methionine (SAM) enzyme, but it is unknown whether vip

209 SPL is a radical S-adenosyl-l-methionine (SAM) enzyme, which uses a [4Fe-4S](+) clus

210 hat viperin is a putative radical S-adenosyl-l-methionine (SAM) enzyme.

211 Radical S-adenosyl-l-methionine (SAM) enzymes are widely distributed and ca

212 The radical S-adenosyl-L-methionine (SAM) enzymes RlmN and Cfr methylate 23S ri

213 Radical S-adenosyl-L-methionine (SAM) enzymes use an iron-sulfur cluster to

214 mily of proteins known as radical S-adenosyl-l-methionine (SAM) enzymes.

215 pe effects (BIEs) of the cofactor S-adenosyl-l-methionine (SAM) for SET8-catalyzed H4K20 monomethylat

216 ed from the reductive cleavage of S-adenosyl-l-methionine (SAM) initiates substrate-radical formation

217 (MATs) catalyze the formation of S-adenosyl-l-methionine (SAM) inside living cells.

218 ne-electron reductive cleavage of S-adenosyl-l-methionine (SAM) into methionine and the 5'-deoxyadeno

219 S-adenosyl-L-methionine (SAM) is converted to 5'-chloro-5'-deoxyade

220 S-Adenosyl-l-methionine (SAM) is recognized as an important cofacto

221 S-adenosyl-L-methionine (SAM) is the sole methyl-donor cofactor of

222 The radical S-adenosyl-L-methionine (SAM) methyl synthases, RlmN and Cfr, both

223 cobalamin (Cbl)-dependent radical S-adenosyl-l-methionine (SAM) methyltransferases have been identifi

224 results indicate that the radical S-adenosyl-L-methionine (SAM) protein PylB mediates a lysine mutase

225 which encodes a putative radical S-adenosyl-l-methionine (SAM) protein, are unable to synthesize BCh

226 urs upstream of genes involved in S-adenosyl-L-methionine (SAM) recycling in many Gram-positive and G

227 s that are members of the radical S-adenosyl-l-methionine (SAM) superfamily was previously predicted

228 QueE is a member of the radical S-adenosyl-l-methionine (SAM) superfamily, all of which use a bound

229 l riboswitches were identified in S-adenosyl-l-methionine (SAM) synthetase metK genes in members of L

230 ne (Cyt) C6, methyl transfer from S-adenosyl-l-methionine (SAM) to Cyt C5, and proton abstraction fro

231 mino-3-carboxypropyl radical from S-adenosyl-L-methionine (SAM) to form a C-C bond.

232 eines in a CX(3)CX(2)C motif, and S-adenosyl-L-methionine (SAM) to generate a 5'-deoxyadenosyl radica

233 e transfer of a methyl group from S-adenosyl-L-methionine (SAM) to magnesium protoporphyrin IX (MgP)

234 -amino-3-carboxypropyl group from S-adenosyl-l-methionine (SAM) to the histidine residue of EF2, form

235 the pyridoxal-5'-phosphate (PLP), S-adenosyl-L-methionine (SAM), and [4Fe-4S]-dependent lysine-2,3-am

236 LAM) utilizes a [4Fe-4S] cluster, S-adenosyl-L-methionine (SAM), and pyridoxal 5'-phosphate (PLP) to

237 y bind to the methyl group donor, S-adenosyl-L-methionine (SAM), it strongly increases the binding of

238 factor in order to stably bind to S-adenosyl-l-methionine (SAM), suggesting that it proceeds accordin

239 showed a single binding site for S-adenosyl-L-methionine (SAM), the methyl donor.

240 S-Adenosyl-l-methionine (SAM), the primary methyl group donor for e

241 a precursor for the synthesis of S-adenosyl-l-methionine (SAM), which is the most commonly used meth

242 The highly conserved S-adenosyl-l-methionine (SAM)-binding residues of the DxG motif are

243 es of Bud23-Trm112 in the apo and S-adenosyl-L-methionine (SAM)-bound forms.

244 Here we report a versatile S-adenosyl-l-methionine (SAM)-dependent enzyme, LepI, that can cata

245 new metalloenzymes, flavoenzymes, S-adenosyl-L-methionine (SAM)-dependent enzymes and others that cat

246 rotein NifB catalyzes the radical S-adenosyl-L-methionine (SAM)-dependent insertion of carbide into t

247 powerful tools for investigating S-adenosyl-l-methionine (SAM)-dependent methylation.

248 es predicted EftM to be a Class I S-adenosyl-l-methionine (SAM)-dependent methyltransferase.

249 me evolution has been observed in S-adenosyl-L-methionine (SAM)-dependent methyltransferases involved

250 ethyltransferases, members of the S-adenosyl-l-methionine (SAM)-dependent O-methyltransferase superfa

251 o comprise two distinct groups of S-adenosyl-l-methionine (SAM)-dependent RNA enzymes, namely the Kgm

252 tion of the piperazyl scaffold is S-adenosyl-l-methionine (SAM)-dependent.

253 methyl group is assembled from an S-adenosyl-L-methionine (SAM)-derived methylene fragment and a hydr

254 3-amino-3-carboxypropyl group of S-adenosyl-l-methionine (SAM).

255 S-box (SAM-I) riboswitch bound to S-adenosyl-L-methionine (SAM).

256 hly abundant methylation cofactor S-adenosyl-l-methionine (SAM).

257 accumulation of the methyl donor S-adenosyl-L-methionine (SAM).

258 amilies of riboswitches that bind S-adenosyl-l-methionine (SAM).

259 e for methyltransferase activity, S-adenosyl-l-methionine (SAM).

260 Posttranslational methylation by S-adenosyl-L-methionine(SAM)-dependent methyltransferases plays ess

261 the remethylation of l-homocysteine to form l-methionine should be considered along with B vitamin s

262 In leukemic mice, administration of L-methionine significantly increased homocysteine levels

263 acupuncture, omega-3 fatty acids, S-adenosyl-L-methionine, St. John's wort [Hypericum perforatum]), e

264 The response to S-adenosyl-L-methionine stimulation or thermal activation varied.

265 amate analogues l-methionine sulfoximine and l-methionine sulfone as substrates, with Km(app) values

266 +/- 23 s-1 for l-methionine sulfoximine and l-methionine sulfone, respectively.

267 onformation was stabilized by phosphorylated L-methionine sulfoximine (MSX), fixing the enzyme in the

268 lease is significantly reduced by the toxins L-methionine sulfoximine and fluoroacetate, which reduce

269 tyltransferase using the glutamate analogues l-methionine sulfoximine and l-methionine sulfone as sub

270 values of 505 +/- 43 and 610 +/- 23 s-1 for l-methionine sulfoximine and l-methionine sulfone, respe

271 ita in complex with one of these substrates (l-methionine sulfoximine) has been solved, revealing the

272 in the absence of glutamine was inhibited by l-methionine sulfoximine, suggesting a role for pita in

273 Neither Gln nor l-methionine sulfoximine-induced ammonium accumulation w

274 e and hyperhomocysteinemia can be induced by L-methionine supplementation.

275 ained a cDNA encoding S-[methyl-14C]adenosyl-l-methionine:t-anol/isoeugenol O-methyltransferase 1 (AI

276 er acceptor of methyl groups from S-adenosyl-L-methionine than was malonyl-CoA.

277 Consequently, the antioxidant seleno-l-methionine, the specific ERK1/2 inhibitor PD98059, or

278 he strong electrophilic nature of S-adenosyl-l-methionine, the transmethylation of the demethylated p

279 sACS [encode enzymes that convert S-adenosyl-L-methionine to 1-aminocyclopropane-1-carboxylic acid (A

280 al transfer of methyl groups from S-adenosyl-L-methionine to arginine residues of proteins.

281 (S)G in DNA can be methylated by S-adenosyl-l-methionine to give S(6)-methylthioguanine (S(6)mG) and

282 transferring a methyl group from S-adenosyl-l-methionine to HA, and is the only well-known pathway f

283 y to transfer a methyl group from S-adenosyl-l-methionine to N(6)-methyladenine-free lambda DNA and t

284 y transfers the methyl group from S-adenosyl-L-methionine to O-4 of alpha-D-glucopyranosyluronic acid

285 ilic replacement of the methyl of S-adenosyl-L-methionine to produce 5-methyl-6-Cys-81-S-5,6-dihydroc

286 ACC) synthases (ACS) that convert S-adenosyl-l-methionine to the immediate precursor ACC.

287 transfer of the methyl group from S-adenosyl-L-methionine to the lysine epsilon-amine has remained un

288 e transfer of a methyl group from S-adenosyl-L-methionine to the N6 position of an adenine, a process

289 sfer of the methyl group from the S-adenosyl-l-methionine to the protein alpha-amine, resulting in fo

290 belongs to the diverse family of S-adenosyl-l-methionine transferases.

291 at are functionally assigned as (i) LipO, an L-methionine:uridine-5'-aldehyde aminotransferase; (ii)

292 epatic apoptosis and reduction of S-adenosyl-L-methionine was detected in both types of animals fed e

293 In the pocket, a molecule of L-methionine was detected in the electron density map.

294 of (18)F- or (3)H-FDG, (123)I-MIBG, and (3)H-l-methionine was significantly increased over the contro

295 Apparent K(m) values for S-adenosyl-l-methionine were 4.6, 3.1, and 11 mum for WT, Trp(173),

296 N-Palmitoyl-l-leucine and N-palmitoyl-l-methionine were found to have the highest affinity, wi

297 ts.(36)S-labeled l-methionine and S-adenosyl-l-methionine were synthesized from elemental sulfur usin

298 rface of EcoDam in the absence of S-adenosyl-L-methionine, which illustrates a possible intermediate

299 redox-active [4Fe-4S]-cluster and S-adenosyl-L-methionine, which is reductively cleaved to L-methioni

300 in a methionine auxotroph in the presence of l-methionine with the side chain methyl group (13)C-labe