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1 exhibit higher activity than alpha-N-acetyl-L-ornithine.
2 shes feedback inhibition of P5CS activity by L-ornithine.
3 ic hydrolysis of l-arginine to form urea and l-ornithine.
4 putrescine, a polyamine, from extracellular L-ornithine.
5 ME but was blocked by the arginase inhibitor L-ornithine.
6 phosphate and a C-terminal domain that binds L-ornithine.
7 ncreasing the extracellular concentration of L-ornithine.
8 dependent on the transcellular transport of L-ornithine.
9 its amino acid substrate, only hydroxylating l-ornithine.
10 d survival in vitro and in vivo by exporting L-ornithine.
11 eld N(5)-((R)-3-hydroxybutyryl)-N(5)-hydroxy-l-ornithine.
12 y for N-succinyl-L-ornithine versus N-acetyl-L-ornithine.
13 emonstrated to be capable of decarboxylating l-ornithine.
14 olution on crystals grown in the presence of l-ornithine.
15 mpetes with iNOS by converting L-arginine to L-ornithine.
16 is action was antagonized in the presence of l-ornithine.
17 amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine (1, PT523), a nonpolyglutamatable antifolate
18 4-amino-4-deoxypteroyl)-N delta-isophthaloyl-L-ornithine (11), N alpha-(4-amino-4-deoxypteroyl)-N del
19 -amino-4-deoxypteroyl)-N delta-terephthaloyl-L-ornithine (12), and N alpha-(4-amino-4-deoxypteroyl)-N
21 -6-yl)ethyl]benzoyl]-N(delta)-hemipht haloyl-L-ornithine (2) and N(alpha)-[4-[5-(2,4-diaminoteridin-6
22 are hydroxylated, including 4R,5R-dihydroxy-L-ornithine, 4R-hydroxyl-L-proline, 3S,4S-dihydroxy-L-ho
23 of NOHA were antagonized in the presence of L-ornithine (500 microM), which suggests that in MDA-MB-
24 t-1-yn-4-yl]benzoyl]-N(delta)-h emiphthaloyl-L-ornithine (6) as analogues of N(alpha)-(4-amino-4-deox
25 H]arginine uptake, l-arginine depletion, and l-ornithine accumulation in the culture medium, were obs
26 nd produce sustained reduction in ammonia by L-ornithine acting as a substrate for glutamine synthesi
27 material via chemoselective acylation of the l-ornithine alpha-amino group using activated succinimid
28 h N-alpha-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide (Cl-amidine), a PAD4 inactivator with
29 r N-alpha-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide (Cl-amidine), a recently described pan
31 sponding bridged analogues of 5-deazapteroyl-L-ornithine and (6R,6S)-5-deaza-5,6,7, 8-tetrahydroptero
33 bridging water molecule between the shorter L-ornithine and key active site residues provides the st
36 sm-based NOS inhibitors, N(5)-(1-iminoethyl)-L-ornithine and N-(3-(aminomethyl)benzyl)acetamidine, pr
37 aims of this study were to determine whether L-ornithine and phenylacetate/phenylbutyrate (administer
38 this study provide proof of the concept that L-ornithine and phenylbutyrate/phenylacetate act synergi
39 pression of arginase in macrophages enhanced L-ornithine and putrescine production and consequently p
40 0 cell line maintained its viability and its L-ornithine and spermine levels in the presence of NOHA.
41 roxy-nor-L-arginine, as well as the products L-ornithine and urea, complete a set of structural "snap
42 the urea cycle that converts L-arginine into L-ornithine and urea, is presently considered a pharmace
43 catalyzes the conversion of L-arginine into L-ornithine and urea, leading to the synthesis of polyam
44 SE I) and arginase II (ASE II) to synthesize L-ornithine and urea, the first being the precursor for
55 etection for Arg, Cit, L-arginino-succinate, L-ornithine, and L-arginine phosphate range from 50 amol
56 inhibitors (type 1), including L-isoleucine, L-ornithine, and L-citrulline, suppresses enzymatic acti
57 proceeds by hydroxylation and acetylation of L-ornithine, and later steps likely involve covalently b
58 and the rate of Schiff base interchange with L-ornithine are partially rate-limiting for the reaction
59 mino acids such as l-arginine, l-lysine, and l-ornithine are transported by cationic (CAT) and y(+)L
60 ences, particularly the reduced affinity for L-ornithine, are sufficient to account for their biochem
62 utant enzymes, E274A ODC and C360A ODC, with L-ornithine as substrate the carbon isotope effect also
63 against OAT; measuring the transformation of L-ornithine at high concentrations by this assay is comp
67 in catalyzes the carbamylation of N-succinyl-L-ornithine but not L-ornithine or N-acetyl-L-ornithine,
68 of substrate binding for both l-arginine and l-ornithine, but it is not sufficient to encode the chan
69 )-methyl-L-arginine, and N(5)-(1-iminoethyl)-L-ornithine, but not the reversible inhibitor 7-nitroind
70 city of PDGF to up-regulate the transport of L-ornithine by inducing the expression of the genes for
72 he decarboxylation of the optimal substrate, L-ornithine, by wild-type ODC, the observed carbon isoto
75 crystal structure of the N5-(1-iminopropyl)-L-ornithine:DDAH-1 complex indicates covalent bond forma
78 nhibitor); and (4) 10 mm N(5)-(1-iminoethyl)-l-ornithine dihydrochloride [endothelial NOS (eNOS) inhi
79 acid to protonate the leaving amino group of l-ornithine during catalysis, and this is a revised mech
82 N-succinyl-L-ornithine rather than N-acetyl-L-ornithine for de novo arginine biosynthesis and theref
83 N5-(1-iminopentyl)- and N(5)-(1-iminohexyl)-l-ornithine for neuronal NOS (1.7, 3, 20, >1,900 microM,
87 with the bisubstrate analog N-phosphonacetyl-L-ornithine has been solved at 1.85-A resolution by mole
88 opionic acid, 2, 4-diamino-L-butyric acid or L-ornithine, have been examined using circular dichroism
92 le inhibitor of DDAH-1, N(5)-(1-iminopropyl)-l-ornithine, indicating this compound's bioavailability
93 c arginine analogues, including L-lysine and L-ornithine, inhibited L-arginine transport, whilst 2-me
94 em with Asp-263 and the alpha-amino group of L-ornithine, instead of with His-302 and Glu-310, as pre
97 ats treated with ammonia-lowering therapy by l-ornithine l-aspartate and rifaximin orally for 4 weeks
98 e (SNAP), and the NOS inhibitor N-iminoethyl-L-ornithine (L-NIO), we performed studies of isolated pe
100 between rat nNOS and N5-(1-imino-3-butenyl)-L-ornithine (L-VNIO), a previously identified mechanism-
101 f NOS-1 with vinyl-L-N-5-(1-imino-3-butenyl)-L-ornithine (L-VNIO, 100 microM) or soluble guanylyl cyc
103 nce was found for the binding of L-arginine, L-ornithine, L-2,4-diaminobutyric acid, and L-alanine.
105 rs of response to lactulose, probiotics, and L-ornithine-L-aspartate therapy in minimal hepatic encep
106 ors of response to lactulose, probiotics and L-ornithine-L-aspartate therapy in minimal hepatic encep
108 ort that vinyl-L-NIO (N5-(1-imino-3-butenyl)-L-ornithine; L-VNIO) binds to and inhibits nNOS in compe
109 lectric field (dcEF) when cultured on a poly-L-ornithine/laminin coated surface, while the fetal-deri
110 rting from methyl N(delta)-benzyloxycarbonyl-L-ornithine led to 2-L-[5-[N-(2-amino-4(3H)-oxopyrido[2,
111 ne and L-arginine (tightly) and L-lysine and L-ornithine (less tightly) in the periplasm, interacts w
112 utants display markedly reduced affinity for L-ornithine, loss of substrate inhibition, alkaline shif
114 fining the contribution of the hemiphthaloyl-L-ornithine moiety to the exceptional in vitro antitumor
115 methods, using heterologously expressed N(5)-l-ornithine monooxygenase from the pathogenic fungus Asp
117 avoprotein VbsO acts as a pathway-initiating l-ornithine N(5)-hydroxylase, followed by VbsA, which tr
120 -arginine is 550-fold higher than for either l-ornithine or l-lysine, which were decarboxylated with
122 bamylation of N-succinyl-L-ornithine but not L-ornithine or N-acetyl-L-ornithine, forming N-succinyl-
124 e N(delta)-(phosphonoacetyl)-N(alpha)-acetyl-l-ornithine (PALAO) indicates that the carboxyl group on
125 th the bisubstrate analog N-(phosphonacetyl)-L-ornithine (PALO) has been determined at 2.8-A resoluti
127 fective as a substrate for arginase-mediated L-ornithine production compared with L-arginine directly
129 amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-l-ornithine (PT523) in comparison with RFC irrespective
130 -amino-4-deoxypteroyl)-Ndelta-hemiphthaloy l-L-ornithine (PT523, 3) were synthesized with a view to d
131 -amino-4-deoxypteroyl)-N delta-hemiphthaloyl-L-ornithine (PT523, 4) were synthesized via straightforw
132 ein suggest that B. fragilis uses N-succinyl-L-ornithine rather than N-acetyl-L-ornithine for de novo
133 -amino-4-deoxypteroyl)-N delta-hemiphthaloyl-L-ornithine], reduced nicotinamide adenine dinucleotide
135 mined whether the transcellular transport of L-ornithine, the cationic amino acid precursor of polyam
136 -oxygenase, which catalyzes hydroxylation of L-ornithine, the first committed step of ferrichrome and
137 e cyclodeaminase catalyzes the conversion of L-ornithine to L-proline by an NAD(+)-dependent hydride
139 thine decarboxylase (ODC), which metabolizes L-ornithine to polyamines, was also induced in H. pylori
141 al 5'-phosphate-dependent decarboxylation of l-ornithine to putrescine, a vital step in polyamine bio
143 in with those recently reported for N-acetyl-L-ornithine transcarbamylase indicates that amino acid r
144 upon substrate binding occurs in N-succinyl-L-ornithine transcarbamylase, while movement of the 80 l
148 The stimulatory effect of thrombin on both L-ornithine transport and ODC activity was reversed by h
150 thrombin initially (0 to 2 hours) decreased L-ornithine uptake, whereas longer exposures (6 to 24 ho
154 finding that PBCV-1 DC prefers l-arginine to l-ornithine was unexpected based on evolutionary analysi
155 or, N(alpha)-acetyl-N(delta)-phosphonoacetyl-L-ornithine, was synthesized and showed a midpoint of in
156 amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L- ornithine] was found to have an inhibition constant (
158 d (6R,6S)-5-deaza-5,6,7, 8-tetrahydropteroyl-L-ornithine were also synthesized as potential inhibitor
159 ne, alpha-ketoglutarate, glyoxylic acid, and L-ornithine were used as dead-end analogues of saccharop
160 s associated with a decrease in affinity for L-ornithine, whereas stimulation was mediated by an incr
161 , and Aquifex showed a strong preference for L-ornithine, whereas the enzyme from Vibrio vulnificus (
162 le to interact with the delta-amino group of L-ornithine which attacks the carbonyl carbon of carbamo
163 er was resistant to cadaverine, L-lysine and L-ornithine, which inhibit the E. coli AdiC antiporter.
165 typical saturation kinetics with respect to l-ornithine while substrate inhibition was observed at h
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