ライフサイエンスコーパス: L-ornithine

1 exhibit higher activity than alpha-N-acetyl-L-ornithine.

2 shes feedback inhibition of P5CS activity by L-ornithine.

3 ic hydrolysis of l-arginine to form urea and l-ornithine.

4 putrescine, a polyamine, from extracellular L-ornithine.

5 ME but was blocked by the arginase inhibitor L-ornithine.

6 phosphate and a C-terminal domain that binds L-ornithine.

7 ncreasing the extracellular concentration of L-ornithine.

8 dependent on the transcellular transport of L-ornithine.

9 its amino acid substrate, only hydroxylating l-ornithine.

10 d survival in vitro and in vivo by exporting L-ornithine.

11 eld N(5)-((R)-3-hydroxybutyryl)-N(5)-hydroxy-l-ornithine.

12 y for N-succinyl-L-ornithine versus N-acetyl-L-ornithine.

13 emonstrated to be capable of decarboxylating l-ornithine.

14 olution on crystals grown in the presence of l-ornithine.

15 mpetes with iNOS by converting L-arginine to L-ornithine.

16 is action was antagonized in the presence of l-ornithine.

17 amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine (1, PT523), a nonpolyglutamatable antifolate

18 4-amino-4-deoxypteroyl)-N delta-isophthaloyl-L-ornithine (11), N alpha-(4-amino-4-deoxypteroyl)-N del

19 -amino-4-deoxypteroyl)-N delta-terephthaloyl-L-ornithine (12), and N alpha-(4-amino-4-deoxypteroyl)-N

20 pteroyl)-N delta-(4,5-dichlorohemiphthaloyl)-L-ornithine (13) were also synthesized.

21 -6-yl)ethyl]benzoyl]-N(delta)-hemipht haloyl-L-ornithine (2) and N(alpha)-[4-[5-(2,4-diaminoteridin-6

22 are hydroxylated, including 4R,5R-dihydroxy-L-ornithine, 4R-hydroxyl-L-proline, 3S,4S-dihydroxy-L-ho

23 of NOHA were antagonized in the presence of L-ornithine (500 microM), which suggests that in MDA-MB-

24 t-1-yn-4-yl]benzoyl]-N(delta)-h emiphthaloyl-L-ornithine (6) as analogues of N(alpha)-(4-amino-4-deox

25 H]arginine uptake, l-arginine depletion, and l-ornithine accumulation in the culture medium, were obs

26 nd produce sustained reduction in ammonia by L-ornithine acting as a substrate for glutamine synthesi

27 material via chemoselective acylation of the l-ornithine alpha-amino group using activated succinimid

28 h N-alpha-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide (Cl-amidine), a PAD4 inactivator with

29 r N-alpha-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide (Cl-amidine), a recently described pan

30 d N alpha-(4-amino-4-deoxy-10-methylpteroyl)-L-ornithine (AMPte-L-Orn, 3).

31 sponding bridged analogues of 5-deazapteroyl-L-ornithine and (6R,6S)-5-deaza-5,6,7, 8-tetrahydroptero

32 ation of N-acetyl-L-citrulline from N-acetyl-L-ornithine and carbamyl phosphate.

33 bridging water molecule between the shorter L-ornithine and key active site residues provides the st

34 putrescine, a polyamine, from extracellular L-ornithine and L-arginine.

35 ad dual specificity functioning well on both L-ornithine and L-lysine.

36 sm-based NOS inhibitors, N(5)-(1-iminoethyl)-L-ornithine and N-(3-(aminomethyl)benzyl)acetamidine, pr

37 aims of this study were to determine whether L-ornithine and phenylacetate/phenylbutyrate (administer

38 this study provide proof of the concept that L-ornithine and phenylbutyrate/phenylacetate act synergi

39 pression of arginase in macrophages enhanced L-ornithine and putrescine production and consequently p

40 0 cell line maintained its viability and its L-ornithine and spermine levels in the presence of NOHA.

41 roxy-nor-L-arginine, as well as the products L-ornithine and urea, complete a set of structural "snap

42 the urea cycle that converts L-arginine into L-ornithine and urea, is presently considered a pharmace

43 catalyzes the conversion of L-arginine into L-ornithine and urea, leading to the synthesis of polyam

44 SE I) and arginase II (ASE II) to synthesize L-ornithine and urea, the first being the precursor for

45 r pylori urea cycle hydrolyzes L-arginine to L-ornithine and urea.

46 loenzyme which hydrolyzes l-arginine to form l-ornithine and urea.

47 Arginase (RocF) hydrolyzes L-arginine to L-ornithine and urea.

48 ginase (EC 3.5.3.1) hydrolyzes l-arginine to l-ornithine and urea.

49 talyzes the hydrolysis of l-arginine to form l-ornithine and urea.

50 talyzes the hydrolysis of L-arginine to form L-ornithine and urea.

51 talyzes the hydrolysis of l-arginine to form l-ornithine and urea.

52 lloenzyme that hydrolyzes l-arginine to form l-ornithine and urea.

53 at catalyzes the hydrolysis of L-arginine to L-ornithine and urea.

54 talyze the hydrolysis of L-arginine to yield L-ornithine and urea.

55 etection for Arg, Cit, L-arginino-succinate, L-ornithine, and L-arginine phosphate range from 50 amol

56 inhibitors (type 1), including L-isoleucine, L-ornithine, and L-citrulline, suppresses enzymatic acti

57 proceeds by hydroxylation and acetylation of L-ornithine, and later steps likely involve covalently b

58 and the rate of Schiff base interchange with L-ornithine are partially rate-limiting for the reaction

59 mino acids such as l-arginine, l-lysine, and l-ornithine are transported by cationic (CAT) and y(+)L

60 ences, particularly the reduced affinity for L-ornithine, are sufficient to account for their biochem

61 RapL also accepts L-ornithine as a substrate, albeit with a significantly

62 utant enzymes, E274A ODC and C360A ODC, with L-ornithine as substrate the carbon isotope effect also

63 against OAT; measuring the transformation of L-ornithine at high concentrations by this assay is comp

64 a carbamoyl phosphate binding domain and an L-ornithine binding domain.

65 decay of this intermediate is accelerated by l-ornithine binding.

66 L-Lysine and L-ornithine but not D-Arg produced currents with charact

67 in catalyzes the carbamylation of N-succinyl-L-ornithine but not L-ornithine or N-acetyl-L-ornithine,

68 of substrate binding for both l-arginine and l-ornithine, but it is not sufficient to encode the chan

69 )-methyl-L-arginine, and N(5)-(1-iminoethyl)-L-ornithine, but not the reversible inhibitor 7-nitroind

70 city of PDGF to up-regulate the transport of L-ornithine by inducing the expression of the genes for

71 he transcellular transport and metabolism of L-ornithine by vascular SMCs.

72 he decarboxylation of the optimal substrate, L-ornithine, by wild-type ODC, the observed carbon isoto

73 TGF-beta(1) also stimulated L-ornithine catabolism by elevating ornithine decarboxyl

74 nge for the CD assay from 10 microM to 2.5 M L-ornithine concentration for this assay.

75 crystal structure of the N5-(1-iminopropyl)-L-ornithine:DDAH-1 complex indicates covalent bond forma

76 The E. coli argE-encoded N-acetyl-L-ornithine deacetylase has been cloned, expressed, and

77 Exogenous l-ornithine did not inhibit NOHA-induced caspase-8 activ

78 nhibitor); and (4) 10 mm N(5)-(1-iminoethyl)-l-ornithine dihydrochloride [endothelial NOS (eNOS) inhi

79 acid to protonate the leaving amino group of l-ornithine during catalysis, and this is a revised mech

80 idA forms a ternary complex with NADP(+) and l-ornithine during catalysis.

81 This siderophore contains N(5)-hydroxylated l-ornithines essential for iron binding.

82 N-succinyl-L-ornithine rather than N-acetyl-L-ornithine for de novo arginine biosynthesis and theref

83 N5-(1-iminopentyl)- and N(5)-(1-iminohexyl)-l-ornithine for neuronal NOS (1.7, 3, 20, >1,900 microM,

84 -L-ornithine but not L-ornithine or N-acetyl-L-ornithine, forming N-succinyl-L-citrulline.

85 The N(delta)-hemiphthaloyl-L-ornithine group of PT523 is less well defined, and the

86 e Cepsilon-NdeltaH2+ bond, yielding urea and L-ornithine(H+).

87 with the bisubstrate analog N-phosphonacetyl-L-ornithine has been solved at 1.85-A resolution by mole

88 opionic acid, 2, 4-diamino-L-butyric acid or L-ornithine, have been examined using circular dichroism

89 flavin- and NADPH-dependent hydroxylation of l-ornithine in ferrichrome biosynthesis.

90 ne and phosphate from carbamyl phosphate and L-ornithine in L-arginine biosynthesis.

91 ugh ATP-PP(i) exchange assay that EcdA loads L-ornithine in the first module.

92 le inhibitor of DDAH-1, N(5)-(1-iminopropyl)-l-ornithine, indicating this compound's bioavailability

93 c arginine analogues, including L-lysine and L-ornithine, inhibited L-arginine transport, whilst 2-me

94 em with Asp-263 and the alpha-amino group of L-ornithine, instead of with His-302 and Glu-310, as pre

95 Since L-ornithine is metabolized to growth-stimulatory polyami

96 High-quality data on the efficacy of L-ornithine L-aspartate (LOLA) in patients with cirrhosi

97 ats treated with ammonia-lowering therapy by l-ornithine l-aspartate and rifaximin orally for 4 weeks

98 e (SNAP), and the NOS inhibitor N-iminoethyl-L-ornithine (L-NIO), we performed studies of isolated pe

99 idine-containing compound, N5-(1-iminoethyl)-L-ornithine (L-NIO).

100 between rat nNOS and N5-(1-imino-3-butenyl)-L-ornithine (L-VNIO), a previously identified mechanism-

101 f NOS-1 with vinyl-L-N-5-(1-imino-3-butenyl)-L-ornithine (L-VNIO, 100 microM) or soluble guanylyl cyc

102 of NOS1 with vinyl-L-N-5-(1-imino-3-butenyl)-L-ornithine (L-VNIO, 500 micromol/L).

103 nce was found for the binding of L-arginine, L-ornithine, L-2,4-diaminobutyric acid, and L-alanine.

104 The cationic amino acids L-ornithine, L-lysine, L-homoarginine (which is not meta

105 rs of response to lactulose, probiotics, and L-ornithine-L-aspartate therapy in minimal hepatic encep

106 ors of response to lactulose, probiotics and L-ornithine-L-aspartate therapy in minimal hepatic encep

107 Lactulose, probiotics, L-ornithine-L-aspartate, and potassium-iron-phosphate-ci

108 ort that vinyl-L-NIO (N5-(1-imino-3-butenyl)-L-ornithine; L-VNIO) binds to and inhibits nNOS in compe

109 lectric field (dcEF) when cultured on a poly-L-ornithine/laminin coated surface, while the fetal-deri

110 rting from methyl N(delta)-benzyloxycarbonyl-L-ornithine led to 2-L-[5-[N-(2-amino-4(3H)-oxopyrido[2,

111 ne and L-arginine (tightly) and L-lysine and L-ornithine (less tightly) in the periplasm, interacts w

112 utants display markedly reduced affinity for L-ornithine, loss of substrate inhibition, alkaline shif

113 Furthermore, thrombin stimulated L-ornithine metabolism by inducing ornithine decarboxyla

114 fining the contribution of the hemiphthaloyl-L-ornithine moiety to the exceptional in vitro antitumor

115 methods, using heterologously expressed N(5)-l-ornithine monooxygenase from the pathogenic fungus Asp

116 The remarkable specificity of the N(5)-l-ornithine monooxygenase-catalyzed reaction suggests ad

117 avoprotein VbsO acts as a pathway-initiating l-ornithine N(5)-hydroxylase, followed by VbsA, which tr

118 sid1 encodes L-ornithine N(5)-oxygenase, which catalyzes hydroxylatio

119 The sid1 and urbs1 genes encode L-ornithine N5-oxygenase and a GATA family transcription

120 -arginine is 550-fold higher than for either l-ornithine or l-lysine, which were decarboxylated with

121 xylation of the primary amine side chains of l-ornithine or l-lysine.

122 bamylation of N-succinyl-L-ornithine but not L-ornithine or N-acetyl-L-ornithine, forming N-succinyl-

123 Individually, L-ornithine or phenylbutyrate were similar to the BDL gr

124 e N(delta)-(phosphonoacetyl)-N(alpha)-acetyl-l-ornithine (PALAO) indicates that the carboxyl group on

125 th the bisubstrate analog N-(phosphonacetyl)-L-ornithine (PALO) has been determined at 2.8-A resoluti

126 talyzes the hydrolysis of L-arginine to form L-ornithine plus urea.

127 fective as a substrate for arginase-mediated L-ornithine production compared with L-arginine directly

128 Binding of N-phosphonacetyl-L-ornithine promotes domain closure.

129 amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-l-ornithine (PT523) in comparison with RFC irrespective

130 -amino-4-deoxypteroyl)-Ndelta-hemiphthaloy l-L-ornithine (PT523, 3) were synthesized with a view to d

131 -amino-4-deoxypteroyl)-N delta-hemiphthaloyl-L-ornithine (PT523, 4) were synthesized via straightforw

132 ein suggest that B. fragilis uses N-succinyl-L-ornithine rather than N-acetyl-L-ornithine for de novo

133 -amino-4-deoxypteroyl)-N delta-hemiphthaloyl-L-ornithine], reduced nicotinamide adenine dinucleotide

134 ized as a structurally unique eight-membered l-ornithine ring-containing jadomycin.

135 mined whether the transcellular transport of L-ornithine, the cationic amino acid precursor of polyam

136 -oxygenase, which catalyzes hydroxylation of L-ornithine, the first committed step of ferrichrome and

137 e cyclodeaminase catalyzes the conversion of L-ornithine to L-proline by an NAD(+)-dependent hydride

138 annaschii have been shown to readily convert L-ornithine to L-proline.

139 thine decarboxylase (ODC), which metabolizes L-ornithine to polyamines, was also induced in H. pylori

140 ne decarboxylase (ODC)-catalyzed reaction of L-ornithine to putrescine and CO2.

141 al 5'-phosphate-dependent decarboxylation of l-ornithine to putrescine, a vital step in polyamine bio

142 N-Acetyl-l-ornithine transcarbamylase (AOTCase), rather than orni

143 in with those recently reported for N-acetyl-L-ornithine transcarbamylase indicates that amino acid r

144 upon substrate binding occurs in N-succinyl-L-ornithine transcarbamylase, while movement of the 80 l

145 ence that this protein is a novel N-succinyl-L-ornithine transcarbamylase.

146 Pea (Pisum sativum L.) ornithine transcarbamylase (OTC) antisera were used

147 The ability of thrombin to upregulate L-ornithine transport and direct its metabolism to growt

148 The stimulatory effect of thrombin on both L-ornithine transport and ODC activity was reversed by h

149 40% stimulation of L-arginine, L-lysine and L-ornithine transport.

150 thrombin initially (0 to 2 hours) decreased L-ornithine uptake, whereas longer exposures (6 to 24 ho

151 ferring substrate specificity for N-succinyl-L-ornithine versus N-acetyl-L-ornithine.

152 rboxyl group is involved in binding N-acetyl-l-ornithine via a water molecule.

153 The potentiating effect of L-ornithine was reversed by the competitive inhibitor of

154 finding that PBCV-1 DC prefers l-arginine to l-ornithine was unexpected based on evolutionary analysi

155 or, N(alpha)-acetyl-N(delta)-phosphonoacetyl-L-ornithine, was synthesized and showed a midpoint of in

156 amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L- ornithine] was found to have an inhibition constant (

157 eal saline (placebo), OP, phenylbutyrate, or L-ornithine were administered after randomization.

158 d (6R,6S)-5-deaza-5,6,7, 8-tetrahydropteroyl-L-ornithine were also synthesized as potential inhibitor

159 ne, alpha-ketoglutarate, glyoxylic acid, and L-ornithine were used as dead-end analogues of saccharop

160 s associated with a decrease in affinity for L-ornithine, whereas stimulation was mediated by an incr

161 , and Aquifex showed a strong preference for L-ornithine, whereas the enzyme from Vibrio vulnificus (

162 le to interact with the delta-amino group of L-ornithine which attacks the carbonyl carbon of carbamo

163 er was resistant to cadaverine, L-lysine and L-ornithine, which inhibit the E. coli AdiC antiporter.

164 Arginase converts L-arginine to L-ornithine, which is the precursor of polyamines, which

165 typical saturation kinetics with respect to l-ornithine while substrate inhibition was observed at h

166 y and that the short isoform is inhibited by L-ornithine with a Ki of approximately 0.25 mM.