ライフサイエンスコーパス: L-proline

1 roup of L-amino acids (with the exception of L-proline).

2 preparing novel OCF2H-analogues of GABA and l-proline.

3 th l-pipecolic acid and, to a lesser extent, l-proline.

4 ne) and other secondary amino acids, such as l-proline.

5 lity of profilin to bind both actin and poly-l-proline.

6 s269Asn mutant bind the zwitterionic form of L-proline.

7 ) and other secondary amino acids, including L-proline.

8 or is possible only with the anionic form of L-proline.

9 been shown to readily convert L-ornithine to L-proline.

10 ative protein and was also inhibited by poly-L-proline.

11 m upon anaerobic reduction with sarcosine or L-proline.

12 ined in reductive half-reaction studies with L-proline.

13 d affinity of Acanthamoeba profilin for poly-L-proline.

14 ere coupled to the side chain of cis-4-amino-L-proline.

15 oacylation assays, and showed similar Km for L-proline.

16 from commercially available trans-4-hydroxy-l-proline.

17 significantly affecting the apparent Km for l-proline.

18 ocatalysts is opposite to that obtained with L-proline.

19 only nine linear steps from cheap 4-hydroxy-l-proline.

20 tively alkylated with hexanal and coupled to l-proline.

21 e use of either commercially available d- or l-proline.

22 st human enzyme that acts on trans-3-hydroxy-L-proline.

23 xy-L-homotyrosine, and 3S-hydroxyl-4S-methyl-L-proline.

24 e (AC) is a toxic, natural product analog of l-proline.

25 -imino-L-allonic acid, (3R,4S)-3,4-dihydroxy-L-proline, 1,5-anhydro-4-deoxy-4-amino-D-glucitol, and 1

26 The highest selectivity was obtained with a L-proline-1-indananilide that exhibited alpha values up

27 ve alkaloids originated from trans-4-hydroxy-L-proline (10), which was converted to ketonitrile 13 vi

28 Structures of Amb a 8 in complex with poly(l-proline)10 or poly(l-proline)14 are the first structur

29 8 in complex with poly(l-proline)10 or poly(l-proline)14 are the first structures of the plant profi

30 However, in natural collagen, 3(S)-hydroxyl-L-proline (3(S)Hyp) occurs in the Xaa positions to varyi

31 In natural collagen, a 3(S)-hydroxy-l-proline (3-Hyp) residue occurs in the sequence: 3-Hyp-

32 d derivatives were separated by N-dodecanoyl-L-proline-3,5-dimethylanilide, while polar catecholamine

33 ing 4R,5R-dihydroxy-L-ornithine, 4R-hydroxyl-L-proline, 3S,4S-dihydroxy-L-homotyrosine, and 3S-hydrox

34 L-Proline (Pro) and 4(R)-hydroxyl-L-proline (4(R)Hyp) residues are found most frequently i

35 l-Proline (Pro) and 4(R)-hydroxy-l-proline (4-Hyp) residues occur most often in the Xaa a

36 l limit of detection of 0.02 ppb (0.2 nM) of l-proline-a decade improvement over the industry gold-st

37 es (L-pipecolate, L-proline) and 3,4-dehydro-L-proline act as alternate substrates.

38 ned Kd values for the ES complex formed with L-proline agree with results obtained in spectral titrat

39 hPAT1 interacted with glycine, L-alanine, L-proline, alpha-aminoisobutyrate (AIB) and gamma-aminob

40 l (N2-[(S)-1-carboxy-3-phenylpropyl]-L-lysyl-L-proline; also known as Prinivil or Zestril), at 2.0 A

41 4-N-(Nomega-nitro-l-argininyl)-trans-4-amino-l-proline amide (2), led to the discovery of a conserved

42 Among the compounds, the (l)-proline amino acid-containing prodrugs proved to be t

43 for detecting the production of the enzymes L-proline aminopeptidase and beta-galactosaminidase by y

44 All three test kits detect the enzymes L-proline aminopeptidase and beta-galactosaminidase in y

45 C. albicans; other yeasts may produce either L-proline aminopeptidase or beta-galactosaminidase but n

46 nc., Decatur, Ga.) can be used to screen for L-proline-aminopeptidase produced by Clostridium diffici

47 Poly-l-proline, an inhibitor of profilin 1-mediated actin pol

48 tructure-based catalyst screening identified L-proline and 5,5-dimethyl thiazolidinium-4-carboxylate

49 Starting from L-proline and a substituted tryptophan derivative, this

50 d nearly identical substrate specificity for L-proline and A2C, but for AtProRS-Org the specificity c

51 n highly conserved residues in both the poly-L-proline and actin binding regions of profilin do not e

52 of yeast profilin mutants with altered poly-L-proline and actin binding sites are discussed in the c

53 sion of many l-gamma-glutamylamines to 5-oxo-l-proline and free amine.

54 al with dialkyl azodicarboxylate promoted by l-proline and functionalization of the triple bond by So

55 Here we investigate the use of L-proline and its derivatives to effect synthesis of the

56 tamyl)-l-lysine, which is converted to 5-oxo-l-proline and l-lysine by the action of gamma-glutamylam

57 Mechanistic insight into the L-proline and L-prolinamide catalyzed alpha-selenenylati

58 ility to functionalize biologically relevant l-proline and l-trans-hydroxyproline, delivering unique

59 nt cells and for their association with poly-L-proline and monomeric actin from maize pollen.

60 ructure of P5CR to structures complexed with L-proline and NADP+ in two quite different primary seque

61 en conserved aromatic residues and that poly-L-proline and PRAD act through these aromatic residues t

62 ss II profilins had higher affinity for poly-l-proline and sequestered more monomeric actin than did

63 turated nitrogen heterocycles (L-pipecolate, L-proline) and 3,4-dehydro-L-proline act as alternate su

64 f the conformational transition between poly(L-proline) and ELPs.

65 ate the levels of a putative neuromodulator (L-proline) and the neurotransmitter dopamine, respective

66 gen Amb a 8, Amb a 8 in the presence of poly(l-proline), and Art v 4 (mugwort allergen).

67 A simple secondary amine catalyst, 2-methyl-l-proline, and its tetrabutylammonium salt function as a

68 e carbene precursor was readily derived from L-proline, and the 1,5-CH insertion reaction was perform

69 3-arylidene-1-phenyl-pyrrolidine-2,5-diones, l-proline, and the cyclic ketones 1H-indole-2,3-dione (i

70 ly 2-5% wild-type affinity for actin or poly-L-proline; and 3) special mutations show that the abilit

71 oefficient is found for the complex with the L-proline anion.

72 ine, prokaryotes have been known to use free l-proline as a precursor to form Hyp.

73 Use of the chiral amino acid L-proline as a stereo-directing element provides a diast

74 e obtained via dual activation concept using l-proline as organocatalyst; however, naphthyridines 7a-

75 Charge-transfer interaction with L-proline as the donor and FAD as acceptor is possible o

76 ing copper catalyzed C-N bond-formation with L-proline as the ligand.

77 proline over hydroxyproline (trans-4-hydroxy-l-proline) as the substrate, but the basis for specifici

78 ation, and SAR studies of a series of d- and l-proline- as well as of (4R)-4-hydroxy-l-proline-derive

79 The reductive half-reaction with L-proline at 4 degrees C exhibited saturation kinetics (

80 ing rate of the reductive half-reaction with L-proline at pH 8.0 are, however, nearly 2 orders of mag

81 ation state of the amino-acids l-alanine and l-proline at the air/water surface and in the bulk.

82 e coupling was tested using a series of poly-L-proline based peptides of different length.

83 he 4-hydroxyl group of N-BOC-trans-4-hydroxy-L-proline benzyl ester, via activation as the triflate,

84 DB 2PMQ), 2-epimerization of trans-4-hydroxy-L-proline betaine (tHyp-B) and cis-4-hydroxy-D-proline b

85 1-Y6F) was created and found to enhance poly-L-proline binding activity and to disrupt cytoarchitectu

86 s on actin in living cells and that the poly-L-proline binding function of profilin may have importan

87 ents of the G-actin binding surface and poly-l-proline binding interface.

88 uctive half-reaction shows that the K(d) for L-proline binding is pH-independent (pH 6.46-9.0).

89 Plants expressing the actin and poly-l-proline binding mutants exhibited similar F-actin diso

90 tic extension of the previously defined poly-L-proline binding site for profilin I.

91 profilin RNAi, while a mutation in the poly-l-proline binding site weakly rescues.

92 ophobic residues in and proximal to the poly-L-proline binding site.

93 with the transporter protein at or near the L-proline binding site.

94 Thus, poly-L-proline binding, actin binding, and actin nucleotide e

95 ains support a model in which acquisition of L-proline both regulates the metabolic shift and maintai

96 l folds, and affinities for G-actin and poly-L-proline, budding yeast profilin ScPFY fails to complem

97 ids (N-methyl-L-alanine, N-ethylglycine, and L-proline), but N,N-dimethylglycine, a tertiary amine, i

98 main of fission yeast formin Cdc12p and poly-L-proline, but human profilin-I does not stimulate actin

99 >10% of wild-type affinity for actin or poly-L-proline, but lower affinity for either ligand is incom

100 The ability of nikD to oxidize 3,4-dehydro-L-proline, but not 1-cyclohexenoate, suggests that the e

101 es the affinity of human profilin-I for poly-l-proline by 1000-fold, but overexpression of Y6D profil

102 fibers to 10(-4) M L-alanine, L-arginine and L-proline by 89-100%.

103 e catalyzes the conversion of L-ornithine to L-proline by an NAD(+)-dependent hydride transfer reacti

104 o reactions were observed with cis-3-hydroxy-l-proline (c3LHyp), competing 2-epimerization to trans-3

105 opylcarbamoyl)oxirane-2-carbonyl-L-isoleucyl-L-proline (CA-074 Me) also reduced TNF-alpha-induced liv

106 ropylcarbamoyloxirane-2-carbony)-L-isoleucyl-L-proline (CA-074), at a concentration of 1 microM, caus

107 ted linear models containing the cis-4-amino-L-proline (cAmp) in place of native Pro(2).

108 The mechanism of l-proline-catalyzed alpha-amination of 3-phenylpropional

109 For the first time, the L-proline-catalyzed direct asymmetric self-aldolization

110 reaction: see text] A highly stereoselective L-proline-catalyzed, asymmetric direct Mannich reaction

111 The proline analogue cis-4-hydroxy-L-proline (cHyp) inhibits collagen accumulation but diff

112 Inhibitors of collagen such as cis-4-hydroxy-L-proline (cHyp) may ameliorate bleomycin (bleo)-induced

113 fluoro-L-proline (trans-Flp) or cis-4-fluoro-L-proline (cis-Flp) for trans-4-hydroxy-L-proline (trans

114 ndicate that an ionizable group in the E(ox).L-proline complex (pK(a) = 8.02) must be unprotonated fo

115 The E(ox).L-proline complex formed with the His269Asn mutant or wi

116 The ionizable group in the E(ox).L-proline complex is required for conversion of enzyme-b

117 established their structures as new stilbene-l-proline conjugates, prolbenes A (compound 3) and B (co

118 gates more efficiently than the peptide with l-prolines, consistent with beta-turn formation in aggre

119 iProt ID A0NXQ7 ; 4HypE) and trans-3-hydroxy-l-proline dehydratase (UniProt ID A0NXQ9 ; t3LHypD).

120 SOX closely resembles the alphabeta dimer of L-proline dehydrogenase, a heteroctameric protein (alpha

121 Control experiments with poly(L-proline) demonstrate the similarity of the conformatio

122 f armeniaspirol analogues was achieved using L-proline derived bifunctional squaramide which outperfo

123 and l-proline- as well as of (4R)-4-hydroxy-l-proline-derived MMP inhibitors possessing general form

124 tiated by the NO donor 1-(hydroxy-NNO-azoxy)-l-proline, disodium salt (IC50 approximately 1.3-2.0.10(

125 Since both 4-nitro and 4-amino L-proline esters are efficient organocatalysts of aldol

126 iously shown to be defective in binding poly-l-proline, exhibits little or no evidence of saturable G

127 tachment of a carboxymethylene unit to C5 of L-proline followed by beta-lactam ring closure.

128 s 2 were prepared as single enantiomers from L-proline following a "self-reproduction of chirality" p

129 imulated collagen production is dependent on L-proline formation.

130 imulated collagen production is dependent on L-proline formation.

131 g of proline amino acid, cis-4-[(18)F]fluoro-L-proline (FP), was tested for potential use in PET for

132 MCs to generate the polyamine putrescine and L-proline from extracellular L-arginine.

133 ly increased the capacity of SMC to generate L-proline from L-arginine while inhibiting the formation

134 C14orf149 serves to degrade trans-3-hydroxy-L-proline from the diet and originating from the degrada

135 hylamino-1-naphthalenesulfonamide and dansyl-l-proline from the two major drug-binding sites on HSA (

136 x is required for conversion of enzyme-bound L-proline from the zwitterionic to the reactive anionic

137 inhibitor alpha-difluoromethylornithine, and L-proline generation was blocked by the OAT inhibitor L-

138 The inhibitory L-proline has been observed in the crystal structure.

139 s and enthalpies of dilution of l-serine and l-proline have been determined in water and in aqueous s

140 xperimental Young's moduli of two known poly-l-proline helical forms, right-handed all-cis (Form I) a

141 one of the features characteristic of a poly-L-proline helix (or alpha- or 3(10)-helix) were observed

142 Although a 6 residue type II poly(L-proline) helix can span the binding site, highest affi

143 e observed for an alternated N-benzylglycine/L-proline hexameric cyclopeptoid.

144 rd 1.2% calcium diet with 5% trans-4-hydroxy-l-proline (hydroxyproline) so that the rats would exclus

145 We found that l-proline (i) inhibited the adoption of the conformation

146 ifferent fractions of residues adopting poly-l-proline II (PPII), extended beta-strand, and alpha-hel

147 al. suggested that indolicidin forms a poly-L-proline II helix based upon the circular dichroism (CD

148 In contrast, we found no evidence of poly-L-proline II helix formation in the CD spectra of native

149 ask spectral features characteristic of poly-L-proline II helix.

150 repeat of three, as in the left-handed poly-L-proline II helix.

151 ded polypeptide, which is mainly in the poly(L-proline) II (PPII) conformation.

152 tely 1318 cm(-1) that may be due to the poly(l-proline) II (PPII) helical conformation.

153 oximately 1315 cm(-1) characteristic of poly(L-proline) II (PPII) helix that is present in the ROA sp

154 maller quantities of beta-structure and poly(l-proline) II (PPII) helix were also identified.

155 ding domain and its potential to form a poly(L-proline) II (PPII) helix.

156 appears instead that is assigned to the poly(l-proline) II (PPII)-helical conformation.

157 An extended poly(L-proline)II helix between residues 11 and 19 serves as

158 line transporter SLC6A20 was associated with L-proline in CSF (beta=0.28; P=9.68 x 10(-9)).

159 ansporter and its presumed natural substrate L-proline in excitatory synaptic transmission.

160 from commercially available trans-4-hydroxy-L-proline in four steps.

161 onfirm that model insect pathogens can sense L-proline in insect blood.

162 Reaction of nitric oxide (NO) with L-proline in methanolic sodium methoxide yields a diazen

163 proline dehydrogenase), were associated with L-proline in plasma (beta=0.29; P=6.38 x 10(-10)).

164 nes from naturally occurring trans-4-hydroxy-L-proline in six chemical operations.

165 We report that the inclusion of poly-L-proline in the extraction buffer out-competes proteins

166 01 and Xenorhabdus nematophila revealed that L-proline in the insect's hemolymph initiates a metaboli

167 quality and hydration number of l-serine and l-proline in the presence of the studied preservatives.

168 Amb a 8 binds the poly(l-proline) in a mode similar to that observed in human,

169 higher selectivity at the acceptor residue (L-proline) in the formation of the chain-initiating D-Ph

170 sine, L-arginine, L-cysteine, L-alanine, and L-proline--in aqueous solution adsorbed at model hydroph

171 To identify the L-proline-induced signaling pathway, we deleted the prol

172 Profilins that bind both actin and poly-l-proline inhibit nucleation by Cdc12(FH1FH2)p, but poly

173 lysine analog epsilon-aminocaproic acid and L-proline inhibited the binding of Lp(a) and apo(a) to P

174 ofilin:actin complexes through profilin:poly-L-proline interactions to particular cytoskeletal locati

175 Although L-proline is a poor substrate, aromatic heterocyclic car

176 related human pathogen Helicobacter pylori, L-proline is a preferred respiratory substrate and is fo

177 L-proline is an amino acid that plays an important role

178 The rigidity of poly-l-proline is an important contributor to the stability o

179 (O,O-diisopropyl phosphoryl)-trans-4-hydroxy-L-proline is converted in a one-pot process to (2S)-cis-

180 These findings suggest that L-proline is desaturated to pyrroline-5-carboxylic acid

181 In contrast, the affinity of ZmPRO4 for poly-L-proline is nearly twofold higher than that of native p

182 We demonstrate that l-proline is recognized by PrnB via interactions with re

183 l-Proline is selected and activated as l-prolyl-AMP by a

184 the only other nearby base, we conclude that L-proline is the ionizable group in the ES complex and t

185 e dissociation equilibrium constant for poly(L-proline) is about 10 microM proline decamer units for

186 Binding of poly(L-proline) is favored both entropically and enthalpicall

187 The binding to poly(L-proline) is used for the affinity purification of prof

188 n of delta1-pyrroline-5-carboxylate (P5C) to L-proline, is catalyzed by delta1-pyrroline-5-carboxylat

189 rization of alpha-oxyaldehydes, catalyzed by l-proline, is then followed by a tandem Mukaiyama aldol

190 4 min(-1); K(m) = 5.2 microM) or 3,4-dehydro-L-proline (k(cat) = 18 min(-1); K(m) = 13 mM) were deter

191 Turnover with L-proline (k(cat) = 25 min(-)(1)) at 25 degrees C occurs

192 pS, was activated by high concentrations of L-proline (L-Pro) (0.1-3 mM), which is the range necessa

193 utamine, l-threonine, l-arginine, l-glycine, l-proline, l-serine, l-alanine, and l-glutamic acid.

194 Amino acids such as l-proline, l-threonine, and l-methionine elicited comple

195 L-Proline labeled with deuterium or tritium at the diast

196 ith a propargyl borolane and the N-isopropyl-l-proline ligand is presented.

197 lin and its interactions with actin and poly-l-proline ligands are required to properly organize F-ac

198 metabolites are dramatically upregulated by L-proline, linking the recognition of host environment t

199 pper-involved reaction occurs because copper-l-proline "locks" the alkene anion intermediates into th

200 ithelial cells by affinity binding to a poly-L-proline matrix, stimulated the actin-saturated RSV tra

201 and direct its metabolism to polyamines and L-proline may contribute to arterial remodeling at sites

202 inine transport and direct its metabolism to L-proline may play an important role in stabilizing vasc

203 An intramolecular L-proline-mediated aldol reaction was employed to genera

204 anide addition, and the carboxylate group of l-proline mediates stereofacial addition.

205 Rate constants for the hydrolysis of L-proline methyl ester to form proline and methanol in D

206 ctone was synthesized by the condensation of l-proline methyl ester with an enantiomerically pure hyd

207 the extent to which the amino acid osmolyte l-proline might impact bivalent Fab complexation.

208 d 60 to 80% by antiprofilin antibody or poly-L-proline, molecules that specifically bind profilin.

209 calculations on the model compound N-acetyl-L-proline-N-methylamide (Ace-Pro-NMe) with coordinates t

210 a 1-pyrroline-5-carboxylate reductase (P5CR, L-proline:NAD[P]+ 5-oxidoreductase, EC 1.5.1.2), which c

211 tant profilin with reduced affinity for poly-l-proline.Nucleation by the Arp2/3 complex is a function

212 e about the binding sites for actin and poly-L-proline on the profilin molecule.

213 ith in situ generated azomethine ylides from l-proline or acenaphthenequinone, formation of spiroaddu

214 arboxylative multicomponent coupling between l-proline or pipecolic acid, aldehydes, and isonitriles

215 tor (NMDAR) coagonists glycine, D-serine and L-proline play crucial roles in NMDAR-dependent neurotra

216 n1 as a phosphorylation site within the poly-l-proline (PLP) binding pocket.

217 Moreover, the affinity of RcPRO1 for poly-L-proline (PLP) was significantly higher than that for r

218 l-Proline (Pro) and 4(R)-hydroxy-l-proline (4-Hyp) resid

219 L-Proline (Pro) and 4(R)-hydroxyl-L-proline (4(R)Hyp) re

220 iological solutions between -140 and -40 mV, L-proline (PRO) and its six-member ring congener L-pipec

221 tionalized in a separate synthesis step with L-proline (PRO).

222 The reductive half-reaction with L-proline proceeds via a rapidly attained equilibrium (K

223 -beta(1)-mediated increase in putrescine and L-proline production was reversed by methyl-L-arginine,

224 The stretch-mediated increase in L-proline production was reversed by methyl-L-arginine,

225 small-molecule NO donor (N-diazeniumdiolated l-proline, PROLI/NO) and a NO-releasing xerogel film wer

226 replaced Gly-Pro-Hyp (where Hyp is 4-hydroxy-L-proline) repeats.

227 L-isoleucine)-L-methyloxazoline residue, one L-proline residue, and one (L-proline)thiazole residue,

228 gamma-amino acid being flanked by two d- or l-proline residues, have been synthesized and tested as

229 The Ena protein sequence has multiple poly-(L-proline) residues with similarity to both profilin and

230 boxylic acid (A2C), a structural analogue of L-proline, results from its incorporation into proteins

231 te that TGF-beta(1) stimulates polyamine and L-proline synthesis by inducing the genes that regulate

232 that cyclic stretch coordinately stimulates L-proline synthesis by regulating the genes that modulat

233 ecificity constant was 77.6 times higher for L-proline than A2C, suggesting that A2C-sensitivity may

234 eld with an alternate substrate (3,4-dehydro-L-proline) that is aromatized in a single two-electron o

235 tes that MSOX binds the zwitterionic form of L-proline, the predominant species in solution at neutra

236 human pathogens to dehydrate trans-4-hydroxy-l-proline, the product of the most abundant human posttr

237 ine residue, one L-proline residue, and one (L-proline)thiazole residue, were established through ext

238 an aziridine aldehyde dimer, isocyanide, and l-proline to afford a chiral piperazinone was studied to

239 Addition of poly-L-proline to culture medium, or coexpression with the N-

240 catalyze the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C).

241 drogenase (PRODH) catalyzes the oxidation of l-proline to Delta-1-pyrroline-5-carboxylate.

242 on in which the endergonic cleavage of 5-oxo-L-proline to form L-glutamate is coupled to the exergoni

243 The oxidation of l-proline to glutamate in Gram-negative bacteria is cata

244 mbrane-bound PutA catalyzes the oxidation of L-proline to glutamate.

245 nhibition of these interactions (3,4-dehydro-l-proline to inhibit collagen secretion, K-201, a specif

246 flavoenzymes that catalyze the oxidation of L-proline to L-glutamate by the sequential activities of

247 5CDH) domains that catalyze the oxidation of l-proline to l-glutamate in two successive reactions.

248 Simultaneous addition of L-proline to the cultures resulted in blockade of these

249 required for conversion of the zwitterionic L-proline to the reactive anionic form, indicating that

250 ted mice harboring a mutation causing a P-to-L (proline-to-leucine) substitution at residue 394 (the

251 single-site incorporation of trans-4-fluoro-L-proline (trans-Flp) or cis-4-fluoro-L-proline (cis-Flp

252 uoro-L-proline (cis-Flp) for trans-4-hydroxy-L-proline (trans-Hyp).

253 Leu-enkephalin elevated the apparent K(m) of L-proline transport in transfected HeLa cells without al

254 The high-affinity mammalian brain L-proline transporter (PROT) belongs to the GAT1 gene fa

255 h-affinity Na+-dependent (and Cl--dependent) L-proline transporter (PROT) in subpopulations of putati

256 The high affinity L-proline transporter (PROT) is a member of the family o

257 PrnB, a highly specific l-proline transporter, only weakly recognizes other Put4

258 revealed that the PEP region adopted a poly-L-proline type II (PPII) helix.

259 igomers are consistent with a populated poly-L-proline type II conformation in CDCl3 and D2O.

260 to human collagen P4H and proteins with poly-l-proline type II helices.

261 tide studied compared to a rigid linear poly-L-proline type II helix structure.

262 al for peptides in the extended helical poly(L-proline) type II conformation (PPII), suggesting that

263 re calculation using DIANA suggest that poly(L-proline) type II conformers of the peptide molecules c

264 s are reminiscent of the CD spectrum of poly(L-proline) type II structure in aqueous and nonaqueous s

265 Our results suggest that poly(L-proline) type II structure may, indeed, be the biologi

266 posed, left-handed extended helical or poly (L-proline)-type (PII) conformation at 20 degrees C with

267 ed and left-handed extended helical or poly (L-proline)-type II structures.

268 7% of the residues of rGmDHN1 adopt or poly (L-proline)-type II-like helical conformation at 12 degre

269 f the physiological role(s) of high affinity L-proline uptake have been precluded by the lack of spec

270 ntly and selectively inhibited high affinity L-proline uptake in rat hippocampal synaptosomes and in

271 and acts on peptidyl substrates but not free l-proline, using elements characteristic of an Fe(II)/al

272 lization in the presence of K2CO3 and copper-l-proline, using surveys of the experimental literature

273 port capacity for D-glucose, D-fructose, and L-proline was also greatest during lactation, and the la

274 Naturally occurring trans-4-hydroxy-L-proline was chosen as the precursor to the target's co

275 The affinity of yeast profilin for poly-L-proline was determined from fluorescence measurements

276 3,4-Dehydro-l-proline was found to be an efficient substrate, and l-

277 A molecule of l-proline was observed near the FAD, and this ligand sup

278 ines and to the essential collagen precursor L-proline, we examined whether TGF-beta(1) regulates the

279 decreased affinity for either actin or poly-l-proline were less effective at restoring activity.

280 ons and brush border uptake of D-glucose and L-proline were measured using an in vitro everted sleeve

281 cessive cytosolic levels of the GABA-mimetic l-proline which impairs GABA synthesis and gamma oscilla

282 ng interaction and a hydrogen bond with poly-L-proline which may account for the increased affinity o

283 The observation that the anionic form of L-proline with a neutral amino group is the reactive spe

284 he acid chloride of 4-alkyl(aryl)sulfonyloxy-l-proline with imines are also discussed.

285 ion of a thiol, derived from trans-4-hydroxy-L-proline, with the carbapenem nucleus activated as the

286 Monomeric sarcosine oxidase (MSOX) binds the L-proline zwitterion (pKa = 10.6).