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1 y modulate operator binding (gamma-S-ATP and L-tyrosine).
2 -alkyl-l-cysteines, l-tyrosine, and 3-fluoro-l-tyrosine.
3 in a single step from carbobenzoxy-protected l-tyrosine.
4 thyl-l-tyrosine preferentially compared with l-tyrosine.
5 that required myeloperoxidase, H(2)O(2), and L-tyrosine.
6 ered radical located on the aromatic ring of L-tyrosine.
7 ect the cellular L-phenylalanine turnover to L-tyrosine.
8 or = 3 h by supplementation of the diet with L-tyrosine.
9 tyrosine to form the stable product 3-nitro-L-tyrosine.
10 uoro-L-tyrosine reacted at twice the rate of L-tyrosine.
11 fluoro-L-tyrosine was comparable to that for L-tyrosine.
12 c marker for Cl2-dependent oxidation of free L-tyrosine.
13 he presence of the substrate analog 3-fluoro-l-tyrosine.
14 [FeFe] hydrogenase originate from exogenous l-tyrosine.
15 in synthesis was imaged using 2-(18)F-fluoro-l-tyrosine.
16 order and for its substrate specificity for L-tyrosine.
17 L-tyrosine, (3) 5 mm BH(4), and (4) BH(4) + L-tyrosine.
18 L-lysine, L-phenylalanine, L-tryptophan, and L-tyrosine.
19 kinetic activity toward L-phenylalanine over L-tyrosine.
22 -established tracers O-(2-(18)F-fluoroethyl)-l-tyrosine ((18)F-FET) and (18)F-FDG in a murine model o
23 acid transport using O-(2-(18)F-fluoroethyl)-l-tyrosine ((18)F-FET) and proton MR spectroscopy (MRS)
26 cated that PET using O-(2-(18)F-fluoroethyl)-l-tyrosine ((18)F-FET) may be helpful for solving this d
27 have suggested that O-(2-(18)F-fluoroethyl)-L-tyrosine ((18)F-FET) PET adds valuable clinical inform
28 ate the potential of O-(2-(18)F-fluoroethyl)-L-tyrosine ((18)F-FET) PET for differentiating local rec
29 Experience regarding O-(2-(18)F-fluoroethyl)-L-tyrosine ((18)F-FET) PET in children and adolescents w
30 he clinical value of O-(2-(18)F-fluoroethyl)-l-tyrosine ((18)F-FET) PET in the initial diagnosis of c
32 ted the potential of O-(2-(18)F-fluoroethyl)-L-tyrosine ((18)F-FET) PET to noninvasively detect malig
36 T with the amino acid O-(2-(18)F-fluorethyl)-L-tyrosine ((18)F-FET) to search for focal changes of di
37 ne ((18)F-FLT), and O-(2-(18)F-fluoro-ethyl)-l-tyrosine ((18)F-FET) were used as surrogate markers of
38 id transport such as O-(2-(18)F-fluoroethyl)-l-tyrosine ((18)F-FET), 3,4-dihydroxy-6-(18)F-fluoro-l-p
40 amino acid tracer, O-(2-[(18)F]fluoroethyl)-l-tyrosine ([(18)F]FET), in the delayed brain tumor (DBT
43 lexes with 2-fluoro-L-tyrosine, 2,3-difluoro-L-tyrosine, 2,5-difluoro-L-tyrosine, and 2,6-difluoro-L-
44 quinonoid absorbance peak at 500 nm, whereas L-tyrosine, 2-fluoro-L-tyrosine, and all difluoro-L-tyro
46 A (1) was determined to be (R)-beta-methoxy-L-tyrosine, (2R,3R,4S)-4-amino-7-guanidino-2,3-dihydroxy
49 spectra of 2-fluoro-L-tyrosine and 3-fluoro-L-tyrosine (3-Y(f)) obtained with 229 nm excitation are
50 of (1) Ringer solution (control), (2) 0.5 mm L-tyrosine, (3) 5 mm BH(4), and (4) BH(4) + L-tyrosine.
51 acid identity (approximately 65%) with plant L-tyrosine/3,4-dihydroxy-L-phenylalanine and L-tryptopha
52 ecularly imprinted polymer (MIP) for 3-nitro-L-tyrosine (3NT), an oxidative stress marker associated
53 peptide N-succinyl-L-leucyl-L-leucyl-L-valyl-L-tyrosine-7-amido-4- methylcoumarin or the microtubule-
54 bstrate N-succinyl-L-leucyl-L-leucyl-L-valyl-L-tyrosine-7-amido-4-methylcouma rin, as well as the end
55 A inhibition by peroxynitrite, and exogenous L-tyrosine abrogated the inhibition by peroxynitrite.
56 , and dithiothreitol, reversed and exogenous L-tyrosine abrogated the peroxynitrite-induced NCA inhib
58 Comparison of the structure of SgTAM to the l-tyrosine ammonia lyase from Rhodobacter sphaeroides pr
59 se oxidation of synthetic 3-nitroso-N-acetyl-L-tyrosine and 2) peroxidase oxidation of free L-tyrosin
60 fically, resonance Raman spectra of 2-fluoro-L-tyrosine and 3-fluoro-L-tyrosine (3-Y(f)) obtained wit
65 y prepared in chiral nonracemic fashion from L-tyrosine and do not show a propensity to undergo racem
67 that wild-type and mutant proteins can bind L-tyrosine and form quinonoid complexes with similar rat
68 was undetectable when BSA was incubated with L-tyrosine and HOBr, peroxynitrite, hydroxyl radical, or
70 ies at the B3LYP/6-31G** level of theory for L-tyrosine and its 3-fluorine substituted analog are com
71 This activity is subject to inhibition by L-tyrosine and its analogues and by ATP and ATP analogue
73 s as a competitive inhibitor with respect to L-tyrosine and serves as an alternative substrate for th
77 ilar pathways (beginning with the amino acid L-tyrosine), and the pathway has been completely delinea
78 osine, 2,3-difluoro-L-tyrosine, 2,5-difluoro-L-tyrosine, and 2,6-difluoro-L-tyrosine exhibited much l
80 peak at 500 nm, whereas L-tyrosine, 2-fluoro-L-tyrosine, and all difluoro-L-tyrosines, had a much red
81 e generation required myeloperoxidase, H2O2, L-tyrosine, and chloride ion; it was inhibited by the H2
85 al in the hydroxylation of L-phenylalanine-, L-tyrosine-, and L-tryptophan-regulating catecholamine a
86 pathways to lignin from L-phenylalanine and L-tyrosine are distinct beyond the formation of 4-coumar
89 thesis, exhibits minimal activity with 2-aza-L-tyrosine as an alternative substrate but generating (S
92 irst report on an enzymatic C-prenylation of l-tyrosine as free amino acid and altering the substrate
95 by coupling sulphanilamide as the ligand and L-tyrosine as the spacer arm to a cyanogen bromide (CNBr
97 In particular, some members of a class of L-tyrosine-based compounds designed as selective agonist
98 the SgcC4-catalyzed interconversion between L-tyrosine, beta-tyrosine, and 4-hydroxycinnamate was me
100 these were identified as L-phenylalanine and L-tyrosine but it may be that metabolically-related comp
101 ellular system could be replaced by HOCl and L-tyrosine but not by a wide variety of other oxidation
102 e generated p-hydroxyphenylacetaldehyde from L-tyrosine by a pathway inhibited by azide, cyanide, and
104 investigations indicated that activation of l-tyrosine by the K233A variant of Bacillus stearothermo
108 ctivation of human neutrophils adherent to a L-tyrosine coated glass surface also stimulated 3-chloro
109 nnosyltryptophan, pseudouridine, and O-sulfo-L-tyrosine concentrations associated with incident CKD (
110 ) residues and the bound l-phenylalanine and l-tyrosine, conferring the deamination reaction through
111 n the pH dependence of k(cat)/Km of TPL with L-tyrosine, conformational changes induced by binding of
112 required cofactor for catalysis, and maximal L-tyrosine conversion to L-DOPA is observed in the prese
113 N-termini consisting of Dmt (2',6'-dimethyl-l-tyrosine) coupled to a pyrazinone ring platform by mea
114 (k(cat)/K(m) = 4.1 x 10(4) M(-1) s(-1)), and l-tyrosine-d-leucine (k(cat)/K(m) = 1.5 x 10(4) M(-1) s(
115 lene hydrogen HFC data along with equivalent l-tyrosine data has led to a new computational method th
116 s recently biochemically characterized as an L-tyrosine decarboxylase (AtTYDC), whereas the function
117 l series of antidiabetic N-(2-benzoylphenyl)-L-tyrosine derivatives which are potent, selective PPARg
120 orbance, as did the reaction of 3,5-difluoro-L-tyrosine, due to increased accumulation of quinonoid i
121 of L-alanine, L-glutamic acid, L-lysine, and L-tyrosine, effective both in suppression of experimenta
124 tyl) amino]-1-cyclopentyl]carbonyl]-O-methyl-L-tyrosine ethyl ester), administered at 11.7 mg/kg po,
126 e, 2,5-difluoro-L-tyrosine, and 2,6-difluoro-L-tyrosine exhibited much lower absorbance intensity at
127 s (e.g., Nalpha-acetyllysine and taurine) to L-tyrosine exposed to either HOBr/OBr- or the EPO-H2O2-B
128 ta-tyrosine biosynthesis starting from 2-aza-L-tyrosine, featuring KedY4 as a putative MIO-containing
129 urbed by replacement of Tyr225 with 3-fluoro-L-tyrosine (FlTyr) by in vitro transcription/translation
131 erein is reported 4'-O-[2-(2-fluoromalonyl)]-L-tyrosine (FOMT,6) a new fluorine-containing nonphospho
132 osine, 2-fluoro-L-tyrosine, and all difluoro-L-tyrosines, had a much reduced intensity for this peak.
135 within SM bundles were immunoreactive to PHA-L, tyrosine hydroxylase, and dopamine beta-hydroxylase,
136 onal antibodies were used to demonstrate PHA-L, tyrosine hydroxylase, dopamine beta-hydroxylase, phen
138 res of human IYD and its complex with 3-iodo-l-tyrosine illustrate the ability of the substrate to pr
139 report here the detection of the non-protein L-tyrosine iminoxyl radical generated by two methods: 1)
143 ine family of enzymes that transforms Fe and L-tyrosine into an [Fe(CO)2(CN)] synthon that is incorpo
144 hydroxylase (TH) catalyzes the conversion of l-tyrosine into l-DOPA, which is the rate-limiting step
145 oration of the synthetic amino acid O-methyl-l-tyrosine into protein in response to an amber nonsense
147 e that adding a tyrosine derivative, 3-Nitro-L-tyrosine, into DMEM can mitigate the degradation of PS
151 with an 8.5-fold lower affinity than that of l-tyrosine (K (D-Tyr)(d) = 102 microm) and exhibits a 3-
152 pproximately KIK(Abz)-NH(2) (Y(NO2), 3-nitro-L-tyrosine; K(Abz), epsilon-(2-aminobenzoyl)-L-Lys; hydr
155 ted terphenyls)) on monolayers of l-cysteine-l-tyrosine, l-cysteine-l-phenylalanine, or l-cysteine-l-
156 s a random synthetic amino acid copolymer of L-tyrosine, L-glutamic acid, L-alanine, and L-lysine tha
157 nce of other aromatic amino acids, including l-tyrosine, l-phenylalanine, and l-tryptophan, in the re
158 ntial of three amino acids (l-phenylalanine, l-tyrosine, l-tryptophan) and a polypeptide (epsilon-pol
159 catalyzed transamination of l-phenylalanine, l-tyrosine, l-tryptophan, l-methionine, and l-leucine, a
160 , a mixture of various biologically relevant l-tyrosines, l-DOPA, and several catecholamines were res
161 ptor antagonist H-Dmt-Tic-OH (2',6'-dimethyl-L-tyrosine-L-1,2,3,4-tetrahydroisoquinoline-3-carboxylat
162 trong binding of this compound suggests that L-tyrosine may be bound to the active site of TPL as the
163 re prepared starting from l-phenylalanine or l-tyrosine methyl esters and supporting the imidazolidin
164 (short ragweed pollen allergoid adsorbed to L-Tyrosine + MPL) versus placebo in reducing allergic rh
165 The mpk6-2 mutant was sensitive to 3-nitro-l-tyrosine (NO2 -Tyr) treatment with respect to mitotic
166 xiliary is prepared in four steps from N-Boc-L-tyrosine on a multigram scale in high yield and attach
167 nd potassium cyanide, but preincubation with L-tyrosine or 4-hydroxycinnamate largely prevents this i
168 duced coordinately in the presence of either L-tyrosine or L-phenylalanine, but PhhB exhibits a signi
171 ylacetaldehyde (pHA) is the major product of L-tyrosine oxidation by the myeloperoxidase/hydrogen per
174 nsport imaging using O-(2-(18)F-fluoroethyl)-l-tyrosine PET ((18)F-FET) and investigate whether (123)
176 and N-(3-dehydrophenyl)pyridinium (c) toward L-tyrosine, phenylalanine, and tryptophan was investigat
177 oyl-L-serine-phosphoric acid and N-palmitoyl-L-tyrosine-phosphoric acid, which had been previously sh
178 larvae spores germinated only in response to l-tyrosine plus uric acid under physiologic pH and tempe
179 tyrosyl tRNA synthetase to activate O-methyl-l-tyrosine preferentially compared with l-tyrosine.
182 f the rate of L-tyrosine, while 2,3-difluoro-L-tyrosine reacted at twice the rate of L-tyrosine.
185 vivo site-specific incorporation of O-methyl-L-tyrosine reported previously, demonstrate that this me
187 thetic polypeptide composed of glutamate and L-tyrosine residues to the myeloperoxidase-H2O2-L-tyrosi
190 the reaction of tryptophan indole-lyase with L-tyrosine resulted in formation of external aldimine, w
191 Reaction of synthetic Cl-NO2 with N-acetyl-L-tyrosine results in the formation of 3-chlorotyrosine
192 machinery engineering and a high-throughput L-tyrosine screen towards improving L-tyrosine productio
193 ing the 4-aminobenzohydrazide ligand and the l-tyrosine spacer-arm to CNBr-activated-Sepharose-4B.
197 he presence of ring fluorine substituents in L-tyrosine that are remote from the site of the chemical
198 talyzes the conversion of L-phenylalanine to L-tyrosine, the rate-limiting step in the oxidative degr
199 nd rpoD) exhibiting up to a 114% increase in L-tyrosine titer over a rationally engineered parental s
200 ecifically catalyzes the conversion of 2-aza-L-tyrosine to (R)-2-aza-beta-tyrosine, exhibiting no det
201 aminomutase that catalyzes the conversion of L-tyrosine to (S)-beta-tyrosine and employs 4-methyliden
202 ereospecifically catalyzes the conversion of L-tyrosine to (S)-beta-tyrosine in C-1027 biosynthesis,
204 ls of phagocytosis human neutrophils convert L-tyrosine to 3-chlorotyrosine, indicating that a Cl2-li
208 vity of Orf13 for the ortho-hydroxylation of L-tyrosine to L-DOPA by a molecular oxygen dependent pat
212 The ability of microorganisms to degrade L-tyrosine to phenol, pyruvate, and ammonia is catalyzed
214 nosylmethionine (SAM) enzyme HydG lyses free l-tyrosine to produce CO and CN(-) for the assembly of t
215 execute the chloride-dependent conversion of L-tyrosine to the lipid-soluble aldehyde, p-hydroxypheny
216 , and Cl- to oxidize the aromatic amino acid l-tyrosine to the reactive aldehyde p-hydroxyphenylaceta
218 are synthesized from the aromatic amino acid l-tyrosine (Tyr) and replaced the otherwise ubiquitous p
220 ginosa metabolically prelabeled with [(13)C]-l-tyrosine, unveiling defective intraphagolysosomal HOCl
221 es the hydroxylation of l-phenylalanine into l-tyrosine utilizing the cofactors (6R)-l-erythro-5,6,7,
225 d L-phenylalanine uptake and its turnover to L-tyrosine was identified in normal human melanocytes (n
226 at chlorination of the aromatic ring of free L-tyrosine was mediated by Cl2 and not by HOCl/ClO-.
228 e.g., Nalpha-acetyl,Nepsilon-bromolysine) by L-tyrosine was shown to result in the loss of reactive h
231 tion partially depended on whether L-dopa or L-tyrosine was the substrate, suggesting that tyrosinase
232 -1-oxobutyl) amino]-1-cyclopentyl]-carbonyl]-L-tyrosine) was a potent dual inhibitor in vitro (IC50 (
234 containing horseradish peroxidase, H2O2, and L-tyrosine, we detected free tyrosyl radical (a2,6H = 6.
235 asts, whereas the differences in turnover to L-tyrosine were insignificant, suggesting a pooling of L
236 onoid intermediate at about half the rate of L-tyrosine, while 2,3-difluoro-L-tyrosine reacted at twi
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