ライフサイエンスコーパス: L. interrogans

1 L. interrogans LpxA furthermore displays absolute select

2 were challenged intraperitoneally with 10(8) L. interrogans serovar Pomona bacteria (NVSL 1427-35-093

3 alleys where the patients may have acquired L. interrogans; polymerase chain reaction (PCR) analysis

4 n was discovered to be at risk for acquiring L. interrogans: urban residents who are sporadically exp

5 igA is a potential vaccine candidate against L. interrogans serovar Pomona infection.

6 mer was unable to discriminate strains among L. interrogans serovar copenhageni isolates, it was able

7 o Leptospira species, L. borgpetersenii, and L. interrogans.

8 Infection led to weight loss and L. interrogans dissemination from blood to urine, and sp

9 e inoculum of high-passage-number attenuated L. interrogans strains resulted in dissemination to all

10 l (i.p.) and intradermal (i.d.) challenge by L. interrogans serovar Copenhageni strain Fiocruz L1-130

11 orses demonstrated that LfhA is expressed by L. interrogans during mammalian infection.

12 as a vaccine candidate against infection by L. interrogans serovar Pomona in a hamster model.

13 Inner-city rats often carry L. interrogans.

14 rats by microagglutination assay to confirm L. interrogans infection.

15 A PCR assay detected L. interrogans DNA in samples of body fluid obtained fro

16 We examined L. interrogans LigA, domains 7 to 13 (LigA7-13), as an o

17 tively acylated by LpxAs of A. ferrooxidans, L. interrogans, and M. loti.

18 nt, suggesting that additional receptors for L. interrogans await identification.

19 LPS from L. interrogans cells is unusual in that it activates TLR

20 gomyelinases Sph2 and Sph1 (N terminus) from L. interrogans serovar Lai.

21 To better understand how L. interrogans serovar Copenhageni adapts to osmolar con

22 lso required for acyltransferase activity in L. interrogans.

23 revealed a candidate gene (renamed lmtA) in L. interrogans showing distant homology to the yeast iso

24 fects of temperature on protein synthesis in L. interrogans.

25 We also show that for intact L. interrogans, it is LPS, not lipoprotein, that constit

26 antly altered the transcript levels of 6% of L. interrogans genes.

27 Intact hexa-acylated lipid A of L. interrogans Pomona was also analyzed by NMR, confirmi

28 ty is relevant in studying the adaptation of L. interrogans to host conditions.

29 An in-depth structural characterization of L. interrogans is needed to understand its biology and p

30 f glycolipoprotein, a cell wall component of L. interrogans that is known to inhibit the expression a

31 ral difference between the cell envelopes of L. interrogans and Leptospira biflexa involving variatio

32 f both the virulent and nonvirulent forms of L. interrogans serovar Icterohaemorrhagiae (strain Verdu

33 s intrinsically labeled during incubation of L. interrogans in medium containing [14C]palmitic acid,

34 ese assays to several new animal isolates of L. interrogans from Nicaragua, which recently had an out

35 gned to identify clones in a gene library of L. interrogans serovar Pomona expressing host-inducible

36 Lipid A was released from LPS of L. interrogans serovar Pomona by 100 degrees C hydrolysi

37 The mechanism of L. interrogans LpxA appears to be similar to that of E.

38 Differences may be related to the number of L. interrogans spirochetes that succeed in overcoming th

39 Chronic shedding can enable persistence of L. interrogans within the sea lion population.

40 ues were positive by PCR for the presence of L. interrogans.

41 Screening of L. interrogans and L. kirschneri expression libraries wi

42 Given the selectivity of L. interrogans LpxA for 3-hydroxylaurate, we propose tha

43 The substrate selectivity of L. interrogans LpxA is consistent with the structure of

44 und as a single gene copy in all serovars of L. interrogans but not in other Leptospira spp. except L

45 of qlp42 and hsp15 in pathogenic serovars of L. interrogans but not in the nonpathogenic Leptospira b

46 The structure of L. interrogans lipid A has now been determined by a comb

47 ans LpxA is consistent with the structure of L. interrogans lipid A.

48 B PGs appeared to be the primary targets of L. interrogans attachment, while heparan sulfate PGs wer

49 e (strain Verdun) were identical to those of L. interrogans Pomona by the above criteria.

50 ctor in the invasiveness and transmission of L. interrogans.

51 tified an abundant protein from the pathogen L. interrogans, exposed on the PF surface, and named it

52 inity blot analyses revealed that pathogenic L. interrogans produces at least two factor H-binding pr

53 Purified L. interrogans lipid A is inactive against human THP-1 c

54 ogen, Salmonella: In contrast to Salmonella, L. interrogans did not alter transepithelial electrical

55 core group of pathogenic Leptospira species: L. interrogans, L. kirschneri, L. noguchii, L. borgpeter

56 In this work, we demonstrate that L. interrogans induces NLRP3 inflammasome-dependent secr

57 oratories and another have demonstrated that L. interrogans can acquire host plasminogen on its surfa

58 s LpxA for 3-hydroxylaurate, we propose that L. interrogans lipid A is acylated with R-3-hydroxylaura

59 D protein orthologs were not detected in the L. interrogans genome.

60 The recent determination of the L. interrogans lipid A structure revealed an unprecedent

61 atients had high levels of antibodies to the L. interrogans serogroup icterohaemorrhagiae.

62 PS, is not involved in cellular responses to L. interrogans.

63 ar to those of hosts infected with wild-type L. interrogans.

64 Characterization of various L. interrogans exoprotein mutants in the animal infectio

65 thin 1 h after inoculation of 10(8) virulent L. interrogans bacteria.

66 LigB proteins was substantially higher when L. interrogans proliferated at 37 degrees C instead of t

67 cent sera from mares naturally infected with L. interrogans suggest that Qlp42 is expressed during le

68 nse to an IgG3 response after infection with L. interrogans Histological periodic acid-Schiff D stain

69 result of naturally acquired infection with L. interrogans serovar pomona type kennewicki recognize

70 TLR2/4-deficient mice 3 d postinfection with L. interrogans.