ライフサイエンスコーパス: L. lactis

1 L. lactis HR279 and JHK24 demonstrates two datasets with

2 L. lactis I-1631 may represent a promising vehicle to de

3 L. lactis I-1631 possesses genes encoding enzymes that d

4 L. lactis K1 was rapidly destroyed by the macrophages, a

5 L. lactis KF147, a strain originally isolated from plant

6 L. lactis(pLM1) invaded epithelial cells efficiently in

7 We identified a L. lactis strain, able to attenuate esophageal eosinophi

8 Inactivation of the sodA gene abolished L. lactis I-1631's beneficial effect in the T-bet(-/-) R

9 deficient in binding fluid-phase gp-340, and L. lactis cells expressing AspA were not agglutinated by

10 hydroorotate dehydrogenases from E. coli and L. lactis also have a lysine near N5 of the flavin.

11 oming mechanism in both Escherichia coli and L. lactis.

12 ased internalization of both E. faecalis and L. lactis (with and without AS expression).

13 nted on the cell surfaces of E. faecalis and L. lactis but not on that of S. gordonii.

14 sc10 on the cell surfaces of E. faecalis and L. lactis revealed a significant increase in cell surfac

15 osed by Lactococcus lactis subsp. lactis and L. lactis subsp. cremoris (R704); QLA - with Lactobacill

16 or of S. pyogenes LDH, E. faecalis LDH1, and L. lactis LDH1 and LDH2 at pH 6.

17 ese experiments, the E. faecalis strains and L. lactis K1 were grown in brain heart infusion (BHI) br

18 oup II intron in the Gram-positive bacterium L. lactis and demonstrate for the first time in bacteria

19 ant genes present in the probiotic bacterium L. lactis.

20 in can also be used to differentiate between L. lactis and L. garvieae.

21 ermined the ability to uptake (3)H-biotin by L. lactis.

22 Unlike the scenario in E. coli, L. lactis appears to be auxotrophic for biotin in that i

23 Therefore, like E. coli, L. lactis has a single beta-ketoacyl-ACP reductase activ

24 ti-CD3 with a clinical-grade self-containing L. lactis, appropriate for human application, secreting

25 d significantly better (P < 0.0001) than did L. lactis K1 at each time point.

26 rable to therapy results with plasmid-driven L. lactis Initial blood glucose concentrations (<350 mg/

27 The engineered L. lactis is able to develop biofilms on different surfa

28 ontrast, a strong benefit for the engineered L. lactis strain was observed in acid stress survival.

29 rtance of specific plant-inducible genes for L. lactis growth in ATL, xylose metabolism was targeted

30 a number of different P335 phages, lytic for L. lactis NCK203, have a common operator region which ca

31 , possibly, cephalothin were higher than for L. lactis, and unlike L. lactis, L. garvieae was resista

32 occur when introduced into the plasmid-free L. lactis LM0230 during growth in galactose or lactose,

33 inhibitor binding to the Class 1A DHOD from L. lactis has now been studied in detail and is reported

34 It has recently been shown that HisZ from L. lactis binds to the ATP-PRPP transferase (HisG) and t

35 ssess HisZ) requires both HisG and HisZ from L. lactis.

36 a homodimeric multidrug ABC transporter from L. lactis.

37 In L. lactis, LlPC is required for efficient milk acidifica

38 ly, overexpression of the pilB gene alone in L. lactis enhanced resistance to phagocyte killing, incr

39 endonuclease-independent pathway, and, as in L. lactis, such events have a more random integration pa

40 NA, LtrA, intron splicing and conjugation in L. lactis.

41 to enable primary-active multidrug efflux in L. lactis.

42 and expressed this fusion protein (MBP*) in L. lactis.

43 The aspartate pool in L. lactis is negatively regulated by c-di-AMP, and high

44 Expression of the recombinant protein in L. lactis also markedly increased biofilm formation.

45 high levels in ATL, indicating redundancy in L. lactis carbohydrate metabolism on plant tissues.

46 x LlaI on enhancement of LlaI restriction in L. lactis revealed that growth at elevated temperatures

47 romoter region abolished LlaI restriction in L. lactis.

48 However, in retrotransposition in L. lactis, the intron inserts predominantly into single-

49 monstrated that the AbiR operon was toxic in L. lactis without the presence of the LlaKR2I methylase,

50 Unlike in L. lactis, in E. coli, Ll.LtrB retrotransposed frequentl

51 This effect is weaker in L. lactis and Hfx.

52 Inactivation of ylgG in L. lactis resulted in DHNTP accumulation and folate depl

53 Ll.LtrB intron from Lactococcus lactis into L. lactis 23S rRNA.

54 gens via the gut through Lactococcus lactis (L. lactis) has been demonstrated to be a promising appro

55 Lactococcus lactis LDH2 < E. faecalis LDH1 < L. lactis LDH1 </= Streptococcus pyogenes LDH.

56 ray crystallographic and kinetic analyses of L. lactis galactose mutarotase complexed with D-glucose,

57 n of E. faecalis by HT-29 enterocytes and of L. lactis by HT-29 and Caco-2 enterocytes.

58 In phage challenges of L. lactis(pTRK414H) with phi31, the efficiency of plaqui

59 modify the L. lactis AcpA and the chimera of L. lactis AcpA helix II in AcpP).

60 proved MIC values against liquid cultures of L. lactis HP.

61 AcpP helix II was due to incompatibility of L. lactis AcpA helix I with the downstream elements of A

62 lypeptides mediated higher binding levels of L. lactis cells to surface immobilized gp340 than did S.

63 By testing a panel of L. lactis cell wall mutants, we observed that Lc-Lys and

64 These findings show that certain strains of L. lactis are well adapted for growth on plants and poss

65 expression of AspA protein on the surface of L. lactis conferred biofilm-forming ability.

66 n the tip of pili external to the surface of L. lactis might constitute a successful vaccine strategy

67 yCEP expression was required for survival of L. lactis but not S. pyogenes.

68 t form of this protein either in vesicles of L. lactis or B. subtilis or in intact cells of B. subtil

69 Heterologous expression of Asc10 on L. lactis also allowed the recognition of its binding li

70 P335 group phages failed to form plaques on L. lactis harboring pTRKH2::CI-per2, while 4 phages form

71 tion activity was not apparent in E. coli or L. lactis prior to phage infection.

72 on indicator gene previously employed in our L. lactis studies.

73 In contrast to the parent L. lactis strain (lacks SpyCEP), which was avirulent whe

74 h DNA interacts with crystalline Dps phases, L. lactis DNA:Dps complexes appeared as non-crystalline

75 Furthermore, such piliated L. lactis cells evoked a higher TNF-alpha response durin

76 KR2I methylase, which is required to protect L. lactis from AbiR toxicity.

77 Expression of the AcpP protein L. lactis AcpA helix II allowed weak growth, whereas the

78 in accordance with the growth rate, provides L. lactis cells the means to ensure optimal CW plasticit

79 owth in ATL than the dairy-associated strain L. lactis IL1403.

80 essment of the immune changes induced by the L. lactis-based therapy revealed elevated frequencies of

81 However, the L. lactis fabH deletion mutant requires only long-chain

82 er)-L-Lys(3); moreover, they do not lyse the L. lactis mutant containing only the nonamidated D-Asp c

83 cuous Sfp transferase required to modify the L. lactis AcpA and the chimera of L. lactis AcpA helix I

84 Replacement of the L. lactis AcpA helix II residues in this protein showed

85 ucts showed that the lack of function of the L. lactis AcpA-derived protein containing E. coli AcpP h

86 Both of the L. lactis genes are adjacent to (and predicted to be cot

87 olecular mass and subunit composition of the L. lactis HisZ-HisG heteromeric ATP-PRTase is investigat

88 low-resolution cryo-EM reconstruction of the L. lactis ribosome fused to the intron-LtrA RNP of a spl

89 entially be used in the future to tailor the L. lactis-based combination therapy for individual patie

90 pA helix II allowed weak growth, whereas the L. lactis AcpA-derived protein that contained E. coli Ac

91 Mucosal immunization of mice with this L. lactis strain expressing pilus-linked MBP* results in

92 of the phenotypic variation in resistance to L. lactis and E. faecalis, respectively, most of the mol

93 omic analyses, we identified genes unique to L. lactis I-1631 involved in oxygen respiration.

94 The in vivo function of the two L. lactis birA genes was judged by their abilities to co

95 eport that expression of only one of the two L. lactis proteins (that annotated as FabG1) allows grow

96 Wild-type L. lactis strain KF147 but not an xylA deletion mutant w

97 n were higher than for L. lactis, and unlike L. lactis, L. garvieae was resistant to clindamycin, ind

98 We used L. lactis strain to colonize material surfaces and produ

99 crophages, and by 24 h postinfection, viable L. lactis could not be recovered.

100 d with pretreated HT-29 enterocytes and when L. lactis was incubated with pretreated Caco-2 and HT-29

101 ise, chimeric ACPs were constructed in which L. lactis helix II replaced helix II of E. coli AcpP and

102 reducing flavin and Lys 168 (by analogy with L. lactis DHODase A).

103 e induction of those genes corresponded with L. lactis KF147 nutrient consumption and production of m

104 ults demonstrate that oral immunization with L. lactis expressing an Ag on the tip of the group A Str

105 In this EoE model, supplementation with L. lactis NCC 2287 significantly decreased esophageal an