ライフサイエンスコーパス: LAA

1 LAA closure was confirmed with transesophageal echocardi

2 LAA closure was independently associated with an increas

3 LAA closure with the LARIAT device can be performed effe

4 LAA closure with the Watchman device can be safely perfo

5 LAA effective refractory period (ERP) was measured befor

6 LAA ERP decreased significantly after 48 hours (116+/-3

7 LAA length, width, orifice size, and number of lobes wer

8 LAA occlusion was successful in all 20 patients.

9 LAA represents one of the major sources of cardiac throm

10 LAA sealing was confirmed by intracardiac echocardiograp

11 LAA structure was analyzed by the echocardiographer and

12 using a Hounsfield unit threshold of -950 (%LAA-950).

13 tors to help ensure a successful launch of a LAA occlusion program and optimize patient selection, pr

14 Persistent AF ablation, LAA electric isolation, and mechanical occlusion can be

15 tion, 25+/-15 months) underwent AF ablation, LAA electric isolation, and occlusion.

16 Among 22 patients who underwent ablation, LAA electric isolation was possible in 20.

17 (3) The compound Ac-LAA-ep was found to favor subunit beta5c over beta5i by

18 h focal lesion (n=56; group 2) or to achieve LAA isolation by placement of the circular catheter at t

19 Introduction of lipoamino acid (LAA), Lys-palmitoyl, and cationization into a series of

20 The highest lipophilic antioxidant activity (LAA) was recorded in red lettuce and rocket, whereas asc

21 eek-old cultures with L-alpha-amino adipate (LAA), an inhibitor of the cerebellar glutamate uptake tr

22 ealth check-up on laboratory animal allergy (LAA) by questionnaires and specific-IgE antibody test fo

23 At univariate analysis, %LAA-950insp and %LAA-910exp values higher than the mean

24 Little is known about the anatomic LAA remodeling after Lariat ligation.

25 at 4.55, followed by dabigatran at 4.64 and LAA occlusion at 4.68.

26 ismatch between the small aortic annulus and LAA tertiles, but a higher rate of moderate-to-severe pa

27 imaging assessment, dogs were euthanized and LAA was examined for device healing, migration, perforat

28 and lipophilic antioxidant activity (HAA and LAA) in vitro, were evaluated.

29 ug/100g pasta f.w.), and the highest HAA and LAA.

30 hydrophilic antioxidant activity (HAA), and LAA by 12.5%, 10.0%, 12.6%, 23.7%, 14.1%, 11.9%, and 18.

31 Anatomic maps of LA and LAA stasis and velocity were calculated to quantify atri

32 (P<0.01) and 3.0-fold (P<0.02) in the LA and LAA, respectively.

33 ly variable flow dynamics in both the LA and LAA.

34 increased O2*- production in both the LA and LAA.

35 unction, limited to the left atrium (LA) and LAA and manifest as reduced nitric oxide (NO*) productio

36 o difference or correlation between PAPm and LAA% (rho = 0.12; P = 0.33).

37 ation underwent TEE before the procedure and LAA assessment by ICE.

38 both %LAA-950insp (R(2) = 0.75 vs 0.46) and %LAA-910exp (R(2) = 0.83 vs 0.63).

39 At univariate analysis, %LAA-950insp and %LAA-910exp values higher than the mean value of this coh

40 Conversely, %LAA-950insp and %LAA-910exp values lower than the mean value were correla

41 multivariate models including age, sex, and %LAA-950, lobe-specific measurements of BV5/TBV were dire

42 laser-assisted fluorescent-dye angiography (LAA) to assess perfusion in the gastric graft and to cor

43 Several leukemia-associated antigens (LAAs) have now been identified and validated for their p

44 s specific for leukemia-associated antigens (LAAs) is thought to mediate, at least in part, the curat

45 test pacing from the left atrial appendage (LAA) at 5% or 50% greater than the sinus rate.

46 ion of thrombi in the left atrial appendage (LAA) before ablation for atrial fibrillation.

47 tudy investigated the left atrial appendage (LAA) by computed tomography (CT) and magnetic resonance

48 afety and efficacy of left atrial appendage (LAA) closure in nonvalvular atrial fibrillation (AF) pat

49 surgical technique of left atrial appendage (LAA) closure is most successful by assessing them with t

50 fficacy and safety of left atrial appendage (LAA) closure via a percutaneous LAA ligation approach.

51 Randomized trials of left atrial appendage (LAA) closure with the Watchman device have shown varying

52 ical isolation of the left atrial appendage (LAA) could improve success at follow-up.

53 plete ligation of the left atrial appendage (LAA) during mitral valve surgery.

54 Left atrial appendage (LAA) electric isolation is reported to improve persisten

55 rief episode of AF on left atrial appendage (LAA) emptying velocity is unknown.

56 left atrial (LA) and left atrial appendage (LAA) flow dynamics in patients with atrial fibrillation

57 The left atrial appendage (LAA) has been identified as a predominant source of thro

58 The left atrial appendage (LAA) is an underestimated site of initiation of atrial f

59 ctic exclusion of the left atrial appendage (LAA) is often performed during cardiac surgery ostensibl

60 The left atrial appendage (LAA) is the source of the vast majority of these thrombo

61 Electric left atrial appendage (LAA) isolation (LAAI) may occur during catheter ablation

62 Transcatheter left atrial appendage (LAA) ligation may represent an alternative to oral antic

63 Left atrial appendage (LAA) ligation with the Lariat device is being used for s

64 Percutaneous left atrial appendage (LAA) occlusion and novel pharmacological therapies are n

65 fibrillation (NVAF), left atrial appendage (LAA) occlusion was noninferior to warfarin for stroke pr

66 Left atrial appendage (LAA) procedures have been developed to isolate the LAA f

67 impact of incomplete left atrial appendage (LAA) sealing and consequent peri-device residual blood f

68 with left atrial (LA)/left atrial appendage (LAA) spontaneous echo contrast, sludge, and thrombus.

69 to be associated with left atrial appendage (LAA) thrombi.

70 sively to emboli from left atrial appendage (LAA) thrombi.

71 The left atrial appendage (LAA) was snap-frozen in situ after pacing (640 bpm) for

72 e for visualizing the left atrial appendage (LAA).

73 fied by the ratio of PVfast to LA appendage (LAA) AF CL.

74 ons and percentage of low attenuation area (%LAA) on computed tomographic scans.

75 CT emphysema % low-attenuation areas (%LAA) and standardized measure for AWT (AWT-Pi10) were ma

76 AI as Locus of Adhesion and Autoaggregation (LAA).

77 ng risk scores, follow-up interval, baseline LAA volume, or morphology.

78 During sinus rhythm, the baseline LAA emptying velocity was measured 5 times and averaged.

79 significant associations were found between %LAA and cancer and lung cancer mortality.

80 er adjustment for treatment allocation bias, LAA closure during routine cardiac surgery was significa

81 er than single multivariate regression both %LAA-950insp (R(2) = 0.75 vs 0.46) and %LAA-910exp (R(2)

82 laced in an area of less robust perfusion by LAA (2% vs 45%, P < 0.0001).

83 fferent morphologies were used to categorize LAA: Cactus, Chicken Wing, Windsock, and Cauliflower.

84 1-year TEE (n = 65), there was 98% complete LAA closure, including the patients with previous leaks.

85 t-ligation, 95% of the patients had complete LAA closure by TEE.

86 Concomitant LAA electric isolation and occlusion as part of conventi

87 For all 15 controls, LAA mean and peak velocities were consistently lower (by

88 Conversely, %LAA-950insp and %LAA-910exp values lower than the mean v

89 either spontaneous or electrical conversion, LAA emptying velocity was measured immediately on resump

90 d TEE was obtained (both techniques detected LAA thrombus in 2 patients and excluded LAA thrombus in

91 onance imaging (MRI) to categorize different LAA morphologies and to correlate the morphology with th

92 The distribution of different LAA morphologies was Cactus (278 [30%]), Chicken Wing (4

93 ong never smokers, except that differential %LAA in childhood-onset asthma were not seen in them.

94 e in multiple planes to visualize the entire LAA.

95 In an exploratory study, we evaluated LAA 3-dimensional geometry via computed tomographic scan

96 cted LAA thrombus in 2 patients and excluded LAA thrombus in the remaining patients).

97 nant LAA (residual stump >1 cm), or excluded LAA with persistent flow into the LAA were identified as

98 0insp) and less than -910 HU at expiration (%LAA-910exp) obtained with single univariate and multivar

99 a patient taking dabigatran, and $27 003 for LAA occlusion.

100 s medium aortic annulus tertile, P=0.035 for LAA versus small aortic annulus tertile).

101 isted in multivariable analysis (P=0.048 for LAA versus medium aortic annulus tertile, P=0.035 for LA

102 maging from pulmonary artery is accurate for LAA visualization.

103 hemic stroke and intracranial hemorrhage for LAA closure and medical anticoagulation.

104 nd to identify the optimal ICE placement for LAA visualization.

105 the incremental cost-effectiveness ratio for LAA occlusion was $41 565.

106 re significantly different between sexes for LAA size (P=.011) and width (P=.006).

107 n ablation; however, it can also be used for LAA imaging.

108 icted CD8(+) T-cell populations specific for LAAs that are over-expressed in myeloid leukemias.

109 significant (P < 0.005) after adjusting for %LAA-950.

110 We found LAA thrombus to be present in 28 of 68 patients (41%) wi

111 radient vector occurred during recovery from LAA pacing, was more marked at rapid pacing rates, and m

112 dulthood also was associated with a greater %LAA (1.69% and 4.30%, respectively; P < .001).

113 mong asthmatic patients who smoked, greater %LAA in later life.

114 ty mask method with a threshold of -950 HU (%LAA-950).

115 The nature of some important LAAs, their efficacy in current preliminary clinical vac

116 thod detected no DNA double-strand breaks in LAA-treated cerebellar cultures, it displayed clear evid

117 Age- and sex-related differences in LAA dimensions exist.

118 A similar 3.0-fold (P<0.01) increase in LAA O2*- production was observed using a cytochrome C re

119 ties contributed to the observed increase in LAA O2*- production.

120 al tissue homogenates confirmed increases in LAA NAD(P)H oxidase (P=0.04) and xanthine oxidase (P=0.0

121 Incomplete LAA ligation after Lariat is common.

122 phageal echocardiography detected incomplete LAA ligation in 18 of 50 (36%) patients.

123 n contrast, lower LAA velocity and increased LAA stasis were only found in a fraction (38 of 60) of A

124 on values less than -950 HU at inspiration (%LAA-950insp) and less than -910 HU at expiration (%LAA-9

125 Intraoperative LAA was used to assess graft perfusion in 150 consecutiv

126 Intraprocedural LAA reconnection occurred in 17 of 20 (85%) patients, pr

127 ty in detecting left atrial/LA appendage (LA/LAA) thrombi.

128 of cardiac computed tomography assessing LA/LAA thrombi in comparison with TEE.

129 25%/68% for LA/LAA stasis and 38%/60% for LA/LAA peak velocities.

130 ted flow in the normal range: 25%/68% for LA/LAA stasis and 38%/60% for LA/LAA peak velocities.

131 No patient with a CHADS(2) score of 0 had LA/LAA sludge/thrombus.

132 The prevalence of LA/LAA sludge/thrombus in patients with AF undergoing a pre

133 or clinical trials assessing detection of LA/LAA thrombi by cardiac computed tomography when compared

134 The incidence of LA/LAA thrombi was 8.9% (SD, +/-7).

135 e alternative to TEE for the detection of LA/LAA thrombi/clot, avoiding the discomfort and risks asso

136 The prevalence of LA/LAA thrombus, sludge, and spontaneous echo contrast were

137 The prevalence of LA/LAA thrombus/sludge increased with ascending CHADS(2) sc

138 ban (UAA), rural/remote (RAA), and landfill (LAA) ambient air samples, as well as in situ surface flu

139 In contrast, lower LAA velocity and increased LAA stasis were only found in

140 In the control group, no LAA thrombus was detected and no stroke occurred (P<0.00

141 and analyzed to estimate the association of LAA closure with early postoperative atrial fibrillation

142 ective, nonrandomized study was conducted of LAA closure with the Watchman device in 150 patients wit

143 d survival, costs, and cost effectiveness of LAA closure with Watchman, compared directly with warfar

144 Data on effectiveness of LAA exclusion devices is lacking in patients ineligible

145 illation; however, the cost-effectiveness of LAA occlusion compared with dabigatran and warfarin in p

146 ted the feasibility, safety, and efficacy of LAA electric isolation and occlusion in patients undergo

147 udy was to assess the safety and efficacy of LAA occlusion for stroke prevention in patients with NVA

148 safely and effectively for the evaluation of LAA in patients undergoing atrial fibrillation ablation.

149 important in the accurate TEE evaluation of LAA.

150 In this initial multicenter experience of LAA ligation with the Lariat device, the rate of acute c

151 However, the clinical impact of LAA closure in humans remains inconclusive.

152 fter LAAI, an unexpectedly high incidence of LAA thrombus formation and stroke was observed despite O

153 This study evaluated the incidence of LAA thrombus formation and thromboembolic events after L

154 However, loss of LAA mechanical function may increase thromboembolic risk

155 Moreover, upon mutagenesis of LAA at the C terminus in native DesA3 to either of these

156 and incremental cost-effectiveness ratio of LAA occlusion in relation to dabigatran and warfarin in

157 sA3 having the native C-terminal sequence of LAA, which apparently serves as a binding determinant fo

158 Several surgical techniques of LAA closure are used to theoretically reduce the stroke

159 The use of LAA may contribute to reduced anastomotic morbidity.

160 Fifty-four percent of LAAs had two lobes (range, 1 to 4), with no age or sex d

161 were morphologically similar to the original LAA, albeit significantly smaller in volume (22.5+/-13.3

162 Patent LAA, remnant LAA (residual stump >1 cm), or excluded LAA

163 In 13 patients, LAA emptying velocity was measured by transesophageal ec

164 In the remaining 47 patients, LAA thrombus was identified on transesophageal echocardi

165 In the remaining patients, LAA firing was not ablated (n=43; group 1).

166 way remodeling and low lung area percentage (LAA%) to quantify emphysema extent.

167 Percutaneous LAA devices are associated with high rates of procedure-

168 Percutaneous LAA occlusion represents a novel therapy for stroke redu

169 l appendage (LAA) closure via a percutaneous LAA ligation approach.

170 efits and harms of surgical and percutaneous LAA exclusion procedures.

171 During percutaneous LAA closure for stroke prophylaxis, the geometric variab

172 A novel implanted device for percutaneous LAA transcatheter occlusion (PLAATO) has been designed t

173 serious harms with a variety of percutaneous LAA procedures.

174 AF at elevated risk for stroke, percutaneous LAA closure met criteria for both noninferiority and sup

175 ound low-strength evidence that percutaneous LAA exclusion confers similar risks of stroke and mortal

176 ood flow in patients undergoing percutaneous LAA closure with the Watchman device (Atritech, Inc., Pl

177 at 1 day, 30 days, 90 days, and 1 year post-LAA ligation.

178 Using data from PREVAIL, LAA closure was dominated by warfarin and dabigatran, me

179 iconvulsant activity, orthogonally protected LAAs were synthesized in which the Lys side chain was co

180 PVfast/LAA ratio <69% predicted AF termination after PV isolati

181 Within the termination group, PVfast/LAA ratios were notably lower if AF terminated after PV

182 er than the LAA CL resulting in lower PVfast/LAA ratios compared with the nontermination group (71+/-

183 gs was achieved in most patients with PVfast/LAA ratios <69% as opposed to the remaining population (

184 on of either apocyanin or oxypurinol reduced LAA O2*-, implying that NADPH and xanthine oxidases both

185 We hypothesized that reduced LAA NO* levels observed in AF may be associated with inc

186 e identity and nature of clinically relevant LAA-specific CD8(+) T-cell populations have proven diffi

187 Remarkably, LAA-specific CD8(+) T-cell populations, regardless of fi

188 Patent LAA, remnant LAA (residual stump >1 cm), or excluded LAA with persist

189 However, the remodeled LAA cavity is dramatically reduced.

190 Furthermore, bone marrow-resident LAA-specific CD8(+) T cells frequently engaged cognate a

191 Three of 85 patients had a </= 2-mm residual LAA leak by TEE color Doppler evaluation.

192 , 10 patients (32%) had recanalized residual LAA cavities, which were morphologically similar to the

193 Successful LAA closure occurred more often with excision (73%) than

194 ve (96%) of 89 patients underwent successful LAA ligation.

195 At time of TEE, 6 patients with successful LAA closure (11%) and 12 with unsuccessful closure (15%)

196 Surgical LAA ligation is frequently incomplete.

197 Although surgical LAA exclusion during heart surgery does not seem to add

198 There is low-strength evidence that surgical LAA exclusion does not add significant harm during heart

199 137 of 2,546 patients who underwent surgical LAA closure from 1993 to 2004 had a TEE after surgery.

200 s a high occurrence of unsuccessful surgical LAA closure.

201 s tertile, and large aortic annulus tertile [LAA], respectively) as measured by transthoracic echocar

202 This trial provides additional data that LAA occlusion is a reasonable alternative to warfarin th

203 Atrial Fibrillation) trial demonstrated that LAA closure with the Watchman device (Boston Scientific,

204 vailable in the NCBI database indicates that LAA PAI is exclusively present in a subset of emerging L

205 The LAA appears to be responsible for arrhythmias in 27% of

206 The LAA was occluded in all cases.

207 The LAA was properly visualized in 56 of 64 (87.5%) patients

208 To study the relationship between the LAA structure and anticonvulsant activity, orthogonally

209 echanical approaches designed to exclude the LAA from the circulation have recently been developed.

210 ty-six patients (27%) showed firing from the LAA and became the study population.

211 e report the prevalence of triggers from the LAA and the best strategy for successful ablation.

212 surements included color Doppler flow in the LAA and interrogation for thrombus.

213 erapy to eliminate thrombus formation in the LAA has been the standard of care for several decades, b

214 evere paravalvular leaks was observed in the LAA tertile (5.9% versus 11.5%; P=0.009).

215 Patients in the LAA tertile had a higher mortality rate at 1-year follow

216 In the LAA tertile, there were no differences in the rate of pr

217 follow-up study, the device remained in the LAA, with benign healing and no evidence of new thrombus

218 r stroke, with 90% of clots occurring in the LAA.

219 s had intraprocedural residual flow into the LAA (leak).

220 cate that residual peri-device flow into the LAA after percutaneous closure with the Watchman device

221 Residual leaks into the LAA are commonly reported after the procedure.

222 r excluded LAA with persistent flow into the LAA were identified as unsuccessful closure.

223 rocedures have been developed to isolate the LAA from circulating blood flow, as an alternative to OA

224 (8.7%; 5 paroxysmal, 81 nonparoxysmal), the LAA was found to be the only source of arrhythmia with n

225 tion sequence to percutaneous closure of the LAA and subsequent discontinuation of warfarin (interven

226 patients underwent cardiac CT or MRI of the LAA and were screened for history of TIA/stroke.

227 Isolation of the LAA could achieve freedom from atrial fibrillation in pa

228 cy and safety of percutaneous closure of the LAA for prevention of stroke compared with warfarin trea

229 nd efficacy of transcatheter ligation of the LAA for stroke prevention in atrial fibrillation.

230 f the circular catheter at the ostium of the LAA guided by intracardiac echocardiography (167 patient

231 LSPAF, empirical electrical isolation of the LAA improved long-term freedom from atrial arrhythmias w

232 This study defined the morphology of the LAA in normal autopsy specimen hearts and considered the

233 Exclusion of the LAA is believed to decrease the risk of embolic stroke.

234 ertain whether prophylactic exclusion of the LAA is warranted for stroke prevention during non-atrial

235 Closure of the LAA might provide an alternative strategy to chronic war

236 Diminished cavity size and tightening of the LAA orifice may play a role in the reduction of thrombus

237 rophylaxis, the geometric variability of the LAA ostium may result in an incomplete seal of the LAA.

238 t that varying the length or polarity of the LAA residue adjacent to positively charged amino acid re

239 Ligation of the LAA to prevent future thromboembolic events is commonly

240 lled to undergo percutaneous ligation of the LAA with the LARIAT device.

241 The efficacy of percutaneous closure of the LAA with this device was non-inferior to that of warfari

242 tium may result in an incomplete seal of the LAA.

243 ent mitral valve surgery and ligation of the LAA.

244 suture that is guided epicardially over the LAA.

245 usion (PLAATO) has been designed to seal the LAA.

246 oup, the PVfast CL was much shorter than the LAA CL resulting in lower PVfast/LAA ratios compared wit

247 , and even patients randomly assigned to the LAA closure arm received concomitant warfarin for 6 week

248 A PLAATO implant was delivered to the LAA through a 12F transseptal catheter in 25 dogs.

249 The %LAA-950 was inversely related to all calculated vascular

250 This LAA effect was dose-dependent and suppressed by NMDA rec

251 m cerebellar cultures chronically exposed to LAA revealed increased radioactive nucleotide incorporat

252 red, but changing the pacing site from RA to LAA altered the P and Ta waves.

253 Transcatheter LAA occlusion is simple and feasible.

254 the feasibility and safety of transcatheter LAA occlusion in dogs.

255 Using data from the PROTECT AF trial, LAA closure with the Watchman device was cost effective;

256 In this trial, LAA occlusion was noninferior to warfarin for ischemic s

257 andomly assigned (in a 2:1 ratio) to undergo LAA occlusion and subsequent discontinuation of warfarin

258 ter study of consecutive patients undergoing LAA ligation with the Lariat device at 8 U.S. sites.

259 early POAF among the patients who underwent LAA closure was 68.6% versus 31.9% for those who did not

260 ation area less than -950 Hounsfield units (%LAA-950), local histogram-based measures of distinct CT

261 in 28 of 68 patients (41%) with unsuccessful LAA exclusion versus none with excision.

262 intraoperative perfusion was assessed using LAA before bringing the graft up through the mediastinum

263 The presence of various LAAs or Lys(MPEG(4)) did not affect the receptor binding

264 these still were lower in PREVAIL (Watchman LAA Closure Device in Patients With Atrial Fibrillation

265 ective Randomized Evaluation of the Watchman LAA Closure Device in Patients With Atrial Fibrillation

266 ective Randomized Evaluation of the Watchman LAA Closure Device In Patients With Atrial Fibrillation

267 d trial, PREVAIL (Evaluation of the WATCHMAN LAA Closure Device in Patients With Atrial Fibrillation

268 nsistently lower (by 21%/12%; P<0.001) while LAA stasis was higher (by 58%; P<0.001) compared with th

269 From the right atrium, the whole LAA cavity could not be seen in any patient.

270 In those patients in whom LAA was visualized properly by ICE, a perfect agreement

271 Patients with Chicken Wing LAA morphology are less likely to have an embolic event

272 Cultures treated for 24 hr with LAA and subjected to in situ nick translation showed an

273 ative real-time assessment of perfusion with LAA correlated with the likelihood of an anastomotic lea

274 provide some evidence that vaccination with LAAs might confer protective immunity to leukemia and of

275 bjects with %LAA less than 3 died, 18% with %LAA 3-10 and 44% with %LAA greater than or equal to 10 d

276 han 3 died, 18% with %LAA 3-10 and 44% with %LAA greater than or equal to 10 died.

277 Subjects with %LAA greater than or equal to 10 had 33 and 37 months sho

278 Although 4% of the subjects with %LAA less than 3 died, 18% with %LAA 3-10 and 44% with %L

279 d of $50 000 per quality-adjusted life year, LAA closure was cost effective 90% and 9% of the time un