ライフサイエンスコーパス: LAAM

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1 t patients (N = 180) were assigned to 1 of 3 LAAM doses.

2 e long-acting opiate l-alpha-acetylmethadol (LAAM), adult male and female rats were assessed for thei

3 xposed to the opiate l-alpha-acetylmethadol (LAAM).

4 n, while methadone, l-alpha-acetylmethadone (LAAM), morphine, meperidine, DADL, beta-endorphin(1-31),

5 methadone derivative l-alpha-acetylmethydol (LAAM) in rats.

6 Data for methadone and LAAM suggest possible contribution from their enhanced d

7 nd phosphorylation mediated by methadone and LAAM were disproportionate to their efficacies in two di

8 At 5-6 months, prenatal water- and LAAM-exposed males (n=6 each; non-littermates) received

9 Levomethadyl acetate hydrochloride (known as LAAM) is a mu-opioid agonist approved for the treatment

10 Clinical trials comparing LAAM and methadone have reported lower patient retention

11 Female rats received 1.0 mg/kg/day LAAM or water via daily oral gavage for 28 days prior to

12 is study compared induction with 3 different LAAM dosage levels.

13 eported lower patient retention rates during LAAM induction; however, this may reflect dose and sched

14 Few studies have systematically examined LAAM dose induction.

15 Induction with higher LAAM doses can be safely achieved within 17 days, but ma

16 Induction with low and medium LAAM doses can be safely and effectively achieved within

17 The clinical efficacy of LAAM is positively related to dose.

18 Thrice-weekly (Monday/Wednesday/Friday) oral LAAM dose conditions of 25/25/35 mg, 50/50/70 mg, and 10

19 Overall, LAAM doses were well tolerated by most patients.

20 Prenatal LAAM exposure resulted in a blunted fever response to LP

21 lating IL-1beta was not affected by prenatal LAAM exposure, nor was IL-1beta protein in the spleen.

22 in the synaptic fraction of trained prenatal LAAM-treated rats compared to prenatal water-treated tra

23 s elevated in the hypothalamus of prenatally LAAM-treated rats.

24 Rats prenatally exposed to LAAM had poorer maze performance, decreased percent corr

25 Opioid substitution treatment with LAAM substantially reduces illicit opioid use.

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