ライフサイエンスコーパス: LAMP-1

1 LAMP-1, a marker for late endosomes and lysosomes, was d

2 LAMP-1, a membrane receptor for LRAP in mesenchymal cell

3 ned lysosomal-associated membrane protein 1 (LAMP-1) and 40% contained cathepsin D; 50% of the vacuol

4 ired lysosome-associated membrane protein 1 (LAMP-1) and MHC-II, THP-1 phagosomes that support format

5 d by lysosome-associated membrane protein 1 (LAMP-1), with peak coassociation frequencies occurring a

6 tain lysosome-associated membrane protein 1 (LAMP-1).

7 ired lysosome-associated membrane protein-1 (LAMP-1), MHC-II, and H2-DM.

8 lysosome-associated membrane protein type 1 (LAMP-1), enhanced DNA vaccine potency.

9 anti-lysosome-associated membrane protein-1 [LAMP-1]), were redistributed to the cell periphery.

10 receptor cross-linking and trafficked into a LAMP-1-positive lysosomal compartment like multimeric Fc

11 rin receptor-containing early endosomes to a LAMP-1+, beta-hexosaminadase+, multivesicular compartmen

12 cal points adjacent to centrally accumulated LAMP-1.

13 nic hfq and bacA mutants remained in acidic, LAMP-1(+) phagosomes and failed to initiate intracellula

14 indicates that these phagosomes also acquire LAMP 1 and cathepsin D prior to the accumulation of prot

15 pe L. pneumophila phagosomes did not acquire LAMP-1.

16 ntion, presence of Rab5B, failure to acquire LAMP-1 and inability to acidify.

17 es were also labeled with antibodies against LAMP-1, CD81, and CD82, which were also incorporated int

18 tered intracellular distribution of CD1d and LAMP-1 in LT-treated cells, similar to the case for ERK1

19 CD62P and LAMP-1 were found only on mouse microparticles from acti

20 decreased while remaining cathepsin D(-) and LAMP-1(+).

21 with antibodies against EEA1 (endosome) and LAMP-1 (late endosome/lysosome).

22 is phagosomes with high levels of MHC-II and LAMP-1 and MIIC both have the potential to form peptide-

23 exhibited a striking accumulation of LC3 and LAMP-1 positive autolysosomes containing undigested cyto

24 The colocalization of CXCR2 with LDL and LAMP-1 suggests that CXCR2 is targeted to lysosomes for

25 s occurred independently of class II MHC and LAMP-1.

26 YFP chimeras of beta-actin, Rab5a, Rab7, and LAMP-1, and no association of YFP chimeras marking endop

27 ding Rab7, mannose-6-phosphate receptor, and LAMP-1.

28 gometry and FACS analysis for P-selectin and LAMP-1 exposure.

29 they were not labeled with anti-CD63 or anti-LAMP-1.

30 cytic receptors DC-LAMP and CD68, as well as LAMP-1 and LAMP-2.

31 SseJ and SifB localize to the SCV as well as LAMP-1-positive, vesicular-appearing structures distant

32 ras comprised of the lumenal domain of avian LAMP-1 and the alternatively spliced domains of avian LA

33 HC-II complexes had increased levels of both LAMP-1 and MHC-II.

34 t gave full functional rescue, as assayed by LAMP-1 sorting.

35 ce of ARF-GEP(100) with AP-1, AP-2, catenin, LAMP-1, or 58K was observed.

36 l killer (NK) cells and deficiency of CD107a/LAMP-1 in mice resulted in increased NK cell apoptosis u

37 Importantly, knockdown of CD107a/LAMP-1 in primary human natural killer (NK) cells and de

38 hus, our data support a novel role of CD107a/LAMP-1 in the protection of NK cells from degranulation-

39 Moreover, surface expression of CD107a/LAMP-1 reduced binding of perforin to cells.

40 Intracellular expression of CD107a/LAMP-1, and to a lesser extent that of CD107b/LAMP-2, co

41 Engineered surface expression of CD107a/LAMP-1, but not of CD107b/LAMP-2, reduced the granule-me

42 was dependent on glycosylation of the CD107a/LAMP-1 hinge.

43 oparticles isolated from mice were CD62P(-), LAMP-1(-) and expressed full-length filamin A, indicatin

44 RNA encoding a chimeric CEA/LAMP-1 lysosomal targeting signal enhances the induction

45 oring more than five bacteria also contained LAMP-1, inhibition of vacuole acidification and maturati

46 ion in an aberrant compartment that contains LAMP-1, LAMP-2, and NPC1, but not CI-MPR, similar to the

47 2308 persisted within these cathepsin D(-), LAMP-1(+), and acidic vesicles; however, at the onset of

48 hese strategies, mice vaccinated with Sig/E7/LAMP-1 DNA mixed with Bcl-x(L) DNA showed the greatest i

49 shock protein 70, calreticulin/E7, or Sig/E7/LAMP-1 resulted in further enhancement of the E7-specifi

50 Furthermore, treatment with the Sig/E7/LAMP-1 vaccinia vaccine cured mice with small establishe

51 V-16) E7 antigen, creating a chimera (Sig/E7/LAMP-1).

52 Moreover, recycling of endocytosed LAMP-1 and CD63 back to the cell surface is greatly incr

53 more, B. neotomae exhibited early endosomal (LAMP-1) and late endoplasmic reticulum (calreticulin)-as

54 n intracellular compartment where exocytosed LAMP-1 was retrieved.

55 replaced both YXXM motifs with a motif from LAMP-1, YQTI.

56 r and to the lysosomal membrane glycoprotein LAMP 1 did not.

57 d accumulation of the lysosomal glycoprotein LAMP-1 as early as 5 min after uptake, whereas the major

58 inum labeled with the lysosomal glycoprotein LAMP-1, but the percentage of vacuoles that labeled was

59 he lysosome-associated membrane glycoprotein LAMP-1, preferentially contained the H-type structure an

60 ne marker proteins, such as the glycoprotein LAMP-1, that are indicators of the normal endocytic path

61 lysosomal-associated membrane glycoprotein (LAMP-1), a recognized lysosomal marker.

62 ed with the lysosomal membrane glycoprotein, LAMP-1.

63 cathepsin D and the lysosomal glycoproteins LAMP-1 and LAMP-2 localized to the C. burnetii vacuole b

64 sing DCs transfected with the chimeric hTERT/LAMP-1 RNA in vaccine trials to facilitate generation of

65 We show that processing of hTERT/LAMP-1 transcripts leads to enhanced stimulation of hTER

66 In this study we identify LAMP-1 (CD107a) and LAMP-2 (CD107b) on the surface of hu

67 ocalization of lp120 [correction of IgpI20] (LAMP-1), a membrane protein of late endosomes and lysoso

68 These markers included LAMP-1, cathepsin L, and fluorescent proteins or dextran

69 late endosomal/lysosomal markers, including LAMP-1, LAMP-2, and cathepsin D.

70 dosomal compartment and rapidly matured into LAMP-1(+), cathepsin D(+), and acidic phagosomes.

71 d to be enclosed within large, juxtanuclear, LAMP-1-positive vacuoles called Francisella-containing v

72 dosomes (dextran bead uptake) and lysosomes (LAMP-1 staining), demonstrating a pleiotropic role for t

73 rab5) or late endosomes and early lysosomes (LAMP-1 and -2).

74 c lumen, acquisition of the endosomal marker LAMP-1, and recruitment of the 18-kDa host protein LC3.

75 The late endosomal/lysosomal marker LAMP-1 accumulated around the parasite in CD40-stimulate

76 We observed that lysosomal marker LAMP-1 localized at the center of podosome rosettes prot

77 compartment expressing the lysosomal marker LAMP-1.

78 ently co-localized with the lysosomal marker LAMP-1.

79 ments, which label with the lysosomal marker LAMP-1.

80 tially colocalized with the lysosomal marker LAMP-1.

81 colocalizes with mature phagolysosome marker LAMP-1 and with vacuolar proton ATPase in macrophages.

82 acquired vacuolar-ATPase, lysosomal markers LAMP 1 and 2, and the lysomotrophic dye LysoTracker to a

83 d the absence of endosomal/lysosomal markers LAMP-1 and beta-hexosaminidase.

84 Accumulation of LAMP-1 and killing of T. gondii were dependent on the au

85 The association of LAMP-1 with phagosomes containing dotA mutant bacteria w

86 AA100 phagosome in that they were devoid of LAMP-1 and cathepsin D, and they were colocalized with t

87 charides along with reduced glycosylation of LAMP-1, a major substrate for GnT-V.

88 y revealed no difference in the intensity of LAMP-1 immunofluorescence in phagolysosome membranes in

89 In contrast, the kinetics of LAMP-1 and Rab7 association indicate that the dotA mutan

90 Silencing of LAMP-1 reverts this phenotype by interfering with the do

91 that of these distinct cargo proteins, only LAMP-1 and LAMP-2 are concentrated in the AP-3-positive

92 EEA-1-positive (EEA-1(+)) early endosomes or LAMP-1(+) late endosomes/lysosomes.

93 n of Col-I with LC3, an autophagy marker, or LAMP-1, a lysosome marker, whereas treatment with TFP, a

94 and in patients' fibroblasts, oversialylated LAMP-1 enhances lysosomal exocytosis.

95 rapidly acquired the late endosomal protein LAMP-1, but not the lysosomal marker Texas red-ovalbumin

96 Lysosomal protein LAMP-1 that was exocytosed during degranulation accumula

97 rmans and the MDM lysosomal membrane protein LAMP-1 was demonstrated, establishing that fusion of C.

98 alic acids on the lysosomal membrane protein LAMP-1.

99 g both lysosome-associated membrane protein (LAMP-1) as a membrane marker and rhodamine dextran as a

100 with lysosomal associated membrane protein (LAMP-1) positive vacuoles, indicating that intracellular

101 hTERT/lysosome-associated membrane protein (LAMP-1) protein, carrying the endosomal/lysosomal sortin

102 of the lysosome-associated membrane protein (LAMP-1) to the cytoplasmic/nuclear human papilloma virus

103 nism of lysosomal integral membrane protein (LAMP-1) transport, cDNAs for human Rab7 and Rab9 were is

104 e.g., lysosomal-associated membrane protein [LAMP-1]) with lysosomes.

105 urface levels of lysosomal membrane proteins LAMP-1 (CD107a) and LAMP-2 (CD107b) after peptide stimul

106 hagosomes with late endosomal markers (Rab7, LAMP-1) and increases in the secretion of monocyte chemo

107 ype IV secretion system: sodium sensitivity, LAMP-1 evasion, and pore formation.

108 These data indicate that LAMP-1 and DC-LAMP Ag chimeras follow different traffick

109 Staining for the LAMP-1 and LAMP-2 antigens showed that the vesicles are

110 he endosomal/lysosomal sorting signal of the LAMP-1, are capable of stimulating concomitant hTERT-spe

111 causing bacterium, Borrelia burgdorferi, to LAMP-1 lysosomal compartments.

112 e, L. pneumophila targets inappropriately to LAMP-1-positive compartments during macrophage infection

113 whereas monomeric forms of CpG-A localize to LAMP-1-positive endosomes accompanied by the loss of IFN

114 th AP-3 and properly localize PI4KIIalpha to LAMP-1-positive endosomes.

115 -DR*0401, the majority of gp100 is sorted to LAMP-1(high)/MHC-II(+) late endosomes.

116 tor 1 enhanced bacterial colocalisation with LAMP-1 and reduced their intracellular survival.

117 th LAMP-2 and BiP, while colocalization with LAMP-1 and cathepsin D was not affected.

118 erve fibers but was found to colocalize with LAMP-1 and cathepsin D during early stages of axonal spr

119 tA or katB mutant Legionella colocalize with LAMP-1, a late endosomal-lysosomal marker, at twice the

120 . tularensis LVS Delta ripA colocalized with LAMP-1 then escaped the phagosome at the same rate and f

121 ontent in the vWf -/- cells colocalized with LAMP-1, a lysosomal marker.

122 re found in phagosomes that colocalized with LAMP-1, indicating defects in intracellular trafficking.

123 in STP-O-treated cells that overlapped with LAMP-1, a membrane marker for lysosomes.

124 treatment only, IL-1beta was detected within LAMP-1-positive multivesicular bodies.