ライフサイエンスコーパス: LAT1

1 LAT1 (SLC7A5) is a transporter for both the uptake of la

2 LAT1 and SNAT2 protein content increased during the post

3 LAT1 is overexpressed in several types of tumors, and it

4 LAT1 was also identified on human cornea.

5 LAT1 was identified by RT-PCR in rabbit corneal, SIRC, a

6 LAT1-dependent calcium signals required for mast cell de

7 LAT1/LAT2/CD98 was strongly expressed in neurons and end

8 The l-type amino acid transporter 1 (LAT1) is a transmembrane protein carrying bulky and neut

9 l-amino acid transporter-1 (LAT1) is a highly conserved gene identified as a light c

10 for large neutral amino acid transporter-1 (LAT1) was performed on total RNA from rabbit cornea, SIR

11 y described for the chimeric virus HSV-2 333/LAT1 and indicate that the HSV-1 latency phenotype can b

12 Comparison of SLP-76(-/-) LAT1(-/-) and SLP-76(-/-) mast cells revealed that some

13 ase Fgr and shifted signals from the adapter LAT1 to the related adapter LAT2.

14 We hypothesize that the altered LAT1 expression observed in hepatocarcinogenesis gives c

15 encoding MCT8, MCT10, OATP3A1 variant 1 and LAT1 were similar.

16 We propose that while SLP-76 and LAT1 depend on each other for many of their functions, L

17 ucleated by the adaptor molecules SLP-76 and LAT1 is required for activation through this receptor.

18 AT1(-/-) mast cells and that SLP-76(-/-) and LAT1(-/-) mast cells harbored distinct functional and bi

19 on of the Gln transporters SNAT1, ASCT2, and LAT1 by CD138(+) cells across the progression of monoclo

20 ystem A amino acid transporter isoforms) and LAT1 and LAT2, but not CD98, (System L amino acid transp

21 A), SN1 and SN2 (isoforms of system N), and LAT1 and LAT2 (isoforms of system L) were investigated i

22 f neuronal, endothelial, and less astroglial LAT1/LAT2/CD98 amino acid transporter expression.

23 Northern blotting with the bovine BBB LAT1 cDNA showed that the LAT1 mRNA is 100-fold higher i

24 into frog oocytes coinjected with bovine BBB LAT1 mRNA and the mRNA for 4F2hc, which encodes the heav

25 The bovine BBB LAT1 mRNA produced a 10-fold enhancement in tryptophan t

26 Both LAT1 and LAT2, when co-expressed with 4F2 heavy chain, w

27 nd compensates for impaired uptake of CD98hc/LAT1 and CD98hc/y(+)LAT2.

28 In conclusion, LAT1 is modulated by cholesterol impacting on its stabil

29 This mutant, LAT3.3A (previously designated LAT1.5a), thus showed that the expression of just the fi

30 Mammalian cells were shown to express LAT1 and LAT2.

31 embrane, LAT2 only partially compensated for LAT1-mediated cell signaling due to its decreased abilit

32 These data definitively identify LAT1 and LAT2 as members of system L that mediate transm

33 ocalization and phosphorylation of SLP-76 in LAT1(-/-) mast cells.

34 ransport activity correlates with changes in LAT1.

35 was associated with a selective increase in LAT1 mRNA and protein.

36 phosphorylation of SLP-76 were preserved in LAT1(-/-) mast cells and that SLP-76(-/-) and LAT1(-/-)

37 assess the functional relevance of increased LAT1 expression and the requirement for 4F2 heavy chain,

38 2/SLP-76 interactions and SLP-76-independent LAT1 functions also mediate a positive signaling pathway

39 The capacity of vascular mitogens to induce LAT1 expression may represent a basic mechanism by which

40 e stimulated L-leucine transport by inducing LAT1 expression.

41 te system L amino acid transport by inducing LAT1 gene expression and that system L amino acid transp

42 However, known LAT1 inhibitors lack selectivity over other transporters

43 The system L LAT1/4F2hc amino acid transporter was examined through u

44 ific System A (SNAT2, SLC38A2) and System L (LAT1, SLC7A5) transporter isoforms without affecting glo

45 -treated tumors showed only weak or marginal LAT1 staining, whereas CD98 staining remained unchanged.

46 accompanied by reduced expressions of MCT8, LAT1, CD98 and OATP4A1.

47 rs mediate uptake, we expressed two members, LAT1 and LAT2, in Xenopus oocytes.

48 embers of the 4F2 light chain family, namely LAT1 (4F2-lc1), y(+)LAT1 (4F2-lc2), y(+)LAT2 (4F2-lc3),

49 Immunohistochemical assessment of LAT1/LAT2/CD98 amino acid transporters was performed in

50 nterest in view of the ongoing evaluation of LAT1 substrates and inhibitors for cancer therapy.

51 lation leading to constitutive expression of LAT1 can contribute to oncogenesis.

52 ous studies we found increased expression of LAT1 in primary human cancers.

53 ) mast cells revealed that some functions of LAT1 could occur independently of SLP-76.

54 The induction of LAT1 by PDGF was dependent on de novo RNA and protein sy

55 Overexpression of LAT1 alone in mouse hepatocytes, but not fibroblasts, wa

56 Overexpression of LAT1 in T24 cells using recombinant adenoviruses led to

57 inhibitor (1), which inhibited the uptake of LAT1 substrate, l-leucin as well as cell growth.

58 oth proteins, whereas T24 cells express only LAT1.

59 e designed and synthesized a novel selective LAT1 inhibitor (1), which inhibited the uptake of LAT1 s

60 (SLC38A1), SNAT2 (SLC38A2), SNAT4 (SLC38A4), LAT1 (SLC7A5), and ASCT2 (SLC1A5).

61 anscripts specific for ATA1, ATA2, SN1, SN2, LAT1, and LAT2 were expressed in Muller cells.

62 -independent, facilitative transport system, LAT1, was identified and functionally characterized on r

63 We have demonstrated also that LAT1 response to arginine availability is lost in transf

64 T-cell studies, current dogma dictates that LAT1 is required for plasma membrane recruitment and fun

65 The LAT1-like molecule LAT2 was responsible for the preserve

66 th C6 rat glioma cells or rat brain, and the LAT1 mRNA was not detected in rat liver, heart, lung, or

67 ter than 95% in all tested cell lines by the LAT1/2 inhibitor 2-amino-2-norboranecarboxylic acid.

68 Deleting the LAT1 gene abolishes life span extension induced by CR.

69 interacts with the conserved regions in the LAT1 transporter that have been shown to bind to cholest

70 terol reduced the Vmax but not the Km of the LAT1 mediated uptake of a model substrate into cells (L-

71 with other tissues, and the abundance of the LAT1 mRNA at the BBB is manyfold higher than that of tra

72 required for the stable purification of the LAT1 with its chaperon CD98 (4F2hc,SLC3A2) and that this

73 ith the bovine BBB LAT1 cDNA showed that the LAT1 mRNA is 100-fold higher in isolated bovine brain ca

74 These studies show that the LAT1 transcript is selectively expressed at the BBB comp

75 no acid sequence was 89-92% identical to the LAT1 isoform.

76 The level of one of these, LAT1, is increased in many tumors.

77 as metabolically stable and selective toward LAT1.

78 induction of the amino acid (AA) transporter LAT1 and enhanced expression of the glucose transporter

79 ses the large neutral amino acid transporter LAT1 (SLC7A5) in cells.

80 ndent, large neutral amino acid transporter, LAT1, on rabbit corneal epithelium and human cornea.

81 on of the SNAT2 or the System L transporter, LAT1, suppressed mTOR activation by arsenite, supporting

82 l and small neutral amino acid transporters (LAT1, SNAT2) and CD98], and myofibrillar protein synthes

83 or tumor imaging and quantification of tumor LAT1 activity.

84 of three (18)F-labeled leucine analogues via LAT1 mediated transport in several cancer cell lines is

85 endocrine and nonendocrine tumor models via LAT1 transport but is not decarboxylated by AADC.

86 CD98hc-associated transporters (i.e. xCT, LAT1, and y(+)LAT2 in wild-type cells) are crucial to co

87 e and plasma membrane levels of CAT1 and y(+)LAT1 amino acid transporters in endothelial cells.

88 ght chain family, namely LAT1 (4F2-lc1), y(+)LAT1 (4F2-lc2), y(+)LAT2 (4F2-lc3), xCT (4F2-lc4), and L