ライフサイエンスコーパス: LCR

1 LCR activities have been discovered in numerous T cell l

2 LCR decreased with decreasing dose for all reconstructio

3 LCR was attempted in 36,228 patients (42.2%), with 5751

4 LCRs activate an inward Na(+)-Ca(2+) exchange current (I

5 LCRs activated an inward Na(+)/Ca(2+) exchange current t

6 LCRs at higher Pup exhibit larger amplitudes and faster

7 kb (chr 8) and approximately 287-kb (chr 12) LCR clusters.

8 40 male (20 HCR and 20 LCR) and 40 female (20 HCR and 20 LCR) rats were randoml

9 HCR and 20 LCR) and 40 female (20 HCR and 20 LCR) rats were randomly assigned to 3 weeks of activity

10 re: HCR (4726 +/- 3220), SD (2293 +/- 3461), LCR (672 +/- 323).

11 At 25 weeks of age, LCR livers displayed reduced mitochondrial content (redu

12 ta indicate that establishing full TCR-alpha LCR activity requires critical molecular events occurrin

13 High-level, copy number-related TCR-alpha LCR-linked reporter gene expression levels are cell type

14 eport that de novo introduction of TCR-alpha LCR-linked transgenes into existing T cell lines yields

15 Functional homology to the mammalian alpha-LCR MCS-R2 region was confirmed by robust and specific r

16 of atypical deletions utilizing alternative LCRs have been described.

17 ither IBMX nor milrinone was able to amplify LCRs, accelerate diastolic depolarization rate, or incre

18 ts on transcriptional bursting, we forced an LCR-beta-globin promoter chromatin loop.

19 pathway by which long-range looping from an LCR impacts on local chromatin architecture that is link

20 the C terminus was sufficient to generate an LCR(-) phenotype, with variant LcrV capping type III nee

21 trol region (LCR) may function as part of an LCR holocomplex within a larger active chromatin hub (AC

22 ivity depends on the LCR, consistent with an LCR-promoter looping mechanism.

23 topathologic evaluation, HPV L1, E2, E6, and LCR regions were amplified, and phylogenetic analysis of

24 equency between the (G)gamma-globin gene and LCR.

25 gene as well as in the beta-globin gene and LCR.

26 formation between the gamma-globin genes and LCR, which is a critical step for the transcription of t

27 HCR and LCR rats were fed a chow or HFD for 3 days and received

28 d hepatomegaly and steatosis in both HCR and LCR rats, while producing greater cholesterol ester accu

29 led 1514 +/- 91 vs. 200 +/- 12 m for HCR and LCR, respectively) to investigate if low aerobic capacit

30 elay between AP-induced Ca(2+) transient and LCR appearance, defines the time of late diastolic depol

31 sites analyzed are important for appropriate LCR function, some sites are more important than others

32 ding proteins and transcription complexes at LCR HS2 and the adult betamajor-globin gene promoter but

33 When feasible, attempted LCR had better outcomes than open colectomy in the immed

34 LCR period, leading to earlier and augmented LCR Ca(2+) release, Na(+)/Ca(2+) exchange current, and a

35 a corticosterone levels were similar between LCR and HCR, and these populations had similar behaviora

36 bbed I(spark)), we explored the link between LCRs and I(spark) in our model.

37 ed (OVX) rats bred for low-running capacity (LCR), a model that has been previously shown to mimic hu

38 cient form of LDB1 in LDB1 knock down cells: LCR/beta-globin proximity was restored without mediator

39 under the regulation of a well characterized LCR containing four DNase I hypersensitive sites (HSs).

40 mpared to sham-operated (SHM) intact control LCR rats.

41 letions mirror their cytosolic counterparts, LCRs, and occur following SR Ca(2+) refilling.

42 d on unique evolutionary patterns, we create LCR mutations, which systematically tune its biophysical

43 Additionally, in rats aged to natural death, LCR livers had significantly greater hepatic injury (fib

44 creased LCR amplitude and size and decreased LCR period, leading to earlier and augmented LCR Ca(2+)

45 r, more synchronized, and stronger diastolic LCR signal activating an earlier and larger inward NCX c

46 Interestingly, although eight different LCRs are located in proximal 22q, only a few cases of at

47 cells in which two developmentally distinct LCR-regulated globin genes are cotranscribed in cis, bur

48 Four novel adjacent DP-LCR-flanked and NAHR-prone regions, involving 2q12.2q13,

49 The computationally defined DP-LCRs were cross-referenced with our chromosomal microarr

50 Several features of DP-LCRs, including length, distance between NAHR substrate

51 tly oriented paralogous low-copy repeats (DP-LCRs) in the most recent version of the human haploid re

52 During LCR, the AuNPs were ligated together, resulting in a dis

53 human papillomavirus (HPV) DNA and HPV E5a, LCR and/or full-length genomic variants.

54 Interestingly, each LCR mutation showed contrasting effects on cytokine expr

55 tinguishes itself from other electrochemical LCR detection schemes by integrating a peroxidase-mimick

56 ese HSs had been deleted from the endogenous LCR, and the effect on Th2 cytokine expression was asses

57 ents revealed that the beta-globin enhancer (LCR) predominantly augments transcriptional burst fracti

58 n of numerically simulated LCRs and examined LCR regulation by SR Ca pumping rate (Pup) that provides

59 ly disfavored, suggesting mutually exclusive LCR-gene contacts.

60 Importantly, WD-fed low-fitness LCR rats displayed greater inflammatory cell infiltratio

61 oriented paralogous subunits of the flanking LCR clusters, demonstrating non-allelic homologous recom

62 between the 2 trial groups were as follows: LCR patients were older at randomization, and their path

63 ition between the beta-type globin genes for LCR contacts and suggest that LCR-promoter loops are for

64 ce-dependent competition between L and M for LCR.

65 peats (LCRs), indicating a possible role for LCRs in chromosome breakage.

66 tant LDB1 to the beta-globin promoter forced LCR loop formation in the absence of mediator or cohesin

67 sulin sensitivity in glycolytic muscles from LCR rats.

68 Further, LCR rats had greater WD-induced decreases in complete FA

69 Furthermore, LCR as a target amplification step resulted in a 6000-fo

70 of all key features of mouse TCR-alpha gene LCR function in T cells derived in vitro from mouse embr

71 y regulated locus, we have targeted the hCD2-LCR as a single copy into the endogenous mouse CD8 gene

72 t differ in the integration site of the hCD2-LCR within the mCD8 gene complex were generated, and the

73 HCR, LCR, and SD rats were grouped by strain and randomly ass

74 We utilized sedentary HCR/LCR rats (generation 17; max running distance equalled 1

75 ow-capacity for running on a treadmill (HCR; LCR) also differ in wheel-running behavior, but whether

76 of HSII, expanding the role of POU1F1 in hGH LCR activity, and provide insight on the molecular evolu

77 e that a major function of the placental hGH LCR is to insulate the transgene locus from site-of-inte

78 Here, we demonstrate that the hGH LCR 'loops' over a distance of 28 kb in primary placenta

79 HSII as a nonredundant component of the hGH LCR essential for establishment of robust levels of hGH-

80 The hGH LCR mediates a domain of histone acetylation targeted to

81 ing through binding sites at HS-I of the hGH LCR.

82 n modification mechanism associated with hGH LCR activity.

83 U1F1 binding to cognate sites within the hGH-LCR and hGH1 promoter, but not to sites within the PRL p

84 ses binding affinity to sites within the hGH-LCR.

85 that contribute to the repression of the HPV LCR.

86 RNA polymerase II (Pol II) with immobilized LCR templates, USF and NF-E2 together regulate the assoc

87 ng greater cholesterol ester accumulation in LCR compared to HCR rats.

88 mportantly, HSP72 induction was decreased in LCR rats after only 3 days of eating the HFD.

89 es were used to interpret the differences in LCR relative to FBP images acquired at 16 mGy.

90 e that a stable MARE-associated footprint in LCR HS2 is important for the recruitment of transcriptio

91 Sufficiency of HSI and HSII in LCR activity was explored by establishing two additional

92 o separate the roles of LDB1 and mediator in LCR looping, we expressed a looping-competent but transc

93 g EPM and restraint that was not observed in LCR animals.

94 other transcription factor binding sites in LCR HS2 or in the adult beta-globin gene promoter region

95 h-sucrose diet produced greater steatosis in LCR and high capacity runner (HCR) rats.

96 The transition in LCR characteristics was steeply nonlinear over a narrow

97 The variation in LCR period and size with I(spark) is sufficient to accou

98 into existing T cell lines yields incomplete LCR activity.

99 ng those of fetal cells, including increased LCR-gamma-globin contacts.

100 rcolemmal LCRs, ie, PDE inhibition increased LCR amplitude and size and decreased LCR period, leading

101 chromosome synapsis increases with increased LCR length, and that ectopic synapsis is a necessary pre

102 To determine the contribution of individual LCR DNaseI hypersensitive sites (HSs) to transcription a

103 Previously, we induced LCR-promoter looping by tethering the self-association d

104 50%, both IR techniques resulted in inferior LCR at both strength settings.

105 25%-50% dose reductions resulted in inferior LCR for vendors 1 and 2 for FBP and 25% dose reductions

106 in the eventual inactivation of the inserted LCR, probably as a result of multiple rounds of replicat

107 -globin gene (beta(m)), coupled to an intact LCR, a 5'HS3 complete deletion (5'DeltaHS3) or a 5'HS3 c

108 length and inversely influenced by the inter-LCR distance.

109 nalyses and identified 1143 interchromosomal LCR substrate pairs, >5 kb in size and sharing >94% sequ

110 he potential involvement of interchromosomal LCRs in recurrent chromosomal translocation formation, w

111 eas the distance between the cluster and its LCR impacts the level of placental expression.

112 ndel, or amino acid change in the E5a-E5b-L1-LCR fragment and were sequenced in full.

113 Initially, a 2,800-bp E5a-E5b-L1-LCR fragment was sequenced from 492/530 (92.8%) HPV6-pos

114 Background Ca (in locations lacking LCRs) quickly decays to resting Ca levels (<100 nM) at h

115 ion is facilitated at higher Pup by a larger LCR amplitude, whereas at low Pup by higher background C

116 crV produced variants with wild-type LCR(+), LCR(-), or dominant negative LCR(-) phenotypes, thereby

117 ace-bound capture probes, the DNAzyme-linked LCR products induce electrocatalytic responses that are

118 in short-term surrogate oncological markers, LCR was not inferior to OCR in direct measures of surviv

119 In fact, regardless of the mechanism, LCRs can mediate or stimulate rearrangements, inciting g

120 nd methylation throughout the minichromosome LCR/hGH-N domain.

121 ld-type LCR(+), LCR(-), or dominant negative LCR(-) phenotypes, thereby allowing us to identify discr

122 ls in potato tuber would require ANR but not LCR and that an epimerization process is involved.

123 c looping activity of CTCF sites can nullify LCR function.

124 wholly supports all the critical aspects of LCR activity.

125 tly shifted the cecal microbial community of LCR rats, resulting in a lower Firmicutes:Bacteroidetes

126 bal waves), LCR rhythmicity, and decrease of LCR period that parallels the changes observed experimen

127 in promoters as well as de novo formation of LCR/gamma-globin contacts.

128 d mediator occupancy and resulted in loss of LCR/beta-globin proximity.

129 tence of powerful compensatory mechanisms of LCR regulation via a complex local cross-talk of Ca pump

130 ese data support a site specificity model of LCR HS-globin gene interaction.

131 rythroleukemia cells, but phosphorylation of LCR-associated Pol II at serine 5 of the C-terminal doma

132 tissue inflammation, and aortic stiffness of LCR rats.

133 le, and more rapid approach for the study of LCR activity in T cells, and its translation to therapeu

134 was a trend toward increasing utilization of LCR from 37.5% in 2008 to 44.1% in 2011.

135 here is a trend of increasing utilization of LCR, with acceptable conversion rates, across hospitals

136 es of plasmodial proteins, the occurrence of LCRs cannot be associated with any specific metabolic pa

137 We propose that the presence of LCRs in the vicinity of the MECP2 gene may generate an u

138 to 24 bp within interchromosomal paralogous LCRs of approximately 130 kb in length and 94.7% DNA seq

139 In addition, analysis of a partial LCR deletion mutant reveals that H3 K79 dimethylation is

140 We observed persisting, roughly periodic LCRs in depolarized rabbit sinoatrial node cells (SANCs)

141 of Radiology (ACR) CT accreditation phantom LCR section at volume CT dose indexes of 8, 12, and 16 m

142 ping, via specific deletion of the placental LCR components, triggers a dramatic disruption of the hC

143 rythroblasts increases gamma-globin promoter-LCR contacts, stimulating transcription to approximately

144 While at low Pup LCRs show smaller amplitudes, their larger durations and

145 ranscription or silencing through long-range LCR interactions involving an intergenic site of noncodi

146 of the product of a ligation chain reaction (LCR) and the use of gold nanoparticles (AuNPs) as signal

147 r, we developed the ligation chain reaction (LCR) assay on the Fiber Optic Surface Plasmon Resonance

148 achieved by using the ligase chain reaction (LCR) to recognize and amplify a C to T base change at a

149 on reaction (LDR) and ligase chain reaction (LCR), respectively.

150 able colon cancer were randomized to receive LCR or OCR.

151 Transcripts of leucoanthocyanidin reductase (LCR), which generates catechin, could not be detected.

152 etween the beta-globin locus control region (LCR) and active globin genes, and although TAL1 is one o

153 n erythroid cells, the locus control region (LCR) and beta-globin promoter form a chromatin loop that

154 etween the beta-globin locus control region (LCR) and downstream genes on a transgene fulfills the cl

155 etween the beta-globin locus control region (LCR) and gene in adult mouse erythroid cells, but whethe

156 ke (Nipbl) bind to the locus control region (LCR) at the CTCF insulator and distal enhancer regions a

157 nd E4) and a non-coding long control region (LCR) between L1 and E6.

158 regulated by a distal locus control region (LCR) composed of five deoxyribonuclease I hypersensitive

159 n erythroid cells, the locus control region (LCR) contacts beta-type globin genes in a developmental

160 e binding of Pol II at locus control region (LCR) element HS2, suggesting that Pol II is transferred

161 ion is controlled by a locus control region (LCR) embedded within this locus.

162 derived from WT/Delta locus control region (LCR) heterozygous mice reveals no significant H3 K79 dim

163 tion element (MARE) in locus control region (LCR) hypersensitive site 2 (HS2) reveals a remarkably hi

164 eviously described TH2 locus control region (LCR) in the mouse.

165 The beta-globin locus control region (LCR) is able to enhance the expression of all globin gen

166 The beta-globin locus control region (LCR) is necessary for high-level beta-globin gene transc

167 that the L/M enhancer locus control region (LCR) loops with either the L or M promoter in a near 3:1

168 the human beta-globin locus control region (LCR) may function as part of an LCR holocomplex within a

169 The long control region (LCR) of human papillomavirus (HPV) regulates early gene

170 udy the influence of a locus control region (LCR) on the expression of a highly characterized, develo

171 protein can silence the long control region (LCR) promoter that controls viral E6 and E7 oncogene exp

172 repression of the viral long control region (LCR) promoter.

173 ing of the beta-globin locus control region (LCR) to the active beta-globin promoter.

174 re that juxtaposes the locus control region (LCR) with downstream globin genes.

175 obin locus, called the locus control region (LCR), dynamically interacts with the developmental stage

176 11A binds the upstream locus control region (LCR), epsilon-globin, and the intergenic regions between

177 egulatory element, the locus control region (LCR), was revealed by analyzing DNase I hypersensitive s

178 gulated by the distant locus control region (LCR), which is brought into direct gene contact by the L

179 regulated by a distal locus control region (LCR), which is required in cis for the proper expression

180 ich are members of the locus control region (LCR)-associated remodeling complex (LARC).

181 is by a multicomponent locus control region (LCR).

182 trol of a reduced-size locus-control region (LCR).

183 moter, enhancer, and a locus control region (LCR).

184 components of a remote locus control region (LCR).

185 in to establishment of locus control region (LCR)/beta-globin proximity.

186 nes from the enhancer (locus control region [LCR]).

187 eats associated with low complexity regions (LCRs) in proteins of the malarial parasite Plasmodium fa

188 proteins depend upon low-complexity regions (LCRs) or RNA for phase separation, whereas Pab1's LCR is

189 Locus control regions (LCRs) are cis-acting gene regulatory elements with the u

190 Locus control regions (LCRs) comprise sets of DNA elements capable of establish

191 al (HSIII, IV, and V) locus control regions (LCRs).

192 of SR Ca pump and release channels regulates LCRs and Ca transient decay to insure fail-safe pacemake

193 rolled, in part, by local Ca(2)(+) releases (LCRs) from the sarcoplasmic reticulum, which couple to t

194 Intracellular Local Ca releases (LCRs) from sarcoplasmic reticulum (SR) regulate cardiac

195 kb and approximately 215-kb low-copy repeat (LCR) clusters, respectively, by aCGH and SNP array analy

196 ssociated with the flanking low-copy repeat (LCR) length and inversely influenced by the inter-LCR di

197 between nonallelic flanking low-copy repeat (LCR) sequences located in 22q11.2.

198 ns both direct and inverted low-copy repeat (LCR) sequences; this same region undergoes polymorphic s

199 ombination between distinct low-copy repeat (LCR) substrates.

200 nce of a GOLGA8E-associated low copy repeat (LCR).

201 us recombination involving low copy repeats (LCR) that are found clustered in the region.

202 (NAHR), occurring between low-copy repeats (LCRs) >10 kb in size and sharing >97% DNA sequence ident

203 sion polymorphisms between low-copy repeats (LCRs) might predispose chromosomes to meiotic non-alleli

204 c architecture, especially low copy repeats (LCRs) or segmental duplications (SDs).

205 flanked by large, complex low-copy repeats (LCRs) with directly oriented subunits of ~109 kb in size

206 akpoints are in regions of low copy repeats (LCRs), indicating a possible role for LCRs in chromosome

207 ted and directly oriented, low-copy repeats (LCRs), known as REPA and REPB that apparently lead to ge

208 deletions are mediated by low-copy repeats (LCRs), located distal to the 22q11.21 DiGeorge/velocardi

209 ments mediated by flanking low-copy repeats (LCRs), NF1 intragenic rearrangements vary in size, locat

210 aring laparoscopic-assisted colon resection (LCR) with open colon resection (OCR) for colon cancer.

211 ts undergoing laparoscopic colon resections (LCR).

212 he absence of calcium (low-calcium response [LCR(+)] phenotype) was exploited to isolate dominant neg

213 ed to LMO2, sufficient to completely restore LCR-promoter looping and transcription in LDB1-depleted

214 Translation of these asparagine-rich LCRs demands extraordinarily high amounts of asparaginyl

215 m single As exposure (Life time Cancer Risk, LCR>1x10(-4)).

216 aerobic capacity in the low capacity runner (LCR) rat increases susceptibility to acute and chronic h

217 r low aerobic capacity (low capacity runner; LCR) displayed susceptibility to high fat diet-induced s

218 city runners (HCR) and low capacity runners (LCR) that in a sedentary condition have robustly differe

219 selectively bred to be low-capacity runners (LCRs) and high-capacity runners (HCRs)-selective breedin

220 nsic aerobic capacity (Low Capacity Runners, LCR), and 3) unselected Sprague-Dawley (SD) rats with or

221 w intrinsic endurance (low capacity runners; LCR).

222 or RNA for phase separation, whereas Pab1's LCR is not required for demixing, and RNA inhibits it.

223 known transcription factors but not the same LCR architecture.

224 This resulted in a progression in simulated LCR size (from sparks to wavelets to global waves), LCR

225 automatic detection of numerically simulated LCRs and examined LCR regulation by SR Ca pumping rate (

226 The single placenta-specific LCR component, HSIV, is located at -30 kb to the cluster

227 Moreover, the FO-SPR LCR assay could discriminate single nucleotide polymorph

228 g was critically dependent on subsarcolemmal LCRs, ie, PDE inhibition increased LCR amplitude and siz

229 -LCR, we refer to this lncRNA cluster as TH2-LCR lncRNA.

230 Given its genomic synteny with the TH2-LCR, we refer to this lncRNA cluster as TH2-LCR lncRNA.

231 mals exhibited more anxiotypic behavior than LCR animals on the EPM, and exhibited an increase in pla

232 HCR rats expressed less ENK than LCR rats in the nucleus accumbens among females (p<0.01)

233 r obstacle to study these mechanisms is that LCR exhibit complex Ca release propagation patterns (inc

234 obin genes for LCR contacts and suggest that LCR-promoter loops are formed and released with rapid ki

235 The LCR and beta-globin gene establish proximity in these ce

236 The LCR is composed of a number of DNase I-hypersensitive si

237 The LCR livers also displayed a lipogenic phenotype with hig

238 The LCR period, a critical determinant of the spontaneous SA

239 The LCR period, ie, a delay between AP-induced Ca(2+) transi

240 between the BGL3/gamma-globin region and the LCR is established.

241 n loop formation between beta-globin and the LCR, and instead forms a new loop with endogenous HS5 th

242 ment of SMAR1-HDAC1 repressor complex at the LCR and E6 MAR sequences, thereby decreasing histone ace

243 a domain of histone hyperacetylation at the LCR and hGH-N promoter in these cells similar to that ob

244 racted with endogenous Ldb1 complexes at the LCR to form a chromatin loop, causing recruitment and ph

245 were no significant differences between the LCR and OCR groups in 5-year follow-up of overall surviv

246 ed the frequency of interactions between the LCR and the adult beta-globin promoter.

247 ntial for efficient interactions between the LCR and the beta(maj)-promoter as well as transcription

248 the CTCF insulator elements and between the LCR distal enhancer and the target gene.

249 In adult erythroid cells, the LCR can be redirected from the adult beta- to the fetal

250 Mechanisms that control the LCR period, however, are still unidentified.

251 ggesting that Pol II is transferred from the LCR to the globin gene promoters.

252 and secondary-structure levels; however, the LCR chromatin is packaged more tightly in embryonic eryt

253 However, the LCR rat demonstrated greater susceptibility to increased

254 omoter contains consensus MAR element in the LCR and E6 sequences where SMAR1 binds and reinforces HP

255 ere associated with hepatic steatosis in the LCR including higher liver triglycerides (6.00 +/- 0.71

256 lcoholic fatty liver disease observed in the LCR rats following western diet feeding was associated w

257 Fs tested, 28 activated and 36 inhibited the LCR of HPV-18 by more than 2-fold.

258 roxidase-mimicking DNAzyme sequence into the LCR amplification probes design which in turn, serves as

259 dogenous HS5 that topologically isolates the LCR.

260 roteins were inactive at alleles lacking the LCR, demonstrating that their activities depend on long-

261 However, the chromatin structure of the LCR at the different developmental stages is not well de

262 s at the DNase I hypersensitive sites of the LCR could be either depleted or retained depending on th

263 e switching, a change in conformation of the LCR holocomplex, or both.

264 tion and the gene activation function of the LCR in mammalian cells.

265 DNase I-hypersensitive site I (HSI) of the LCR is essential to full developmental activation of the

266 new TFs implicated in the regulation of the LCR of HPV-18 and HPV-16.

267 on at the hGH-N promoter, and looping of the LCR to its target promoter.

268 is dependent not only on the actions of the LCR, but also on the multigene composition of the cluste

269 eved to encompass the regulatory core of the LCR.

270 de insight on the molecular evolution of the LCR.

271 pe-specific hGH-N activation function of the LCR.

272 ith DNaseI hypersensitive site (HS) I of the LCR.

273 possess distinct chromatin structures of the LCR.

274 This activity depends on the LCR, consistent with an LCR-promoter looping mechanism.

275 Ectopic HS5 does not perturb the LCR but blocks gene activation by interfering with RNA p

276 e diagnostic medical physicists reviewed the LCR images in a blinded fashion and graded the visibilit

277 ifted T-90(C) and proportionally shifted the LCR period and spontaneous cycle length (R(2)=0.98).

278 e sensitivity and 3C assays suggest that the LCR chromatin is more open in embryonic erythroblasts th

279 Recruitment of Pol II to the LCR occurs in undifferentiated murine erythroleukemia ce

280 strated FOXA1 and MYC in vivo binding to the LCR of both HPV types using chromatin immunoprecipitatio

281 In addition to the LCR, we found robust NLI complex occupancy at a site dow

282 to the globin gene promoters but also to the LCR.

283 pected fluid chromatin dynamics, whereby the LCR can be initially dominant over the endogenous CD8 ge

284 looping of the (G)gamma-globin gene with the LCR was disrupted with decreased occupancy of the comple

285 wnstream promoter region interferes with the LCR-mediated recruitment and activity of Pol II.

286 d MYC have putative binding sites within the LCR sequence, as indicated using the TRANSFAC database.

287 The LCRs flanking a contiguous genomic interval encompassing

288 The LCRs overlap with Ca transient decay, causing an elevati

289 spite their abundance, the function of these LCRs remains unclear.

290 The features of these LCRs were reproduced by a numerical model consisting of

291 lected TF expression plasmids in addition to LCR-luciferase vectors of different molecular variants o

292 ehavior in the novel environment compared to LCR animals.

293 were 27.0 and 18.0, respectively while total LCR values for adult and children were 0.0049 and 0.0032

294 ons of LcrV produced variants with wild-type LCR(+), LCR(-), or dominant negative LCR(-) phenotypes,

295 e (from sparks to wavelets to global waves), LCR rhythmicity, and decrease of LCR period that paralle

296 eletions of 2 HSs, and deletion of the whole LCR and found all of the HSs had a similar spectrum of a

297 ther the short-term benefits associated with LCR for colon cancer could be achieved safely, without s

298 points are not significantly associated with LCRs.

299 plifies how large genomic regions laden with LCRs still represent a technical challenge for both dete

300 on boundaries for all individuals are within LCRs distal to the DiGeorge/velocardiofacial microdeleti

301 Motifs within the zebrafish LCR include CACCC, GATA, and NFE2 sites, suggesting func