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1 LDHA also promoted GH3 cell proliferation through induct
2 okinase 1 (HK1) and lactate dehydrogenase A (LDHA) - both of which regulate the metabolic switch - an
4 lls (HSCs), whereas lactate dehydrogenase A (LDHA) deletion significantly inhibits the function of bo
6 Here, we show that lactate dehydrogenase A (LDHA) is induced in activated T cells to support aerobic
7 kinase 2 (HK2), and Lactate Dehydrogenase A (LDHA) were each significantly higher in MYCN-amplified n
8 duced activation of lactate dehydrogenase A (LDHA), an enzyme that catalyses the interconversion of p
9 h as those encoding lactate dehydrogenase A (LDHA), solute transporter MCT1, and hexokinase 1 (HK1) -
10 ate lactate through lactate dehydrogenase A (LDHA), which is encoded by a target gene of c-Myc and hy
14 together, these data suggest that HIF1A and LDHA are important targets for hypoxia-driven drug resis
17 onserved canonical E boxes in ENO1, HK2, and LDHA occur in 31- to 111-bp islands with high interspeci
21 sion of the glycolytic genes GLUT1, PKM2 and LDHA, and of CDC25A; thus, Cdc25A upregulates itself in
22 , thereby activating transcription of BNIP3, LDHA, PDK1, and SLC2A1, which encode proteins that are r
23 such as 63 exhibit low nM inhibition of both LDHA and LDHB, submicromolar inhibition of lactate produ
24 in this interval, resulting in the order CEN-LDHA-SAA1-TPH-D11S1310-(D11S1888/KCNC1 )-MYOD1-D11S902D1
25 leic acid or expression of phospho-deficient LDHA Y10F sensitized the cancer cells to anoikis inducti
26 hexokinase (HK2) and lactate dehydrogenase (LDHA) expression, together with a switch in pyruvate kin
29 icantly associated with expression of GLUT1, LDHA, PDK1, LOX, LOXL2, and L1CAM mRNA in human breast c
32 )C MRS of pyruvate to monitor alterations in LDHA activity and expression caused by PI3K pathway inhi
34 suggesting that Y10 phosphorylation-mediated LDHA activity promotes cancer cell invasion and anoikis
36 lation and transcription of Ifng Ablation of LDHA in T cells protects mice from immunopathology trigg
39 ple myeloma, and that specific inhibition of LDHA and HIF1A can restore sensitivity to therapeutic ag
40 Accordingly, oxamate-induced inhibition of LDHA suppressed glucose uptake, lactate secretion, invas
43 and were associated with a drop in levels of LDHA mRNA and LDHA and hypoxia-inducible factor-1alpha p
44 udy, we showed that the expression levels of LDHA mRNA and protein were significantly elevated in inv
46 ells, suggesting that Y10 phosphorylation of LDHA may represent a promising therapeutic target and a
51 udies have focused on the ubiquitous role of LDHA in tumor metabolism and growth, our data reveal tha
54 e show that overexpression of either PDK1 or LDHA in a rat CNS cell line (B12) confers resistance to
55 In contrast, cells expressing either PDK1 or LDHA maintained a lower mitochondrial membrane potential
56 s inhibited in the absence of either PKM2 or LDHA, indicating that the cell-state-specific responses
57 in multiple myeloma, specifically targeting LDHA, can be beneficial to inhibit tumor growth and over
61 h reduction of LDHA expression indicate that LDHA is involved in tumor initiation, but its role in tu
62 ctor T cell differentiation and suggest that LDHA may be targeted therapeutically in autoinflammatory
65 henotype in inducing drug resistance through LDHA and HIF1A in multiple myeloma, and that specific in
66 lified neuroblastoma cells are "addicted" to LDHA enzymatic activity, as its depletion completely inh
67 l lines while gain-of-function studies using LDHA or HIF1A induced resistance in bortezomib-sensitive
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