ライフサイエンスコーパス: LES

1 LES contraction is mediated by the calcium-dependent PKC

2 LES practices were less likely to refer patients to seco

3 LES pressure (LESP) in the GERD group was significantly

4 LES relaxation and axial stretch were each significantly

5 LES sera more strongly reduced calcium currents in moton

6 A LES that is independent of mass- or area-normalization a

7 re the causal functional relationships among LES traits that give rise to their strong global covaria

8 orsal motor nucleus of the vagus to evoke an LES relaxation in decerebrate unanesthetized ferrets.

9 types of contractile activity in the ESO and LES are mediated by different PKC isozymes.

10 Esophageal and LES pressure, crural diaphragm electromyographs, and pH

11 The neurologic linkage of vagal fundic and LES relaxation may have clinical relevance, because it h

12 s nerve-stimulated LES relaxation as well as LES cranial displacement.

13 d cranial displacement of the LES as well as LES relaxation in a dose-dependent manner.

14 not with either E2 or DHT alone, attenuated LES in castrated rats.

15 L-NAME (100 mg/kg, intravenously) attenuated LES relaxation to both stimuli (P < 0.05).

16 These data suggest that T attenuates LES, but not fear-potentiated startle, through a mechani

17 Basal LES pressure and swallow- and vagal-evoked LES relaxatio

18 secondary outcome was the difference between LES and non-LES practices for hospital first and follow-

19 nce in achievement of QOF indicators between LES and NLES practices.

20 or DM12(BP) and DM17(lipid) outcomes between LES and NLES practices.

21 that there are striking similarities between LES- and fundic-projecting preganglionic neurons in term

22 mature postnatal ages (15-17 d after birth) LES rat calyces showed prolonged spike latencies, indica

23 he nitrergic pathway has been shown to cause LES hypertension and impaired relaxation in achalasia.

24 d not have a hiatal hernia larger than 2 cm, LES pressure less than 8 mmHg, or Barrett's esophagus.

25 This combined LES/PMF computational approach, which offers a straightf

26 city in Galleria mellonella larvae of common LES phenotypes (ie, low production, intermediate product

27 However, interactions of common LES phenotypic variants with other members of the polymi

28 ing swallowing, and seven (33%) had complete LES relaxation.

29 t differences between patients with complete LES relaxation and those with incomplete LES relaxation

30 ere available for six patients with complete LES relaxation at manometry and 10 with incomplete relax

31 treatment in all six patients with complete LES relaxation.

32 Results derived from the coupled LES-NPZ model, run with and without the presence of Lang

33 r E2 in ovariectomized rats did not decrease LES.

34 A manometrically defective LES can be restored to normal sphincter, whereas a norma

35 ll, patients with a manometrically defective LES were restored 67% of the time to a normal sphincter

36 structurally defective or severely defective LES improved to a normal LES in 77% and 56% of patients,

37 ristalsis, (3) retained complete deglutitive LES relaxation, and (4) intact transient LES relaxation.

38 gal stimulation elicited frequency-dependent LES relaxation without evoking esophageal contractions a

39 that global-scale models may poorly describe LES covariation at non-global scales.

40 l lines [lox-containing ES lines (designated LES)] were created that contain a '-neo-lox' cassette in

41 ey concluded that an unmeasured trait drives LES covariation, sparking efforts to identify the latent

42 aryngeal stimulation induced a long-duration LES relaxation in the absence of swallow and esophageal

43 E-LES exhibited scattered erosions and displayed inflammat

44 E-LES muscle strips developed lower in vitro tone (0.78 g)

45 E-LES tone was essentially restored to normal by the H2O2

46 E-LES was examined histologically, and its in vitro circul

47 ned a human LES specimen with esophagitis (E-LES) and characterized its pathophysiologic mechanical a

48 her and H2O2 levels were 4 times higher in E-LES circular muscle (0.85 nmol/mg protein) than in N-LES

49 In E-LES, levels of PAF, PGE2, and F2-isoprostane were 4, 6,

50 transmission in the murine lower esophageal (LES) and pyloric sphincters (PS).

51 esophago-UES contractile reflex and esophago-LES relaxation response, and rapid air injection activat

52 In functional studies, centrally evoked LES relaxation (-73% +/- 8% mm Hg) was significantly att

53 l LES pressure and swallow- and vagal-evoked LES relaxations were quantified in wild-type, Nomega-nit

54 al unmeasured traits are required to explain LES covariation.

55 preganglionic neurons innervating the ferret LES, with special attention to their relationship with g

56 There were significantly fewer LES-labeled profiles that innervated the antrum (16 +/-

57 Because antibodies from LES patients reduce Ca2+ influx in a variety of cell typ

58 Furthermore, LES rat afferent fiber-evoked APs showed a pronounced lo

59 relations between N and LMA followed general LES theory, but topo-edaphic conditions strongly mediate

60 reassess these conclusions using both global LES data as well as data collected across scales in the

61 For global LES data, accounting for phylogenetic non-independence i

62 nNOS(-/-) mice have LES hypertension with impaired relaxation resembling ach

63 ta or LF according to size of hiatal hernia, LES pressure, Barrett's esophagus, and significant pulmo

64 Patients with larger hiatal hernias, LES pressure less than 8 mmHg, or Barrett's were offered

65 ents exhibit different GERD symptoms, higher LES pressures and a decreased prevalence of hiatal herni

66 However, LES practices were more likely to achieve the DM23(glyca

67 Human LES tone is maintained by the activity of sPLA2-I that p

68 for the first time, we have obtained a human LES specimen with esophagitis (E-LES) and characterized

69 sPLA2-I in the maintenance of tone in human LES samples obtained from organ donors.

70 orphology using a block containing the human LES and crural diaphragm, serially sectioned at 50 mum i

71 ibited the bethanechol-mediated hypertensive LES.

72 In contrast, W/W(v) mice have hypotensive LES with unimpaired relaxation, suggesting that ICC-IM d

73 receptor was highly expressed in identified LES-projecting preganglionic neurons.

74 or absence of primary peristalsis, impaired LES opening, esophageal dilatation, delayed emptying of

75 In LES single cells isolated by enzymatic digestion and per

76 hat Ca2+ channels may be broadly affected in LES patients.

77 There were no changes in LES or esophageal pressures during the study period in t

78 TH immunoreactivity was never identified in LES-projecting neurons.

79 d PKC-alpha, -betaII, and -gamma isozymes in LES circular muscle, but only PKC-betaII translocated fr

80 into the role of the longitudinal muscle in LES relaxation and descending relaxation of the esophagu

81 the loss of length there was a reduction in LES pressure (27.4-23.4 mm Hg, P = 0.02).

82 The HVA current remaining in LES-treated motoneurons was little affected by micromola

83 Fourteen patients (67%) had incomplete LES relaxation at manometry during swallowing, and seven

84 Six (60%) of 10 patients with incomplete LES relaxation had resolution of symptoms after treatmen

85 ete LES relaxation and those with incomplete LES relaxation in mean age (P = .59), duration of dyspha

86 Tetrodotoxin did not block the CGRP-induced LES relaxation.

87 Nitric-oxide-induced LES relaxation was not affected by fundoplication.

88 o determine if a pharyngeal stimulus-induced LES relaxation is associated with crural diaphragm inhib

89 e data all suggest that GBR agonists inhibit LES relaxation via a site of action associated with vaga

90 CGRP 8-37 did not inhibit LES relaxation or esophageal contraction.

91 ntral subdiaphragmatic vagus causes isolated LES relaxation and activates neurons in select vagal sub

92 nduced contraction of enzymatically isolated LES smooth muscle cells were measured in the absence or

93 the abdominal vagal-afferent-evoked isolated LES relaxation.

94 duced and gastric afferent-mediated isolated LES relaxations.

95 sPLA2-I-induced contraction of isolated LES smooth muscle cells was reduced by indomethacin, per

96 failures at impressive rates of up to 1 kHz, LES calyces were unable to do so.

97 equire venting, and contains a modified LES (LES 2) to reduce the possibility of false positives.

98 W(v) mice lacking ICC-IM have achalasia-like LES dysfunction.

99 eflux and the hope that measurement of a low LES pressure would mark the presence of GERD.

100 tients with a normal preoperative manometric LES deteriorated to a lower category.

101 Mean LES resting and relaxation nadir pressure are lower afte

102 Mean LES resting and relaxation nadir pressure were lower aft

103 re was a significant reduction in the median LES length from 4 to 2.6 cm (P = 0.001).

104 iated with an overall increase in the median LES resting pressure (18 pre-MSA vs 23 mm Hg post-MSA; P

105 owever, how environmental conditions mediate LES trait interrelationships, particularly at large bios

106 In anesthetized mice, LES pressures were recorded using a manometric technique

107 not require venting, and contains a modified LES (LES 2) to reduce the possibility of false positives

108 ested the hypothesis that baclofen modulates LES motor tone via GBR expressed by vagal efferent neuro

109 Wild-type mouse LES maintained a basal pressure (24 +/- 3 mm Hg; N = 8)

110 In contrast, W/W(v) mouse LES was significantly hypotensive (11 +/- 2 mm Hg; N = 6

111 ular muscle (0.85 nmol/mg protein) than in N-LES (0.19 +/- 0.05 nmol/mg protein).

112 and 40 times, respectively, higher than in N-LES.

113 duced dose-dependent reductions in tone of N-LES muscle strips.

114 tory mediators were compared with those of N-LES.

115 sed the normal lower esophageal sphincter (N-LES) of human organ donors to examine the physiologic si

116 eveloped lower in vitro tone (0.78 g) than N-LES (3.3 +/- 0.2 g).

117 When N-LES smooth muscle was incubated in H2O2 (70 micromol/L,

118 tcome was the difference between LES and non-LES practices for hospital first and follow-up appointme

119 severely defective LES improved to a normal LES in 77% and 56% of patients, respectively.

120 stored to normal sphincter, whereas a normal LES remains stable.

121 Much of the structure in the mass-normalized LES results from normalizing area-proportional traits by

122 undus both labels were noted in 56 +/- 3% of LES-labeled profiles overall.

123 In the rostral DMN, 15 +/- 4% of LES-projecting neurons also contained NADPH-diaphorase a

124 the current study, Western blot analysis of LES and ESO revealed PKC-alpha, -betaII, and -gamma isoz

125 -2-dioctanoylglycerol-induced contraction of LES and ESO smooth muscle cells.

126 Contraction of LES cells was reduced by the alpha beta gamma pseudosubs

127 ess climatic and geophysical determinants of LES traits and their interrelationships.

128 We compared effects of LES sera on whole-cell currents of cultured nerve and mu

129 led to show a reduction in the expression of LES.

130 nested climatic and geophysical filtering of LES traits and their interrelationships, with important

131 r and can account for a clinical hallmark of LES, facilitation of neuromuscular transmission produced

132 im of the study was to examine the impact of LES in terms of diabetes Quality Outcome Framework (QOF)

133 our knowledge, the first biospheric maps of LES traits, here centered on 76 million ha of Andean and

134 rks through a stretch-sensitive mechanism of LES relaxation.

135 The neurochemistry of LES-projecting neurons was also investigated using two m

136 e central organization and neurochemistry of LES-projecting preganglionic neurons.

137 dopamine), is synthesized by a population of LES-projecting neurons.

138 The pathogenic potential of LES phenotypic variants can be enhanced by the presence

139 th air resulted in progressive shortening of LES (R = 0.89, P < 0.0001).

140 es at neuromuscular synapses, specificity of LES antibodies for the Ca2+ channels that control transm

141 The CM fascicles on the ventral surface of LES are arranged in a helical/spiral fashion.

142 le of a specific beta3 agonist (CL316243) on LES pressure (LESP) in vivo.

143 a infection model, with killing dependent on LES phenotype and AGS species.

144 Overall, LES practices performed better in the achievement of DM2

145 r border (2.65 vs 4.1 cm; P = .027) and peak LES pressure (0.1 cm proximal vs 2.1 cm distal; P = .007

146 Preoperative LES pressure was higher in the Stretta group.

147 Elevated preoperative LES pressure represents the strongest positive outcome p

148 High preoperative LES pressure remained an independent predictor of excell

149 esophageal sphincter (LES) resting pressure, LES relaxation pressure, and intraesophageal-intragastri

150 for this receptor has been found in the rat LES in vitro.

151 In contrast to gonadally intact male rats, LES was seen reliably in castrated male rats and in fema

152 Fundoplication reduces LES relaxation by interfering with axial stretch on the

153 prostane, which are responsible for reducing LES tone in human esophagitis.

154 e cells in the lateral extrastriolar region (LES) mostly formed at E13.5.

155 REK-LES promotes and regulates the extent of Bright multimer

156 Resting and residual LES pressures were recorded to determine whether LES rel

157 ed annealing with locally enhanced sampling (LES) in a primary hydration shell (PHS) aqueous environm

158 dynamics (MD) and locally enhanced sampling (LES) methods in order to predict the favourable topologi

159 We now report a locally enhanced sampling (LES) strategy for modeling ammonia transfer between the

160 ting, and contains a liquid emulsion sensor (LES).

161 In the UK, Local Enhanced Services (LES) have been commissioned for diabetes.

162 tory brainstems using the Long-Evans Shaker (LES) rat, a spontaneous mutant where compact myelin wrap

163 al axons and those of the Long-Evans shaker (LES) rat, which lacks compact myelin.

164 of the coupling of a large-eddy simulation (LES) model of the mixed layer with an advection-diffusio

165 was found only at the times of simultaneous LES and crural diaphragm relaxation.

166 The presence of NOS in some LES-projecting neurons may contribute to LES relaxation,

167 asshouse study, for leaf economics spectrum (LES) and related traits: photosynthesis (A(mass), A(area

168 asshouse study, for leaf economics spectrum (LES) and related traits: photosynthesis (A(mass), A(area

169 The leaf economics spectrum (LES) describes multivariate correlations that constrain

170 The leaf economics spectrum (LES) is a prominent ecophysiological paradigm that descr

171 Leaf economics spectrum (LES) theory suggests a universal trade-off between resou

172 eparation of the lower esophageal sphincter (LES) and crural diaphragm was quantified by measuring th

173 a morphological lower esophageal sphincter (LES) and those who did not.

174 elaxation of the lower esophageal sphincter (LES) are mediated by nitric oxide (NO.)-producing myente

175 In contrast, lower esophageal sphincter (LES) circular muscle maintains spontaneous tone and rela

176 transduction of lower esophageal sphincter (LES) circular muscle.

177 The lower esophageal sphincter (LES) in patients with gastroesophageal reflux disease of

178 er border of the lower esophageal sphincter (LES) in subjects with a large WC (2.77 vs 3.54 cm; P = .

179 r control of the lower esophageal sphincter (LES) is critical for normal swallowing and emesis, as we

180 tor sites in the lower esophageal sphincter (LES) of animals and humans.

181 re and increased lower esophageal sphincter (LES) pressure and length based on objective testing over

182 igher preoperative low esophageal sphincter (LES) pressure than nonresponders: 42.6 +/- 13.1 versus 2

183 y have low or no lower esophageal sphincter (LES) pressure.

184 Isolated lower esophageal sphincter (LES) relaxation associated with belching and vomiting an

185 a long-duration lower esophageal sphincter (LES) relaxation that is an important feature of a transi

186 c nerves mediate lower esophageal sphincter (LES) relaxation with intramuscular interstitial cells of

187 during transient lower esophageal sphincter (LES) relaxation, longitudinal muscle contracts independe

188 during transient lower esophageal sphincter (LES) relaxation-associated reflux in GERD patients.

189 that it reduces lower esophageal sphincter (LES) relaxation.

190 nce of transient lower esophageal sphincter (LES) relaxations.

191 gation velocity, lower esophageal sphincter (LES) resting pressure, LES relaxation pressure, and intr

192 cat spontaneous lower esophageal sphincter (LES), tone is maintained by the activity of group I secr

193 ion (MSA) on the lower esophageal sphincter (LES).

194 unterpart of the lower esophageal sphincter (LES).

195 ophagus, and the lower esophageal sphincter (LES).

196 Lower oesophageal sphincter (LES) pressure was higher in patients with T2D (median 10

197 previously shown that in vitro, spontaneous LES tone and contraction of ESO in response to acetylcho

198 a phenomenon called light-enhanced startle (LES), is dependent on the bed nucleus of the stria termi

199 ed axial stretch- and vagus nerve-stimulated LES relaxation as well as LES cranial displacement.

200 omonas aeruginosa Liverpool epidemic strain (LES) is an important cystic fibrosis (CF) pathogen and i

201 , which are increasingly being used to study LES relaxation.

202 as demonstrated that Lambert-Eaton syndrome (LES) antibodies reduce calcium currents in nonneuronal c

203 autoimmune disorder, Lambert-Eaton syndrome (LES).

204 a better and more integrated parameter than LES pressure for determining efficacy of treatment for p

205 ility by EndoFLIP is a better parameter than LES pressure for evaluating efficacy of treatment for ac

206 trasts with untreated cells and suggest that LES sera primarily spare L-type currents in motoneurons.

207 The LES and PS contain spindle-shaped IC-IM, which form clos

208 The LES in nNOS(-/-) was significantly hypertensive (36 +/-

209 The LES pressure was monitored with a 2F solid-state pressur

210 evidence of excessive reflux 5 cm above the LES in either group.

211 In addition, the LES formed pathogenic partnerships with AGS in the G. me

212 We assessed the LES and esophageal hiatus morphology using a block conta

213 S and gastric fundus is logical, because the LES has similar functions to the fundus, which relaxes t

214 rt the hypothesis that CGRP may decrease the LES basal tone and modulate the timing and amplitude of

215 Smooth muscle strips from the LES and the body of the esophagus were stimulated by an

216 IC-IM were absent in the LES and PS of c-kit (W/Wv) mutant mice.

217 d whether IC-IM mediate neural inputs in the LES and PS.

218 ole in NO-dependent neurotransmission in the LES and PS.

219 ncorporation of a 'vortex-force' term in the LES code in order to generate Langmuir circulations.

220 c(1) and c(2) on the number of copies in the LES method and the thickness of the PHS.

221 tion of temperature, number of copies in the LES method, and shell thickness.

222 at the heminode and terminal was lost in the LES rat.

223 arization peak following the AP spike in the LES rat.

224 erent fluorescent tags was injected into the LES and fundus both labels were noted in 56 +/- 3% of LE

225 ange occurred in the abdominal length of the LES (2.6-1.4 cm [P = 0.001]) and not in the thoracic len

226 ve shortening of the abdominal length of the LES and a reduction in its pressure.

227 propose that circumferential squeeze of the LES and crural diaphragm is generated by a unique myo-ar

228 it helps explain why motor disorders of the LES and fundus frequently occur together.

229 Coinnervation of the LES and gastric fundus is logical, because the LES has s

230 int was 0.5 cm above the lower border of the LES and with distension moved a median of 1 cm cephalad

231 mulation induced cranial displacement of the LES as well as LES relaxation in a dose-dependent manner

232 s were then targeted to the lox sites of the LES cell lines.

233 The discovery of the LES focused attention on the sphincter as the main deter

234 ne abolished nerve-induced relaxation of the LES muscle and the esophageal off-response but not the r

235 In the fasting state, none of the LES relaxations induced by pharyngeal stimulation were a

236 Cranial displacement of the LES was recorded using piezoelectric crystals.

237 in significant manometric improvement of the LES without apparent deleterious effects on the esophage

238 The large WC group had shortening of the LES, attributable to loss of the distal component (total

239 e effacement of the abdominal portion of the LES, exposing it to acid injury resulting in mucosal and

240 H monitoring led to the understanding of the LES, its contribution to GERD, and the complication of B

241 roxidase (HRP) into the muscular wall of the LES-labeled profiles throughout the rostrocaudal extent

242 logical trait underlying the 'origin' of the LES.

243 se, and it increased the resting tone of the LES.

244 ith the more resource-acquisitive end of the LES.

245 of the pharynx has different effects on the LES and crural diaphragm.

246 hageal reflux disease, but its effect on the LES has not been elucidated.

247 ects the effect of gastric distension on the LES length and pressure and its exposure to acid gastric

248 the esophagus to exert axial stretch on the LES, and the vagus nerve was isolated in the neck for el

249 ion by interfering with axial stretch on the LES.

250 ency of the off-response, and it relaxed the LES.

251 CGRP relaxes the LES and decreases the amplitude of esophageal peristalsi

252 This suggests that the LES approach is beneficial and needs to be further explo

253 h expanded first toward the MES, then to the LES by E15.5.

254 All practices in the PCT were invited to the LES initiative, which ensured avoiding selection bias.

255 n associated with vagal motor outflow to the LES.

256 acidity extended more proximally within the LES in the large WC group, compared with the upper borde

257 n moved a median of 1 cm cephalad within the LES.

258 Eleven asymptomatic volunteers had their LES length and pressure measured before and during gastr

259 Thus, even though LES is expressed as a neuromuscular and autonomic disord

260 increased by almost 10% when GPs belonged to LES groups compared with GPs in NLES group.

261 patients with achalasia and, in contrast to LES pressure, is associated with esophageal emptying and

262 ome LES-projecting neurons may contribute to LES relaxation, as it does in the case of fundic relaxat

263 ertain whether the impact exerted was due to LES.

264 rom general practices (GPs) who signed up to LES were given additional training (and a monetary incen

265 table to loss of the distal component (total LES length, 3 vs 4.5 cm; P = .043).

266 that is an important feature of a transient LES relaxation.

267 the constituents of reflux during transient LES relaxation.

268 ive LES relaxation, and (4) intact transient LES relaxation.

269 with belching and vomiting and the transient LES relaxation associated with gastroesophageal reflux a

270 In vitro LES tone and sPLA2-I-induced contraction of enzymaticall

271 In vitro LES tone was reduced by inhibitors of sPLA2-I, by indome

272 eading to the EGJ opening during tLESRs were LES relaxation, crural diaphragm inhibition, esophageal

273 Even when LES pressure was low, EGJ distensibility could be reduce

274 pressures were recorded to determine whether LES relaxation was complete or incomplete.

275 This model may explain why LES is expressed as a neuromuscular disorder and can acc

276 Relaxation of crural diaphragm along with LES relaxation is essential for the occurrence of gastro

277 hagia, and weight loss) were correlated with LES relaxation at manometry.

278 Patients with LES pressure >35 mm Hg had an odds ratio of 21.3, making

279 We tested sera from four patients with LES.

280 elief after myotomy compared with those with LES pressure < or =35 mm Hg (odds ratio, 21.3; 95% confi