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1 LH-RH receptor-positive (MCF-7) and -negative (UCI-107)
5 sing hormone (LH-RH), is more potent against LH-RH receptor-bearing cancers and produces less periphe
6 increase in medium concentrations of AA and LH-RH induced by high [K(+)], suggesting that NO mediate
9 tagonists suppress gonadotroph functions and LH-RH receptor (LH-RH-R) production are incompletely und
10 reas CP hydrolysis gives rise to CCK5-GR and LH-RH-GK, both of which are susceptible to the dipeptidy
11 no acids from the C-terminus of CCK5-GRR and LH-RH-GKR, but only CP is responsible for converting dia
12 (10(-5) to 10(-3) M) had no effect on basal LH-RH release but completely blocked high [K(+)]- and ni
16 This study demonstrates that the cytotoxic LH-RH analog AN-207 exerts highly selective effects on t
18 we applied an in vitro method to desaturate LH-RH receptors by chaotropic agents such as manganous c
23 ecreased the level of membrane receptors for LH-RH by 83% (P < 0.01) after 7 days, and 86% (P < 0.01)
24 e number of pituitary membrane receptors for LH-RH in a time-dependent manner with the nadir occurrin
25 the binding characteristics of receptors for LH-RH in membrane fractions from rat anterior pituitarie
27 eatment of tumors that possess receptors for LH-RH such as prostatic, mammary, ovarian, and endometri
31 ment, the concentration of binding sites for LH-RH in the nuclei of rat pituitaries was significantly
33 Lys6] luteinizing hormone-releasing hormone (LH-RH) (AN-207), was demonstrated to be less toxic than
34 og of luteinizing hormone-releasing hormone (LH-RH) containing DOX, at 0.3 mg/ml is 19.49 +/- 0.74 mi
35 ts of luteinizing hormone-releasing hormone (LH-RH) leads to down-regulation of pituitary LH-RH recep
36 on of luteinizing hormone-releasing hormone (LH-RH) release from medial basal hypothalamic explants b
37 07 of luteinizing hormone-releasing hormone (LH-RH), consisting of an intensely potent derivative of
38 Lys6]-luteinizing hormone-releasing hormone (LH-RH), is more potent against LH-RH receptor-bearing ca
39 ts of luteinizing hormone-releasing hormone (LH-RH), unlike the LH-RH agonists, suppress gonadotropin
44 -pyrrolinodoxorubicin conjugated to [D-Lys6] LH-RH, exerted through induction of apoptosis and modula
45 p of the D-Lys side chain of agonist [D-Lys6]LH-RH or antagonistic analog AC-D-Nal(2)-D-Phe(4Cl)-D-Pa
46 nd on the cellular uptake of AN-152, [D-Lys6]LH-RH, or doxorubicin was assessed by the 3-(4,5-dimethy
48 x can affect the concentration of measurable LH-RH binding sites, we applied an in vitro method to de
50 esults show that the percentages of occupied LH-RH receptors at 1, 3, and 6 h after administration of
51 Our results indicate that administration of LH-RH antagonist Cetrorelix produces a marked down-regul
53 These highly potent cytotoxic analogs of LH-RH were designed as targeted anti-cancer agents for t
55 n the superfusion system, which is devoid of LH-RH, did not cause any significant changes in LH-RH-R
57 this study was to investigate the effects of LH-RH antagonist cetrorelix on the binding characteristi
60 ults demonstrate that the down-regulation of LH-RH receptors on the cell membranes of rat pituitaries
62 ansmitter that blocks NOergic stimulation of LH-RH release by chemically reducing the NO released by
66 ased the concentration of mRNA for pituitary LH-RH-R by 72.6% in OVX rats, but only by 32.9% in norma
68 trorelix on the mRNA expression of pituitary LH-RH-R and luteinizing hormone (LH) secretion in three
69 effects on the gene expression of pituitary LH-RH-R by counteracting the stimulatory effect of endog
70 ase occurred in the mRNA levels of pituitary LH-RH-R in ovariectomized (OVX) rats with high pituitary
72 esaturation, demonstrated that rat pituitary LH-RH receptors were significantly (P < 0.01) down-regul
74 transfected COS cells with a LH-RH receptor (LH-RH-Rc) mammalian expression vector and examined the e
77 nitroprusside, which releases NO, stimulated LH-RH release and decreased the concentration of AA in t
82 LH-RH antagonists is similar to that of the LH-RH agonists, but the mode of action of antagonists is
83 ormone-releasing hormone (LH-RH), unlike the LH-RH agonists, suppress gonadotropins and sex steroid s
84 d (OVX) rats with high pituitary exposure to LH-RH, but there was a significant 23.2% reduction in cy
87 conjugate was: (a) specific for cancers with LH-RH receptors; (b) up-regulated by EGF; (c) down-regul
89 single injection or prolonged treatment with LH-RH antagonist also decreased the mRNA expression of p
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