ライフサイエンスコーパス: LHRH

1 LHRH agonists provide an additional class of agents for

2 LHRH agonists showed similar efficacy to chemotherapy (r

3 LHRH agonists were ineffective in hormone-receptor-negat

4 LHRH cell number after drug treatment as determined by i

5 LHRH cells exhibit neurophilic migration moving from the

6 LHRH mRNA levels were examined in young and middle-aged

7 LHRH mRNA levels were measured in cytosolic extracts, an

8 LHRH patients assessed their overall health as fair or p

9 LHRH patients reported more breast swelling than did orc

10 LHRH patients reported more physical discomfort and worr

11 LHRH receptors are expressed in a very high percentage o

12 LHRH-conjugated nanocapsules selectively delivered recom

13 LHRH-negative neurons in culture exhibited only occasion

14 LHRH-R mRNA expression in female pituitaries was reduced

15 In 20 cultures, 572 LHRH-positive cells exhibited [Ca(2+)](i) oscillations a

16 e not known to self-aggregate (amylin, ACTH, LHRH, angiotensin II, atrial natriuretic peptide, somato

17 e c-Fos expression in both SCN and activated LHRH neurons, with the percentage of LHRH+/c-Fos+ double

18 All LHRH mRNA positive neurons present in 4 anatomically mat

19 ng an l-GnRH-III polyclonal antiserum and an LHRH monoclonal antiserum.

20 No trials had assessed an LHRH agonist versus chemotherapy with tamoxifen in both

21 onal pseudorabies virus into the brain of an LHRH::CRE mouse line led to the identification of neuron

22 received either placebo (24 subjects) or an LHRH agonist (26 subjects).

23 Treatment with an LHRH agonist for 3.5 years increases adult height by 0.6

24 trial to determine whether treatment with an LHRH agonist increases adult height in short adolescents

25 Treatment with an LHRH agonist resulted in significantly greater adult hei

26 Survival after therapy with an LHRH agonist was equivalent to that after orchiectomy.

27 d, the subjects who had been treated with an LHRH agonist were older than those who had received plac

28 -R mRNA expression in female rats by 23% and LHRH-R protein levels by 119%.

29 nd diminished LHRH-R mRNA to 30% and 26% and LHRH-R protein to 57% and 48% on days 10 and 30, respect

30 pment, including olfactory sensory cells and LHRH cells.

31 lly, we showed that Mn2+ stimulated cGMP and LHRH from the same tissues, and that downstream blocking

32 els were measured in cytosolic extracts, and LHRH primary transcript levels were measured in nuclear

33 d and perfused for localization of c-Fos and LHRH, PRs alone, or c-Fos and PRs.

34 suppress pituitary gonadotroph functions and LHRH-receptor (LHRH-R) expression are incompletely under

35 Preclinical studies revealed that GHRH and LHRH antagonists both can cause a reduction in prostate

36 Pituitary LHRH-R mRNA and LHRH-R protein levels were not significantly different f

37 elix on serum LH, pituitary LHRH-R mRNA, and LHRH-R protein was greater than that of Decapeptyl.

38 itary sites, the interactions of the NPY and LHRH systems may involve diencephalic loci.

39 The overlap between the NPY and LHRH systems was apparent in the periventricular, parave

40 vealed dual expression of nestin protein and LHRH in cells proximal to the vomeronasal organ anlage t

41 ownregulated beginning at E12, so few if any LHRH neurons in the forebrain also express DCC.

42 in Locke solution for 30 min to assess basal LHRH secretion, then incubated with buffer alone or buff

43 gonadotropin release in the presence of both LHRH and AA, whereas sodium nitroprusside, a releaser of

44 bypassed the surge in sex steroids caused by LHRH agonists, the gold standard for clinical ablation o

45 A rapid suppression of serum LH by LHRH antagonists would be advantageous in the treatment

46 idase E.C.3.4.24.15 (EP24.15), which cleaves LHRH at the Tyr5-Gly6 position.

47 These extrahypothalamic neurons contain LHRH fragments, rather than fully mature mammalian LHRH.

48 (LHRH) release, we examined whether cultured LHRH neurons exhibit spontaneous intracellular Ca(2+) ([

49 sed for targeted chemotherapy with cytotoxic LHRH analogue AN-207.

50 was performed to compare the 3-monthly depot LHRH agonist leuprorelin acetate (LAD-3M; n = 299) and c

51 The 3-monthly depot LHRH-agonist leuprorelin acetate is an effective adjuvan

52 The descladinose LHRH antagonist 14 has 1-2 nM affinity for both rat and

53 duced serum LH in female rats and diminished LHRH-R mRNA to 30% and 26% and LHRH-R protein to 57% and

54 Elevated LHRH-R protein levels of ovariectomized rats were reduce

55 ng 100 microg of peptide daily, the elevated LHRH-R mRNA level was decreased by 73%, whereas daily in

56 Embryonic LHRH neurons were examined in vivo for Mash-1 and nestin

57 heterozygous deletion in the nasal embryonic LHRH factor (NELF) gene in pedigree 1 and an additional

58 ion of a novel factor termed nasal embryonic LHRH factor (NELF) that was discovered in a differential

59 trical activity, also significantly enhanced LHRH migration.

60 but it did not block the nerve-firing-evoked LHRH release.

61 Moreover, nicotine evoked LHRH release when [Ca2+] elevation in the terminals was

62 We therefore examined LHRH neuron migration in DCC(-/-) mice and found that tr

63 To address this hypothesis, we examined LHRH mRNA turnover in primary postnatal LHRH neurons mai

64 and its ability to counteract the exogenous LHRH and the agonist triptorelin in the regulation of th

65 n vomeronasal axons in the nose also express LHRH.

66 not Mash-1, was detected in early expressing LHRH cells in the vomeronasal organ anlage.

67 A few LHRH-IR neurons and fibers were scattered in the mamilla

68 Specifically, fewer LHRH mRNA positive neurons were detected at 18:00 h comp

69 onic stage before the migration of bona fide LHRH neurons, and is ultimately distributed in the extra

70 at embryonic days (E) 32-E36, are bona fide LHRH neurons.

71 imary tumors or metastases were examined for LHRH receptor expression by immunohistochemistry.

72 Combined immunohistochemistry for LHRH neurons and in situ hybridization for GABAA subunit

73 Cells were fixed and immunostained for LHRH and neuron-specific enolase.

74 The mRNA for LHRH receptors, receptor protein and binding sites for L

75 which is similar to the period observed for LHRH release, whereas in 5 of 17 cultures the less tight

76 tors, receptor protein and binding sites for LHRH were detected in both transplantable melanoma tumor

77 cimens examined showed positive staining for LHRH receptors.

78 to identify neurons that synapse with GnRH (LHRH) neurons, the key regulators of reproduction.

79 es of luteinizing hormone-releasing hormone (LHRH) -like neurons, "early" and "late" cells, were disc

80 f the luteinizing hormone-releasing hormone (LHRH) agonist Decapeptyl (25 microg/day) for 30 days or

81 ith a luteinizing hormone-releasing hormone (LHRH) agonist increases adult height in children with LH

82 lamic luteinizing hormone-releasing hormone (LHRH) agonist, [D-Trp6]LHRH.

83 with luteinizing hormone-releasing hormone (LHRH) agonists is an effective adjuvant treatment for pr

84 with luteinising-hormone-releasing hormone (LHRH) agonists, but results have been inconclusive, espe

85 arin, leutinizing hormone releasing hormone (LHRH) and oligonucleotides, across the skin.

86 with luteinizing hormone-releasing hormone (LHRH) antagonist are also reviewed and analyzed.

87 luteinizing hormone (LH)-releasing hormone (LHRH) antagonists suppress pituitary gonadotroph functio

88 og of luteinizing hormone-releasing hormone (LHRH) as a targeting moiety specific to the receptors th

89 Luteinizing hormone releasing hormone (LHRH) gene transcription was examined in ovariectomized

90 o the luteinizing hormone-releasing hormone (LHRH) neuroendocrine phenotype are derived from the nasa

91 on of luteinizing hormone-releasing hormone (LHRH) neurons from the olfactory pit to the CNS.

92 Luteinizing hormone-releasing hormone (LHRH) neurons migrate from the olfactory placode to the

93 Luteinizing hormone-releasing hormone (LHRH) neurons migrate from the vomeronasal organ (VNO) t

94 population afferent to LH-releasing hormone (LHRH) neurons that is co-activated to express c-Fos with

95 lates luteinizing hormone releasing hormone (LHRH) neurons to secrete LHRH, the neuropeptide controll

96 Luteinizing hormone-releasing hormone (LHRH) neurosecretion, which regulates gonadal function,

97 ct of luteinizing hormone-releasing hormone (LHRH) on luteinizing hormone secretion in several specie

98 with luteinizing hormone-releasing hormone (LHRH) peptide via phospholipid, the fcc-FePt NPs can bin

99 ) and luteinizing hormone releasing hormone (LHRH) peptide, resulting in specific and efficient accum

100 ed by luteinizing hormone-releasing hormone (LHRH) receptor antagonism bypassed the surge in sex ster

101 ly inhibits stimulated LH-releasing hormone (LHRH) release from medial basal hypothalamic explants.

102 atile luteinizing hormone-releasing hormone (LHRH) release, we examined whether cultured LHRH neurons

103 ts of luteinizing hormone-releasing hormone (LHRH) release, which was monitored as slow membrane depo

104 ol of luteinizing hormone-releasing hormone (LHRH) secretion and sexual behavior which show diurnal v

105 duces luteinizing hormone-releasing hormone (LHRH) secretion from prepubertal female rats.

106 trols luteinizing hormone-releasing hormone (LHRH) secretion.

107 Luteinizing hormone-releasing hormone (LHRH) was used as a targeting moiety (ligand) to LHRH re

108 ue of luteinizing hormone releasing hormone (LHRH), AN-207, binds with high affinity to LHRH receptor

109 on of luteinizing hormone releasing hormone (LHRH), growth hormone releasing hexapeptide (GHRP-6), an

110 st of luteinizing hormone-releasing hormone (LHRH), reduces levels of serum LH, estradiol, progestero

111 on of luteinizing hormone-releasing hormone (LHRH), the neuropeptide controlling sexual development,

112 on of luteinizing hormone-releasing hormone (LHRH), the neuropeptide controlling sexual development.

113 erents from the SCN to LH releasing hormone (LHRH)-containing neurons in the preoptic area.

114 ge in luteinizing hormone-releasing hormone (LHRH).

115 ptide luteinizing hormone-releasing hormone (LHRH).

116 wn as luteinizing hormone releasing hormone (LHRH)] neurons can exhibit synchronized neuroendocrine s

117 izing luteinizing hormone-releasing hormone (LHRH, also known as gonadotropin-releasing hormone [GnRH

118 lus a luteinizing hormone-releasing hormone [LHRH] agonist if premenopausal).

119 sion (luteinizing hormone-releasing hormone [LHRH] agonist), whereas 75 patients received radiation a

120 However, LHRH cell migration, as determined by the distance immun

121 4 has 1-2 nM affinity for both rat and human LHRH receptors and is a potent inhibitor of LH release (

122 t findings suggest that the hypophysiotropic LHRH-synthesizing neurons may be innervated by intrahypo

123 ctively, for patients who received immediate LHRH agonist versus 10% [corrected] and 4% for patients

124 onadectomized males evokes Fos activation in LHRH and AVPV neurons as it does in females.

125 upport a role for age-related alterations in LHRH gene expression in the disruption of regular estrou

126 Alterations in LHRH primary transcript levels preceded changes in level

127 ulating levels of LH, there was no change in LHRH immunoreactivity at any time.

128 onfirm earlier reports of dynamic changes in LHRH mRNA levels on the day of an LH surge.

129 onsistent with a role for dynamic changes in LHRH transcriptional activity in modulating parameters o

130 stent with a relative age-related decline in LHRH mRNA levels.

131 Moreover, the decrease in LHRH gene transcription during the ascending phase of th

132 These results were duplicated in LHRH neurons maintained in vitro in nasal explants.

133 e receptor subunits that may be expressed in LHRH neurons at this phase in development.

134 ut not the gamma 1 subunit, are expressed in LHRH neurons.

135 Prolonged nestin expression in LHRH cells after midline removal is consistent with nasa

136 een postulated that the pubertal increase in LHRH secretion in female animals also requires neuron-gl

137 This early activation did not occur in LHRH neurons.

138 In turn, the reduction in LHRH release is caused by the inability of hypothalamic

139 es of evidence that PSA-NCAM plays a role in LHRH cell migration: promotion of cell movement along th

140 iciting the well-known diurnal variations in LHRH neuronal activity and male sexual behavior.

141 dings suggest a potential role for increased LHRH gene transcription in the accumulation of LHRH prio

142 nicotine at very low concentrations induced LHRH release via a Na+-dependent, Ca2+-independent mecha

143 th KT5823 (10 microM) inhibited Mn2+-induced LHRH release.

144 and reversibly blocked the nicotine-induced LHRH release, but it did not block the nerve-firing-evok

145 d 250 microM MnCl2 all significantly induced LHRH release, the two lowest doses did not stimulate tot

146 NMMA also inhibited LHRH-induced LH and FSH release and gonadotropin release

147 iption-PCR analyses were used to investigate LHRH receptors in MRI-H255 and MRI-H187 transplantable h

148 udies suggested that both "early" and "late" LHRH cells expressed mammalian LHRH mRNA.

149 ian luteinizing hormone-releasing hormone (m-LHRH).

150 tantly, neurons that expressed l-GnRH-III, m-LHRH, or both peptides were also detected in the ventral

151 Immunopositive neurons for l-GnRH-III, m-LHRH, or neurons coexpressing both peptides were detecte

152 slightly dorsal to neurons containing only m-LHRH.

153 , but not by l-GnRH-I, chicken-GnRH-II, or m-LHRH.

154 The m-LHRH neurons were not observed in this area.

155 mone release but also are colocalized with m-LHRH neurons in areas primarily controlling LH release.

156 tes, a group of neurons containing mammalian LHRH mRNA arises at an early embryonic stage before the

157 y" and "late" LHRH cells expressed mammalian LHRH mRNA.

158 ragments, rather than fully mature mammalian LHRH.

159 Comparison of mammalian LHRH mRNA 3'-untranslated regions showed two conserved r

160 s are found in the basal forebrain, and many LHRH neurons are displaced into the cerebral cortex of D

161 CC function results in the migration of many LHRH neurons to inappropriate destinations.

162 essed on TAG-1(+) axons that guide migrating LHRH neurons.

163 M, and a preference of a subset of migrating LHRH cells for a PSA-positive axon branch over a PSA-neg

164 Whereas monthly LHRH agonist therapy has been well established, the valu

165 In mice, most LHRH neuron migration is dependent on axons that origina

166 sary for establishment of the neuroendocrine LHRH system, cells critical for reproductive function.

167 roglial erbB receptor activation on neuronal LHRH release.

168 data indicate that, in primary LHRH neurons, LHRH mRNA has an intrinsically high rate of turnover and

169 itary cells in vitro to 3-min pulses of 1 nM LHRH or 0.1 nM triptorelin for 5 h increased the LHRH-R

170 hylerythromycin A that are novel, nonpeptide LHRH antagonists, is described.

171 in male pituitaries to 58% on day 30 but not LHRH-R protein.

172 RH gene transcription in the accumulation of LHRH prior to the start of the LH surge and in the reple

173 blockade of the LH surge, both activation of LHRH and pePOA neurons was low or absent.

174 Addition of LHRH agonists to tamoxifen, chemotherapy, or both reduce

175 nd brains for immunocytochemical analysis of LHRH and c-fos.

176 neuraminidase N, followed by the analysis of LHRH cell positions, and examination of LHRH cell positi

177 the direct inhibitory action of GHRH and of LHRH antagonists exerted through prostatic receptors.

178 Blockade of LHRH receptors by an excess of LHRH agonist Decapeptyl s

179 en both AA and an effective concentration of LHRH were incubated together, there was no additive resp

180 n sites, the distribution and connections of LHRH and NPY-immunoreactive (IR) neuronal elements in th

181 reviously implicated in the glial control of LHRH secretion.

182 eatment time showed a rapid initial decay of LHRH mRNA (t1/2, 5-13 min), followed by a slower decay r

183 Foremost, decay of LHRH mRNA, the fastest reported for a neuropeptide to da

184 peptide to date, corresponds to the decay of LHRH peptide pulses.

185 andidates for determining the destination of LHRH neurons.

186 idline tissues modulating differentiation of LHRH neurons from the nasal placode.

187 uently, we investigated the direct effect of LHRH antagonist cetrorelix in vitro on the expression of

188 ges, but prevented the stimulatory effect of LHRH pulses on the receptor mRNA expression.

189 , by counteracting the stimulatory effect of LHRH.

190 s of LHRH cell positions, and examination of LHRH cell positions in mutant mice deficient in the expr

191 Blockade of LHRH receptors by an excess of LHRH agonist Decapeptyl suppressed the effects of AN-207

192 We investigated the expression of LHRH receptors in surgical specimens of human malignant

193 one inhibition is manifested by a failure of LHRH and pePOA neurons to become activated at the time o

194 The molecular form of LHRH in "early" cells differs from "late" cells, because

195 study, we investigated the molecular form of LHRH in the "early" cells in the nasal regions and brain

196 any specific antisera against known forms of LHRH.

197 -6, which cross-reacts with several forms of LHRH.

198 es employed indicate that only a fraction of LHRH neurons are endowed with GABAA receptors.

199 t effect observed was dramatic inhibition of LHRH cell migration in explants cultured in the presence

200 The putative innervation of LHRH neurons by NPY-IR fibers was also seen in 1-microm-

201 ary LHRH receptor (LHRH-R) and the levels of LHRH-R protein were evaluated in rats.

202 indirectly, in the neurophilic migration of LHRH cells.

203 ns can have profound effects on migration of LHRH neurons and suggests that GABA participates in appr

204 t outgrowth of olfactory axons, migration of LHRH neurons in association with a subset of these axons

205 omeronasal axons that guide the migration of LHRH neurons.

206 Accordingly, chemosensory modulation of LHRH neuronal activity and mating behavior are dramatica

207 rast to established notions on the nature of LHRH neuronal inputs, our data identify major olfactory

208 migration, resulting in an excess number of LHRH cells in the accessory olfactory bulb, was observed

209 Fewer than the normal number of LHRH neurons are found in the basal forebrain, and many

210 s olfactory axon outgrowth and the number of LHRH neurons that migrate out of the nasal tissue.

211 placode and the ventral migratory pathway of LHRH neurons from rhesus monkey embryos at embryonic age

212 tivated LHRH neurons, with the percentage of LHRH+/c-Fos+ double-labeled cells approximately fivefold

213 A plot of LHRH mRNA level per cell versus DRB treatment time showe

214 tectable response of the cytoplasmic pool of LHRH mRNA to changes in gene transcription at this time.

215 he caudal vomeronasal nerve and positions of LHRH neurons are abnormal.

216 involved in the developmental regulation of LHRH secretion.

217 ium did not block Mn2+-stimulated release of LHRH, even with the higher dose of MnCl2.

218 one secretion, caused by impaired release of LHRH, the hypothalamic neuropeptide that controls sexual

219 of the LH surge and in the replenishment of LHRH stores depleted during the surge.

220 ODQ blocked the Mn2+-stimulated secretion of LHRH in a dose-dependent manner, indicating that GC is t

221 rnating left- and right-sided stimulation of LHRH neurons; under such circumstances, the functional a

222 rbB-dependent, glia-mediated, stimulation of LHRH release.

223 hours encompassing the preovulatory surge of LHRH.

224 t not always Decapeptyl, paralleled those of LHRH-R protein.

225 t GABA participates in appropriate timing of LHRH neuronal migration into the developing brain.

226 The results showed that the use of LHRH peptide as a targeting moiety in the anticancer DDS

227 OA neurons in transducing steroid effects on LHRH neurons.

228 nhibitory and stimulatory effects of GABA on LHRH neurons.

229 we evaluated the role of GABAergic input on LHRH neuronal migration using olfactory explants, previo

230 the effect of GABAA receptor stimulation on LHRH and/or gonadotropin release in prepubertal animals,

231 the functional impact of NPY-IR terminals on LHRH-IR neurons.

232 in the vomeronasal organ anlage that turn on LHRH gene and peptide expression subsequently migrate in

233 sence of E and P and activate either AVPV or LHRH neurons.

234 st Decapeptyl (25 microg/day) for 30 days or LHRH antagonist Cetrorelix pamoate (100 microg/day) for

235 eripherin-immunoreactive olfactory fibers or LHRH cell number.

236 e of gonadotropin-releasing hormone (GnRH or LHRH), is the active pharmaceutical ingredient used to t

237 dotropin hormone releasing hormone (GnRH, or LHRH) neurons in the rostral medial preoptic region of t

238 cancer cell line (A2780) that overexpresses LHRH receptors and exhibit high toxicity to these tumor

239 Pituitary LHRH-R mRNA and LHRH-R protein levels were not significa

240 rum LH and testosterone levels and pituitary LHRH-R in male rats are also decreased by high doses of

241 days on the expression of mRNA for pituitary LHRH receptor (LHRH-R) and the levels of LHRH-R protein

242 effect of Cetrorelix on serum LH, pituitary LHRH-R mRNA, and LHRH-R protein was greater than that of

243 esterone, and the concentration of pituitary LHRH receptors (LHRH-Rs) and their mRNA expression.

244 ix, inhibit the gene expression of pituitary LHRH-R indirectly, by counteracting the stimulatory effe

245 in vitro on the expression of the pituitary LHRH-R gene and its ability to counteract the exogenous

246 ined LHRH mRNA turnover in primary postnatal LHRH neurons maintained in long-term hypothalamic/preopt

247 generating cGMP and resulting in prepubertal LHRH release.

248 roscopy revealed that subsets of prepubertal LHRH neurons are endowed with alpha 1, alpha 2, beta 2/3

249 These data indicate that, in primary LHRH neurons, LHRH mRNA has an intrinsically high rate o

250 een of migrating versus nonmigrating primary LHRH neurons.

251 cotinic acetylcholine receptors and produced LHRH release via a mechanism that is different from the

252 f LH responses in female rats, while raising LHRH-R mRNA expression in female rats by 23% and LHRH-R

253 ression of mRNA for pituitary LHRH receptor (LHRH-R) and the levels of LHRH-R protein were evaluated

254 ary gonadotroph functions and LHRH-receptor (LHRH-R) expression are incompletely understood.

255 e concentration of pituitary LHRH receptors (LHRH-Rs) and their mRNA expression.

256 Decapeptyl microcapsules reduced LHRH-R mRNA expression in male pituitaries to 58% on day

257 l cell type of the median eminence, regulate LHRH release during the estrous cycle by undergoing plas

258 Relative LHRH mRNA content per cell was quantitated by single-cel

259 releasing hormone (LHRH) neurons to secrete LHRH, the neuropeptide controlling sexual development.

260 The hazard ratio showed LHRH agonists to be essentially equivalent to orchiectom

261 Both 50 and 250 microM MnCl2 stimulated LHRH release (P < 0.05 and P < 0.01, respectively).

262 ess the effect of the blockers on stimulated LHRH secretion.

263 Such LHRH cells expressed nestin mRNA but not Mash-1 mRNA and

264 Our results confirm that LHRH antagonists, such as cetrorelix, inhibit the gene e

265 al studies in rodents have demonstrated that LHRH neurons are innervated by GABA-containing processes

266 ll in peptide secretion, we hypothesize that LHRH mRNA levels rapidly decay.

267 The results indicate that LHRH neurons derived from the monkey olfactory placode p

268 Analysis of covariance showed that LHRH-agonist treatment resulted in an increase of 0.6 (9

269 y GABA-containing processes, suggesting that LHRH secretion is under direct transsynaptic GABAergic c

270 The LHRH receptor targeting DDS did not show in vivo pituita

271 The LHRH-IR perikarya were located mainly in the preopticose

272 of difference in overall survival among the LHRH agonists, although CIs were wider for leuprolide (h

273 hows a difference in effectiveness among the LHRH agonists.

274 tion of treatment was 3.5+/-0.9 years in the LHRH-agonist group and 2.1+/-1.2 years in the placebo gr

275 The principal adverse event in the LHRH-agonist group was decreased accretion of bone miner

276 or 0.1 nM triptorelin for 5 h increased the LHRH-R mRNA level by 77-88%.

277 tively allow or prevent direct access of the LHRH nerve terminals to the portal vasculature.

278 nhibited the migration of nearly half of the LHRH neuron population, without affecting the VNN tract

279 tration of cetrorelix and triptorelin on the LHRH-R mRNA level and gonadotropin secretion in ovariect

280 le rats, cetrorelix treatment suppressed the LHRH-R mRNA level by 33%, but triptorelin increased it b

281 ructural analysis would demonstrate that the LHRH system in the human hypothalamus is regulated by NP

282 viewed in relation to circulating LH titers, LHRH primary transcript levels were high prior to the st

283 Further visualization of afferents to LHRH neurons across the brain offers a unique opportunit

284 (LHRH), AN-207, binds with high affinity to LHRH receptors and can be targeted to tumors expressing

285 tification of neuronal networks connected to LHRH neurons.

286 tatory transsynaptic and astroglial input to LHRH neurons during sexual development.

287 caused by changes in trans-synaptic input to LHRH neurons.

288 ) was used as a targeting moiety (ligand) to LHRH receptors that are overexpressed in the plasma memb

289 together, there was no additive response to LHRH and the response was the same as to either compound

290 sed as the only systemic adjuvant treatment, LHRH agonists did not significantly reduce recurrence (2

291 an LH surge in response to E + P treatment, LHRH and AVPV neurons in males failed to show increased

292 ne-releasing hormone (LHRH) agonist, [D-Trp6]LHRH.

293 65% on days 10 and 30, respectively, whereas LHRH-R protein was 64% of control on day 10 and returned

294 nist increases adult height in children with LHRH-dependent precocious puberty and is prescribed by s

295 arged prostates alone or in combination with LHRH antagonists.

296 wed NPY-IR axon varicosities in contact with LHRH-IR perikarya and main dendrites.

297 In 17 of 20 cultures with LHRH-positive cells, [Ca(2+)](i) oscillations occurred s

298 s that is co-activated to express c-Fos with LHRH neurons at the time of the LH surge, the present st

299 reatment withdrawals were less frequent with LHRH agonists (0% to 4%) than with nonsteroidal antiandr

300 ond to stimulation of AMPARs and mGluRs with LHRH release, and this response is prevented by blocking