ライフサイエンスコーパス: LINE

1 LINE retrotransposons actively shape mammalian genomes.

2 LINE, ERE1 and mariner elements were present in the comm

3 LINE-1 (L1) elements are retrotransposons that insert ex

4 LINE-1 (L1) insertions comprise as much as 17% of the hu

5 LINE-1 (L1) retrotransposons are a noted source of genet

6 LINE-1 (L1) retrotransposons are mobile genetic elements

7 LINE-1 (L1) retrotransposons are mobile genetic elements

8 LINE-1 (L1) retrotransposons are the most abundant type

9 LINE-1 (L1) retrotransposons represent approximately one

10 LINE-1 (L1) retrotransposons represent one of the most s

11 LINE-1 (L1) retrotransposons represent the most abundant

12 LINE-1 (or L1) is an autonomous non-LTR retrotransposon

13 LINE-1 and AIM1 methylation status was assessed in paraf

14 LINE-1 and AluYb8 methylation levels were found to be si

15 LINE-1 elements represent a significant proportion of ma

16 LINE-1 expression damages host DNA via insertions and en

17 LINE-1 hypomethylation and AIM1 hypermethylation have pr

18 LINE-1 methylation was related to maternal RBC folate (P

19 LINE-1 protein expression is a common feature of many ty

20 LINE-1 retrotransposons are abundant repetitive elements

21 LINE-1 retrotransposons are fast-evolving mobile genetic

22 LINE-1 U-Index (hypomethylation) and AIM1 were analyzed

23 LINE-1 U-Index level was elevated with increasing Americ

24 LINE-1s are active human DNA parasites that are agents o

25 LINEs and SINEs are retrotransposons; that is, they tran

26 cluding long interspersed nuclear element 1 (LINE-1 or L1) and human endogenous retrovirus, accompani

27 Long Interspersed Element 1 (LINE-1 or L1) is capable of causing genomic instability

28 The long interspersed element 1 (LINE-1 or L1) ORF2 protein is the genomic source for RT

29 t for increased long-interspersed element 1 (LINE-1 or L1) retrotransposition.

30 Long interspersed element 1 (LINE-1 or L1) retrotransposons have generated one-third

31 Long interspersed element 1 (LINE-1 or L1) retrotransposons have markedly affected th

32 and the long interspersed nuclear element 1 (LINE-1) in genomic DNA extracted from whole blood in 913

33 AcMNPV FP25K to long interspersed element 1 (LINE-1) open reading frame 1 protein (ORF1p), which cont

34 and long interspersed nucleotide element 1 (LINE-1) retrotransposition.

35 of the long interspersed nuclear element 1 (LINE-1) retrotransposon and with aberrant expression of

36 ent over long interspersed repeat element 1 (LINE-1).

37 Long interspersed nuclear element 1 (LINE-1; L1) retrotransposons are the most common retroel

38 Long interspersed element-1 (LINE-1 or L1) retrotransposition continues to affect hum

39 ngineered human Long INterspersed Element-1 (LINE-1 or L1) retrotransposition in HeLa cells.

40 Long interspersed element-1 (LINE-1 or L1) retrotransposition is known to create mosa

41 Long INterspersed Element-1 (LINE-1 or L1) retrotransposition poses a mutagenic threa

42 Long interspersed element-1 (LINE-1 or L1) retrotransposons account for nearly 17% of

43 Long interspersed nuclear element-1 (LINE-1 or L1) retrotransposons comprise a large fraction

44 Long interspersed element-1 (LINE-1 or L1) retrotransposons encode two proteins (ORF1

45 e (i.e., "hot") long interspersed element-1 (LINE-1 or L1) sequences comprise the bulk of retrotransp

46 s in long interspersed nucleotide element-1 (LINE-1) and absent in melanoma-1 (AIM1; 6q21) associated

47 vels of long interspersed nuclear element-1 (LINE-1) and the Alu element AluYb8 were determined in 38

48 active long interspersed nuclear element-1 (LINE-1) lacked CW methylations but not CG methylations.

49 f human long interspersed nuclear element-1 (LINE-1) quantitive real-time PCR.

50 port widespread long interspersed element-1 (LINE-1) repeat expression in human cancers.

51 and long interspersed nucleotide element-1 (LINE-1).

52 osons including Long Interspersed Element-1 (LINE-1).

53 Long interspersed element-1 (LINE-1, also known as L1), the only currently autonomous

54 fy and sequence long interspersed element-1 (LINE-1, L1) retrotransposon insertions selectively in th

55 F1p, encoded by long interspersed element-1 (LINE-1; L1) retrotransposon, in PDAC.

56 Long interspersed nuclear elements-1 (LINE-1 or L1s) are abundant retrotransposons that compri

57 predicted to mediate CNVs and identified 25 LINE-LINE rearrangements.

58 f all human cancers are immunoreactive for a LINE-1-encoded protein.

59 For the new version of L1Base, a LINE-1 annotation tool, L1Xplorer, has been used to mine

60 DNA hypomethylation of a LINE retrotransposon related to rice Karma, in the intro

61 his process in humans is the highly abundant LINE-1 (L1) element.

62 y reported that in cancer, aberrantly active LINE-1 promoters can drive transcription of flanking uni

63 The currently active LINE-1 (L1) codes for two proteins (ORF1p and ORF2p), bo

64 d with few exceptions there is a sole active LINE family (L1).

65 ltavif, while not affecting activity against LINE-1 retrotransposition.

66 APOBEC2, had no detectable activity against LINE-1.

67 y cytoplasmic A3G, which is inactive against LINE-1 retrotransposition, the A3G/B protein, while loca

68 nterspersed repetitive elements such as Alu, LINE, long-terminal repeats and simple tandem repeats ar

69 The type and position of Alu/LINE repeats are also different at each breakpoint.

70 Retrotransposition amplifies LINE-1 (L1) to high copy number in mammalian genomes.

71 rth: IGF2 (P = 0.038), PEG3 (P < 0.001), and LINE-1 (P < 0.001).

72 d methylator phenotype-high (P = 0.013), and LINE-1 hypomethylation (P = 0.017).

73 3 (-0.5%; 95% CI: -0.9, -0.1; P = 0.018) and LINE-1 (-0.3%; 95% CI: -0.6, -0.04; P = 0.029).

74 18), KRAS mutation (OR = 0.66; P = .40), and LINE-1 hypomethylation (for a 30% decrease; OR = 1.92; P

75 retrotransposition, often involving AluY and LINE elements.

76 roteins from a representative set of DNA and LINE transposable elements and used the obtained structu

77 Mov10l1(-/-) mice show activation of LTR and LINE-1 retrotransposons, followed by cell death, causing

78 vels and derepression of endogenous LTR- and LINE-repetitive DNA elements during differentiation of m

79 on of the histone methyltransferase MLL5 and LINE-1 elements transposons.

80 dependent hypomethylation of D4Z4, NBL2, and LINE-1 repetitive DNA sequences; up-regulation of H19, I

81 lator phenotype, and KRAS, BRAF, PIK3CA, and LINE-1 methylation.

82 repeats, such as endogenous retroviruses and LINE-1 elements.

83 t nucleosomes containing methylated SINE and LINE elements and CpG islands are the main sites of DNMT

84 one genes have a lower frequency of SINE and LINE retrotransposons near their transcription start sit

85 ecting hypomethylation hot spots of LTRs and LINEs.

86 ution of SCOP classes in DNA transposons and LINEs indicates that the proteins of DNA transposons are

87 erminants of A3A deaminase activity and anti-LINE-1 activity are not the same.

88 ng interspersed element-1 (L1, also known as LINE-1) transposons.

89 , whereas several repeated elements, such as LINE 2, and several LTR elements, are hypomethylated in

90 some human endogenous retroviruses, such as LINE-1 and Alu retrotransposon elements, in tumour micro

91 es which vary substantially in size, such as LINE-1 repeats.

92 viruses and endogenous retroelements such as LINE-1, but it can also edit genomic DNA, which may play

93 -1Deltavif, and HTLV-1 infection, as well as LINE-1 retrotransposition.

94 ation status of repetitive elements, such as LINEs, in the human genome, thereby revealing the strong

95 -Hydroxymethylcytosine was found enriched at LINE-1 prior to a decrease in both 5-hydroxymethylcytosi

96 BOTTOM LINE Compared with serodiscordant couples without treatm

97 BOTTOM LINE Continuous macrolide antibiotic use for prophylaxis

98 BOTTOM LINE Weak opioids (such as codeine, dextropropoxyphene,

99 ments (LINE-1 or L1) and sequences copied by LINE-1 remain mobile in our species today.

100 is mediated primarily by proteins encoded by LINE-1 (L1) retrotransposons, which mobilize in pluripot

101 on of RNA molecules into the human genome by LINE retrotransposons, contributing to the approximately

102 identified 516 CNVs potentially mediated by LINEs.

103 CAlifornia LINE Source Dispersion Modeling, version 4 (CALINE4) was

104 KRAS, BRAF, PIK3CA, p53, p21, beta-catenin, LINE-1 hypomethylation, microsatellite instability (MSI)

105 r to be significantly modified by MSI, CIMP, LINE-1, or the other clinical and molecular variables ex

106 not reveal LINE patterns predicted by common LINE-mediated duplication mechanisms.

107 classified into two types: those containing LINE transposable elements and those containing segmenta

108 d TEs under darkness were enriched in Copia, LINE, and MuDR dispersed across chromosomes.

109 Mili mutants derepress LINE-1 (L1) and intracisternal A particle and lose DNA m

110 and sublineages of cells marked by different LINE-1 (L1) retrotransposition events and subsequent mut

111 r and provide evidence for how the different LINE and SINE subfamilies evolved in these species.

112 upregulated neuronal genes or downregulated LINE transposon expression.

113 TETs drive LINE-1 demethylation, but surprisingly, LINE-1s are kept

114 sequences including segmental duplications, LINE, SINE, and LTR elements.

115 on-autonomous non-LTR retrotransposons, i.e. LINEs and SINEs, and with few exceptions there is a sole

116 of these genes and of the repetitive element LINE-1 in 30 patients with AML, both at diagnosis and re

117 bution of BovB, a long interspersed element (LINE) about 3.2 kb long, that has been found in ruminant

118 e distribution of long interspersed element (LINE) retrotransposon and their potential to mediate NAH

119 nts are a type of long interspersed element (LINE) that is dispersed at high copy numbers within most

120 chment of long interspersed nuclear element (LINE) and long terminal repeat (LTR) retroposons.

121 ansposon, long interspersed nuclear element (LINE) and short interspersed nuclear element (SINE) inse

122 aralogous long interspersed nuclear element (LINE) or human endogenous retrovirus (HERV) repeats as a

123 ession of long interspersed nuclear element (LINE) sequences in Cstf2t(-/-) testes.

124 ts [e.g., long interspersed nuclear element (LINE)-1 repeats] were further confirmed by the increased

125 the most long interspersed nuclear element (LINE)-dense regions of mammalian genomes.

126 The long interspersed nuclear element (LINE-1) (L1) clade of non-LTR retrotransposons has been

127 logous to a repetitive transposable element (LINE; long interspersed nuclear element).

128 Of these, only long interspersed elements (LINE-1 or L1) and sequences copied by LINE-1 remain mobi

129 Long INterspersed Elements (LINE-1s, L1s) are responsible for over one million retro

130 INE) and long interspersed nuclear elements (LINE), but not in long terminal repeats (LTR).

131 ution of long interspersed nuclear elements (LINE)-1 (L1) along mouse autosomes at a 1-Mb scale, and

132 revealed long interspersed nuclear elements (LINE-1) flanking the rearranged segment and a DNA repair

133 sites in long interspersed nuclear elements (LINE-1) retrotransposons, resulting in increased LINE-1

134 ation of long interspersed nuclear elements (LINE; R = 0.94, P < .001), but not with LINE methylation

135 wo types of TEs: long interspersed elements (LINEs) and short interspersed elements (SINEs).

136 lements (SINEs), long interspersed elements (LINEs), and long terminal repeat (LTR) retroelements, wh

137 Long interspersed elements (LINEs), through both self-mobilization and trans-mobiliz

138 (SINEs), long interspersed nuclear elements (LINEs) and the endogenous retrovirus (ERV) superfamily.

139 ation on long interspersed nuclear elements (LINEs) in germ cells.

140 res, and long interspersed nuclear elements (LINEs) to the neutrophil nuclear lamina.

141 such as long interspersed nuclear elements (LINEs).

142 sposable long interspersed nuclear elements (LINEs).

143 dance of long interspersed nuclear elements (LINEs)/short interspersed nuclear elements (SINEs).

144 asses and subclasses of repetitive elements (LINEs, endogenous retroviruses, DNA transposons, simple

145 1 occurs frequently in cancer and can enable LINE-1 mobilization but also has retrotransposition-inde

146 Finally, ORF0 enhances LINE-1 mobility.

147 utionarily stable V1R loci are exceptionally LINE-rich compared to other genome loci, including loci

148 We find that V1R loci are exceptionally LINE-rich compared to other regions of similar AT base c

149 w into the DNA of mammalian cells expressing LINE-1-like elements.

150 ovel retrotransposition-independent role for LINE-1 elements in malignancy.

151 Because recent reports suggest frequent LINE-1 (L1) retrotransposition in human brains, we perfo

152 Accumulated ssDNAs are derived from LINE-1 endogenous retroelements, providing new clues as

153 ts, while possible enrichment for functional LINE-1 ORFs is weaker.

154 ignment of replication timing to isochore GC/LINE-1 content.

155 Genomic features mirror those of germline LINE element retrotranspositions, with frequent target-s

156 ounced for certain members of the SVA, HERV, LINE-1P, AluY, and MaLR families.

157 When analyzed, high LINE-1 U-Index and/or AIM1 methylation in melanomas were

158 We discuss how LINEs and SINEs have expanded in eukaryotic genomes and

159 Although human LINE-1 (L1) elements are actively mobilized in many canc

160 ), impaired the mobility of engineered human LINE-1 (L1) and mouse intracisternal A-type particle ret

161 The antisense promoter of human LINE-1 (L1) retroelements can direct transcription of ad

162 rame, ORF0, on the antisense strand of human LINE-1 encoding a small regulatory protein.

163 , immunization of rhesus macaques with human LINE-1 open reading frame 2 (96% identity with macaque),

164 sites in p16 (n = 7) and p53 (n = 4), and in LINE-1 and Alu repetitive elements (3 CpG sites in each)

165 ors samples were analyzed for methylation in LINE-1 and 16 CpG islands (CACNA1G, CDKN2A [p16], CRABP1

166 Methylation in LINE-1 increased by 1.36% [95% confidence interval (CI):

167 ositively associated with DNA methylation in LINE-1 repeated elements, and to a lesser degree at CpG

168 derstanding of the requirements for ORF1p in LINE-1 retrotransposition and, more generally, nucleic a

169 Repetitive elements, including LINE-1 (L1), comprise approximately half of the human ge

170 y of repeat sequences (C0T-1 RNA), including LINE-1.

171 -1) retrotransposons, resulting in increased LINE-1 mRNA.

172 Finally, we show that individual LINE repeats of a given age at V1R, V2R, and OR loci exh

173 e 1 (HTLV-1), while significantly inhibiting LINE-1 retrotransposition.

174 posons considered here are group II introns, LINEs and SINEs, whereas the EP elements considered are

175 s catalytic domain and was important for its LINE-1 suppression.

176 The L1 (LINE 1) retrotransposable element encodes two proteins,

177 Although members of the L1 (LINE-1) clade of non-LTR retrotransposons can be deleter

178 mon repetitive elements, including L1 and L2 LINEs, and DNA motifs that are significantly enriched ar

179 As young full-length LINE-1 transposons are strongly enriched on the X chromo

180 t human A3H is a potent inhibitor of non-LTR LINE-1 transposition.

181 Retrotransposons, mainly LINEs, SINEs, and endogenous retroviruses, make up rough

182 A codon-optimized mouse LINE-1 element, ORFeus, exhibits dramatically higher ret

183 phenotype, microsatellite instability (MSI), LINE-1 hypomethylation, and p53, CIMP, KRAS and BRAF mut

184 g, A3A inhibited the accumulation of nascent LINE-1 DNA, suggesting interference with LINE-1 reverse

185 New LINE-1 insertions are thought to accumulate mostly durin

186 tromeric and pericentromeric repeats but not LINE-1 elements to the lamina.

187 arly identical active transposons, two novel LINE insertions of identity approximately 99% and length

188 Finally, a greater accumulation of LINE-1 was found in mice that lack IFNAR1 compared with

189 Our findings implicate activation of LINE-1 elements in subsequent epigenetic remodelling of

190 Activation of LINE-1 occurs frequently in cancer and can enable LINE-1

191 Our data suggest that activation of LINE-1 regulates global chromatin accessibility at the b

192 onal experiments revealed that activation of LINE-1 retrotransposons increases the expression of IFNb

193 sely correlated with the evolutionary age of LINE-1 transposons; its deposition is strongly enriched

194 DNA methylation as determined by analysis of LINE-1 repeat elements.

195 rs displayed a significantly lower degree of LINE-1 methylation, a marker for global methylation, tha

196 ed V1R gene blocks are generally depleted of LINE elements, suggesting that these loci did not become

197 Polycomb sites are depleted of LINE repeats but enriched for SINEs and simple repeats.

198 Furthermore, the efficacy of LINE-1 replication was increased in isogenic cell lines

199 were lineage specific, and the enrichment of LINE/L1 and long term repeat/Copia elements in lineage 3

200 her confirmed by the increased expression of LINE-1 retrotransposon-associated repetitive elements in

201 are a previously unseen alternative fate of LINE retrotransposition, and may represent an unexpected

202 SVA insertions display all the hallmarks of LINE-1 retrotransposition and some contain 5' and 3' tra

203 Here, we demonstrate inhibition of LINE-1 by multiple human APOBEC3 cytidine deaminases, in

204 Methylation levels of LINE-1 (Spearman r = 0.82; P = .0072) and CpG island met

205 Although the mechanism of LINE-1 restriction did not seem to involve DNA editing,

206 The current model of LINE retrotransposition, target-primed reverse transcrip

207 /or integration or intracellular movement of LINE-1 ribonucleoprotein.

208 the reporter genes, whereas the presence of LINE in P2 or gypsy LTR retrotransposon in P3 reduced ex

209 d E. dispar share their entire repertoire of LINE and SINE retrotransposons and that Eh_SINE3/Ed_SINE

210 cells with IFN suppressed the replication of LINE-1.

211 placing 82.8% of the human genome at risk of LINE-LINE-mediated instability.

212 To additionally assess the scale of LINE-LINE/NAHR phenomenon in the human genome, we tested

213 contains annotated full-length sequences of LINE-1 transposons including putatively active L1s.

214 We demonstrate that premature silencing of LINE-1 elements decreases chromatin accessibility, where

215 e identification of two novel subfamilies of LINE and SINE retrotransposons in E. dispar and provide

216 nsertions of the human-specific subfamily of LINE-1 (L1) retrotransposon are highly polymorphic acros

217 , while in tumor cells, a specific subset of LINE-1 retrotransposons that arose during primate evolut

218 The predominant tissue of LINE-1 expression has been considered to be the germ lin

219 a selective increase in the transcription of LINE-1 and L1PA2 retroelements upon knockdown of URI.

220 nal data point to guide our understanding of LINE dynamics in eutherians.

221 The dual role of TET action on LINE-1s may reflect the evolutionary battle between TEs

222 Long INterspersed Element one (LINE-1, or L1), is a widely distributed, autonomous retr

223 Methylation of the control IL-2 Site7 or LINE-1 was not a significant predictor of asthma exacerb

224 We identified 17 005 directly oriented LINE pairs located <10 Mbp from each other as potential

225 Disruption of the repressive chromatin over LINE-1 elements in DTPs results in DTP ablation, which i

226 c impact of retrotransposons, in particular, LINE-1(L1) and Alu elements; however, no such assay exis

227 in repeat element methylation, particularly LINE-1, between ERG gene fusion-positive and -negative c

228 tenin, p53, CpG island methylator phenotype, LINE-1 methylation, and John Cunningham (JC) virus T ant

229 bility; the CpG island methylator phenotype; LINE-1 methylation; and KRAS, BRAF, and PIK3CA mutations

230 Preventing LINE-1 activation and interfering with its silencing dec

231 statistics reveals that a subset of primate LINE-1 elements is demethylated preferentially in tumors

232 Here, we show that the primate LINE-1 5'UTR contains a primate-specific open reading fr

233 he ability of dispersion (CALINE4, AERMOD, R-LINE, and QUIC) and regression models to predict PNC in

234 Recently, LINE-1 genomic repeat elements have been proposed as pot

235 The ability of A3A to recognize LINE-1 RNA required its catalytic domain and was importa

236 tion, which is partially rescued by reducing LINE-1 expression or function.

237 global methylation, using repetitive region LINE-1 and ALUYb8 sequences.

238 ers, demethylation of genome-wide repetitive LINE-1 elements, and hypermethylation in specific promot

239 d IFN plays an important role in restricting LINE-1 propagation and discuss the putative role of IFN

240 The retrotransposon LINE-1 (long interspersed element 1, L1) is a transposab

241 We now implicate retrotransposons LINE-1 (L1), activated during epigenetic reprogramming o

242 -chip) to map human L1(Ta) retrotransposons (LINE-1 s) genome-wide.

243 of specific V1R duplications does not reveal LINE patterns predicted by common LINE-mediated duplicat

244 These include simple repeats, satellites, LINEs, and endogenous retroviruses as well as transposon

245 As part of the randomised open-label SECOND-LINE trial, second-line ART NtRTI selection was made by

246 Results of the 96 week SECOND-LINE randomised trial showed that NtRTI-sparing ART with

247 e DNA, we used a targeted method to sequence LINE-1 insertion sites in matched PDAC and normal sample

248 partners with MIWI2 to specifically silence LINE-1 transposons in the fetal germline of male mice.

249 polymorphisms and repetitive elements (SINE, LINE, etc.) have also been incorporated.

250 h other types of transposed elements (SINEs, LINEs, LTRs), even unannotated sequence to form potentia

251 Somatic LINE-1 (L1) retrotransposition during neurogenesis is a

252 We found evidence of 465 somatic LINE-1 insertions in 20 PDAC genomes, which were absent

253 recent study reported high rates of somatic LINE-1 element (L1) retrotransposition in the hippocampu

254 to genetic changes in cancers, with somatic LINE-1 insertions seen in selected types of human cancer

255 he ages of two subfamilies of human-specific LINE-I insertions using both estimation procedures.

256 3' untranslated region of a primate-specific LINE-1 (long interspersed nuclear element 1) retrotransp

257 he IFN receptor chain IFNAR1 also stimulated LINE-1 propagation in vitro.

258 correlates with epigenetic silencing of such LINE-1 transposons, together with their neighbouring enh

259 rive LINE-1 demethylation, but surprisingly, LINE-1s are kept repressed through additional TET-depend

260 atin marks in the 5' sequence of a synthetic LINE-1 element.

261 iduals on a custom aCGH microarray targeting LINE elements predicted to mediate CNVs and identified 2

262 In the adult Mael(-/-) testes, LINE-1 (L1) derepression occurred at the onset of meiosi

263 A new study provides evidence that LINE-1 retrotransposons regulate chromatin dynamics and

264 open reading frame 1 protein, and found that LINE-1 open reading frame 1 protein is a surprisingly br

265 Our data indicate that LINE-LINE-mediated NAHR is widespread and under-recogniz

266 We propose that LINE-1-induced IFN plays an important role in restrictin

267 Together, our findings show that LINE-1 contributes to the genetic evolution of PDAC and

268 Studies have shown that LINE-1 contributes to genetic changes in cancers, with s

269 Thus, these data suggest that LINE-1 retrotransposition events may occur during early

270 the LINE-1 transcript, thus suggesting that LINE-1 functions primarily at the chromatin level.

271 An emerging body of evidence indicates that LINEs and SINEs function to regulate gene expression by

272 We speculate that LINEs at V1R, V2R, and OR loci might be selectively reta

273 The LINE-1 U-Index of melanoma (n = 100) was significantly h

274 ctivation-induced cytidine deaminase and the LINE-1 repeat-encoded ORF2 endonuclease.

275 -) placentas and that protein encoded by the LINE-1 retrotransposon is upregulated in hypomethylated

276 of IL-2 (IL-2 Site7) and methylation of the LINE-1 repetitive element.

277 evels were assessed by pyrosequencing of the LINE-1 retroelement promoter in DNA from 55 salivary gla

278 es independently of the coding nature of the LINE-1 transcript, thus suggesting that LINE-1 functions

279 late this observation with expression of the LINE-1-encoded protein, open reading frame 1 protein, an

280 P1 acts as an enhancer in contrast with the LINE in P2 and the gypsy LTR retrotransposon in P3 which

281 V breakpoints in each patient map within the LINE elements.

282 oci, suggesting a reduced tendency for these LINEs to be disrupted.

283 hat the SIN3A co-repressive complex binds to LINE-1s, ensuring their repression in a TET1-dependent m

284 mal ros sequences accurately corresponded to LINE; retrotransposon insertion sites in ribosomal DNA (

285 neuroendocrine-associated genes proximal to LINE-1 insertions.

286 of flanking unique sequences giving rise to LINE-1 chimeric transcripts (LCTs).

287 We utilized a transgenic LINE-1 mouse model and tracked DNA methylation dynamics

288 full-length elements of actively transposing LINE families, demonstrating the remarkable ability of t

289 Furthermore, serum unmethylated LINE-1 was at higher levels in both stage III (n = 20) a

290 To test whether LINE-1 expression leads to somatic insertions of this mo

291 tigate an adaptive selection model, in which LINEs have contributed to expansions of mouse V1R repert

292 ext, we investigate neutral models, in which LINEs were tolerated by, but not advantageous for, surro

293 sociated with gene pair rearrangement, while LINEs are associated with gene deletions.

294 the centromeres, and is not correlated with LINE depletion.

295 ent LINE-1 DNA, suggesting interference with LINE-1 reverse transcription and/or integration or intra

296 ely at canonical GT-AG splice junctions with LINE and SINE elements forming the most RE splice juncti

297 nts (LINE; R = 0.94, P < .001), but not with LINE methylation or DNA methyltransferase 1 (DNMT1), 3a,

298 e loci did not become densely populated with LINEs simply as a consequence of targeted integration or

299 5' UTR of full-length, evolutionarily young LINE-1 elements, a pattern that is conserved in human ES

300 ivered into ECs by mouse L1s and a zebrafish LINE-2 element, but not when similar reporter genes were