ライフサイエンスコーパス: LIP

1 LIP Fano factor changes are behaviorally significant: in

2 LIP has been associated with the development of inflamma

3 LIP neurons have recently been reported to inaccurately

4 LIP responses during fixation are thought to represent a

5 LIP responses recapitulated MT early weighting and conta

6 LIP ultrasound treatment was performed daily with triple

7 LIP up-regulated the transcription of CXCR4 through dire

8 LIP-expressing C/EBP beta(-/-) MEFs showed enhanced ER s

9 LIP-pursuit correlations were spatially specific and wer

10 deficiencies in the 45RAGKO mice that affect LIP.

11 inear bottom-up integrative mechanisms allow LIP neurons to emphasize task-relevant spatial and non-s

12 Although LIP inactivation did not impair psychophysical behaviour

13 Anatomically, LIP consists of a dorsal and ventral subdivision, but th

14 presenting instantaneous motion evidence and LIP reflecting the accumulated evidence.

15 %SAT, circulating hepcidin, and LIP in macrophages correlate with disease severity and %

16 ding three protein isoforms--LAP1, LAP2, and LIP.

17 In groups LIP and LIP/PROB, the mandibular right first molar of the animal

18 mation is directed to parietal areas MIP and LIP during decision formation.

19 tant deviations from idealizations of MT and LIP and motivate inquiry into sensorimotor computations

20 lyses of the simultaneous activity of MT and LIP during individual decisions.

21 mputations that may intervene between MT and LIP.

22 In groups PROB and LIP/PROB, the PROB was administered orally by addition t

23 nto four groups: control (C), LIP, PROB, and LIP/PROB.

24 show that salience--measured in saccades and LIP responses--was enhanced by both novelty and positive

25 Area LIP neurons that do not fire coherently do not predict R

26 d signals in posterior parietal cortex (area LIP).

27 Neuronal recordings from area LIP revealed two main findings.

28 ed the discharge activity of neurons in area LIP and the parietal reach region (PRR) of the parietal

29 Neurons in area LIP exhibited firing rate patterns that directly resembl

30 idence that eye-position gain fields in area LIP remain spatially inaccurate for some time after a sa

31 ss-adaptation may occur in a homolog of area LIP.

32 h, we identify a population of parietal area LIP neurons that fire spikes coherently with 15 Hz beta-

33 Although the lateral intraparietal area (LIP) and frontal eye field (FEF) are known to represent

34 sulcus (FST) and lateral intraparietal area (LIP) and the animals correctly located the stimuli in a

35 in fields in the lateral intraparietal area (LIP) are unreliable.

36 e neurons in the lateral intraparietal area (LIP) exhibit anticipatory remapping: these neurons produ

37 The lateral intraparietal area (LIP) has been implicated as a salience map for control o

38 The macaque lateral intraparietal area (LIP) has been implicated in both processes, but numerous

39 its, the primate lateral intraparietal area (LIP) has been interpreted as a priority map for saccades

40 responses in the lateral intraparietal area (LIP) have received extensive study for insight into deci

41 (dlPFC) and the lateral intraparietal area (LIP) in monkeys using a memory saccade task in which a s

42 The lateral intraparietal area (LIP) in the macaque contains a priority-based representa

43 ce in the monkey lateral intraparietal area (LIP) in ways that are independent of expected reward.

44 othesis that the lateral intraparietal area (LIP) integrates disparate task-relevant visual features

45 The lateral intraparietal area (LIP) is essential for this process.

46 t neurons in the lateral intraparietal area (LIP) of Macaca mulatta reflect learned associations betw

47 ields (FEFs) and lateral intraparietal area (LIP) of macaques are preferentially activated by saccade

48 ggested that the lateral intraparietal area (LIP) of macaques plays a fundamental role in sensorimoto

49 f neurons in the lateral intraparietal area (LIP) of rhesus monkeys performing this task.

50 ivity in macaque lateral intraparietal area (LIP) provides a useful window into this process.

51 , neurons in the lateral intraparietal area (LIP) reflect learned associations between visual stimuli

52 f neurons in the lateral intraparietal area (LIP) reflected the accumulation of logLR and reached a s

53 , neurons in the lateral intraparietal area (LIP) represent the accumulation of evidence bearing on t

54 activity in the lateral intraparietal area (LIP) represents the gradual accumulation of evidence tow

55 ecordings in the lateral intraparietal area (LIP) reveal that parietal cortex encodes variables relat

56 y earlier in the lateral intraparietal area (LIP) than in an anatomically connected lower visual area

57 f neurons in the lateral intraparietal area (LIP) to a task-irrelevant distractor are strongly suppre

58 s in the macaque lateral intraparietal area (LIP) using histological, electrophysiological, and neuro

59 neurons from the lateral intraparietal area (LIP), a cortical node in the NHP saccade system.

60 we focus on the lateral intraparietal area (LIP), an area that has been shown to play independent ro

61 eye field (FEF), lateral intraparietal area (LIP), and cuneus support early covert targeting of the c

62 ordings from the lateral intraparietal area (LIP), during a perceptual decision-making task.

63 ral cortex (IT), lateral intraparietal area (LIP), prefrontal cortex (PFC), and frontal eye fields (F

64 e neurons in the lateral intraparietal area (LIP), which has been implicated in the planning and exec

65 activity in the lateral intraparietal area (LIP), which is thought to represent the relative value o

66 ctivation of the lateral intraparietal area (LIP), which plays a role in the selection of eye movemen

67 decisions in the lateral intraparietal area (LIP).

68 entations in the lateral intraparietal area (LIP).

69 y of the primate lateral intraparietal area (LIP).

70 parietal sulcus [lateral intraparietal area (LIP)] specifically biased choices made using eye movemen

71 al cortex [human lateral intraparietal area (LIP)], the anterior cingulate cortex (ACC) was specifica

72 the lateral and ventral intraparietal areas (LIP; VIP), the middle temporal area (MT), and the medial

73 city, naive pmel-1 cells were inefficient at LIP in typical lymphopenic hosts.

74 Because LIP cells are (1) highly responsive to the presence of a

75 xtrinsic saliency are signaled in FEF before LIP.

76 A significant positive correlation between LIP and CXCR4 expression was observed in stage III and I

77 escribe dynamic temporal hierarchies between LIP and FEF: stimuli carrying the highest intrinsic sali

78 However, this link between LIP response and decision formation emerged from studies

79 Here, we focus on the relationship between LIP responses and known sensory and motor events in perc

80 dependent innate lymphoid cells (ILCs) block LIP of CD8(+) T cells in neonatal but not adult mice.

81 ne with previous studies, we found that both LIP and PRR encode a reward-based decision variable, the

82 ex (human 7a), which has connections to both LIP and ACC, was activated by surprise and modulated by

83 cluding their variability, were explained by LIP activity in the context of accumulation of logLR to

84 l intestine from reactive changes induced by LIP.

85 e highest intrinsic saliency are signaled by LIP before FEF, whereas stimuli carrying the highest ext

86 domly divided into four groups: control (C), LIP, PROB, and LIP/PROB.

87 In view of the positive effect of CHOP-LIP interaction in mediating their proapoptotic function

88 interplay between physiology and cognition, LIP has served as fertile ground for developing quantita

89 e roles of other parietal areas by comparing LIP and the medial intraparietal area (MIP) during a vis

90 Herein we review factors controlling LIP, including coinhibitory molecules and other attenuat

91 ions are distributed across parietal cortex, LIP and MIP play distinct roles: LIP appears more involv

92 f late expression, and upon differentiation, LIP levels are significantly reduced, allowing LAP-media

93 elds (RFs), dynamics of the high-dimensional LIP network during slowly varying activity lie predomina

94 alized in rostral LIPv rather than in dorsal LIP (LIPd) as previous experiments had suggested.

95 ease-predisposing cofactor is present during LIP.

96 Overexpression of C/EBPbeta-LIP above levels of CaM also initiates liver proliferati

97 C/EBPbeta-LIP also disrupts Rb-E2F1 complexes in C/EBPalpha-S193D

98 ese growth promotion activities of C/EBPbeta-LIP and, therefore, supports liver quiescence.

99 However, high levels of C/EBPbeta-LIP are also observed in non-proliferating livers during

100 for molecular mechanisms by which C/EBPbeta-LIP promotes cell proliferation, we found that C/EBPbeta

101 cell proliferation, we found that C/EBPbeta-LIP releases E2F.Rb-dependent repression of cell cycle g

102 ulin (CaM) inhibits the ability of C/EBPbeta-LIP to promote liver proliferation during APR through di

103 se of a dominant negative isoform, C/EBPbeta-LIP, and subsequent repression of C/EBPalpha, FXR, and T

104 A truncated isoform of C/EBPbeta, C/EBPbeta-LIP, is required for liver proliferation.

105 rotein isoforms C/EBPalpha-p30 and C/EBPbeta-LIP, which is controlled by a single cis-regulatory upst

106 er proliferation via activation of C/EBPbeta-LIP.

107 hich liver regulates activities of C/EBPbeta-LIP.

108 Following LIP, pmel-1 T cells acquired the capacity to control B16

109 Our petrological model for LIP magmatism argues that initial gas emission was domin

110 A negative-binomial model for LIP spike counts captures these findings quantitatively,

111 represent a novel costimulatory pathway for LIP.

112 -CHOP interaction has a stabilizing role for LIP.

113 which they made saccades toward or away from LIP response fields (RFs).

114 We recorded from LIP neurons during performance of a task that required m

115 To test this, we recorded from LIP while monkeys performed a motion discrimination task

116 k-relevant visual features by recording from LIP neurons in monkeys trained to identify target stimul

117 ignificantly higher than the ones from group LIP (VH: 672.1 +/- 83.3 microm and 528.0 +/- 51.7 microm

118 L and ABL were significantly higher in group LIP compared with group LIP/PROB (AL: 3.05 +/- 0.57 mm a

119 In group LIP/PROB, the mean values of VH and CD of the jejunum we

120 ntly higher in group LIP compared with group LIP/PROB (AL: 3.05 +/- 0.57 mm and 1.78 +/- 0.63 mm, res

121 In groups LIP and LIP/PROB, the mandibular right first molar of th

122 d relative to macaque monkeys, so that human LIP paradoxically ends up medial to human VIP.

123 Both F5 and OT-I LIP responses were most accurately described by a single

124 e recorded single neuron spiking activity in LIP during a well-studied moving-dot direction-discrimin

125 We propose that activity in LIP represents attentional priority and that the downstr

126 Test-period activity in LIP showed category encoding and distinguished between m

127 We examined the neural code in LIP at the level of individual spike trains using a stat

128 ally, the target desirability was encoded in LIP at least twice as strongly when choices were made us

129 pected, we found strong category encoding in LIP.

130 relevant spatial and non-spatial features in LIP remain unclear.

131 psychophysical performance, inactivation in LIP had no measurable impact on decision-making performa

132 spatial signals are encoded independently in LIP and underscores the role of parietal cortex in nonsp

133 onger and appeared with a shorter latency in LIP than MIP.

134 dea that value-based decisions take place in LIP neurons.

135 strong evidence for retinotopic remapping in LIP and face-centered remapping in VIP, and weaker evide

136 The polar angle representation in LIP extends from regions near the upper vertical meridia

137 d understanding of neural representations in LIP and a framework for studying the coding of multiplex

138 he flexibility of feature representations in LIP reflect the bottom-up integration of sensory signals

139 In sum, neural responses in LIP simultaneously carry decision signals and decision-i

140 We examined single-trial responses in LIP using statistical methods for fitting and comparing

141 ink the encoding of saccades and saliency in LIP to modulation of several other sensory-motor behavio

142 Thus, decision-related signals in LIP do not appear to be critical for computing perceptua

143 fluence robustly encoded category signals in LIP.

144 Furthermore, trial-by-trial variability in LIP did not depend on MT activity.

145 We reversibly inactivated LIP while monkeys performed memory-guided saccades and r

146 cer cells, and this coincided with increased LIP binding on the CXCR4 promoter.

147 Individual LIP neurons might encode associations only for specific

148 d that optimal decoding requires integrating LIP spikes over two distinct timescales.

149 Intracellular LIP indices were significantly elevated in the subsets o

150 ibly inactivating the lateral intraparietal (LIP) and middle temporal (MT) areas of rhesus macaques p

151 ronal activity in the lateral intraparietal (LIP) area and PFC in monkeys performing a visual motion

152 atial encoding in the lateral intraparietal (LIP) area by training monkeys to perform a visual catego

153 eurons in the macaque lateral intraparietal (LIP) area exhibit firing rates that appear to ramp upwar

154 motor regions such as lateral intraparietal (LIP) area in perceptual decision making.

155 across neurons in the lateral intraparietal (LIP) area of the posterior parietal cortex.

156 dle temporal (MT) and lateral intraparietal (LIP) areas appear to map onto theoretically defined quan

157 neurons in the monkey lateral intraparietal (LIP) cortical area encode only cue salience, and not act

158 Lateral intraparietal (LIP) neurons encode a vast array of sensory and cognitiv

159 ccadic eye movements, lateral intraparietal (LIP) neurons representing each saccade fire at a rate pr

160 how that the bZIP protein C/EBP beta isoform LIP is required for nuclear translocation of CHOP during

161 large isoform (LAP-2) and the small isoform (LIP) of C/EBP-beta can exert suppressive function for mi

162 for the topographic organization of macaque LIP that complements the results of previous electrophys

163 higher brain fluorescence intensity and MAN-LIP relatively concentrated in the cerebellum and cerebr

164 onjugated onto the surface of liposomes (MAN-LIP) to enhance the brain delivery.

165 relationship between the distribution of MAN-LIP and glucose transporters (GLUTs) on the cells.

166 e investigated the brain distribution of MAN-LIP based on our previous studies and tried to explore t

167 osis by GLUT1 and GLUT3 was a pathway of MAN-LIP into brain, and the special brain distribution of MA

168 n, and the special brain distribution of MAN-LIP was closely related to the non-homogeneous distribut

169 ted that the transendothelial ability of MAN-LIP was much stronger when crossing LV-GLUT1/bEND.3 cell

170 metry showed that the cellular uptake of MAN-LIP was significantly improved by GLUT1 and GLUT3 overex

171 The mice administered with MAN-LIP had significantly higher brain fluorescence intensit

172 In many LIP neurons, there was a significant trial-by-trial corr

173 tal gyrus (SFG), middle frontal gyrus (MFG), LIP, anterior intraparietal sulcus (IPSa)] that may coor

174 Moreover, LIP activity is also strongly modulated by the position

175 Moreover, LIP ultrasound stimulation significantly improved learni

176 timal decoder for heterogeneous, multiplexed LIP responses that could be implemented in biologically

177 The conserved N-LIP and haloacid dehalogenase-like domains of Pah1 are r

178 imotor-focused approach offers an account of LIP activity as a multiplexed amalgam of sensory, cognit

179 tional priority by examining the activity of LIP neurons while animals perform a visual foraging task

180 The beneficial effect of LIP ultrasound may be partly induced by upregulation of

181 Task-specific effects of LIP inactivation on blood oxygen level-dependent activit

182 f LIP ultrasound, neuroprotective effects of LIP ultrasound were evaluated with behavioral analysis,

183 g Bayesian inference from small ensembles of LIP neurons without the animal making an eye movement.

184 thors failed to replicate basic hallmarks of LIP physiology observed in those subsequent temporal epo

185 al areas (especially the putative homolog of LIP) were more strongly labeled after 6DR injections.

186 ases in distractibility than inactivation of LIP.

187 This ILC-based inhibition of LIP ensures the generation of a diverse naive T cell poo

188 e processes have enriched interpretations of LIP activity.

189 In contrast with interpretations of LIP as providing an instantaneous code for decision vari

190 egrated with other lines of investigation of LIP function.

191 cue would either shift the initial level of LIP activity before sensory evidence arrived, or it woul

192 rated a clear shift in the activity level of LIP neurons following the arrow cue, which persisted int

193 The majority of LIP cells with steady-state gain fields reflect the pres

194 ne might expect that roughly even numbers of LIP neurons would prefer each set of associated stimuli.

195 d coordination mechanism, located outside of LIP, that actively delays reaches until shortly after th

196 rection from the responses of populations of LIP neurons.

197 ce were identified within dorsal portions of LIP with peripheral representations in ventral portions.

198 paramagnetic ion, into different portions of LIP, examined the effects of the resulting reversible in

199 ariability can also improve the precision of LIP's priority map.

200 reviously showed that the mean spike rate of LIP neurons is strongly influenced by spatially wide-ran

201 -by-trial correlations of the firing rate of LIP neurons with the speed of "glissades" that occur at

202 We found that the firing rates of LIP neurons did not correlate well with the animals' beh

203 uestion, we compared the neural responses of LIP neurons in two subjects with their saccadic behavior

204 We also recorded from a broad sample of LIP neurons, including ones conventionally excluded in p

205 timulus, manifesting as a change in slope of LIP firing rates.

206 Here, we examine the specialization of LIP for categorization and the roles of other parietal a

207 odel accounts for the detailed statistics of LIP spike trains and accurately predicts spike trains fr

208 The structure of LIP population responses is therefore essential for reli

209 The suppressive surrounds of LIP neurons are spatially tuned and wide ranging.

210 ending, the responses in almost one-third of LIP neurons closely resemble the responses that will eme

211 ng CHOP-deficient cells and transfections of LIP-expressing vectors in C/EBP beta(-/-) mouse embryoni

212 This has led to the view of LIP-driven autoimmunity as a two hit model; however, not

213 After 2 weeks of LIP ultrasound, neuroprotective effects of LIP ultrasoun

214 Reexpression of LAP1 but not LAP2 or LIP restores the ability of C/EBPbeta-deficient mammary

215 mentation on ligature-induced periodontitis (LIP) and intestinal morphology in rats.

216 nd temperature Te in a laser-induced plasma (LIP), using a model free of assumptions regarding local

217 ase of the intracellular labile Fe(II) pool (LIP).

218 ometry for quantitation of labile iron pool (LIP) was performed.

219 ecies may constitute the "labile iron pool" (LIP) proposed in cellular Fe trafficking.

220 enhancing lymphopenia-induced proliferation (LIP) in vivo, and that IL-18 synergizes with high-dose I

221 ult mice, lymphopenia-induced proliferation (LIP) leads to T cell activation, memory differentiation,

222 Lymphopenia-induced proliferation (LIP) occurs when resources for T cell survival in a host

223 show that lymphopenia-induced proliferation (LIP) of CD45-sufficient T cells is defective in a host e

224 deling of lymphopenia-induced proliferation (LIP) of two distinct T cell clonotypes.

225 ontaneous lymphopenia-induced proliferation (LIP).

226 y undergo lymphopenia-induced proliferation (LIP, also called homeostatic proliferation) and develop

227 nia with respect to the factors that promote LIP as a tool to predict autoimmune potential and to inf

228 while the liver-enriched inhibitory protein (LIP) isoform negatively regulates late expression.

229 , and the liver-enriched inhibitory protein (LIP) isoform of C/EBPbeta, but not the liver-enriched ac

230 /EBPbeta, liver-enriched inhibitory protein (LIP), as a previously unrecognized transcriptional regul

231 C/EBPbeta isoform, liver inhibitory protein (LIP).

232 426 Ma was part of a large igneous province (LIP) and represents a waning stage in the emplacement of

233 oprotective effects of low-intensity pulsed (LIP) ultrasound on memory impairment and central nervous

234 an intraparietal sulcus (IPS) area, putative LIP, participates in motor decisions.

235 OT-I T cells undergo rapid LIP accompanied by differentiation that superficially re

236 and both dorsal and ventral sensory regions [LIP, IPSa, ventral IPS, lateral occipital region, and fu

237 of the ACC and two parietal saccade regions, LIP and 7a, by which their involvement in diverse tasks

238 le parietal areas (e.g., the saccade-related LIP's).

239 Here, we report LIP and FEF neuronal activities recorded while monkeys p

240 tal cortex, LIP and MIP play distinct roles: LIP appears more involved in the categorization process

241 While [S]-PM and [S]-LIP possessed longer circulation half-lives, the three p

242 ymeric micelles ([S]-PM), and liposomes ([S]-LIP), that are loaded with the HMG-CoA reductase inhibit

243 e by plaque macrophages in comparison to [S]-LIP, while [S]-PM demonstrated the highest uptake by Ly6

244 tates of both Si and C, the example of a SiC LIP is taken to illustrate the consistency and accuracy

245 s demonstrate the low dimensionality of slow LIP local dynamics, and suggest that LIP local networks

246 s suppressed by stimuli outside the RF, slow LIP dynamics markedly deviate from a single dimension.

247 in a TRAF6-dependent manner to induce slow, LIP/homeostatic-like proliferation of naive CD8 T cells

248 ells (Tregs) selectively inhibit spontaneous LIP, which may contribute to their ability to prevent ly

249 cells were unable to rescue the spontaneous LIP in the 45RAGKO mice.

250 tive consequence of unrestrained spontaneous LIP is constriction of the total T cell repertoire.

251 During later ER stress, LIP binds CHOP in both cytoplasmic and nuclear compartme

252 In early ER stress, LIP undergoes proteasomal degradation in the cytoplasmic

253 Conclusion These results suggest LIP ultrasound stimulation protects against brain injury

254 nding into the lateral intraparietal sulcus (LIP) was found.

255 ral recordings shows that, during DMC tasks, LIP and PFC neurons demonstrate mixed, time-varying, and

256 ated with the passage of time, we found that LIP activity decreased at a constant rate between timed

257 We found that LIP responses reflected a combination of temporally over

258 We found that LIP showed stronger, more reliable and shorter latency c

259 a critical prediction of the hypothesis that LIP is a source of top-down attentional signals to early

260 It is compatible neither with the idea that LIP neurons represent action value nor with the idea tha

261 This finding indicates that LIP neurons are sensitive to the motivational salience o

262 tion has been interpreted as indicating that LIP neurons encode saccadic value and that they mediate

263 lts from a variety of tasks, we propose that LIP acts as a priority map in which objects are represen

264 We show that LIP neurons exhibit integrative representations of both

265 In this issue, Fitzgerald et al. show that LIP neurons in monkeys encode categorically distinct tas

266 Here, we show that LIP neurons representing a given saccade fire strongly n

267 These data suggest that LIP activity does not represent value in complex environ

268 These findings suggest that LIP and dlPFC mediate different aspects of selective att

269 These results suggest that LIP contributes to saccade planning but not to reach pla

270 Together, these data suggest that LIP does not always favor expansion of self-specific CD8

271 We suggest that LIP is a component of a salience representation that mod

272 the selection of target-stimuli suggest that LIP is involved in transforming sensory information into

273 These findings suggest that LIP is strongly involved in visual categorization and ar

274 of slow LIP local dynamics, and suggest that LIP local networks encoding the attentional and movement

275 ct on decision-related encoding suggest that LIP plays a role in detecting target stimuli by comparin

276 This suggests that LIP activity encodes timed movements in a push-pull mann

277 This suggests that LIP plays a role in flexibly integrating task-relevant s

278 ed reward leads to lower variability for the LIP representation of both the target and distractor loc

279 However, if the LIP activity was further normalized, it became highly co

280 hemifield in the ventral subdivision of the LIP (LIPv) in both hemispheres of both monkeys.

281 bryonic fibroblasts (MEFs), we show that the LIP-CHOP interaction has a stabilizing role for LIP.

282 Thus, the LIP Fano factor reflects both stimulus and behavioral en

283 ation of endosomes for Fe(II) release to the LIP likely through RapGEF2.

284 aling, with a focus on their contribution to LIP-driven autoimmunity.

285 ed with performance in the dlPFC relative to LIP.

286 conflicting results can be reconciled if two LIP local networks, each underlying an RF location and d

287 owever, most neonatal T cells do not undergo LIP.

288 bles some recent thymic emigrants to undergo LIP and convert into long-lived memory T cells.

289 At the same time, CHOP uses LIP as a vehicle for nuclear import.

290 -related activity in parietal areas V6, V6A, LIP, and caudal intraparietal area and frontal areas FEF

291 Rather than viewing LIP-associated autoimmunity as an n-hit model, we sugges

292 found within LIP, referred to as visuotopic LIP.

293 ated activity was attenuated in MIP, whereas LIP neurons were active while monkeys communicated decis

294 To test this, we asked whether LIP neurons encode learned associations between pairs of

295 l cornu ammonis 1 region was alleviated with LIP ultrasound.

296 duces AL and alveolar bone loss in rats with LIP and 2) can protect the small intestine from reactive

297 antly greater in the BCCAO rats treated with LIP ultrasound than in the untreated BCCAO rats (mean, 9

298 accumulation in the BCCAO rats treated with LIP ultrasound was significantly (P < .05) increased by

299 factor (BDNF) in the BCCAO rats treated with LIP ultrasound were significantly higher than those in B

300 polar angle representation was found within LIP, referred to as visuotopic LIP.